A goat showed loss of appetite and astasia, and died at a goat-breeding farm in Okinawa Prefecture, Japan. The mesenteric and hepatic lymph nodes were enlarged. Histopathologically, granulomatous ileitis with ulcer formation and necrotic granulomatous lymphadenitis of the mesenteric lymph node and colic lymph node were observed. Gram-positive bacteria and
Rhodococcus (R.) equi antigens were mainly detected in the macrophages of the lesions by Gram staining and immunohistochemical staining using anti-
R. equi. R. equi was isolated from the liver, spleen, lungs, intestinal tract and mesenteric lymph nodes. All
R. equi were found to be avirulent by plasmid profiles and PCR. The present case was finally diagnosed as
R. equi infection. This is the first case of
R. equi infection in goats in Japan.
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