Japanese black cattle (16-years-old and an 8-month-old female), which was clinically diagnosed with mesenteric fat necrosis, was presented to the meat inspection center. At dismantling, multiple white nodules were found on the serosal surface of the liver, spleen, omentum, diaphragm, abdominal wall and lungs. Grossly, nodular lesions were not observed in the pre-existing bone tissue. Histopathologically, all of the tumors were composed of osteoid trabecula and osteoblastic tumor cells. Tumor cells showed low cell atypia and occasional mitotic figures, but there was metastasis in the lungs. Immunohistochemically, tumor cells showed positive reaction to osteopontin, keratin sulfate, S-100 and vimentin. Based on these findings, the present case was diagnosed as extraskeletal osteosarcoma which is relatively rarely reported in cattle.
View full abstract