[Purpose] The following experiment was conducted to examine the usefulness of percutaneous dialysis. [Method] Four normal individuals and two diabetic patients were selected and placed in a bathtub filled with 200 l of hypertonic dialysis fluid which is similar to peritoneal dialysis fluid and consists of the following substances: C6H12O6·H2O, 2.5%: NaCl, 0.538%; C3H5Na 0.448%: CaCl2·2H2O 0.025%; MgCl2·6H2O, 0.00508%. Before bathing and 30, 60, and 120 minutes later, the following parameters were examined: weight reduction, VitB12, Creatinine and Urea clearances, amount of protein transudation, blood pressure, pulse rate and electrocardiographic changes. Then, one normal subject and one diabetic patient were selected, and placed in the same bathtub for one hour a day for fourteen consecutive days. [Result] Weight reductions and clearances examined are listed below: As a result of bathing for one hour every day for a week, clearances of various substances were 15-90% of those obtained with peritoneal dialysis or hemodialysis. [Conclusion] Percutaneous dialysis may be a feasible option in the early treatment of patients with renal failure due to diabetic nephropathy.