Labyrinthotomy was performed on 2 cases of end-stage of Meniere's disease. Postoperative vesti- bular inbalance and its compensation were exami- ned for about 200 days after the operation.
The postoperative spontaneous nystagmus were recorded. Goniometer test and Fukuda's eye fol- ded vertical writing test were examined.
Results obtained were as follows :
1. Direction and continuance of the nystagmus
Duing 2 days after the operation the nystag- nnus was directed towards the unoperated side. Three to 10 days after the opertion the direfion of the nystagmus changed towards the operated side, and after that the nystagmus was directed to the operated side again.
2. Deviation of writing axis in the vertical writing test with eyes folded was directed to the same direction of the slow phase of the nystagmus and continued in parallel with the nystagmus.
3. The influence of labyrinthotomy upon gonio- metric inbalance was more manifest than upon the nystagmus.

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This experiment was performed in order to study the effect of noise given to pregnant rats and its fetuses.
White noise of 100 phone was given pregnant rats for 6 hours daily from the 1st day to the 10th day of pregnancy (A), from the 11th day to the 20 th day (B), and from the 1st day to the 20th day (C).
As stress index to pregnant rats, blood eosino- phils were calculated before and after noise-stim- ulation.
The fetuses were examined macroscopically and microscopically on the 21th day.
The results obtained were as follows:
1) In A group, the weight of fetuses were decreased and the mortality of fetuses were incre- ased.
2) In B group, the effects of noise-stimulation were scarcely observed.
3) In C group, blood eosinophils were remar- kably decreased, and growth inhibiting of fetuses and high mortality of fetuses were observed.
4) In all groups, malformation of fetuses were not observed, but there is no denying the tetragenic activity for high mortality of fetuses in C group.

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An attempt was made to explain the reason why the temperoture and humidity of the inspired air in the nasal cavity rise, by applying the theory of alternating contact between water and air.
From these considerations it was concluded that the heat and the humidity of the air in the nasal cavity rise pattly due to the moisture of the exspired air remaining in the nasal cavity and mostly due to vapor emitted at the inferior tubinate caused by the decleine of the relatuie humidity of the inspired air due to heating the air at nostril.
It also facilitates the rise in temperature and hummidity in a very short time.
Moreover, my calculation on the varions accascons proved that the postine and negative presure formation in the nasal cavity held in breathing helps the formation of the respired air stream in it, and has no connection with the heating and the humidification of the inspired air.

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The author had reported two princiles in construction and reaction of the lumen organ (middleear, paranasal sinuses, lung and salivary grand) in the foregoing reports. In this paper an atempted was made to find these principles in the paranasal sinuses.
The first principle is as follows;
The lumen organ consists of two forms, namely cell form and antrum form. And the organ in which the cell form is demonstrated markedly is recognized as well developed, on the contrary the organ in which the cell form is reduced and the antrum form is expressed makedly is recognized as underdeveloped. The well developed organ posesses the strong potentiality in reaction against stimuli and in its regeneration. This principle fits also to sinus and sinuitis. In chronic sinuitis the well developed sinuses revealed edematous hyperplasia and the underdeveloped sinuses fibrous change.
The second principle is as follows;
The lumen organ consists of canal part and chamber part, the latter consists of cell and chamber as mentioned above. In these two parts there exists the csrresponding relation in the developement of these parts. If the chamber part reduces its lumen size, the canal part becomes enlarged, on the contrary if the chamber part develops well, the canal part becomes atrophy.
This principle also fits the sinus. The foramen and ductus of the sinuses are smaller in the large sinuses than the small one. Therefore the large sinuses reveal disposition to stenosis of the foramen or the ductus, resulting in prulent sinusitis or mucocoele.

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Forty-seven specimens of the maxillary sinus cancer removed en bloc with the normal suround- ing tissues were observed macroscopically and his- tologically by means of large section.
The sections were made in mass without sepa- rating organs or tissues of the specimens.
18 cases of those observed were preoperatively irradiated. The specimens were investigated from the points of view of the effect of the preoperative irradiation, invasion of the cell into the bone, the periost, surrounding tissues as such fatty tissues, muscles, etc. and compared with their clinical fin- dings.
The results obtained were as follows.
1) 40 squamous cell carcinomas, 3 basal cell and 4 adenocarcinomas were found in the specime- ns. There was no significant relationship between their histological types and prognosis.
2) In the preoperatively non-irradiated cases, higher structural atypism, smaller alveolar struc- ture, irregularity of cellular structure and direct bony destruction by cancer cells had bad influences upon their prognosis. While in preoperatively irradiated cases, the differences in histological fin- dings were not concerned with their prognosis.
3) In many cases cancer had already destroyed the walls of the maxillary sinus, especially the na- sal wall and posterior wall (85% of the cases).
4) In 12 cases there were submaxillar lymph node metastases and in 4 cases laterocervical lymph node metastases. Their prognosis was worse than those without metastases.
5) The cases undergoing sinectomy, polypoto- my, extraction of teeth, incision of the palate be- fore adjust treatments, also had worse prognosis. In such cases histologically severe invasion into the surrounding tissues were observed.
6) Thickning of the periostal layer on the outer side of the sinus wall were observed in ma. ny cases, and those cases had good prognosis.
7) The preoperative irradiation (4000r) resul- ted into degeneration and necrosis of the cancer cell, the increase of the connective tissues thickning of the periostal layer on the outer side of the sinus wall destroyed by cancer and decrease of the can- cer in size. 18 months after the treatment 66.6% of preoperatively irradiated cases was free of recu- rrences. There were marked differences in progno- sis between the irradiated and non-irradiated cases (35.0%).

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The lymphatic flow in the head and neck was investigated, by avoiding with every possible means the artificial disturbance of the flow, for diagnosis and treatment of metastasis of malignant tumors of the head and neck.
After injection with tracer dosis of radiogold in the various parts of the head and neck in human, with or without tumor, dogs and rabbits, scintiscan- ning of the neck and measurement of radioactivity of the extirpated lymph nodes were performed. From the results of the experiments the following conclusions could be drawn :
1) 20_30% of the injected radiogold was up- taken by the regional lymph nodes of the injected area. The factors which influence these up-takes were density of the lymphatic nets, specific weight and number of the regional lymph nodes and mo- bility of the injected area. The distribution of the gold in the nodes can be informed in quantity and located by the method of scanning.
2) According to the pattern of the pick up, the cervical lymph nodes were divided as follows submental, submandibular; upper-, lateral- and fro- ntal neck; upper-, mid- and lower jugular and supraclavicular nodes. The upper neck nodes, ref- eied by the author, included the preauricular, retropharyngeal and uppermost groups of the jugular nodes. The upper jugular nodes were both the so- called principal node of the tongue and its surrou- nding nodes. The mid-jugular nodes were suprao- mohyoid node and its surrounding nodes.
3) The lymphatic drainages of the head and neck always pass through the upper jugular nodes or the nodes below these. Therefore the amount of the lymphatic flow along the internal jugular nodes was most prominent comparing with the flow of the other routes. The farther the cervical nodes situated from the jugular vein, the lesser the lymph flowed to the nodes.
4) The majority of the flow to the upper neck nodes came from the external meatus, parotid gland, nose, palate and tonsil. The flow to the lateral neck nodes mostly did from the external meatus and parotid gland; to the frontal neck nodes from the larynx and trachea; to the submandibular nodes from the major salivary glands, cheek, nose, palate, lip, gingiva, tongue and floor of the mouth. The contralateral neck flow was observed in the tongue (except its margin), floor of the mouth, floor of the nose, the septum, palate, pharynx, larynx and trachea.
5) The larynx of dogs was divided in five compartments according to its lymph flow: two supraglottic plus marginal; two glottis; one subg- lottic area. The lymph from each compartment flows chiefly to the l omolateral nodes but also u little extralaryngeally (supraglottic, glottic and su- bglottic compartments) and intralaryngeally (subg- lottic compartment) to the contralateral nodes.
6) Intrinsic factors which change the normal lymphatic flow were the primary tumors and the number, location and size of the metastatic tumors, located at the passways of the flow. Extrinsic factors were radiation, mechanical procedures (ope- ration or massage of the neck) and so on. Unilat- eral radical neck dissection caused an increase of the flow to the contralateral nodes.

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We must consider how autonomic nervous sys- tem modifies or influences the results of the test in the vestibular function test.
From this point of view, I have examined 48 (men and women) adults who subjectively and objectively have normal hearing abilities and equ- ilibrious functions.
First, I have classified them into two groups, one is the stable and the other is unstable groups of autonomic nervous system and then have made the so called vestibular labyrinthine function test: vertical writing with covered eyes, rotation test and caloric test.
The conclusions were as follows ;
In unstable groups, the results of the test show longer average duration of after-nystagmus than in stable groups. Therefore, when we examine the so called vestibular test we must consider the subject's condition of the autonomic nervous system.

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