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69 巻, 2sup 号
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小田 雅義1966 年 69 巻 2sup 号 p. 1-10
発行日: 1966年
公開日: 2008/03/19
ジャーナル フリーThere are various therapeutic measures avai lable for malignant tumors, e.g., surgical removal. radiation therapy, chemotherapy, endocrinotherapy, and immunotherapy. Of these, surgical treatment is now unquestionably the most reliable one, and radiation therapy has also become effective enough to give results almost similar to those with the former. But, now when it is generally accepted that malignant tumors, once passed a certain definiteperiod of standing, should be considered as not a local but systemic disease some other systemic therapy should of course be given in combination with these two measures, since they are no more than a local treatment. Nowaday, chemotherapy aiming at the direct inhibition of malignant cells is the most suitable means for the general treatment of cancer, and is going to become the third major therapeutic measure against cancer, having made a considerable progress in recent years.抄録全体を表示PDF形式でダウンロード (2575K) -
主として動脈内注入法について鈴木 安恒1966 年 69 巻 2sup 号 p. 11-19
発行日: 1966年
公開日: 2008/03/19
ジャーナル フリーWe have treated ninety patients of malignant tumors of the head and neck by intra-arterial infusion for the past three years.
The retrograde catheterization of the superficial temporal artery was performed in most cases, by inserting a polyethylene tube of appropriate size until the tip of the tube was placed in the external carotid stream.
The drugs administered and daily doses of them are as follows : Toyomycin (chromomycin A3) 0.5_??_1.0mg/day, Mitomycin C 2.0_??_4, 0mg/day, Endoxan (cyclophosphamide) 100-.200mg/day.
A course of therapy mainly consisted of fractionated intra-arterial infusion of one of these drugs for 10-..14 days.
Out of 90 patients, 75 were evaluated for anticancer effects. Results obtained show that sixteen patients had significant regression of the tumor and thirty-four had partial regression or subjective improvement. Sixty cases were treated by infusion chemotherapy, as an adjuvant method of surgery and most of them were suffered from malignant tumors of maxillary sinus.
Seventeen patients were treated by the combined therapy of irradiation and intra-arterial infusion, followed by surgery in many cases. We selected, if possible, an anticancer drug according to the result of SDI test, which is one of sensitivity tests of anticancer drugs.
We measured serum lactic dehydrogenase activity in many cases before and after infusion, which decreased in most cases when the tumor regressed markedly after infusion.
We conclude that infusion chemotherapy is effective to malignant tumors of the head and neck, as an adjuvant method of irradiation or surgery, especially well indicated for malignant tumors of maxillary sinus and nasopharynx.抄録全体を表示PDF形式でダウンロード (1704K) -
手術,放射線治療との関連について佐藤 靖雄, 森田 守, 高橋 広臣, 林進 武, 鷲津 邦雄, 安河 内浩, 赤沼 篤夫1966 年 69 巻 2sup 号 p. 20-45
発行日: 1966年
公開日: 2008/03/19
ジャーナル フリーBecause there is no anticarcinoma agent which is one hundred per cent effective, various method of administration have been deviced to make those agents which are available more effective.
One of them is intraarterial administration of the agent by the regional blood supply of the tumor.
This is the best way, because it will be able to bring the large dose of drugs to the tumor and it produces least leucopenia.
But the regional chemotherapy by itself cannot substitute the surgery or radiotherapy. The way to combine these modalities differs according to the location, extension or sensitivity of the tumor.
To the carcinoma of the paranasal sinuses, better results were shown by intermittent infusion of radiosensitizing agents to the internal maxillary artery and simultaneous external irradiation followed by surgery, if necessary. The advanced intraoral carcinoma was treated by continuous infusion of radiosensitizing agents combined with interstitual radiotherapy such as radium needling.
The carcinoma of the larynx which had not been cured by external irradiation alone was perfused by anti-carcinoma agents to eradicate the dissemination of carcinoma cells prior to extirpation of the tumor.
In order to make combination therapy more effective, infusion of radiosensitizing agents and irradiation had to be given simultaneously. Besides, more care had to be taken of local and systematic condition of the patient, because the tumor went down to necrosis more rapidly than irradiation alone and the existance of this necrotizing tissue made the therapy less effective.
By combining irradiation with regional chemotherapy, the surgical procedure as well as the dose of irradiation was able to be minimumized.
Thus, in a number of cases of the paranasal sinuses, the orbital contents and/or the hard palate which had been thought to be removed were saved at the time of operation.
COPP and 5-FU were used as the radiosinsitizing agents; the former is given 25mg daily andthe latter 250mg. The daily tumor dose averaged 200rads. Of the group in which tumor disappeared by the combination therapy of infusion times (T) and the radiation dose (D) appeared as follows: D= 12000T-0.25. From the cases of good prognosis for about one year, the relationship between T and D was obtained as D=14000T-0.22. In cases in which complications or the recurrence of the tumor appeared, the function was shown as D=9000T -0.19. These functions showed that the radiotherapy was more effective than the regional chemotherapy.抄録全体を表示PDF形式でダウンロード (8301K) -
佐々木 寛, 涌谷 忠雄, 近藤 斉, 岡田 不二雄, 織田 鹿之1966 年 69 巻 2sup 号 p. 46-50
発行日: 1966年
公開日: 2008/03/19
ジャーナル フリーThe administration of anti-cancer agents into the external carotid artery has been performed on 29 cases of advanced maxillary cancer since December 1962 as an supplemental means to radical operation or radiation therapy on these cases.抄録全体を表示PDF形式でダウンロード (395K)
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