Clinical and histopathological investigations were pergormed on 30 cases of laryngeal carcinoma. sections, including both the central and peripheral tissues of carcinoma, Were cut from each mass, obtained by total laryngectomy from the patients. The results were as follows :
1) There are four main routes of spreading of laryngeal carcinoma outside the larynx: into the pyriform sinus and lower pharyngeal region, into the preepiglottic space, into the frontal region of the larynx by destroying the middle part of the epiglottic space is most frequent, in this case high possibility of metastasis into the cervical lymph node owing to lymph flow in that region. On account of these, hyp-preepiglolaryngectomy is necessary in the case of the upper type laryngeal carcinoma.
2) When the carcinom has originated in the anterior commisure or is sprading into it cancerous infiltration reaches unexpectedly deeper.
3) When the larygeal cartilage is destroyed by carcinoma, the frequency of destruction is in the order of thyroid cartilage, epiglottic cartilage, lel relation is observed between the fraeqency of cartilage destruction, degree of development and malignancy of carcinoma.
4) Out of epithelial changes in the trnasitional part, simple epithelial proliferation is most frcque-nt, Besides this, infiltrating, destructive and atro-phic epithelial proliferation as well as normal epithelium are seen in several cases.
5) As for interstitial reaction to carcinoma, it is considered to inhibit its growth in iome way. And prognosis can be made to a certain degree by means of degree of developmet and interstitial reactivity.
6) For the prognosis of laryngeal carcinoma, it is necessary to take into consideration not only the result of histopathological investigations such as the above mentioned but also clinical findings such as the original site, type, range of invasion, tion, sensitivity of cancer cells to radiation and ver, difficult to expect evpect exact exact prognosis even by these means, and may problems await future studies.
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