日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
89 巻, 6 号
選択された号の論文の10件中1~10を表示しています
  • 吉田 太, 森川 郁郎, 進武 幹, 松尾 浩一, 富田 まり子, 仲秋 功司
    1986 年 89 巻 6 号 p. 689-694
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Pleomorphic adenoma in the neck is extremely rare, and has not been reported in Japanese literature. This paper describes two cases of the pleomorphic adenoma in the neck.
    Case 1: a 56-year-old woman had a painless mass in the right upper neck, located about 3cm. below the mandible on the anterior border of the sternocleidomastoid muscle and lateral to the internal carotid artery. Case 2: an 81-year-old woman had a painless mass in the left upper neck, located beneath the sternocleidomastoid muscle, and slightly posterior, at the angle of the mandible and mastoid process.
    Surgical treatment was performed on both patients, and histological findings showed pleomor-phic adenoma.
    Only 19 cases of pleomorphic adenoma in the neck have been reported up to date. In this paper, etiology, age, sex, location of the tumors, clinical symptoms and treatment modalities were discussed.
  • 第3報 自発放電の規則性と回転刺激に対する反応の関係について
    八木 聰明, 上野 博史
    1986 年 89 巻 6 号 p. 695-698
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Physiological characteristics of first order horizontal canal neurons, especially the relationship between their spontaneous activity and response to angular acceleration were studied in 20 albino guinea pigs. The average resting ISI was 48.9ms and this was clearly lower than that in pigmented guinea pigs. The neurons differentiated into three groups according to their CV values. These called regular, intermediate, and irregular neurons. The average resting ISI of these three groups were 19.9, 32.9, and 124.8ms. respectively.
    The responses to sinusoidal rotation were similar to those found in pigmented guinea pigs and other spieces. That is the regular neurons tend to have lower gains re angular velocity (average-ing 0.16 spikes/sec/deg/sec) and a longer phase lag re acceleration (averageing 93.1 degrees), and the irregular neurons show higher sensitivity re angular acceleration (averageing 0.6 spikes/sec/ deg/sec) and shorter phase lag re acceleration (averageing 72.7 degrees) at a stimulus frequency of 0.3Hz.
  • 高橋 光明
    1986 年 89 巻 6 号 p. 699-705
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    A permanent cell line (AT-MS-1) has been established from a maxillary sinus squamous cell carinoma of the patient (K.I.) and the monoclonal antibodies against maxillary sinus carcinoma cells were generated using the AT-MS-1 cells. AT-MS-1 has been passaged 68 times during 26 months.
    The doubling time of this cell lines is approximately 43 hours.
    In nude mice, AT-MS-1 produced a growing tumor with distinct histological features of squamous cell carcinoma.
    Antibodies-secreting hybridomas were generated by fusion of mouse myeloma cells with mouse spleen cells immunized with the AT-M-1 cells.
    The supernatants of hybridomas were tested against a panel of aceton-alcohol fixed monolayer human cells by indirect immunofluorescence analysis and examined against T cell, B cell and myeloid cell lines using cellular radioimmunoassay.
    The positive supernatants were further examined on tissue sections with immunoperoxidase technique.
    The monoclonal antibody 10B2 reacted with maxillary sinus carinoma cells and did not react with stroma, infiltrating cells and mucous epithelium.
    Monoclonal antibody 10B2 is a useful antibody to discriminate maxillary sinus carcinoma cells from nomal maxillary sinus cells.
  • 異聴地図とDLSI不定幅にみる特徴
    細井 裕司, 西前 忠英, 村田 清高, 太田 文彦, 今泉 敏
    1986 年 89 巻 6 号 p. 706-714
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Abrupt high tone loss in perceptive hearing-impaired patients were investigated by means of Bekesy's self-recording audiometry, DLSI test and a Japanese monosyllable speech audiometry. Two new methods were applied for evaluations of DLSI test and the speech audiometry. Statisti-cal observations were made in regard to the cut-off frequencies, the reduction on the amplitude of the continuous tracing and the gradient of steep incline portion by Bekesy's self-recording audiometry. No case showed any abnormal DLSI values which suggested the retrocochlear lesions. Also there was no case showing abnormal low speech cognitive ability indices which were proposed in our previous paper. Therefore, there would be little possibilities of retrocochlear lesions in subjects showing this type of hearing impairment.
    Two new methods were also applied to these patients. Comparative study of DLSI value and newly proposed the width of uncertainty in DLSI was carried out in lower and higher frequencies than cut-off frequency. The width of uncertainty in DLSI may represent a part of feature in this type of hearing disorder from the results of this comparative study. Each patient's confusion chart was made by using the speech chart on which each patient's confusion was superimposed and drawn. The tendency of confusion was examined by making the confusion charts according to each cut-off frequency group respectively, and characteristics of confusion were clearly identified. As a conclu-sion, all the results in this study indicated that the main lesion of this type of hearing-impaired patients located at in the inner ear.
  • 杉田 公一
    1986 年 89 巻 6 号 p. 715-723
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Since detailed analysis on the structure and property of mucin in human nasal secretion has not so far performed due to the difficulty of its solubilization, we aimed to investigate the solubilization and the carbohydrate composition of the mucin to clarify the function and the possible involvement by pathological conditions.
    Nasal mucopurulent secretions obtained from patients of chronic sinusitis (17 cases, 30ml, dry weight 1650mg) were solubilized with 5mM EDTA-containing phosphate buffered saline (PBS, pH 7.4), and the insoluble materials which were hardly solubilized under the above condition, were solubilized with 8M urea in PBS. According to the two step solubilization procedures, almost all of the nasal secretions could be solubilized and the recoveries of dry weight, protein, hexose and sialic acid were 92.9%, 71.5%, 96.4% and 92.9%, respectively. The soluble fraction with EDTA-PBS and the fraction solubilized with urea-PBS (insoluble fraction) were fractionated by Sepharose CL-4B column chromatography and the mucin fractions in the void volume, which contained glycoprotein with the molecular weight of more than 105 daltons, were collected. Both mucins retained on a DEAE Sephadex A-25 column, indicating that the majority of the mucins are negatively charged, and their purity and molecular weights were confirmed by SDS-Polyacrylamide Gel Electrophoresis.
    In addition, carbohydrate compositions of both soluble and insoluble mucins were determined by gas-liquid chromatography. Molar ratio of carbohydrates in the soluble mucin was Fuc: Man: Gal:GaINAc:G1cNAc:NeuAc=2.31: 0.13:4.36:0.99:1.81:1, and that in the insoluble mucin was Fuc:Man:Gal:Ga1NAc:G1cNAc:NeuAc=1.93:0.33:5.68:2.63:5.44:1. The difference between the two mucins with different solubilities was suggested to be mainly due to the aminosugar, which mediate the formation for intra-and inter-molecular linkages to give the viscous nature of the mucin.
  • 鶴田 至宏, 佐藤 武男, 宮原 裕, 吉野 邦俊, 馬谷 克則
    1986 年 89 巻 6 号 p. 724-730
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Ninety two cases of salivary gland tumors surgically treated since January, 1979 to December, 1984 in our clinic are reported. They were composed of 66 cases of benign tumors and 26 cases of malignant tumors. Salivary gland malignancies constituted about 3 % of all head and neck malignancies.
    Salivary gland tumors were composed of 57 parotid gland tumors, 19 submandibular gland tumors and 16 minor salivary gland tumors and incidence malignant tumors in each region were 19%, 42% and 44%. Later two regions were found significantly different from parotid gland.
    Pleomorphic adenomas were the common of all tumors, which comprised 81% of benign salivary gland tumors. Adenoid cystic carcinomas and adenocarcinomas were most frequently encountered malignancies; the former in submandibular gland and minor salivary gland, and the latter in parotid gland.
    Malignant tumors were significantly more common in men than women. It was characteristic of patients with malignant tumor, as compared with patients with benign tumor, that average age at first examination was about 60 year-old, that interval from onset was short, and that facial palsy, pain and adhesion were observed.
  • 広田 佳治, 清水 弥生, 大澤 博之, 飯沼 壽孝
    1986 年 89 巻 6 号 p. 731-735
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Fifty nine cases of frontal mucocele were studied using clinical informations such as age, gender, side, mode of onset, clinical signs and symptoms, and X-Ray findings. Mucoceles were classified into idiopathic and postoperative groups. Female and left preponderance was dominant in the idiopathic group. An average age for the mucocele surgery was 50. Clinical signs were classified into inflammatory and compressive signs. Inflammatory signs were dominant in the postoperative group, and more compressive signs were dominant in the idiopathic group. Using frontal section films obtained by Polytomography, transverse diameters of the frontal sinus and transverse diameters of frontal mucoceles in the control group (70 sides of adult frontal sinuses without mucocele) were evaluated and compared. The control group showed larger sinus on the left. Left side preponderance of the idiopathic group suggests that this type of mucocele prefers larger frontal sinus.
  • 活性化リンパ球による抗腫瘍性
    武田 哲男
    1986 年 89 巻 6 号 p. 744-753
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Activation of peripheral blood lymphocytes (PBL) from patients with head and neck malignant tumors in human recombinant interleukin 2 (rIL-2) containing complete medium were tried for expression of the lymphokine activated killer (LAK) cells. The cytotoxic activity toward human maxillary sinus carcinoma cell line (OKK-1), human laryngeal carcinoma cell line (LCT-6) and fresh autologous carcinoma cells were tested in 5 hours 51chromium release assay.
    Anti-tumor efficacy of LAK cells and rIL-2 administration to the BALB/c nu/nu mice transplanted LCT-6 carcinoma were observed.
    The results obtained were as follows:
    1. Lymphokine activated killer cells from patients with head and neck malignant tumors or normal individuals resulted in expression of cytotoxicity toward OKK-1, LCT-6 cell lines.
    2. Fresh solid maxillary sinus carcinoma cells were resistant to autologous fresh PBL, but were lysed by autologous LAK cells.
    3. Local transfer of human LAK cells plus systemic rIL-2 administration could mediate the restriction of tumor growth and the elongation of survival rate in LCT-6 transplanted mice.(p<0.05) No restriction of tumor growth was observed in any of these mice treated with either LAK cells alone or rIL-2 alone.
  • 末梢前庭障害における左右方向別動揺速度について
    山本 昌彦
    1986 年 89 巻 6 号 p. 754-762
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    The bodily sway may be quantitatively evaluated in detail when the data are subjected to a computer analysis. Such analyses are feasible for diverse aspects of the phenomenon of "bodily sway" including the distance, extent, direction, velocity, acceleration velocity, and power spectrum. Among these, our interest has been to investigate the change in velocity of laterally-directed bodily sway in vestibular disorders and its correlation with the direction and magnitude of nystagmus. When our velocity analysis method for 8 directions was employed, there was a close correlation between the velocity of lateral sway and the direction of nystagmus when the eyes were closed.
    This report deals with velocity of the bodily sway and lateralized velocity, correlatively studied in patients with peripheral vestibular disorders.
    In acute monophasic peripheral vestibular disorders, the velocity of lateral bodily sway and the difference in counter-directed velocity were both greater than the corresponding control value. However, even among patients with acute vestibulopathies, patients during the first attack and those during an episode of repeated attacks showed a different response; specifically, for those who were in an acute phase of repeated attacks, the bodily sway to the lateral directions was smaller while the nystagmus appeared to be the same in intensity. In bilaterally-involved vestibulopathies in which caloric response was moderately reduced, the velocity of lateral bodily sway and the
    velocity difference were close to a normal value. Those patients who did not respond to 50ml of ice-cold water introduced into the each external meatus and were Romberg phenomenon positive, revealed a large lateral sway velocity, while the velocity difference was rather small both when the
    eyes were opened and closed. Therefore, the postural controls may be maintained rather effectively even in those with bilateral vestibulopathy when the caloric response is only modestly or moderately impaired. These results indicate that the bodily sway as assessed by the velocity of lateral directions and the velocity difference should be interpreted in a different way.
  • 単発矩形波励振による共振特性
    増田 卓
    1986 年 89 巻 6 号 p. 763-773
    発行日: 1986/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Investigation on the mechanical properties of the vocal fold and its change at various phonation is very important to elucidate the nature of the vibration system of the larynx.
    In the present study, resonance characteristics of the human vocal fold in vivo were measured. Oscillation waves of the vocal fold evoked by a single rectangular pulse (0.5msec.) were picked up by am ultrasonic uariant M-mode. These oscillation waves were analysed by a wave analyser with fast Fourier trasnform and the resonance frequencies were obtained.
    The following items have been examined:
    1) Resonance patterns of the vocal fold at various phonation neurtal gesture (without expiratory air flow).
    2) Sex related differences in the resonance pattern of the vocal fold during "quiet" respiration.
    The results were as follows:
    1) It was observed that there existed at least two resonances, which significantly shifted at each frequency of phonation. The lower one was very close but a little lower than the frequency of phonation and tended to closely correlate with the frequency. The higher one was observed in the range lower than the second harmonic of the lower one and directly proportional to the frequency of phonation. The rising rate of the lower resonance was gradually reduced when the phonation pitch became higher than 200Hz. Another weak resonance was constantly observed at around 100Hz when the phonation pitch became higher than 150Hz.
    2) In male adults, the means of the lower and higher resonance frequencies were 92.3Hz and 173.9Hz. In female adults, they were 100.7Hz and 194.3Hz, respectively. These results indicated that both resonance frequencies were significantly lower in males than in females.
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