日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
94 巻, 8 号
選択された号の論文の13件中1~13を表示しています
  • 側頭骨病理学的研究
    上房 啓祐, 児玉 章, 石井 哲夫
    1991 年 94 巻 8 号 p. 1079-1083
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    The purpose of this study is to examine the relation of the grade of the inflammation of the middle ear and the pathological findings of the tympanic membranes using human serial holizontal sections from 16 temporal bones with otitis media with effusion. As controls, we used 96 normal temporal bones. The results were as follows.
    1) In cases with a lot of inflammation cells in the middle ear effusion, there were seen much pathological changes in the epidermal layer and the intermediated layer.
    2) In the pars flaccida and the posterior point of the malleus handle were noted remarkable changes.
    3) The greater part of the cells of the middle ear effusion was neutrophils.
  • 本多 徳行, 斎藤 等, 鳶山 裕彦, 野条 良彰
    1991 年 94 巻 8 号 p. 1084-1097
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    The ototoxicity of aminoglycoside and anticancer platinum drug was analysed using an organ culture system. The effect of calcium antagonism on aminoglycoside ototoxicity was investigated by the same system.
    The inner ears of mice, 16-day embryos, were cultured for 5 days with or without gentamicin (GM) or kanamycin (KM) or streptomycin (SM), or ribostamycin (RSM), including 1, 10, 100, or 1000 pg/ml respectively. The 21th gestational day-inner ear was cultured in vitro during 4 days with or without Cisplatin (CDDP) or platinum analog DWA2114R (DWA), including 0. 1, 1, or 10 μg/ml, respectively. The 16th gestational day-inner ear was cultured in vitro for 5 days with 10 μg/ml KM, adding 5mM Ca2+ or 10mM Ca2+ to the culture medium.
    The damages of crista ampullaris and macula utriculi of cultured inner ear were estimated according to the ototoxicity score based on morphological changes by a light microscopic observation of serial sections of the materials. We difined four grades for the damages according to the following criteria ; grade 1: damage of apical surface of the hair cells, grade 2: the existence of debris in the emdolymph space, grade 3: disappearance of the hair cells, grade 4: degeneration of the supporting cells.
    Uning this system following results were obtained: 1) the effect of aminoglycoside was dose dependent, 2) the order of ototoxicity was following ; GM> KM>SM> RSM, 3) the drug concentration of 1000 μg/ml is sufficient to study its ototoxic potential in this system, 4) the effect of both CDDP and DWA was obvious at a concentration of 0.lug/ml, 5) DWA showed almost the same ototoxicity as CDDP at the same concentration, 6) Adding 5mM Call or 10mM Cal' to the culture medium, the ototoxic damage induced by 10μg/ml of KM was not noticed. A protective effect of Ca2+ against KM ototoxicity was observed in vitro.
    This organ culture and ototoxicity score system can serve as a useful and adequate model system for evaluating the ototoxicity.
  • 野田 哲哉
    1991 年 94 巻 8 号 p. 1098-1103
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Body sway in normal subjects was analyzed by means of various methods to study a role of cervical muscles in galvanic body sway test. Galvanic stimulation through the retro-auricular electrode induced an initial response and a deviation response in body sway.
    When the anodal stimulation was given through the right retro-auricle during standing, a deviation response toward the right side was obseved. While keeping a posture weighted on one foot, the stimulation induced a similar response. The stimulation during squatting produced also a deviation response toward the right side. When the head was rotated to the right, the stimulation produced backward responses. When rotated to the left, it produced forward responses. Even without galvanic stimulation, similar responses were also induced by some other method, for example, inclining the head to one side. Galvanic stimulation while sitting resulted in slight but apparent head inclination.
    The results suggested that cervical muscles played an important role in galvanic body sway test. Initial and deviation responses appeared to be secondarily produced by changes in the cervical muscular tension.
  • 頭頸部に原発した65例の扁平上皮癌進行例における検討
    西罵 渡, 竹生田 勝次, 臼居 洋行, 根岸 達郎
    1991 年 94 巻 8 号 p. 1104-1112
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    From April 1985 to December 1989, 65 patients with advanced head and neck squamous cell carcinoma, underwent simultaneous bilateral neck dissection (SBND) at Saitama Cancer Center. Three and five year survival percentages were 53 and 42%, respectively. In patients without histologic involvement of cervical nodes, five year survival rate was 83%, whereas in those with nodal involvement five year survival fell to 32% (p<0.005). The conclusion were the following:
    (1) Of 38 patients diagnosed to have lymph node involvements on one side of neck before operation, 8 patients (22%) were found to have bilateral lymph node metastasis in clinicopathological study. Of 13 patients having no clinical lymph node metastasis on both sides of neck, 7 patients (54%) were found to have unilateral lymph node metastasis. Of 16 patients diagnosed to have bilateral lymph nodes involvement, 10 pateints were found to have bilateral neck metastasis and 2 had unilateral neck metastasis.
    (2) Of 35 cases of hypopharyngeal caners, 19 cases had clinicaly positive lymph nodes on one side of neck. Of these 19 cases, 5 cases (26%) had histologically positive nodes on the opposite side. 14(40%) of 35 cases had metastasis on the opposite side.
    In conclusion, SBND is a proper treatment for metastatic cervical cancer from a primary lesion of the head and neck, especially in hypopharyngeal cancers, because the rate of reccurence seems to be related more to the difficulty in controlling lymph node metastasis than to the failure in treatment of the primary cancer.
  • 阿部 能之, 荻野 敏, 入船 盛弘, 松永 亨, 今村 育男, 福井 裕行, 和田 博
    1991 年 94 巻 8 号 p. 1113-1122
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Histamine(HA) is the most important mediator of nasal allergy and nasal hypersensitivity. To investigate HA metabolism, HA content and activities of its synthetic enzyme, histidine decarboxylase (HDC) and degrading enzymes, histamine-N- methyltransferase (HMT) and diamine oxidase (DAO) in nasal mucosa of human and toluene diisocyanate (TDI) sensitized guinea-pigs were measured.
    In human nasal mucosa and nasal polyps, HA content and HDC activity were 80-200nmo1/g tissue, 20_??_30fmol/min/mg protein respectively. Among two degrading enzymes, HMT activity was 20_??_200times higher than that of DAO.
    In the nasal mucosa of guinea-pigs, HA content was significantly increased by TDI sensitization, and was decreased immediately after TDI provocation. In 24 hours after provocation, HA content recoverd to 80% of pre-provocation level. HDC activity increased by TDI sensitization significantly. Though HMT activity increased slightly by TDI sensitization and provocation, DAO activity was unchanged. The data suggest that, increase in turnover rate of HA is present in allergic nasal mucosa.
  • 広田 佳治, 竹内 直信, 石尾 健一郎, 高砂 江佐央, 北原 伸郎, 飯沼 壽孝
    1991 年 94 巻 8 号 p. 1123-1135
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Thirty-four cases of blow-out fracture were evaluated by high-resolution CT, Hess test for red and green color and synoptophore. The results of these tests were compared with the final outcome of the fractures. The fractures were classified on the basis of the location (floor, medial wall or roof), extent (total, partial or linear) and type of fragments (punched-out or trapdoor). The medial wall type included many cases (33%) with no complaint of double vision, and many cases with a combination of disturbances in ocular mobility in both the horizontal and vertical directions. The floor type showed a low incidence of disturbances in ocular movement in the horizontal directions. Regarding the extent of the fracture, all cases with the total type showed disappearance of double vision within three months. Many of the partial and linear types had a poor outcome. With regard to the type of fragments, all of the trapdoor type cases showed a favorable result with disappearance of double vision within three months. Some of the punched out type cases, however, showed a poor outcome.
  • 熊川 孝三
    1991 年 94 巻 8 号 p. 1136-1141
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Immediate recall of serial 6 digits was examined in order to clarify whether the electrical information heard via a 22-channel cochlear implant can give rise to normal acoustic memory or not. Serial 6 digits were generated randomly using the digits 1 through 6. Following results were obtained in 2 patients with the implant prosthesis.
    1) There was a normal primary effect, i.e., good performance of recall at the first or two digits, and also a normal recency effect, i.e., an increased probability of recall at the last one or two digits.
    2) There was a normal suffix effect or attenuation of the recency effect when the digits were followed by an another irrelevant speech suffix, the " 8 "
    3) The suffix effect, however, was not observed when the digits were followed by a non-speech noise suffix. Thus, in noise suffix mode, probability of recall was increased at the last one or two digits as similarly with in no suffix mode.
    The primary effect, the recency effect and the suffix effect are already regarded as the characterictic items of acoustic memory produced in subjects with normal hearing ability. Therefore, it was suggested that a speech perception with a 22-channel cochlear implant prosthesis can produce an normal acoustic memory, and that there is a similarity of neurophysiological functions between natural audition and electrical audition. Moreover, it was demonstrated that the patients with the cochlear implant can distinguish between speech and noise.
  • 古賀 慶次郎, 川城 信子, 荒木 昭夫, 渡辺 誠
    1991 年 94 巻 8 号 p. 1142-1145
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    In April 1989 the MMR VACCINATION program had started, and until Octorber, 1989, 630, 000 children received vaccination. In is, however, well known that many children developed various complication including aseptic meningitis after vaccination, and the MMR vaccination program has discontinued. This report described a case of bilateral acute profound deafness most likely due to MMR vaccination.
    The cause of this deafness was presumed to be mumps vaccination. The bases of the presumption are as follows: the meningitis after MMR vaccination was elicited by PCR method to be caused by mumps vaccine, and the complication of CNS after measles vaccination occurs within 14 days after injection, while the onset of vomoting and gait disturbance of the case was 24 daysafter vaccination.
  • 外鼻に発生した多形性腺腫の1例
    安部 治彦, 井上 都子
    1991 年 94 巻 8 号 p. 1146-1150
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    A rare case of pleomorphic adenoma in the external nose is reported. As a result of studies on the correlation between the sites of occurrence of pleomorphic adenomas reported and the sites of secretory glands with myoepithelial cells, it is found that pleomorphic adenomas occur in all secretory glands with myoepithelial cells. There are distinctive differences in the incidence in each part of the body, and in the hollow organs in the digestive and respiratory tracts: it is high in the face and decreases as the sites become farther away from the face. In the integumentary system, it is also high in the face. However, pleomorphic adenomas occurring in secretory glands without myoepithelial cells, and in non-glandular tissue such as the middle ear, paranasal sinuses, mesangial sinuses, vagina and tests can be considered either as those where glandular tissue and myoepithelial cells mingled during development (and thus are ectopic) or as those when invasion into adjacent organs occurred as the pathologic lesion (pleomorphic adenoma) expanded.
  • 星川 智英
    1991 年 94 巻 8 号 p. 1151-1157
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    The detection of human papillomavirus type-16 and -6b was performed in 28 cases of hypopharyngeal squamous cell carcinomas by polymerase chain reaction.
    Human papillomavirus (HPV) DNAs extracted from paraffin-embedded metastatic lymph node tissue were used for polymerase chain reaction with amplification of the El region of HPV genotype 6b and the E6 region of HPV genotype 16. HPV type 6b sequences were detected in three cases ; positive amplification of type 16 sequences was also seen in three cases. These findings suggest that HPV infection might be closely associated with the development of some hypopharyngeal carcinomas as it is with laryngeal and uterine cervical carcinogenesis.
  • 村上 裕
    1991 年 94 巻 8 号 p. 1158-1169
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Evaluations were made concerning the efficiency and location of the optimal index values of the e-OAE recording method of ILO88 on 10 normal hearing subjects and 10 subjects having inner ear hearing loss. Furthermore, noise from the surrounding environment, noise made during the time fo measurement, and the depth fo probe insertion into the external auditory meatus as well as the type of probe tip used, were also studied in relation to its effect on the e-OAE recording method in 5 other normal hearing subjects.
    The results were as follows ;
    1) Total echo power (TEP) and the highest peak between the 1-2kHz frequency range (HPP, -2) were considered to be the optimal index values for 11088.
    2) The surrounding noise did not cause any significant change in the TEP and HPP, -2 values.
    3) Noise during the actual measurement by the patient did not cause any significant change in the TEP and HPP, -, values.
    4) The depth fo probe insertion into the external auditory meatus had no significant effect upon the TEP and HPP, -, values.
    5) Data reproducibility was difficult and e-OAE power was less for the pinch pump type ear cuff compared to the rubber and silicon probe tips.
    In conclusion, TEP and HPP1-2 were considered to be the optimal index values for 11-088, and with the use fo an appropriate probe tip, it is possible to obtain accurate data with the application of the e-OAE recording method regardless of external noise from the surrounding environment or by patients such as infants.
  • 毛利 学, 島津 黛
    1991 年 94 巻 8 号 p. 1202-1205
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
  • 第35回日本音声言語医学会
    小池 靖夫
    1991 年 94 巻 8 号 p. 1206-1207
    発行日: 1991/08/20
    公開日: 2008/03/19
    ジャーナル フリー
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