日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
80 巻, 2 号
選択された号の論文の8件中1~8を表示しています
  • 正常者とハウスダスト鼻アレルギー患者の相違
    渡辺 建介
    1977 年 80 巻 2 号 p. 117-121
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    Endogenous peroxidase activity was demonstrated in seromueous-secreting cells of human nasal glands, using the diaminobenzidine method for cytochemical demonstration of perox-activity was localized in cisternae of rough-surfaced endoplasmic reti-culum including nuclear envelope, some vessicles and saccules of the Golgi complex and secreting granules.
    Peroxidase activity in nasal glands diminished or disappeared in the case of house dust nasal allergy patients.
    After giving steroid hormone(Dexamethasone 5 mg/day for 7 days) to these nasal allergy patients, peroxidase activity appeared again in the nasal glands.
    It can be considered that if nasal glands depend on the same nerve system as salivary glands, the diminution of peroxidase activity is due to the diminution of sympathetic stimu-lation.
  • 平野 新治, 佐々木 幸弘, 橋本 紘治, 上埜 光紀, 寺山 吉彦
    1977 年 80 巻 2 号 p. 125-130
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    Since 1971, more than one thousand patients with habitual angina, chronic tonsillitis and tonsillogeneous focal infection have been treated by splitting the tonsils with an electrically heated cautery.This procedure is called thermosurgery by the present authors.
    The postoperative follow-up for three years in 120 patients with habitual angina is as follows:no recurrence;81.7%, improved;11.7%, recurrence;6.7%, worse than before;0%.Thus the results of thermosurgery were almost the same as those of tonsillectomy.Most pro-minent histological findings of the tonsils treated by thermosurgery were marked enlargement of lacunae, reduction of size and number of germinal centers and lack of scar formation.The enlarged lacunae seemed to prevent retention of inflammatory products and supress the recurrence of tonsillitis.The treated tonsils preserve their proper tissue and probably function which will be immunologically important.The instrument and technique are simple, easy and safe.If satisfactory improvement is not obtained by thermosurgery, tonsillectomy can be performed afterwards.We recommend this method first before tonsillectomy is attempted.
  • 梅田 悦生, 坂田 英治, 大都 京子
    1977 年 80 巻 2 号 p. 131-138
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    It is known that alcohol affects the oculomoto system and elicits positionalacoholnystagmus Recently it has been shown that disturbance in smooth pursuit eye movements occurs depend-ing on the quantity of ingested alcohol.However, it is also known that test is normal at the early stage of alcohol-induced breakdown of smooth pursuit movements.This indicates that alcohol affects the cerebellum prior to affecting the midbrain and pons(WILKINSON et al., 1974).
    In order to further investigate the effect of alcohol on th cerebellum, subjects ingested alcohol(whisky)and their oculomotor function was tested.The followings are general findings obtained.
    1)Low blood-alcohol concentration causes slight disturbance in the caloric eye-tracking pattern and slight positional nystagmus is occasionally evident.
    2)As the blood-alcohol level increases, positional nystagmus becomes more apparent and the eye-tracking pattern begins to break down.The caloric eye-trackingpa ttern be-comes severely disturbed.
    3)Gaze nystagmus does not appear until the blood-alcohol level becomesmuch higher.
    hese findings indicate that alcohol affects the caloric eye-tracking patterns prior to the conventional eye-tracking patterns.Alcohol must therefore initially affect the areas of the cerebellum related tovisual suppression, namely the flocculo-nodular system.
  • 松永 亨, 松永 喬, 古川 裕, 佐野 光仁, 田上 悦子, 川本 浩康, 奥村 薪一, 内藤 儁
    1977 年 80 巻 2 号 p. 139-144
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    The total blood flow of all the tour cervical vessels and the so-called cardiac output were measured by means of impedance cardiography.In the cases of both acute Meniere's disease and brain circulation disturbance, the total cervical blood flow and cardiac output decreased in comparison with those of normal subjects.However, it was imposible to estimate the blood flow of each cervical vessel by this method.Therefore, the blood flow velocity of the vertebral and common carotid arteries was then measured by means of the ultrasonic Doppler's method.In the vertebral arteries of vertigenous patients, low blood flow velocity and asymmetry in blood flow velocity were found more often than in normal subjects.The result suggested that the asymmetry in blood flow velocity in the vertebral arteries enhanced susceptibility to circulatory disturbance in the vestibular area and inner ear.It wus considered that the above mentioned method was useful for estimating the risk factor of induced vertigo and/or dizziness.
  • 舌可動部がん221例の分析より
    小野 勇
    1977 年 80 巻 2 号 p. 145-154
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    Analysis of the factors influencing Prognosis of carcinoma of anterior two-thirds of the tongue was made.
    The factors related to primary lesion were degree of extent(T classification of U.I.C.C.), clinical finding of tumor, histological grading of Broders' classification and direction of tumor extension.Lymph node involvement was also analysed.The results were as follows.
    1.Clinical finding of tumor was well correspondent with degree of extent and histologicalgrading.However, the relation between histological grading and degree of extent was not clear.
    2.Incidence of lymph nodes metastasis on first examination and through all clinical course were 18.1% and 43.3% respectively.Occult metastasis was observed in 24% of all cases.
    3.Lymph nodes involment on first examination and through all clinical course were cor-relative with degree of extent, histological grading, clinical findings of tumor and direction of tumor extension.Occult metastasis was often found in the cases with histologically highly malignant tumor.
    4.Lymph node involvement, extent of tumor, histological malignancy, direction of tumor extension and clinical findings of tumor were correlelative to each other.And all these factors have some Influences on prognosis individually and correspondingly.The most important factor was TNM classification, especially N factor.Histological malignancy and direction of tumor extension were also important.Regarding clinical findings, the patients with endophytic tumor have certainly poor prognosis, but the clinical findings were thought to be integrated appearance of the other factors.It was not comfirmed whether tumor appearance itself has influence on prognosis or not.
  • アミノ配糖体系抗生物質による聴器障害理解のために
    橘 正芳
    1977 年 80 巻 2 号 p. 155-166
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    The fine structure of the membranous cochlea of the guinea pigs was observed using freeze- fracture technique and ultrahistochmical techniques of ruthenium red(RR) staining and of periodic acid methenamine silver(PAM) impregnation in addition to conventional light micro-scopic observation.
    The freeze-fracturing revealed clearly intercellular junctions, pinocytic vesicles and memb-rane particles besides the structures obtained by conventional method of ultrathin sectioning.RR staining and PAM impregnation, which detect principally acidic glycosaminoglicans and glycoprotein respectively, revealed surface cell coat(glycocalyx), ground substance, collagen fibers and others.The obtained results were as follows.
    1) The membranous cochlea had vast extracellular space and the organ of Corti was as if "floating" in it.This phenomenon was discussed in relation to the vulneability of the hair cell to aminoglycoside antibiotics.
    2) The intercellular spaces of the organ of Corti, filled with cortilymph, were strictly sealed towards the endolymph by the "very tight junction"(Claude, P.et al., 1973) at the level of the reticular membrane.Thus the ototoxic substance of large molecule such as aminogly-coside antibiotics may gain access to the hair cell only from the perilymph.
    3) The characteristic findings of the hair cell with thick glycocalyx covering the cell membrane, the periodically arranged particles on the membrane and subsurface cisterna beneath it were discussed to be related possibly to the electrical excitability and/or vulneability to amino-glycoside antibiotics.
    4) Spiral ligament possessed abundant acidic glycosaminoglicans and/or glycoprotein among spiral ligament cells which were regarded as fibroblasts.The administration of aminoglycoside antibiotics may decrease these substances and the retention of such antibiotics in perilymph seemed to be subsequently prolonged.
  • 第2編 実験的研究
    雲井 健雄, 服部 浩, 湊川 徹
    1977 年 80 巻 2 号 p. 167-173
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
    Since the Silverstein's first report(1966) on elevated protein concentration in the perilymph of the patients with acoustic tumor, it appears that "diagnostic labyrynthotomy" can be useful and worthwhile in certain cases of unilateral sensorineural hearing loss where acoustic neurinoma or Meniere's disease is suspected.
    The objective of the present study is to present the data on chemical analysis of the inner ear fluid obtained from experimental animals in which arachnoiditis of the internal auditory canal cistern was produced and also to discuss the pathogenesis of elevated perilymph protein concentration in connection with histopathological findings.
    The results of the animal experiment were as follows:
    1) The arachnoid of the internal auditory canal cistern was markedly thickened and adherent by proliferated fibrous tissues, and subsequent subarachnoid space obliteration was observed.
    2) Elevation in protein concentration in the perilymph of the inner ear was observed particularly in the side of severely affected arachnoiditis, while the concentration of Na and K were within normal range.
    3) In almost half of the animals with arachnoiditis, hearing loss of retrocochlear type was observed on computer audiometry.
    The result of the present study suggested that elevated protein concentration in the perilymph might represent a considerable obstruction of the subarachnoid space and a subsequent severe C.S.F.circulatory disturbance in the internal auditory canal cistern.
  • 足川 力雄
    1977 年 80 巻 2 号 p. 206-209
    発行日: 1977/02/20
    公開日: 2008/03/19
    ジャーナル フリー
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