日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
70 巻, 7 号
選択された号の論文の9件中1~9を表示しています
  • 慢性副鼻腔炎の皮膚反応, 洞粘膜のヒスタミン様物質とプラスミン
    白坂 邦洋
    1967 年 70 巻 7 号 p. 1213-1219
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    The author studied on influence of allergy upn chronic sinusitis. Using various antigen, 123 patients with chronic sinusitis were examined by skin tests. Mucous membrane of the maxillary sinus in 65 cases of these was surgically removed, of which the extract was made. After the extract was reacted in vitro on positive antigen when the skin tests were positive, and on house dust when they were negative, histamine-like substance and plasmin values were calculated. Histological investigation was made on all of the cases and compared with those values.
    The following results have been obtained.
    1. Skin tests were positive in 21 per cent of all the cases with chronic sinusitis. This rate was almost the same as normal one. Positive reaction of skin tests was due to inhalative antigen, which consists of house dust.
    2. Histamine-like substance values in mucous membrane in the maxillary sinus were unrelated with reaction of antigen.
    3. Comparison of values for reacted and non-reacted plasmin by antigen in mucous membrane was performed, and no significant difference was shown.
    4. There was no constant relation between histamine-like substance value reacted by antigen and change of plasmin value.
    5. Histamine-like substance and plasmin were produced after reaction by antigen from cases of positive skin tests and after reaction by house dust from cases of negative skin tests. Comparision of histamine-like substance and plasmin values afteraboth of reactions was shown no significant difference.
    6. There was no particular finding histologically in cases with positive skin tests, increased plasmin value and increased histamine-like substance value.
    As mentioned above, there was no proof that allergy plays an important role in the cause of chronic sinusitis.
  • 石井 大二
    1967 年 70 巻 7 号 p. 1220-1230
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    Fourteen temporal bones of aged Japanese people, on whom hearing tests were performed within six months before death, were studied histopatho-logically. Some cases were studied also on the anterior inferior cerebellar arteries.
    1) The collapse of Reissner's membrane and/or tectorial membrane, though it had been said to be some kind of pathological findings in classical reports, was concluded by the author's cases to be the postmortem changes.
    Very peculiar artifacts were found in one case, in which all the Reissner's membrane and saccular wall were completely missing in spite of good preservation of all the other tissues.
    2) The most frequent pathological type in the author's cases was “neural type” (ganglion atrophy), due to Schuknecht's classification of presbycusis.
    3) The pathological changes of the basilar artery, the anterior inferior cerebellar artery and arteries in the internal auditory meatus had no close relation to the inner ear changes. So it is reasonable to presume that even a severe narrowing of those arteries, if it happens gradually, does not cause a constant pathological changes in the inner ear except in case of their total closures,
    4) The relation between high-grade atrophy of stria vascularis and hearing loss was greatly suspected. The strial atrophy was found mainly in apical and middle turns.
    5) Other aging changes such as pigmentation in the modiolus and stria vascularis, psammoma bodies, corpora amylacea, etc. were found in almost all cases, but they had no close relations to presbycusis itself either histopathologically or au-diometrically. The author would like to conclude that presbycusis is not a part of general aging phenomena, but a quite independent “disease”.
    6) In five cases out of fourteen, hearing loss could not be explained by inner ear pathology. The unknown pathology of inner ear seemed to be still left in our hands, though, central lesions could also be probable.
  • 同種家兎扁桃による実験的研究腎炎について
    白石 輝雄
    1967 年 70 巻 7 号 p. 1231-1236
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    It has been assumed that tonsillogenic nephritis is ascribed to the allergic mechanism resulting from infection with hemolytic streptococci. But a few reports are available of this problem.
    In the present investigation, rabbits were immunized with the mixture of rabbit tonsils emulsion containing type 4, 6, 12, hemolytic streptococci and Freund's incomplete adjuvant. Injections were given intra-muscular once weekly and continued three times. Analysis was made of the rabbit kidney by means of the hematoxylin-eosin stainning method and the fluorescent labelled antibody technique.
    The results were as follow;
    1) All the immunized rabbits showed no proteinuria and haematuria for the period of about 4 to 6 weeks after the last immunization.
    2) In most of rabbits, antibodies to rabbit tonsil developed, which were detectable by means of the precipitin reaction tecfnique. The height of maximum titers varied from 1:32 to 1:512. Preparation containing type 12, hemolytic streptococci showed the highest activity in producing antibodies to tonsil.
    3) Most of rabbits immunized with type 4, 12, hemolytic streptococci-tonsil emulsion showed the enlarged glomerulus, the moderate increase in number of nuclei, the hyaline thrombi in glomerular vessels and the swelling in number of endotherial cells.
    4) A direct immunofluorescent technique was employed for detection of tonsillar antigen in the rabbit kidney.
    Anti-rabbit tonsil globulin was prepared in the chicken and labelled with fluorescent isothiocyanate.
    Bright specific fluorescence of antigen depositions appeared in the walls of glomerular vessels.
    Experimental evidence has been presented that tonsil emulsion added to hemolytic streptococci is capable of producing renal lesion. With respect to the genesis of tonsillogenic nephritis, tonsil infected continuously with hemolytic streptococci could be conceived as the cause of damage of the kidney.
  • 広戸 幾一郎, 野村 和, 進 武幹, 富田 春英, 中島 輝之
    1967 年 70 巻 7 号 p. 1237-1242
    発行日: 1967年
    公開日: 2008/07/31
    ジャーナル フリー
    A case of Cherubism, 7-years old boy, complaining of bilateral painless protrusion of his face with bilateral enlargement of the submandibular lymph nodes was reported. In other members of the family, his mother had enlarged mandible, received a osteoplastic operation about 10 years ago. Other members of the family had normal face appearances.
    The protrusion of his face was first noticed at 1.5 years of age, the protrusion then developed rapidly until the age of about 4-years and resulted in deformity of the face. His speech was normal. All teeth were missing. Another prominent facial feature was the exposure of a rim of sclera between the lower lid and iris. But vision was normal. All protruded areas were firm, nottender and immobile. Submaxillary lymph nodes increased in size. Serum alkaline phosphotase was slightly elevated otherwise serologic findings, routine blood studies and urinalysis were within normal limits. Radiographic examination showed cystic changes in the maxilla and mandible. A skeletal survey revealed no abnormalities in the skeletal, other than that reported in maxilla and mandible. Biopsy of protruded area in maxilla revealed a fibrous dysplasia.
    The diagnosis of CHERUBISM was made on the basis of the family history, the clinical findings, roentogenographic appearance and pathologic findings. No active treatment has been given, but the child is being kept under periodic observation.
    This disease has been reported under a variety of terms such as familial fibrous swelling of the jaws, familial fibrous dysplasia of the jaws, familial intraosseous fibrous swellings of the jaws, familial incidence of bilateral giant cell tumors of the jaws, bilateral giant-celled tumors of the mandible in siblings, disseminated juvenile fibrous dysplasia of the jaws, familial osseous dysplasia of the jaws and cherubism. The term “CHERUBISM” probably best denotes the condition and the author believes it should be the preferred designation. The differrential diagnosis may include many lesions, such as benign giant cell tumor (Osteoclastoma), giant cell reparative granuloma, facial fibrous dysplasia, hyperparathyroidism.
    The author made some comments on cherubism (familial fibro-osseous disease of the jaws).
  • 福崎 隆
    1967 年 70 巻 7 号 p. 1243-1254
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    To observe the development of mastoid cells in adult, the author made the sagittal sections of the temporal bones. The author studied macroscopically and histologically 42 cases including in ages from 18 to 75 years.
    The author classified the pneumatization of mastoid cells macroscopically and compared with Goto's method by radiographical film. Consequently, Goto's method was the best on judgment of the temporal bone's pneumatization.
    It is said that pneumatisation of the temporal bone is developed by apposition and resorption of the bone. These two processes are most remarkable in the last stage of the fetal life and the child age. In these ages, resorption of the bone is lacunar resorption by osteoklasten. Therefore, the author observed histologically the mastoid cells and marrows in adult. The results were summarized as follows:
    1) In the young ages, the submucous coat was thick. The connective tissue was young and netted. There were found remarkably the new formation of capillary blood vessels and the infiltration of cells in submucous coat.
    Osteoblasts were found in 3 cases, but “osteokasten” were not found. But activity of the temporal bone was very strong.
    2) In 40-55 years old, the development of mastoid cells was stable comparatively.
    3) In the old ages, activity of mastoid cells became stable. But, in a part, there were found young connective tissues and new formation of capillary blood vessels. They were found in old aged persons, especially after 55 years old.
    Osteoblasts were found also in 3 cases and the apposition of the bones were found.
    The flat resorption by young connective tissues was found.
    4) They were all found in well-developed mastoid cells.
    5) The marrows were remained much in well-developed mastoid cells.
    As based on these findings, in the temporal bones, the resorption prosess in the preadolescence and postadolescence period was not the same.
  • 棚橋 汀路
    1967 年 70 巻 7 号 p. 1255-1285
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    Cineradiographic method has made possible detailed visual analysis of the 2nd stage of deglutition and its pathologic physiology. In this study were done the cineradiographic examinations at 54 subjects; 10 were considered to be normal, 44 were pathologic.
    According to measurement of tongue base mortion and pharyngeal peristal wave at every frame of the cineradiograph was formed the cineradiographic pattern of deglutition which consist of upper, middle and lower pharyngeal peristaltic wave pattern (U.P.W.P., M.P.W. and L.P.W.P.) and tongue base mortion pattern (T.B.M.P.).
    In normal cases, U.P.W.P. was consisted of a large positive wave, M.P.W.P.; a small negative and medium positive wave, L.P.W.P; a large negative wave, T.B.M.P.; the 1st small negative and positive, the 2nd large negative and positive waves. From these elements, author concluded that the positive waves of U.P.W.P. and M.P. W.P., the negative wave of L.P.W.P., and the 1st positive and the 2nd negative wave of T.B.M.P. were considered basic factor at swllowing.
    In pathologic cases; a dominant pharyngeal peristaltic wave was found in patients who were suffered tongue base resection, the 12th cranial nerve paralysis, cleft palate or upper esophageal stricture. In laryngectomized patients was observed a large pharyngeal peristaltic wave or abnormal pharyngeal constrictive wave. A most dominant tongue base mortion was observed in laryngectomized patients with partial hypopharyngeal constrictor and cervical esophagus resection, and the 9th and 10th cranial nerve paralysis. In the patients who were suffered the 9th, 10th and 12th cranial nerve paralysis, were observed that pharyngeal peristaltic wave and tongue base mortion were weak and showed incomplete deglutition.
    Based on the above results, author concluded that the distortion in pathologic deglutition was considered to be adaptation by the residual function with its hyperactivity and fenctional modification and deglutition was classified 4 types; normal tongue base mortion, pharyngeal peristaltic and paralytic types.
  • 山田 昇
    1967 年 70 巻 7 号 p. 1286-1302
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    The author produced equilibrium disturbance in rabbits by infecting them with Candida albicans. Out of ninty nine rabbits under experiment, sixty six (67%) developed equilibrium disturbances. By comparing the histological specimens of labyrinth and brain from thirty two of the affected animals with labolatory data of vestibular functions of each animal the author has tried to find the cause of the disturbance. Some of the findings are listed below.
    1) In the brain and labyrinth of the affected rabbits mycetogenic microabscesses were found. The rabbits showed no allergic reactions.
    2) Development of infection in the labyrinth seemed to be caused by embolism of the vesseles with candida bodies.
    3) Labyrinthitis caused by Candida infection reached its maximum activity about fifteen days after injection of alive candida, thereafter healing with scar tissue left behind.
    4) There were cases in which Candida bodies were found after three to four months in labyrinth which is believed to be an organ with high affinity to Candida.
    5) In the brain mycetogenic microabscess were proved in the majority of cases, of which the cause had been ascertained to be the embolism by candida bodies.
    6) In blood vessels of the brain, extensive periangitis was developed through Virchow Robin's space, as seen in a case of encephalitis by other causes.
    7) In the brain, severe inflamation was resulted in two to three days after injection of alive candida. No Candida body was found after two weeks.
    From the fact that in the Candida albicans infected rabbits, such symptoms as distorted head position and spontaneous nystagmus appear in early stage, it can not be denied that central nervous system plays a certain part at that stage. However, later symptoms may best be caused by deteriorated labyrinth.
  • 経静脈感作家兎口蓋扁桃の免疫組織学的考察
    斎藤 載
    1967 年 70 巻 7 号 p. 1303-1311
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    It has been widely accepted by many convincing experiments that the palatine tonsils consisting of a defensive mass of lymphoid tissue often show a clinical symptom signified by infection.
    The immunological characteristics of the tonsils have been discussed by many workers.
    The present study was attempted to know the immunological charactors of the palatine tonsils, when they were exposed to antigenic substances by application of direct fluorescent-antigen technique.
    Seven month-old male rabbits were intravenously immunized by ovalbumin for about a month.
    When the serum antibody exhibited the optimal titers, they were sacrified and the palatine tonsils were dissected.
    The specimens were fixed by cold 95% ethanol and made 4μ in thickness of paraffin sections.
    Fluorescein coupled antigen was prepared by Coons' method and absorbed by rabbit's liver powder after elution through the Serhadex column to remove non-specific staining.
    Following the successful staining, it was proved under fluorescence microscope that there were many cells stained strongly by the fluorescein coupled antigen in the tonsillar tissues from immunized rabbits.
    The fluorescent cells contained antibody were recognized around hilus, perifolliclar and subepithelial regions, while they were hardly observed in germinal center.
    These cells were mostly considered to be plasmacytic cells or lymphoid cells by histological findings.
    The results indicated that tonsils might contribute to immunological defense for invasion of microorganism.
  • 舘田 要
    1967 年 70 巻 7 号 p. 1312-1319
    発行日: 1967年
    公開日: 2007/06/29
    ジャーナル フリー
    Qualitive measurement of DPN-diaphorase in the organ of Corti was performed by means of spectrophotometer as well as histochemistry. One hundred five guinea pigs were used for this study. Each of the animal exposed to white noise 120db for ten minutes except the control. After the stimulation of the noise, they were divided into groups just after exposure, 24 hours later, 3 days later, one week later and 3 weeks later. After the noise exposure, the cochleas were removed. The organ of Corti between the upper half of the basal turn and the lower half of the third turn was dissected out, and was homogenized. Then, they were put into a stated solution, and DPN-diaphorase activity was carefully examined. The control had a mean value of 288mμmols/min./mg. protein. DPN-diaphorase was shown an increase in activity right after the noise exposure; the mean value was 318mμmols/min./mg. protein. It was no significant difference between both of the means. That of 24 hours later was found to be remarkably decreased in activity; the mean was 128mμmols/min./mg. protein. It was shown clearly significant difference between control and this mean. Recovery pattern in the activity was shown as follows. Activity of DPN-diaphorase between 24 hours later and one week later was found in very low level, then it increased slowly up to 3 weeks after the noise exposure. At that time, the mean value was 258mμmols/min./mg. protein. That activity was almost the same as control, and no significant difference was shown between them. It was reasonable to presume that DPN-diaphorase was decreased in activity after noise exposure, then that enzyme was recovered in activity very slowly up to the third week or so. After that, DPN-diaphorase was the same in activity as normal.
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