巻号一覧
後続誌
前身誌
83 巻, 7 号
選択された号の論文の8件中1～8を表示しています
- |<
- <
- 1
- >
- >|
-
ラット耳道腺腫瘍に対する制癌剤効果の検討原田 壽利1980 年 83 巻 7 号 p. 757-768
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーEar duct tumor induced in rats by DMBA and DAS shows a very high incidence within a rather short period, appearing similar histological features of squamous epithel-origin. Besides, the tumor has well been established its microscopical stage of tumorigenesis and its advancement toward macroscopical formation of tumor. Rat ear duct tumor induced by DMBA and DAS is thus far superior to the other chemically induced tumors so far employed as experimental models.
Effects of BLM and 5-FU against the ear duct tumors induced in rats by DMBA and DAS were studied. BLM inhibited strongly the tumors, while 5-FU proved to have no inhibitory effect. It was also revealed that BLM exerted its inhibitory effect on growth of tumor, failing to play its action in earlier stage of tumorigenesis.抄録全体を表示PDF形式でダウンロード (963K) -
織田 正道, 三橋 重信, 平野 実1980 年 83 巻 7 号 p. 769-774
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーNeurogenic neoplasm of the larynx is rare. Especially, neurofibroma of the vocal fold has not been reported in the Japanese literatures. This paper describes a case of neurofibroma of the vocal fold.
The patient was a 64-year-old man. He first developed hoarseness in November 1977. In June 1978, he noticed occasional inspiratory dyspnea. He was first seen by another laryngologist and a mass of the left vocal fold was found. Biospy specimen revealed that the mass was a neurofibroma. He was, then, referred to our hospital for treatment. The mass was localized in the left vocal fold. In stroboscopy, no mucosal wave was observed on the mass. The mass was removed with the use of CO2 laser. The port-operative phonatory function was almost normal. Since 1948, only 25 cases of neurogenic neoplasm of the larynx have been reported in the Japanese literatures. They were reviewed in terms of age, sex, duration of the symptoms, location of the tumors, clinical symptoms, diagnostic problems and treatment modalities. The advantages of laser microsurgery were emphasized in connection with the post-operative phonatory function.抄録全体を表示PDF形式でダウンロード (1153K) -
清水 元博1980 年 83 巻 7 号 p. 775-786
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーThe vestibulo-ocular reflex (VOR) helps to hold a stable retinal image by compensatory eye movements against head rotation. Recent experiments using reversing prism have cleary demonstrated that the VOR is not only plastic but also adaptive. Robinson reported that the adaptive gain control of VOR was abolished after removal of the vestibulocerebellum in the cats. From the fundamental experiments mentioned above, the clinical observation of adaptive changes in the VOR by prism-reversal of vision expected to be an useful diagnostic tool for detecting the cerebellar dysfunction.
Prior to the clinical application for detecting cerebellar dysfunction, twenty-six normal adults, ranging in age from 19 to 34 years, without any vestibular and oculomotor disorders, were tested. The subjects sit on the pendular rotation chair and the eye movements (E), eye velocities (E) and head movements (H) were recorded during the pendular rotation (0.25Hz, 30° amplitude)under the condition of the eyes covered in the dark. After initial recording of E, E and H, subjects wore the reversing prism and the rotation continued up to one hour. During the test period, subjects were asked to watch the fixed small spot light in 2m distance at the center of the rotation angle. Every 15 minutes, subjects wore dark goagle over the reversing prism and E, E and H were recorded. The results showed clear reduction of the gain of the VOR (apploximately 50% decrease relative to control value), but no phase shift was observed.
Thirteen patients with cerebellar lesions were examined using the same test. The adaptation of the VOR was cleary reduced in comparison to normal subjects, (the gain was approximately 20%), but no remarkable changes of the phase were observed. The degree of the gain reduction was related to the extents of the cerebellar lesions.
The analysis of the data of the thirteen cases with cerebellar lesions, revealed the clinical application of the adaptive changes in the VOR by prism-reversal of vision was an useful tool for detecting the cerebellar disorders.抄録全体を表示PDF形式でダウンロード (1788K) -
金子 康治1980 年 83 巻 7 号 p. 787-792
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーUsing a phase contrast microscope and electron microscope, the effect of DHSM on the cochlea of KK mouse was studied. DHSM 200mg per kg of body weight was administrated daily, into the peritoneal space for 21 days.
Same number of dd-strain mice were served as the control. No pathological finding was observed in the cellular element of stria vascularis, but a micro-embolism of destructed cell element was formed in the capillary space of KK mouse, but not of dd-strain mouse.
It was suspected that these findings may be the initial stage of the degenerative process in the stria vascularis of KK mouse, and further the vascular vulnerability of this animal for the DHSM ototoxicity.抄録全体を表示PDF形式でダウンロード (3815K) -
奥村 新一1980 年 83 巻 7 号 p. 793-805
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーFor the purpose of detecting endolymphatic hydrops, the author developed "furosemide test for pendular rotation" (the furosemide test) and clinically applied the test on patients with Ménière's disease and patients with other peripheral or central vertiginous disorders. It was also experimentally studied on guinea pigs with endolymphatic hydrops induced by surgical obliteration of unilateral endolymphatic sac and on normal ones. In the present report, the author concluded that this test would be a useful method for diagnosis of endolymphatic hydrops.
1. Twenty seven out of 60 patients with Ménière's disease (45%) were positive on the furosemide test. Of the above 60, 39 were tested in the attack stage and 25 (64%) were positive, but among the 21 patients tested in their remission stages, only 2 (10%) were positive.
2. The patients with Ménière's disease who had been positive on the furosemide test before the endolymphatic shunt operation all had uneventful post-operative courses without any further attacks.
3. None of the 25 patients who had vertigo with other causes than Meniere's disease were positive on the furosemide test whether they were in peripheral or central disorders.
4. The guinea pigs with experimental endolymphatic hydrops induced by surgical obliteration of unilateral endolymphatic sac showed positive results in the furosemide test in a similar way as Meniere's disease patients.
5. The histological view of the inner ears of the guinea pigs with positive furosemide test revealed either normalizing or collapsing of the endolymphatic hydrops once produced in the affected ear, while the opposite ear was almost normal.
6. In the control group of normal guinea pigs, the positive furosemide test was not found, and histologically the bilateral inner ears of them had almost normal endolymphatic space.抄録全体を表示PDF形式でダウンロード (4284K) -
第1報Control, Anoxia負荷及び炭酸ガス負荷鈴木 浩二1980 年 83 巻 7 号 p. 806-815
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーOxygen transport to the inner ear is carried out by the inner ear blood flow and diffusion, and oxygen is necessary to maintain the inner earfunction. Particulary perilymph of scala tympani ought to be the pool of the oxygen which is utilized in the organ of Corti. The oxygentension of scala tympani war studied on guinea pig in anoxia, CO2 gas inhalation and autonomic nerve poisoning, oxygentension of scala tympani was 26.4mmHg in an average and lower than that of cerebrospinal fluid. The anoxia for 4 minutes and ligature of the inner ear artery for 3 minutes showed the same titre of oxygentension. From these results, it is likely that oxygentension of perilymph depends on the inner ear artery.
Oxygentension of perilymph and cerebrospinal fluid was increased by inhalation pure O2 gas. When CO2 gas was mixed in an increasing way, the oxygentension was further increased and reached to the maximum by inhalation of 85%O2+15%CO2 gas. From this result the responses of inner ear vessel and cerebral vessel to CO2 gas inhalation seemed to be the samen.抄録全体を表示PDF形式でダウンロード (1666K) -
斎藤 洋三, 渡辺 建介, 竹田 英子, 高橋 早恵子1980 年 83 巻 7 号 p. 816-821
発行日: 1980/07/20
公開日: 2008/03/19
ジャーナル フリーTwo cases of pleomorphic adenoma of the nasal septum were reported, and a statistical and clinical observation was made on 19 cases of pleomorphic adenoma of the nasal septum collected from Japanese literature.
Case 1: A 70-year-old woman was admitted to the out-patient clinic of the ENT department of the Tokyo Medical and Dental University on October 17, 1975, with the complaints of right-sided nasal obstruction, recurrent epistaxis, and a swelling on the right side of the external nose.
Examination showed a large, grayish pink, rounded mass almost completely filling the right nasal cavity.
Successful surgical excision was performed via the intranasal approach.
Histopathological examination showed plemorphic adenoma (mixed salivary tumor) showing mainly masses of oval cells with duct-like structure, mucinous tissue and cartilage-like tissue also seen with occasional of squamous metaplasia foci.
Postoperative course was uneventful and there has been no recurrence.
Case 2: A 67-year-old woman was admitted to the university hospital on May 23, 1978, with the complaints of right-sided nasal obstruction and recurrent epistaxis of 5 years' duration.
Examination showed a large, smooth, grayish pink, rounded mass almost completely filling the right nasal cavity.
The tumor was excised by lateral rhinotomy as it was too big to be completely removed otherwise.
Histopathological examination showed pleomorphic adenoma. Postoperative course was uneventful and there has been no recurrence.
From the statistical and clinical observation on 19 cases of pleomorphic adenoma of the nasal septum in Japanese literatures, the following results were obtained.
1) Ages ranged from 23 to 70-year-old.
2) There were 12 female and 7 male patients.
3) The most frequent chief complaints were epistaxis, nasal obstruction, and a swelling of the external nose.
4) In 11 cases, tumors located in the right side, and in 8 cases, in the left side.
5) The duration of symptoms ranged from 3 months to 20 years.
6) As surgical procedure, the intranasal approach was used more frequently, that was in 12 cases while the extranasal approach was employed in 6 cases.
7) All cases were followed and no recurrence was reported.抄録全体を表示PDF形式でダウンロード (1806K) -
小玉 直志1980 年 83 巻 7 号 p. 822-834
発行日: 1980/07/20
公開日: 2008/12/08
ジャーナル フリーThe human acoustic reflex in binaural and monaural hearing were observed in free field by means of the impedance method to clarify the mechanisms of the intratympanic muscles.
The results were obtained as follows.
1) When the sound source was the front, the impedance-change was larger in binaural hearing than in monaural hearing. (Phenomenon I )
2) When the sound source was the side, the difference of the impedance-change between both ear was smaller in binaural hearing than in monaural hearing, furthermore the impedancechange was larger of ipsilateral ear of the sound source than of contralateral one everytime. (Phenomenon II)
3) It was deduced that both Phenomenon I and II obtained from this study were caused by that the binaural interaction generated in superior olivary complex had influence on the acoustic reflex with bilateral are.
4) The meaning of Phenomenon I was that the binaural summation as result of binaural interaction was confirmed by observation on the acoustic reflex.
The meaning of Phenomenon II was that the intratympanic muscles which contracted as reflection of binaural interaction was able to transmit loud sound changing for attenuated one to each inner ear keeping the approximate value of sound pressure-difference between both ear.
In conclusion, it was suggested that the acoustic reflex not only protect inner ear from loud sound but also perticipate in the mechanisms of the directional hearing.抄録全体を表示PDF形式でダウンロード (1726K)
- |<
- <
- 1
- >
- >|