Vestibular function and of principle cause of sudden loss of cochleo-vestibular function which did not occcure repeatedly was studied.
The results were as follows:
1) Many patients with this disorder seemed to have vasomotor disturbances showing sudden flushig and chills, headaches and stiff shoulders. The next main factor was allergic diathesis. Chiefly they complaind of mental and physical fatigue and cold. A few cases showed attacks after extraction of teeth and under a drier for permanentwave.
Furthermore some cases accompanied with acoustic tumor, subarachnoideal bleeding and cranial polyneuritis, were seen. Two cases, in which numerous Dihydrostreptmycin injections had been carried out, attacks appeared shortly after the chest surgery under general anesthesia.
2) Nystagmus in 91 cases out of 113 cases was found. Abnormal nystagmus were found especially by positional and positioning nystagmus test. Many kinds of nystagmus, namely direction fixd, direction changing, horizontal, rotatoric and vertical nystagmus were found. That findings of nystagmus had very important meaning for the diagnosis of the affected area was also emphasized.
3) In Caloric Test 71% out of 113 cases were CP. This test is also important for the diagnosis of the degree of lesion and of the affected area. When there is no response of the Caloric Test we must differentiate it from acoustic tumor.
4) In Optokinetic Nystagmus (OKN) Test, examined by Optokinetic Pattern (OKP) Test, many cases showed peripheral type, but some cases showed semicentral and central type.
5) Many cases showed laterality in Optokinetic After Nystagmus (OKAN) Test. This finding is useful for the diagnoss of DP.
On the other hand rotatoric test is not useful for the diagnosis of the side and degree of the lesin.
6) In Counterrolling Test of the eye, many cases showed abnormal value at the affected side. This finding is helpfull for the diagnosis of affected area as a method of diagnosis of otolithic function.
7) Some cases showed abnormality in neurological findings, vertebral angiography and electroencephalography. This fact shows that some cases of sudden loss of cochleo-vestibular function hav central, especially brainstem lesion.
From the results above mentioned it can be concluded that the genesis and the affected area of these disease were various, and we could locate the affected area in the labyrinth and centrum more fully by not only the hearing tests, but also by varius vestibular function tests and vertebral angiography, electroencephalography etc, as the case may be.
And furthermore it was indicated that some cases, in this disease, having their genesis in the lesion of the central nervous system.

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Electron microscopic studies of metaplasia of epithelium in atrophic rhinitis and the normal human nasal epithelium was made.
In the present study the materials were obtained from the lower edge of the inferior nasal choncha. The materials were fixed in buffered osmium tetroxide, dehydrated, and embedded in Epon 812. Thin sections were stained with uranyl acetate followed by lead hydroxide.
The results obtained were follows:
The nasal epithelium consists of four kinds of cells; the ciliated cells, the goblet cells, the basal cells and the nonciliated cells found rarely. The fine structure of these cells is similar to that of the rat trachea reported by Rhodin and Dalhamn (1956).
In the case of atrophic rhinitis metaplastic epithelium is often found. Metaplastic epithelium is composed of three cell layers; the external layer, piling up of flat or oval cells with the long axis mainly parallel to the upper surface, the middle layer of spinous cells and the basal cell layer. Each cell is combined with irregularly tiny processes and desmosomes.
The intercellular space varies in width somewhat but is usually conspicuously dilated.
The tonofilaments are scattered over the whole cytoplasma. Most of them anastomose each other and some of them aggregate in larger bundles, mostly running parallel to the long axis of cells.
A lot of tiny processes, microvilli, are found on the upper surface of the metaplastic epithelium.
The basement membrane is observed close and parallel to the plasma membrane at the basal surface of the epithelial cells. It is about 0.15μ, approximately three times as thick as that of the normal nasal epithelium. The collagenous fibriles in the connective tissue layer adjacent to the basement membrane show considerable decrease in amount. Fibroblasts, leucocytes and other planocytes can often be found as infiltration in this layer.

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Many cases of metaplasia to stratified squamous epithelium are seen in the atrophic rinitis. The maxillary epithelium also falls in metaplasia after the transplantion to the inferior turbinate by Kubo's maxilloturbinal plasty. We suppose that these changes are caused by many factors but the decrease of the blood supply in the mucosa plays an important role.
A small graft from the septal mucosa of the nose in the rabbit was transplanted to the maxillary sinus. In 4 days the the transplanted graft falls in necrobiosis, but in 14 days regenerates a squamous like epithelium. In 30 days pseudostratified columnar epithelium and a few glands are seen and in 90 days the columnar epithelium matures containining many goblet cells and the glands increase in number.
These regenerative changes co-relate closely with the reconstruction of the vascular network, which was confirmed quantitatively by the photomicrogram of the vascular network of the graft produced by injecting the latex solution from the carotid artery.
The vascular network and the gland in the graft resemble to those in the original maxillary mucosa, and the epithelium becomes that of the nasal membrane.

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In order to explore the relationship of the localization of epipharyngitis with one-sided nasal obstruction due to nasal septum deviation, observation was made on the difference in the cytologic picture of epipharyngeal mucosa and in the nasal ventilation between right and left side in 58 cases of nasal septum deviation of various degrees.
The results were rather clear than those reported in the previous paper; the severer is the onesided nasal obstruction on convex side with increase of deviation, the more remarkable is the localization of inflammation in the epipharyngeal region to the same side.

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The serum proteins of Wegener's granulomatons and similar diseases 9cases) and so-called “rhininitis necroticans” (13cases) were investigated with the purpose of clearing up a part of the pathologic mechanics and underlying pathogenesis.
As the results of the observations of the total protein, fraction of serum protein by paper electrophoresis and screening tests (CR-, RA-, LE-test), lowering of A/G, the increase of α-, β- and γ- globulin especially of the fast moving γ-globulin and the positive reaction to CR- and RA-test were found.
Still more the factors of the RA-test positive and increase of fast moving γ-globulin in these cases were investigated by means of F II precipitating test, DEAE cellulose colomn chromatography, ultracentrifugation and immunoelectrophoresis. The factor of the RA-test positive in these cases was same as the so-called “rheumatoid factor” in 19S macroglobulin. And the factors of the increase of fast moving γ-globulin in paper electrophorsis consisted of a slight increae of macroglobulin, γ2- globulin and the tailing of α- and β-globulin.
Otherwise, no particular serum proteins were found by means of polyacrylamide gel electrophoesis and immunoelectrophoresis.
To sum up, the important serological findings of Wegener's granulomatosis and similar diseases and some of so-called “rhinitis necroticans” were the slight increase of macroglobulin and the positive reaction to RA-test.

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Four cases of multiple primary malignant tumor were reported.
The first case was 59 years old female who had reticulosarcoma in the epipharynx and adenocarcinoma of the stomach. The second one was a 58 years old male suffering from adenocarcinoma in the calcum and squamous cell carcinoma of the upper jaw. Adenocarcinoma of the stomach and squamous cell carcinoma of the larynx was seen the third patient of a 56 years old male. The last patient, a 65 years old male had a complaint of laryngeal squamous cell carcinoma and adenocarcinoma of the stomach.
In the first and last cases the second tumor was found in the post-mortem examination.
The incidence, age and sex, interval of the two tumors, and affected organs were discussed from clinical observations in the previous reports.

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For a period of over a year 42 children with retarded deve lopment of speech in whom neither hearing impairment nor marked mental retardation was initially detected were observed for their natural progress of speech and language development, and the following results were obtained:
1) Natural progress of retarded speech development was poorer in the children with a prolonged delay of unsupported walking than in the children with normal begining of walking.
2) Out of a total of 42 children 4 had been diagnosed earler as so-called “audimutitas” These children with audimutitas had not only extremely poor progress of speech and language development, but also various neurological impairments; such as severe articulatory apraxia, developmental apraxia, slight nerve deafness and slight mental defficiency associated with severe language retardation. According to this fact it was concluded that so-called audimutitas is not an isolated speech disorder but a group of severe developmental speech and language disorders showing aphasic syndrome.

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