By histochemical and ultraviolet photographic analysis, the author investigated the nucleic acid in spiral ganglion cells of the guinea pigs, three days, one week, two weeks and three weeks after the exposure to 1000cps, 135db, for different duration (5, 10, 15, 30, 60, 120 & 180minutes), The results obtained were, as follows: 1. The results obtained by Mg-Py staining analysis and ultraviolet photographic analysis were almost similar. 2. Changes of RNA in the cytoplasm were much more sensitive than of DNA. 3. Three days after the exposure, RNA increased temporarily. 4. One week and two weeks after the exposure, RNA was decreased. 5. Three weeks after the exposure, RNA recovered to normal limits in the cases with5-15minutes' exposure, however, in the cases with more prolonged exposure, RNA was markedly decreased.
A new term of "Focused Reaction" is proposed. The adjective "focal" which is in common use in medical terminology, as in "focal reaction" or "focal infection", is derived from the Latin word "Focus", meaning a fire place or a hearth, and is refered to the point from which light, heat or waves spread. In the term "Focused Reaction" proposed in this paper, "focused" is considered to be the burning point of a lens, i.e., the point where light, heat or waves come together. When an excessive stimulation is given to the skin, tonsils or paranasal sinuses, it brings about circulatory disturbance or vascular damage in distant organs through the route such as skin-to-tonsils, tonsils-to-kindneys etc. For explaining this phenomenon, it seems reasonable to assume that the stimsilation is "focused" on those distant organs (tonsils, heart, or kidneysetc.) producing some pathology in those organs, and this course of event is what is proposed to be called " Focused Reaction "- The site which is generally considered to be the " hearth " of "focal infection" is one of the sources of the stimuli which are to be focused on the target organ.
Taking X-ray pictures of the pneumatic cell system of the mastoid and paranasal sinuses in 39 pairs of monozygotic twins and 22 pairs of dizygotic twins, the auther studied the similarity between twin brothers at dimentions of the pneumatic cell of the mastoid and paranasal sinuses as well as types and forms; so the results were as follows: 1) In measuring of dimentions and comparing of froms, no difference on the similarity of the cell pneumatization of the mastoid, and paranasal sinuses in both side in person between monozygotic twins and dizygotic twins. 2) Similarity of the pneumatic cell the mastoid and paranasal sinuses between monozygotic twins was higher then that between dizygotic twins, both in the width and at the forms, 3) Above the results, it was concludet that the development of the pneumatic cell system of the mastoid have a strong analogy with that of the paranasal siuses and heredity played a important role in those development.
For a clear understanding of physiological mechanism involved in cochlear function, blood supply to inner ear, blood pressure, relationship between inner ear function and vegetative nervous system, and between physical and biological mechanism. Should be corefully studied. By means of vestibulo-tympanal recording after Tasaki in guinea pigs and round window recording in cats, microphonics and action potentials were measured and at the same time in some animals blood pressure, blood viscosity and the velocity of the blood flow using Rein's "Thermostromuhr" in the carotid artery and the vertebral artery, was also measured. Then following results were obtained: 1) The blood presuere has no influence on the generation of CM and AP, as far as is no there influence to the vital phenomenon, of the animale. 2) Energies which were required on generation of CM in the inner ear, were obviously supplied by blood flow, but their stocks were very little. Cochlear circulation under physiological conditions, was supplied with great surplus. 3) Ap disappeared when CM decreased down to 50% of original CM magnitude. 4) The generating mechanism of CM1 was clearly based on biological mechamism, but of CM2 was not decided whether on biological or on physical mechanism. But CM2 was thought to be more like physical. 5) On CM2 for clicks, the responce disappeared after loud sound stimulation (4000c.p.s. 95db) and then gradually recovered under asphyxia in the same mrnner as on CM1. 6) The origin of the half wave rectification that was observed frequently near the CM2 level, was not traced. 7) The blood flow in the stria vascularis were related directly to the cochlear function. Then the observation of the behavior of the blood flow is necessary to know the cochlear function. And the author investigated the changes of the strial blood flow corresponding to the changes of the electrical phenomenon on the cochlea, and it was felt keenly that DC and SP should be measured at the same time. 8) The increase of blood viscosity had no influence on CM and AP. 9) Except the changes in conductive efficiency in the middle ear or the intense change of the blood circulation, the vegetal nervous siistem had no direct influences on the cochlear function. 10) The change of body temperature from 37°C down to 27°C seems unrelated to cochlear function.
The author had succeeded in preparing large section specimens including the eye ball, upper jawand other surrounding soft tissues. The materials from 8 cases with maxillary squamous cell carcinoma were obtained en bloc. The observation of the specimens was made by chiefly macro skopicaly and sometimes with 6-1Cfold magnifier. The results obtained were as follows: 1) In stained large section specimens, the relationship between tumors and bones or neighboring tissues and hence, the, growth and spreading of cancer were evidently demonstrated. 2) There were 2 types of the destructive processes of bony walls of maxillary sinus with tumor, the expansive and the infiltrative bone destruction. The former is caused by compression due to the expansive growth of tumor without direct contact with bone, while the latter is found at the bonewall in direct contact with tumor. Then the tumor invades marrow cavity. 3) In the apical portion of tumor having completely destroyed bone, the capsule-like layers were often observed. The layers are formed chiefly of the thickened periostium accompanied with the proliferation of stroma in fat tissue. However at the muscle layers in direct contat with tumor they were generally unrecognized. 4) And there are two kinds of types in spreading manner of maxillary sinus cancer, one is the "expansively spreading form" that the carcinoma having expansively destroyed bone invades the soft tissues surrounding the maxillary bone and the formation of the capsule-like layers around tumor is prominent. The other, "infiltratively spreading form" that carcinoma destroys infiltratively bone and in the apical portion of tumor the formation of the capsule-like layer is not evident. 5) The expansively spreading form was observed in 4 of the 8 cases, and the infiltratively spreading form in the others. After operation the prognosis of the former is relatively good, and that of the latter is poor.
By measuring the protein fraction in the nasal polyp tissue extracted from 50 nasal polyp patients by paper eletrophoresis, I have got following conclusions. 1) In the nasal polyp tissue, much Globulin rather than Alubumin was examined, furthermore, r. Globulin was found most in the Globulin fraction and its order was γ>β>α. 2) 30% of all the examined patients had much γ-Globulin in particular in the nasal polyp tissue proteins fraction, and in the serum proteins of these patients γ-Globulin was found out very much. Many of them probaby might be allergic patients due to the past anammesis or family history. 3) Serum proteins fraction of the nasal polyp patients had little difference to that of normal persons, but γ-Globulin was found a little more than in normal persons. 4) In the maxillary sinus mucous menbrane protein fraction of chronic Sinusitis patients with nasal polyps. I found more Globulin than in the nasal polyp tissue, and, β-Globulin was found most, and its order was β>γ>α. This order was admitted not only in chronic Sinusitis mucous menbrane but in the inferior turbinated bone mucons menbrane of hypertrophical chronic Rhinitis. 5) From the biochemical and histopathalogical point of view, I could find out no relation between γ-Globulin in the nasal palyp tissue and infiltration of plasma cells and Lymphcytes.
In refernce to chronic dacryocystitis, when a daryocystectomy is performed, for a long time afterward the patient suffers form persistent watering of the eyes. First, to planed this complate cure of dacryocystitis and to avoid its unhappy effects, in a number of improved cases we performed Toti's madified dacryocystorhinostomy, which posits a new tear duct between the lacrymal sac and the nasalcavity, and we made public the fact that our results were qiute felicitous. However, for this operation, one should first consult an ophthalmologist to determine the Application of this operation, then an otologist to decide whether an operation can be done, or to consider pre-operations Treatment (including Rhinolcgical pre-operrtion). If this procedure is followed, a higher percentage of complete cure can be expected by performing, this operation. However, if it is a question of Parasinustis chronica or severe deviatio septi nesi, it is preferred that the surgeors treat (or operation) for these maladies first before performing this toti's operation. Once done Toti's operation, all fallowing treadment must be performed from the inside of the nasal cavity, If the preparation for the operation is through, and the operation itself performed with. skill, the patient should enjoy a complete cure of the malady with in two weeks. For three years we have performed this operation and carefully observed the patients who have undergone the operation, and in every case the results have been most successfull. Opetations-window, which posits at the Ager uasi should 1 or 2 years after a molphological chang. regarding to the Function of pumping which has lacrymal sac.
A congenital epiglottic cyst was found in a 3 months old female infant, with symptoms of dyspnea and dysphagia. The cyst, rare for this age, was removed with a cold snare, and the patient restored her health. Also, the author described some information about tracheotmy in infants, which was done on this case.