The effect of aging on discrimination of filtered speech was examined. There are some words, which are increasingly difficult to discriminate as the age progresses, among the filtered speech words list, and thus the effect of the aging of the examinees is one of the influential factors for the articulation scoring. Four kinds of filters, 2000Hz low pass, 1700Hz low pass, 1200Hz low pass and 850-1700Hz band pass, were used to distort 20 speech words list, which were recognized to bring about less discrimination as age progresses. Thus made speech words list was heared by the examines, aging from 20 to 74 years old, monoaurally at the pure tone threshold according to the corresponding age, and the articulation score of discrimination was compiled for each age groups at 5 years of intervals. The articulation score of discrimination for some words list was 76% in average in the twentieth, which fell with age reaching 12% in average in more than 70 years old population. Distinct correlation between the articulation score of discrimination and age was observed (correlation coefficient, 0.879), and there was no sex difference in any age populations. The test speech words list was applied to four groups of young subjects, aging from 20 to 34 years old, having elevated pure tone threshold, (500Hz+1000Hz+2000Hz/3) (<10dB, 15-25dB, 35-45dB, >60dB). There was less effect of elevation of the pure tone threshold on the articulation score of the filtered speech up to about 20dB., The pure tone discrimination of the young subject, showing elevated threshold, was almost the same as that in the aged, more than 60 years old in the articular score, and thus lowering of the articular score in 40-50dB correcting for the pure tone threshold was estimated in the aged subjects at the post-labyrinth. The age dependent change in the auditory system may be gradually and continuously changed after 20 years of age, from the inner ear to the central nerve and from the low frequency to high frequency regions both in male and in female. Modification of noise and arterial screlosis would reflect to the audiogram in the aged subjects.
The origin and nature of the lymphoid cell component of Warthin's tumor are controversial. The present report described the application of immunologic study to the Warthin's tumor lymphocytes. Not only subpopulation of T and B cells and numbers of surface immunoglobulins were comparable to those of other lymph nodes. These findings, in conjuction with morphologic observations, support the concept that the lymphoid component of Warthin's tumor is derived from a pre-existing lymph node.
Partitioning of egg-white lysozyme between the serum and paranasal tissue was investigated using the ELISA method. 1) Egg-white lysozyme was detected in the paranasal tissues of 7 of 8 subjects given exogenous lysozyme reached a peak concentration in the serum in 60 minutes, whereas, 90 minutes was required to reach peak concentrations in the paranasal tissues. 2) Antibodies against egg-white lysozyme were detected in the serum of 4 of 5 subjects given exogenous lysozyme. 3) Differences in serum concentrations of lysozyme between subjects given exogenous lysozyme and subjects non-receiving lysozyme were not significant. However, lysozyme concentrations in the paranasal tissues of all subjects receiving exogenous lysozyme were higher than in subjects not receiving an exogenous source of the enzyme.
This study demonstrates the morphological development of the vestibular sensory cells in the mouse using SEM and TEM. Vestibular organs from the 11. 5th gestational day to the 2 weeks postnatal day of CBA/CBA mouse were observed. Sensory hairs were first noticed as stereocilia only, then, the kinocilim was recognized. At last, the step-like appearance of stereocilia was formed. Afferent nerve endings developed earlier than efferent nerve endings. Nerve chalice was recognized on the 20.5th gestational day. The development of vestibular sensory cell was completed until the 7th postnatal day.
Nuclear magnetic resonance (NMR)-CT rapidly developed recently and is regarded as a very useful method of evaluation for the diagnosis of various disorders. Many reports for NMR-CT are published in these three years, but few report concerning the otorhinolaryngological disorders in seen. In this report, the applicability of NMR-CT for otorhinolaryngology is discussed. NMR-CT scans were performed in 60 patients with a variable scope of otorhinolaryngological disorders and the results were compared with X-ray CT scans. BNT 1000J scanner (Bruke, West Germany) with Carr-Purcell-Meiboom-Gill (GPMG) pulse sequence was used in this study. In lesions of nose and paranasal sinus, NMR-CT with CPMG pulse sequence proved to be very useful for the differential diagnosis between tumors and inflammations or other lesions (e. g. aspergillosis). NMR-CT was also useful in other head and neck disorders. Malignant tumors (cancer, malignant lymphoma and malignant melanoma) showed almost equal proton density, T1, T2 to those of the brain. In the small lesions, however, such as acoustic neurinoma in its early stage, NMR-CT gave less contribution than X-ray CT. Advantages of NMR-CT over X-ray CT include specific sensitivity to pathologic changes, feasibility for arbitrary planes for slices, lack of bone artifact and no known hazard to living subjects. More detailed evaluation is awaited, but NMR-CT seems to be an important battery to the conventional armamentum for image diagnosis.
This paper describes our newly designed scanning acoustic microscope (SAM). Our concern is to determine the mechanical properties of each histological component of the vocal fold in normal and varying pathological states. Generally speaking, the images obtained by means of an acoustic microscope not only present structure of the object to be investigated but also reflect its mechanical properties. Our present SAM has the following features. 1) The frequency of ultrasonic waves is variable between 100 and 200 MHz. The best resolution is about 5μm(at 200MHz). 2) This single device can function as three different types of SAM: i. e. reflection-, transmission-, and interference-type. 3) Linear and logarithmic conversions of the image intensity are available. The range of the intensity covered by linear conversion is about 20dB, whereas, by logarithmic conversion, it is about 40dB. 4) Tilting mechanism is installed to the sample bed so as to adjust the angle of specimen to be parallel to focal plane of the acoustic lens. 5) As far as one direction is concerned, consecutive images are obtained easily by simply pushing a button. 6) The image stored in the digital memory can be recorded by an ordinary video recorder. Also, as concerns the reflected image, a brief explanation of the preparation of the specimen and the operation of the device are presented. In Discussion, several advantages of the acoustic image compared with the optical image are mentioned. Then, a method of quantifying the mechanical property of biological tissues based on the acoustic image is briefly explained. A preliminary result on the vocal fold tissue shows that the 'hardness' increases in the order of the ground substance, the epithelium, and the fibrous components (a mixture of elastic and collagenous fibers).