日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
79 巻, 6 号
選択された号の論文の8件中1~8を表示しています
  • 脳血管写および脳シンチグラフィーからの考察も含めて
    時田 信仁
    1976 年 79 巻 6 号 p. 645-659
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Of 143 appoplectic patients who were studied by neuro-otological tests, 50 cases whose cerebral lesions were detected by cerebral angiography, brain scintigraphy and neurological examinations, were selected for the following investigations;
    1) The relationship between affected site of the brain and abnormal neuro-otological findings.
    2) Diagnostic significance of neuro-otological tests for evaluating the sequela of apoplexy.
    3) Diagnostic significance of neuro-otological tests for the detection of abnormality of vestibular system in the brain stem, especially the supratentorial lesion.
    The results obtained were as follows:
    1) Nystagmus was observed in approximately half the cases of cerebral hemorrhage without distinct difference between lateral and combined type.This is presumably due to the secondary effect on the brain stem.
    2) In optokinetic pattern test(OKP test), the abnormal findings were observed more frequently in the combined type of cerebral hemorrhage than in the lateral type.It is useful to localize the site of hemorrhage.
    3) In about half the cases of cerebral hemorrhage, abnormal findings were obtained in interaural differentiation test in both lateral and combined type.The abnormality in the interaural differentiation test suggests the extension of the lesion and if aphasia developed, the site of hemorrhage extends beyond the cerebral subcortex to the cerebral cortex.
    4) Nystagmus was observed in more than half the cases of cerebral infarction, but no definite correlation was recognized between the occlusion site and appearance of any special type of nystagmus.
    5) The OKP findings were abnormal in all patients with the major cerebral artery occlusion.This is due to the size of cerebral infaction in the cerebral hemisphere.
    6) In many patients OKP test and interaural differentiation test could not performed.This probably due to the size of the supratentorial lesion.
    From these results, it is concluded that the vestibular and auditory function tests as well as the neurological tests may be useful in the diagnosis of exact site and extension of the cerebral lesion, and to find out the presence and degree of brain stem lesion, and to presume the prognosis of the apoplectic patients
  • 村上 泰
    1976 年 79 巻 6 号 p. 660-666
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Electrophysiological studies on the activity of the internal laryngeal muscles during laryngospasm experimentally induced in the cat were done.Factors causing inspiratory dyspnea during laryngospasm were detected.Conclusions are as follow;
    1) Laryngosoasm is organized by spasmic after-discharges seen in adductors, mainly in the thyroarytenoid muscle.Tensor mechanism of the vocal fold including the cricothyroid and the posterior cricoarytenoid, on the contrary, is inhibited, and sphyncteric type of closure is obser.ved.
    2) In inspiration during laryngospasm, the posterior cricoarytenoid muscle does not fire at all contrary to cosistent activities of the diaphragmatic muscle.
    3) Spasmic after-discharges in the adductors almost disappear in inspiratory phases during laryn.gospasm.
    4) inspiratory dyspnea during laryngospasm is not due to spasmic contraction of the adductor muscles, but mainly due to inactivity of the abductor.
    5) Aerodynamic effect of inspired air strem plays a cooperative part for dyspneic inspiration of laryngospasm.
  • 奥田 稔, 海野 徳二
    1976 年 79 巻 6 号 p. 667-669
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Immunoglobulins of different classes are known to play a role in humoral defense mechanism, and Immunoglobulin E, without any actual evidence, is also expected to perform the same function.From the point of the defensive role, the present study was undertaken in nasal allergy by observing the way in which powdered carbon particles previously insufflated in the nasal cavity are rapidly removed in the nasal provocation test with causative allergen extract.
    The ratio of disappearance time of the carbon powder after/before the provocation test decreased markedly in good proportion with the intensity of the provocative reaction.Both sneezing and nasal secretion provocated by allergen contributed to this removal of the powder.When the nasal cavity in one side wastested, the non-tested side also showed a rapid disapp arance of the powder.
    In conclusion, Immunoglobulin E serves as a gate keeper by removing allergens from the surface of the nasal mucous membrane and by inhibiting the penetration of allergens into the nasal mucosa
  • 酒井 俊一, 中島 章雄, 池畑 貞雄, 尾崎 正義, 池田 寛, 山本 邦之, 吉田 淳一, 矢野 和栄
    1976 年 79 巻 6 号 p. 670-679
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Therapeutic results of 130 primary cases of maxillary sinus carcinoma from1967 to 1969 and 80 primary cases in 1972 and 1973, were analysed in December 1975.The 2-year and the 5-year crude survival rates for the former were 42% and 30%, and the 2-year crude survival for the latter was 53%.
    The treatment policy over these periods consisted of combined irradiation and intraarterial infusion given as the first step and maxillectomy performed in only recurrent cases.
    Therefore, a numerical comparison could be made between survival rate in the initial combined therapy alone and that in the following maxillectomy.The survival rates of both groups from 1967 to 1969 were almost equal, but, in 1972 and 1973, the therapeutic weight of the initial combined therapy became much heavier than that of the following operation.
    A randomized study, carried out from 1967 to 1969, concerning 25 cases treated by intraarterial infusion of 5-FU alone, 35 cases by intraarterial infusion with other combined drugs and 45 cases by irradiation alone, resulted in the significantly better survival rate and the local nonrecurrence rate of the 5-FU intraarterial infusion group than that of the other groups.
    In a trial undertaken in 1972 and 1973, 63 cases, 70% of the total cases, were treated by the combination of intraarterial infusion of 5-FU and irradiation with a total irradiation dose of 5000 rads in 10 fractions during 5 weeks or 3500 rads in 7 fractions during 3.5 weeks.There was no significant difference of the rates concerned between the two groups.
    At the same time, therapeutic results of the group in which tumor tissue was removed from the maxillary sinus by curettage were compared with those of group treated without curettage and no significant difference crude survival rates was found between the two groups.However, the 2-year non-recurrence rate by initial treatment combined with curettage was significantly better than that without curettage.This could be evaluated as a worth treatment for preservation of both the figure and the function.On the other hand, this mode of treatment left us such problems as difficulty in following maxillectomy and increase in occurrence of distant metastases.
    The authors concluded that in the series of trials for the principle treatment policy of maxillary sinus carcinoma, the best results were obtained by initial treatment by 5000 rads irradiation of Co-60 gamma-ray in 25 fractions during 5 weeks combined with continuous intraarterial infusion of 5-FU in the amount of 2000mg during 4 weeks, and antrostomy in all cases and curettage, if necessary.The following treatment composed of maxillectomy as a rule and the intracavital or external irradiation additionally depending upon the situation
  • 島田 国益
    1976 年 79 巻 6 号 p. 680-685
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    The author investigated the rate of correct judgment of 5 untrained, 2 semi-trained and 2 fully trained scorers in the detection of the auditory evoked response of young children during sleep, and searched how much proficiency in the judgment could be acquired by the untra- fined scorers by a short term training.
    Auditory evoked responses were recorded on 9 young children aged 2 to 9 years with normal hearing during sleep.The recording was performed with a 1000Hz pure tone at the intensity levels of 0, 20, 40, 60 and eodB and without stimulation.From 2 out of 9 subjects, 10 averaged traces were obtained with consecutive 50 stimuli at each intensity level and without stimulation, and from the remaining 7 subjects 4 traces at each test condition.Out of 288 traces thus obtained, 210 were used for testing and 78 were prepared for a training material.
    At the first test, the 5 untrained scorers were given a guide-pattern of the response with its peak latencies and they judged the presence or absence of a response on the 210 traces with the aid of the guide-pattern.As was presumed, a significantly lower detectability of the response was found in the untrained scorers as compared with the trained scorers.After the second test which was carried out with an interval of 20 days under the same condition as the first test, a short term training was performed on the response detection by using 78 traces prepared for this purpose.In the third and fourth tests which were performed after the traing, the scorers made a marked progress in the detection of the response, showing a slight difference in the rate of correct judgment between them and the fully trained scorers.
    From the results obtained, the conclusion can be drawn that it is not difficult to reach a certain level of proficiency in judgment of auditory evoked response in young children during sleep.However, it is extremely difficult to surpass this level because of a substantial lack of information obtainable from an averaged pattern of the evoked response in young children during sleep
  • 石田 稔, 中島 章雄, 井上 博雄
    1976 年 79 巻 6 号 p. 686-694
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
    Malignant tumors of the ear, nose and throat are derived mainly from epithelial cells.The only established cell strain of such neoplasms has been HEp-2.
    Nobody has ever reported any cell strain derived from the epithelium of the paranasal sinus.We have successfully to cultivated tumor cells originating in paranasal sinuses of one of the 25 patients.A cell line from this patient has passed through i5 transfer generations.
    The patient was a 48-year-old man with cancer of the left paranasal sinus.The tumor had clinically advanced to the degree of T3N, Mo, and was histologically a differentiated sguamous cell carcinoma with marked cornification.
    Furthermort the character of the cultured cells was studied for chromosome type, plating efficiency and growth curve.A histological study of the cultured cells was done by a light microscope, a phase contrast microscope and an electron microscope.
    The results were as follows:
    1) Morphologically the cultured cells were polygonal and characterized by nuclei of various sizes, which had 2 or more cells nucleoli, and a high nucleus vs.cytoplasm ratio was noted.
    2) The karyotype histogram revealed the presence of 2n and occassionally 4n bodies which caused the wide distribution of the chromosomal number.
    3) The plating efficiency with Eagle's MEM solution was 42%.The cells were shown to multiply even in specially prepared soft agar suspension.
    4) The growth curve showed that a period of 6 days was required for the cells to attain a twentyfold count.
    These findings strongly suggest that the cultured cells are derived from the malignant tumor of the patient and are of an epithelial origin
  • 猪 初男
    1976 年 79 巻 6 号 p. 695-701
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
  • 法貴 昭
    1976 年 79 巻 6 号 p. 712-715
    発行日: 1976/06/20
    公開日: 2008/03/19
    ジャーナル フリー
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