日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
85 巻, 8 号
選択された号の論文の8件中1~8を表示しています
  • 過去10年間の観察
    石田 稔, 堀 哲二, 玉置 弘光, 松永 亨, 尾崎 正義, 原田 保, 吉野 邦俊, 中尾 雄三, 大本 達也
    1982 年 85 巻 8 号 p. 903-911
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
  • 伊東 眞人, 吉田 淳一, 松永 亨, 酒井 俊一
    1982 年 85 巻 8 号 p. 912-917
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    The larynx is considered to be one of the target organs of male sex hormone.
    Androgen receptors were estimated in cytosols of laryngeal carcinomas from 19 male patients. 3H-Dihydrotestosterone(3H-DHT) and 3H-Methyltrienolone(3H-R1881) binding proteins were assayed by the dextran coated charcoal method and specific binding was analysed by Scatchard analysis.
    No binding proteins for R1881 were found in all 19 tumors. However, DHT binding proteins were found in all the tumors examined. The number of binding sites for DHT were 2.9-40.0 fmol/mg cytosol protein and the dissociation constants were 5.3-19.0×10-10M. The nature of DHT binding was examined with the inhibition test by utilizing several kinds of competitors.
    Most DHT binding was found to be sex hormone binding globulin but unknown DHT binding proteins were also present in cytosols of laryngeal carcinomas.
    These findings seems to show that no or very small amounts of androgen receptors are present in human laryngeal cancer.
  • 横井 久, 柳田 則之, 坂堂 正生
    1982 年 85 巻 8 号 p. 918-925
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    The influences of blast on auditory organs were studied experimentally with a scanning electron microscope. Guinea pigs were exposed by blast of maximum pressure 1.0kg/cm2 for 0.2sec. via the external auditory canal. Then, guinea pigs were sacrificed immediately after the blast and, 1 day, 3 days, 1 week, 2 weeks and 4 weeks after exposure. Changes of sensory hairs of inner and outer hair cells were observed with a scanning electron microscope. Furthermore, changes of sensory hairs in 1 second exposure were observed. The following results were obtained.
    1. Sensory hairs were injured more in basal and second turns than in third and subsequent turns.
    2. Outer sensory hairs were injured morn than inner ones but in the place where outer hairs were injured severaly, inner hairs were injured, too.
    3. The sensory hairs were lost uncontinuously, and the extent of injury area was not constant.
    4. The basilar membrane was more resistant than sensory hairs.
    5. The perforation of tympanic membrane was seen in all cases.
    6. Rupture of the round window membrane was also seen in some cases, but whether the rupture was present or not, there was not a great difference in injury of sensory hairs.
    7. When pressure loading was prolonged to 1sec., the injury of sensory hairs became severer, the extent of injury became wider, and the injury often continuous from the basal to the upper turns.
  • 村橋 けい子, 柳田 則之
    1982 年 85 巻 8 号 p. 926-940
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Concerning factors for the hearing recovery of sudden deafness, various studies have been done, but there are still many unknown things.
    On 600 cases (604 ears) of sudden deafness examined within two weeks after onset and observed until the fixed time of hearing, the factors of prognosis were studied in groups of various days after onset. Data obtained were statistically examined using λ2 test and analysis of variance etc., and the following results were obtained.
    1) The severer hearing loss, the worse hearing recovery. This tendency was noted earlier in the low frequencies than in the high ones. Even within four days after onset, in cases that mean hearing loss of 250, 500, 1k, 2k, 4k Hz was above 80dB, especially in cases of severe deafness above 90dB, prognosis was poor.
    2) The marked hearing recovery was observed within two weeks after onset, and the faster recovery in this period, the better prognosis. The hearing recovery was worse and the fixation of hearing was about one week earlier in the high frequencies than in the low ones.
    3) In cases within ten days after onset, prognosis was poorer in those with vestibular symptoms than without then. Furthermore, prognosis was poorer in vertigo than in dizziness concerning the properties of vestibular symptoms.
    4) Many cases with positive ABLB test revealed complete recovery. However, the prognosis was not related with the result of other recruitment test, age and time from onset to initial examination, etc.
    5) Among various factors concerning the prognosis, the most important factor is the degree of hearing loss on the day after onset by multiple regression analysis.
  • 蝸牛有毛細胞聴毛の障害を中心に
    坂堂 正生, 柳田 則之, 横井 久
    1982 年 85 巻 8 号 p. 941-950
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    In order to investigate the influence of high pressure on the inner ear sudden atmospheric pressure changes were given to the guinea pigs in a chamber.
    They were sacrificed immediatele, 1 week, 2 weeks, 1 month and 2 months after the conditional loading.
    The morphological changes of cochlear sensory hairs were observed by means of a scanning electron microscope. The time required to increase or decrease atmospheric pressure was changed from 8, 4 to 2 minutes. As the result, the followings were clarified.
    1) The sensory hairs were damaged less than 4 minutes by both increasing and decreasing pressures, showing barotrauma in the inner ear.
    2) The main morphological changes of sensory hairs were swelling, bleb formation, derangement, fusion, break-off and/or disappearance.
    3) The damage of sensory hairs was noted immediately after the conditional loading in all cochlear turns, and there was hardly any difference in the degree of damage in each turn. Outer hairs were more easily damaged than inner ones.
    4) The damage of sensory hairs became severe by rapid change and decreasing rather than by gradual change and increasing of pressure.
    5) Round window membrane rupture was noted in about one third of animals in the group of decreasing pressure for 2 minutes, and the damage was severer than that without membrane rupture.
    6) The damage of sensory hairs was not noted, when the tympanic membrane had been perforated previously.
    7) Strong pressure itself, starting with pressure differences between the middle and outer as well as inner ear, and reaching the inner ear via the inner ear window, is the direct cause of the inner ear barotrauma, and it is not caused temporarily as a result of round window membrane rupture.
  • 佐藤 文彦, 矢野原 邦生, 竹之内 智, 鈴木 由一, 久 育男, 日向 誠
    1982 年 85 巻 8 号 p. 951-956
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    A study was made of the mechanical properties of the canine intrinsic laryngeal muscles; thyroarytenoid, cricothyroid, posterior cricoarytenoid, and lateral cricoarytenoid. These muscles were stimulated electrically with constant voltage stimulation of 1 Volt.
    The contraction time was found to differ between the relatively fast group (thyroarytenoid, 14 msec; lateral cricoarytenoid, 21 msec) and the relatively slow group (cricothyroid, 40 msec; posterior cricoarytenoid, 45 msec). The fusion frequency was also found to differ between the two groups, i. e. higher in the former (95Hz and 90Hz, respectively) and lower in the latter (40Hz and 45Hz, respectively). There was a certain correlation between the contraction time and the fusion frequency; the shorter the contraction time was, the higher was the fusion frequency.
    The mechanical properties of the laryngeal muscles were compared with the movement and biomechanics of the glottis induced by stimulation of the laryngeal nerve branch distributing to each intrinsic laryngeal muscle. The results indicated that the laryngeal movements and biomechanics, especially the glottic pressure, the size of the glottic chink and the adduction-abduction tension were affected significantly by the mechanical properties of the intrinsic laryngeal muscles and other anatomical structures such as the so-called elsetic recoil.
  • 丸山 毅, 村上 泰, 猪狩 武詔, 原口 茂徳, 岡田 康司, 安藤 真姿子, 藤村 昭子, 小津 雷助, 岡本 亮二, 細田 兵之助
    1982 年 85 巻 8 号 p. 957-962
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
  • 佃 守
    1982 年 85 巻 8 号 p. 963-970
    発行日: 1982/08/20
    公開日: 2008/03/19
    ジャーナル フリー
    Tumor associated antigen (TAA) of a nasopharyngeal carcinoma (NPC) cell line (NPC-204) was extracted and its specificity was examined by the lymphocyte proliferation assay in 40 Japanese and 12 Chinese NPC patients.
    1. The simulation index was significantly high in 27 of the 40 Japanese and 7 of the 12 Chinese NPC patients.
    2. PPD skin test and measurement of total lymphocyte count and the subpopulation of T and B lymphocytes were performed. These parameters showed no correlation with the stimulation index.
    3. Tumor associated antigen of Raji cells was extracted and its specificity was examined by the same assay. The stimulation index was also significantly high in NPC patients.
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