The histo-pathological studies were made on the rabbit-tonsils inoculated with the strain SK 5 of herpes simplex virus. The results were as follows. 1) Microscopic examination of the palatine tonsil for each areas showed degenerative necrosis with polymorphonuclear leucocytes, ballonierende degeneration of the crypt epithelial cells, partial desquamation of the crypt epithelial layer, swelled endothelial cells and disappearance of lymphcytes in the lymph follicles. Tthese changes were appeared already within 12 hours after inoculation and became marked withen 72 hours, however, these changes returned nearly to the normaly after 7 days. The inclusion bodies were found as " Lipschiitz Type " in the crypt epithelial cells after 72 hours. 2) After intratonsillar inoculation, the rabbits were killed on the 1st, 3rd, 5th and 7th day and the infected tonsils emulsion were inoculated intracerebrally in the mice. They died apparently from encephalitis and their brain were found cell infiltration of the meninges, hypertrophy of the endothelium, degeneration or necrosis of nerve cells, neuroglial proliferation and perivascular cell day infiltration microscopically. The mice were injected, however, with the tonsil emulsion of the 7th after inoculation showed no signs of encephalitis and healthily survived for a long time. 3) From the results above mentioned experiments it is clear that the tonsils of the rabbits also have the sensitivity equally to the mucous membrane of the mouth against the herpes simplex virus and the tonsillitis studied histopathologically are surely viral inflamation.
Sialography has gained in importance as a method of diagnosis of the diseases of the salivary glands of late years. In the basic studies of sialography, one of the most important problems involves the amount of contrast medium (moljodol) to be injected. The amount to be injected is determined based on several criteria that have been established for the purpose of.obtaining unvarying sialograms for each case at all times. Reviewing the criteria established for injection of moljodol, the author evolved the method of determining the amount based on intraductal pressure. A device for measuring intraductal pressure was perfected, and experiments were carried out in animals and humans to study the intraductal pressure with varying amounts of moljodol in the ductal system. In animals, injections were done by three different methods, with intraductal pressure being measured in each case. The relation between intraductal pressure and the amount of moljodol injected was clarified and the validity of the criteria based on intraductal pressure was proved by comparing the results with cinesialographic and sialographic findings, as well as with the specimens of the salivary glands injected with acrylic resin and histologic specimens of the glands stained with Sudan III. After injection of moljodol, patients were followed with X-rays to see how long it will take for injected moljodol to be withdrawn entirely.
The authors reported a case of 46 yrs. old man, who had experienced repeated massive pharyngeal hemorrhage during the past twenty years. He had received X-ray radiation therapy under the diagnosisof pharyngeal angioma. However, according to the result of clinical investigations including arteriographicexamination, the authors was leading to the following diagnosis: unusual arterio-venous fistula arising from the deep tissue of the nasopharynx. For the purpose of controlling the recurrent hemorrhage, in the first step, the ligation of right external carotid artery was performed. But this procedurehad only a temporary effect and followed by the reapearance of massive hemorrhage. Therefore the authors decided to ligate the right common carotid artery. Before the ligation was performed, the patient had received the excercises to resist against the temporary blocking of the blood stream of common carotid artery with finger pressure. Electroencephalographies were made befor and after the blocking until no change occured by this procedure. After the ligation of right common carotid artery recurrent homorrhage was completely disappeared. The authors reviewed the literature of arterio-venous anastomosis and found that this was an especially unusual and interesting case.
As a result of some comparative basic investigations between the so called long acting sulfa drugs such as sulfisomezole, sulfamethoxypyridazine, sulfaphenazol, and sulfadimethoxine and the short acting one such as sulfisomidine, the authors found the fact that the formers had much more excellent characteristics than the latter. These excellent characteristics, namely, were their maintenance of high concentration in blood and tissue due to the very slow urinary excretion and the low acetylation rate. From these data, when the authors payed attention to the therapy of chronic sinusitis hitherto using with sulfa drugs, it seemed to be expected that the long acting sulfa drugs could improve the effect of therapy in chronic sinusitis. However, as to excellent characteristics, there was little to choose among them, while each of them had the excellent characteristics itself respectively. On the other hand, concluding from investigations in vitro, although staphylococci were a little more sensible to the long acting sulfa drugs than the previous short acting ones, they were easily to get the resistance against the formers comparatively in early stage and the degree of resistance did not diminish in a long period of time. So, in these points, it was to be considerable that these long acting sulfa drugs have not been improved.