In allergic patients, a decreased β-adrenergic responsiveness are thought to cause excessive release of mediators. Therefore, the present study was undertaken to evaluate possible β-adrenoceptor alterations in nasal allergy. β-Adrenoceptors in lymphocytes of 15 nasal allergy subjects and 15 non-allergy healthy subjects were measured using radioligand 3H-dihydroalprenolol (DHA) binding techniques.
The results were as follows.
1. The amount of β-adrenoceptors in lymphocytes of nasal allergy subjects was similar to the amount of β-receptors in non-allergy subjects. There was also no difEerence in lymphocyte β-adrenoceptors between house-dust allergy patients and Japanese cedar allergy patients.
2. The amount of β-adrenoceptors in patients with nasal allergic symptoms were significantly smaller than patients without symptom (p<0.01).
3. The amount of β-adrenoceptors in patients without any medication was small, but not significant compared with patients who were treated with the desensitization by allergens or with γ-globulin plus histamine.
4. The amount of β-adrenoceptors in patients who had eosinophilia (more than 6% of total leucocytes) was significantly smaller than in patients who had no eosinophilia (p<0.01).
The results suggest that β-adrenergic hyporesponsiveness in nasal allergy follows allergic reaction, and that the hyporesponsiveness is not the predispodition to nasal allergy.
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