日本耳鼻咽喉科学会会報
Online ISSN : 1883-0854
Print ISSN : 0030-6622
ISSN-L : 0030-6622
87 巻, 9 号
選択された号の論文の8件中1~8を表示しています
  • 第2報:鼻閉による局所抗体産生,および感染防御に及ぼす影響について
    岡本 美孝
    1984 年 87 巻 9 号 p. 1071-1074
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    As a part of the study of host defense mechanisms of the nose, the following experiments were performed.
    1. The rats having an artificially obstructed noses, were exposed, along with control-group rats, to bacterial extract aerosols.
    After the first exposure, the antibody titer of the nasal washings did not appreciably exceed the measurable level in either group. However, the second exposure evoked a definite rise in the titer of nasal washings by the control group, but not by the other.
    2. Following the second exposure of the bacterial extract aerosols, the rats in both groups were infected with aerosol inhalation of viable bacterial cells. Those on which the extract was administrated intraperitoneally were also exposed in the similar manner. The rise and fall in the bacterial counts by the lungs and noses were thoroughly studied.
    No bacterial cells were found in the noses of the group having high antibody titer in the nasal washings within 2 week after bacterial inhalation. The group having low antibody titer, however, showed a residue of bacteria. They showed, however, a high serum antibody titer.
    These results suggest that antibodies in the nose exert a wide defensive influence on inhalated bacteria, and that the obstruction of the nasal breathing prevents the production of the nasal local antibodies.
  • 間島 雄一, 坂倉 康夫, 伊藤 博, 松原 隆志, 三吉 康郎
    1984 年 87 巻 9 号 p. 1075-1085
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    Decelerated nasal mucociliary clearance has been demonstrated in patients with chronic sinusitis. However, it is as yet known whether this depression in mucociliary clearance is related to changes in the rheological properties of mucus, in the number and function of the cilia, or other factors. The purpose of this study was to determine if abnormal rheological properties of mucus or decrease of number of cilia contribute to the mucociliary dysfunction in chronic sinusitis.
    Nasal mucus was collected from 38 patients with chronic sinusitis and then, nasal mucociliary clearance (ST) was determined by saccharin granule technique. ST of the 16 patients was within normal range and ST of the other 22 patients was decelerated. Mucociliary transport rate of the nasal mucus on mucus depleted bullfrog palate was 5.93±1.04 mm/min in the patients whose ST was normal, and was 5.54±1.94 mm/min in the patients whose ST was decelerated. Significant difference in the mucociliary transport rate on frog palate was not observed between these two groups. This result suggests that rheological properties may not contribute to the slowing of nasal mucociliary clearance.
    The quantitative scanning electron microscopic study was performed on both nasal turbinate and maxillary sinus mucosae of 14 coupled samples. The epithelial surface occupied by cilia was determined using an image analyzer. The ciliated area of the epithelium was 90.2±9.9% in the nasal turbinate and 54.4±35.1% in the maxillary sinus mucosa from the patients undergone radical surgery. Cilia were not injured in the nasal cavity and were injured in the maxillary sinus in various degrees. This result shows that the slowing of nasal mucociliary clearance is not due to the decrease of the number of cilia.
    There was no decrease in the number of cilia in the nasal cavity in patients with chronic sinusitis. Rheological properties of nasal mucus are not the cause of the impairment of nasal mucociliary clearance in this disease. In conclusion, other factors such as tethering between outer mucous layer and mucus secreting cells and/or decrease of the thickness of periciliary fluid layer may play a major role for the deceleration of nasal mucociliary clearance associated with chronic sinusitis.
  • 11例の報告と文献的考察
    末永 通, 酒井 昇, 福田 諭, 田中 克彦, 寺山 吉彦
    1984 年 87 巻 9 号 p. 1082-1088
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    3年5カ月の問に11例の鼻副腔真菌症を経験し,外来患者数に対する発生率は0.06%であった.この中には稀有とされる鼻腔例,両側上顎洞例,蝶形骨洞例,各1例が含まれており,鼻副鼻腔真菌症は,潜在的に多いものと思われた.
  • 渡辺 行雄, 大橋 直樹, 今村 純一, 水越 鉄理
    1984 年 87 巻 9 号 p. 1089-1095
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    Previously we reported a computer system to analyze ENG by on-line real time process.
    In this paper, some fundamental conditions about computer analysis of ENG, that is, the characteristics of ENG recording system and the analyzing process of computer, and some technical problems in the use of micro-computer were studied. Amplitude and velocity of slow phase were little influenced by time constant, but fast phase velocity was influenced significantly. The experiment on effects of noise filter showed that the velocity of the fast phase was significantly lowered by a low frequency noise filter.
    Sampling frequency also affected to fast phase velocity as noise filter did. It would be better to sample with high frequency, however, high sampling frequency might increase the processes work for the computer analysis.
    It was generally accepted that the programing of micro-computer was simple and easy, however, in a case of complicated program as real time process of ENG, it is not simple, but rather difficult than programing of mini-computer. This might be due to the lack of detailed informations about the operating system offered by a computer maker.
  • 小林 俊光, 桜井 時雄, 草刈 潤, 相原 坦道, 府川 修, 石井 正三
    1984 年 87 巻 9 号 p. 1096-1102
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    Auditory evoked brain stem response (ABR) and electrocochleogram (ECoG) were simultaneously recorded during six cerebellopontine angle surgeries (three acoustic neuromas and three microvascular decompressions for hemifacial spasm or trigeminal neuralgia).
    This study indicated that ECoG is more useful than ABR in identifying the wave I and in detecting the subtle latency change of the wave I during the operative manipulations. It is suggested that simultaneous recording of ABR and ECoG can be more advantageous than merely relying an ABR in the intraoperative monitoring of the auditory function during the cerebellopontine angle surgery.
  • 尾股 丈夫, 小針 啓生, 大内 仁, ワルター シェッレ
    1984 年 87 巻 9 号 p. 1103-1110
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    Morphological changes of the afferent and efferent nerve endings of the outer hair cells after acoustic exposure were studied by means of a transmission electron microscope. Thirtyone rabbits were exposed to the pure tone of 2kHz 100dB for two hours. Afterwards they were morphologically examined at regular intervals for one month. In the afferent and efferent nerve endings the mitochondria dilated and small vesicles decreased in number immediately after acoustic exposure. The recovery of these changes was observed. The agglomerations of the synaptic vesicles along the synaptic membrane and the gaptructures in the synaptic cleft were noted in the efferent nerve endings after acoustic exposure. These changes were discussed from an electron microscopical viewpoint.
  • 緑川 周子, 高橋 正紘, 辻田 直美, 星川 治子
    1984 年 87 巻 9 号 p. 1111-1119
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    1. 少量注水法による冷水刺激検査を客観的に評価するために,正常者10名に対し,1)20°C 5ml 10秒間注水20秒間刺激(少量注水法)2)20°C 20ml 10秒間注水,3)20°C 50ml 20秒間注水,4)簡易法による冷温交互試験(20ml 10秒間注水)を行った.1),2)は暗所開眼下およびフレンッェル眼鏡下,3),4)は暗所開眼下に観察し,眼振最大緩徐相速度,眼振持続時間を比較した.
    2. 眼振最大緩徐相速度は注水条件,観察条件により異なり,暗所の20°C 5ml 10秒間注水20秒間刺激が最も反応が強く(34.6度/秒),個体間の変動も小さかった.これに対し簡易法による冷温交互試験ではきわめて反応が弱く,温刺激では冷刺激の約2倍の反応が得られたが,8.4度/秒にすぎなかった.フレンツェル眼鏡下では,注水条件に関係なく,暗所の約1/3に減弱した.
    眼振持続時間は,注水条件による影響を受け難かった.フレンッェル眼鏡下では,暗所の約2/3に短縮した.
    3. 多数の臨床例の結果を基に,少量注水法による冷水刺激検査の判定基準を作成した.正常者における眼振最大緩徐相速度の分布より,20度/秒以上,左右差20度/秒以内を正常とし,以下slight difference, moderate CP, severe CP, complete CPの5段階に分類した.
    4. めまい患者における5段階評価の分布は,疾患にょり差が認められた.ストレプトマイシン使用量と眼振最大緩徐相速度の関係より,少量注水法は迷路機能障害の出現,進行の有無の把握に役立つことがわかった.
    5. 少量注水法は,ネラトンカテーテルによる灌流刺激法に比べ精度が高く,眼振最大緩徐相速度を指標とした新しい判定法により,従来の左右差による判定法と異なり,左右耳の正常異常を個別に判定できる.
  • 卵白グリセリンの音響像への影響とアーチファクトの検出
    井上 要二郎, 平野 実, 垣田 有紀
    1984 年 87 巻 9 号 p. 1120-1125
    発行日: 1984/09/20
    公開日: 2008/03/19
    ジャーナル フリー
    As a part of the series of study of the mechanical properties of the human vocal folds by means of a scanning acoustic microscope (SAM), the effect of the egg albumin, which was used for fixating the specimen on a sample plate, on the acoustic image was examined.
    In the first part of the study, a double blind comparison was made on the acoustic images of sample plates with and without the egg albumin. As a result, it was revealed that the egg albumin affected the acoustic image by giving unfavorable stains when the lens was focussed on the surface of the sample plate. The stains were observed even when the focus was set 20μm above the plate.
    The following method was then devised to detect the stains or artifacts in the acoustic image obtained by SAM. First, two slides of acoustic images were made from two serial sections. The slides were then projected on a screen using two separate projectors with red and blue cellophane cover on the lens respectively. If there existed any artifacts in the acoustic image, they manifested themselves colored on the screen.
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