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93 巻, 8 号
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声門癌T1•T2症例の検討安田 範夫, 大森 敦子, 後藤 達也, 久 育男, 村上 泰, 大槻 晃直1990 年 93 巻 8 号 p. 1171-1178
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーThe stage classification is most frequently used at the present in predicting the outcome of laryngeal carcinoma. Recently, DNA ploidy pattern as detected by DNA flow cytometry and cytofluorometry has been also shown to be predictive. In this study, DNA cytofluorometry was performed on formalin-fixed paraffin-embedded tissues from 18 patients with TI and T2 glottic squamous cell carcinoma for whom long-term Hollow-up data were available.
The DNA ploidy pattern was classified into three types, diploid, diploid+tetraploid and aneuploid according to the DNA content of Go/G1, cells and mitotic cells. In these 18 cases, 8 cases (44%) had diploid pattern, 3 cases (17%) had the diploid +tetraploid pattern and 7 cases (39%) had the aneuploid pattern. The ploidy pattern was significantly associated with the relapse-free rate, but did not correlate with the stage of the carcinoma and differentiation of the cancer cells.Distribution of the patients by histology, stage and therapy was almost equal among the diploid, diploid+tetraploid and aneuploid groups. All the patients were treated with irradiation (60Gy).In the group as a whole, no patient died of glottic carcinoma. Relapse-free survival rates for diploid, diploid+tetraploid and aneupoid were 88%, 33% and 29% respectively.This retrospective study of glottic cancer treated with radiation therapy suggests the possibility that the DNA ploidy pattern would significantly predict patient outcome and would be useful for selecting patients whose poor prognosis demands more aggressive therapy.抄録全体を表示PDF形式でダウンロード (591K) -
湯川 久美子, 熊川 孝三, 高橋 整, 城間 将江, 舩坂 宗太郎1990 年 93 巻 8 号 p. 1179-1185
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーPsycophysical responses of the patients to electrical stimulation were examined in order to clarify long-term effects of the cochlear implant in 9 patients who had received a 22-channel cochlear implant. Measured items were the minimal threshold level (T-level), the maximum comfortable level (C-level), and the dynamic range between T- and C-level. Measurements were repeated for each electlode every three months over more than 6 months.
Following results were obtained.
1) The changes of the T-level were classified into four types as follows, a type with no change, a type with gradual decrease, a type with decrease in two to three months followed by gradual increasing threshold and a type with gradual increasing just after surgery. Even in a last type, the maximum increase in the T-level did not exceed 200-A and, in most cases, these changes were stabilized wihthin a few months after implantation.
2) The dynamic range gradually increased. It was obvious in both in the middle and apical electrodes, while such increased threshold was not observed in the basal electrodes.
3) In some cases, a few basal electrodes could not been used since they caused uncomfortable sensation or those dynamic ranges became below a certain extent.
As a result, it was suggested that the electrical stimulation had not induced serious degeneration of the ganglion cells and the auditory nerve fibers. The reduction in the number of usable electrodes might be due to the surgical trauma to the intracochlear tissue. Therefore, exposing of the scala tympani should be minimal in order to avoid the damage of the cochlea.抄録全体を表示PDF形式でダウンロード (491K) -
第一報:活動型真珠腫と非活動型真珠腫におけるEGFの局在の比較後藤 友佳子1990 年 93 巻 8 号 p. 1186-1192
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーThe localization of epidermal growth factor (EGF) in human cholesteatoma tissue was examined immunohistochemically, using sections of formalin-fixed, paraffin-embedded tissue with avidin-biotin peroxidase complex method.
Thirty-three cases of active cholesteatoma which had abundant granulation and debris were studied. Out of 33 cases, EGF was positive in 32 cases (97%) in the epidermis, 30 cases (91%) in the fibroblast, and 21 cases (64%) in the endothelial cells. In 9 cases of inactive cholesteatoma, on the other hand, EGF was positive in 5 cases (56%) in the epidermis, no case in the fibroblast, and a case (11%) in the endothelial cells.
Active cholesteatoma had higher immunoreactivity in the epidermis than inactive cholesteatoma. This suggests that the activity of cholesteatoma is indicated by the immunoreactivity of EGF.
Difference of EGF immunoreactivity between active and inactive cholesteatoma was bigger in the fibroblast in the subcutaneous tissue of cholesteatoma than in the epidermis. This gives the reason that the activity of cholesteatoma exists in the subcutaneous tissue.
These results suggest that EGF plays an important role in accelerating the growth of cholesteatoma.抄録全体を表示PDF形式でダウンロード (1256K) -
第二報;重層扁平上皮細胞角化層におけるEGFの局在後藤 友佳子1990 年 93 巻 8 号 p. 1192-1201
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーThe localization of epidermal growth factor (EGF) in human cholesteatoma tissue, normal ear drum and external auditory canal skin was examined immunohistochemically, using avidin-biotin peroxidase complex method.
Bouin-fixed tissue was stained for investigation of horny layer in the epidermis, because fixation in Bouin's solution provides better preservation of the antigen. In the horny layer of cholesteatoma tissue, 19 out of 24 cases had EGF-positive immunoreactivity (79%). In 2 cases of normal external auditory canal skin, 4 cases of normal ear drum and a case of postauricular skin, no EGF-immunoreactivity was revealed in the horny layer.
EGF was assayed in the debris of cholesteatoma and the horny layer of the normal bony external canal with dot blot immunoassay. EGF content of the debris was higher than that of the horny layer of normal skin.
The result of the first report suggests the activity of cholesteatoma exists in the subcutaneous tissue (see the previous paper). In this report EGF content of cholesteatoma in the horny layer was found higher than that of normal external skin. This result demonstrates that EGF in the horny layer plays an important role in accelerating the growth and bony destruction in cholesteatoma.
To summarize these two reports, the following conclusion was reached. In the epidermis EGF content is equal in cholesteatoma and normal skin. But in the subcutaneous tissue and the horny layer EGF content of cholesteatoma is higher than that of normal skin. EGF in situ may be strongly related to the growth and bony destruction of cholesteatoma.抄録全体を表示PDF形式でダウンロード (1989K) -
鼻アレルギー患者における昆虫抗原皮内反応成績荻野 敏, 入船 盛弘, 洪 蘇玲, 原田 保, 菊守 寛, 野瀬 道宏, 松永 亨1990 年 93 巻 8 号 p. 1200-1206
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーThe present study was undertaken to assess the importance of insects as allergens causing nasal allergy. We performed intradermal skin tests with extracts from three insects, chironomid, caddis fly, and silkworm moth, on patients with nasal allergy and on volunteers among medical students. Twenty-two (27.5%) of 80 nasal allergic patients showed positive reactions to chironomid allergen and 9 (11.3%) had positive reactions to caddis fly allergen and 18 (22. 5%) to silkworm moth allergen. These positive rates were as frequent as those to Candida or ragweed.
Medical students were divided into two groups, symptomatic and asymptomatic, according to the presence or the absence of nasal allergy. Three (11.5%) of 26 symptomatic group showed positive reactions to chironomid and one (3.8%) to caddis fly and 5 (19.2%) to silkworm moth. While even 4 (8.3%) of 48 asymptomatic group showed positive reactions to chironomid, 2 (4.8%) to caddis fly, and 6 (12.5%) to silkworm moth.
These results suggested that these insects, chironomid, caddis fly, and silkworm moth, are relatively common than we expected and suspected as important allergens in nasal allergy. Key words: nasal allergy, intradermal skin test, chironomid抄録全体を表示PDF形式でダウンロード (478K) -
鶴窪 一行, 服部 康夫1990 年 93 巻 8 号 p. 1207-1221
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーAfter the respiratory tract is damaged by trauma or infection, it is repaired rapidly. The purpose of this study is to observe morphologically the regenerative process of tracheal mucosae, especially the regeneration of blood vessels in the mechanically injured tracheal mucosa of rats.
The total mucosal layer of trachea was removed by curetting in 95 adult rats. Then, at several interval from one hour to ten weeks after treatment, 5 rats were killed, and their curreted area of the trachea were removed as specimen for transmission electron microscopical and scanning electron microscopical observation. For scanning electron microscopy, vascular network casts were made by the infusion of Mercox resin through the aortic arch.
One hour after curetting, the injured blood vessels formed terminal blind branches. From three hours to one week after curetting, many vascular bud-like-processes appeared in venules at the floor and margin of the curetted wound. Twelve hours after curetting, new vascular network were observed in the curetted area. One week after curetting, the vascular network was consisted of capillaries, veins, and arteries. The vascular networks were almost completely rearranged at six weeks after curetting. However the irregular arrangement were still observed partially after ten weeks of curetting.
The formation of terminal blind branches in vessels were noted as the initial healing process of injured vascular networks. Then many "bud-like-processes" appeared. Six weeks after curetting, the vascular networks were almost completely rearranged.
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川原 孝文, 宮口 衛, 石田 京子, KYOKO ISHIDA1990 年 93 巻 8 号 p. 1222-1226
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーA 23-years-old female with no known previous contact with tuberculosis complained of right otorrhea. Treatment with antibiotics agent was resisted, and a tympanic perforation became two.
Her tuberculin test was positive, but her chest X-ray showed no signs of lung tuberculosis. Posterior rhinoscopy revealed a granuloma in the epipharynx.
Histological examination of a biopsy specimen revealed tubelculosis changes.
Treatment with antituberculosis agents, SM INH RFP greatly reduced the mass and the tympanic perforation.抄録全体を表示PDF形式でダウンロード (1506K) -
原田 保1990 年 93 巻 8 号 p. 1227-1240
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーComplement is known to relate to many inflammatory reactions. C4a, C3a and C5a, known as anaphylatoxins, are known to cause strong inflammatory reactions.
In this study, the role of anaphylatoxins on the pathogenesis in the cochlea was examined. On hundred forty six male Harley guinea pigs, weighing about 350 grs, all susceptible to preyer's reflex, were used in this study.
Anaphylatoxins were made from guinea pig serum treated with zymosan, and inoculated into the carotid artery of the guinea pigs. Parts of these animals were sacrificed and examined at ten minutes, one day, two days, three days, seven days, ten days and fifteen days after injecton of anaphylatoxins.
Pathological changes in inner ears were observed by light microscopy. After 10 minutes, inner ears were found morphologically normal.
After one day, inner ears were found to be almost morphologically normal but the stria vascularis was observed with cystic formation. After two days, cystic formations in the stria vascularis were enlarged and Reissner's membranes were collapsed in some other animals.
After three days, the stria vascularis in the various cochlear turns except in the basal turn, were extremely atrophied, some cochlear nerves showed degeneration and some cochlea showed endolymphatic hydrops. After seven days, ten days and fifteen days, the morphological changes showed atrophy in the stria vascularis similar to the results observed on the third days.
Atrophy in the stria vascularis was improved gradually with time, but the degeneration of the cochlear nerve was not improved.
Opinions have been divided on the cause of inner ear disease including Meniere's disease. Many authors have reported that infectious diseases, for example mumps, measles and cytomegalovirus infection, have caused human sensorineural hearing loss. These diseases have been reported to result in atrophy in the stria vascularis, degeneration of the cochlear nerve and some other pathological changes.
In this study, it was clearly observed that the atrophy of the stria vascularis, the endolymphatic hydrops and other morphological changes were caused by introduction of anaphylatoxins.
These results were similar to the pathological changes observed in inner ear diseases in humanbeings. Therefore, inflammatory substances, including anaphylatoxins, were closely related to the cause of inner ear diseases. The animal model used in this report is considered to be important for elucidating the pathogenesis of inner ear diseases.抄録全体を表示PDF形式でダウンロード (4187K) -
朝倉 光司, 中野 勇治, 新谷 期子, 松田 史明, 秋田 信人, 形浦 昭克1990 年 93 巻 8 号 p. 1241-1249
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーWe performed uvulopalatopharyngoplasty (UPPP) in 51 adult patients with obstructive sleep apnea syndrome (OSAS). After UPPP, there were statistically significant improvements in apnea-hypopnea index (AHI), the lowest value of oxygen saturation during sleep and total time of apnic episodes. 28 patients (54. 9%) were good responders who represented more than 50% improvements in their AHL Poor responders tended to be more severe and older than good responders. After cephalometric analysis, poor responders were revealed to show significantly poor mandibular prognatism and also lower positioned hyoid bone than good responders.抄録全体を表示PDF形式でダウンロード (641K) -
各種ストレス負荷時秋岡 勝哉1990 年 93 巻 8 号 p. 1250-1261
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーRecently Meniere's disease is believed to show a pathological features of endolymphatic hydrops, but the etiology of this disease has not yet been ascertained. Many investigators tried to create animal models with endolymphatic hydrops by obliterating endolymphatic sac and duct. However, these methods have not been adequate to explain the mechanism of development of Meniere's disease, because it gives mechanical damage to destroy endolymphatic sac and duct. On the other hand, Meniere's disease is thought to develop even as a result of stress. The present paper reported the conduction of an acute experiment, creating active endolymphatic hydrops by stress load, to study the occurrence rate of endolymphatic hydrops and the pathological findings of inner ears by a light microscope. This was followed by a light and electron microscopic study on the changes in permeability of the cochlear lateral wall with horseradish peroxidase and a study of the develop- ment mechanism of endolymphatic hydrops.
Results obtained were as follows:
1. Although it was impossible to cause endolymphatic hydrops with a single stimulation, four kinds of stress stimulations could cause endolymphatic hydrops with the rate of 37.8%.
2. Judging from the different pathological findings between the group with four kinds of stress stimulations and the untreated control group, vessel permeability in the stria vascularis was highly chageable, while that in the spiral ligament was not.
3. It was found out that increased permeability of the stria vascularis vessels was by increased pinocytotic vesicular transport and through tight junctions from vessel lumen to basal lamina and that it was presumably only by increased pinocytotic vesicular transport beyond basal lamina.
4. It was assumed that increased permeability of the stria vascularis vessels was one of the causes of endolymphatic hydrops which were believed to be pathological features of Meniere's disease.抄録全体を表示PDF形式でダウンロード (3421K) -
犬山 征夫1990 年 93 巻 8 号 p. 1288-1291
発行日: 1990/08/20
公開日: 2008/03/19
ジャーナル フリーPDF形式でダウンロード (190K)
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