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92 巻, 11 号
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伊藤 久子1989 年 92 巻 11 号 p. 1863-1868
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーTo determine the effects of circulatory disorder on the cochlear function, compound action potentials (AP) were measured in cats with the anterior cerebellar and the labyrinthine arteries occluded. While transitory AP depression followed the anterior cerebellar artery occlusion in approximately one third of the animals, there were no changes in the others. In contrast to this, approximately one third of the animals, there were no changes in the others. In contrast to this, AP disappeared rapidly in all cases with labyrinthine artery occlusion and recoverd only after release of the occlusion in a period of time proportionate to the duration of occlusion. The different ways of response in the two occlusion sites seem to be attributed mainly to a greater chance of collateral circulations in the proximal. In addition, wide range of variance was observe from cat to cat in the effect of the anterior cerebellar artery occlusion and in the recovery following the release of occlusion in the labyrinthine artery, which may be attributed to anatomical variation inherent in the artery system.抄録全体を表示PDF形式でダウンロード (338K) -
木村 恭之, 古川 仭, 上出 文博, 作本 真, 三輪 高喜, 梅田 良三1989 年 92 巻 11 号 p. 1869-1875
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーAlthough the topical treatment with steroids is the widespread method for olfactory disorders in human, the reports are limitted to clinical observations. The aim of this report is to evaluate the effect of topically applied of steroids in mice on the repairing course by the experimental olfactory disorders caused by zinc sulfate. The olfaction of mice was estimated by the record of behavioral task, using Cycloheximide, commonly used as repellent in rodents. When mice taste Cycloheximide for the first time, immediately the mice experience a very to the simultaneus memory of the odor of Cycloheximide. Those who once experienced the taste and odor of Cycloheximide, will avoid simply by the odor next time. Two bottles were offered to mice, one containing distilled water and the other 0. 01% Cycloheximide. When the mouse drank the distilled water, the response was interpreted as a correct response. When the Cycloheximide solution was chosen, an error. Twenty four mice were tested at ten times during a 10-minute trial, and the rates of correct response were counted. From the next day after the treatement of zinc sulfate, nasal application of 0. 1% β-methasone (group A), or nasal application of distilled water (group B) were applied to each group of twelve mice for five days.
The results were as follows.
1. In the first experiment, the correct response was 85% (group A), and 80.8% (group B), however at the second trial, all responses were correct.
2. One day after nasal application with a 1% aqueous solution of zinc sulfate, the correct response dropped significantly to 85% (group A), and 86.7% (group B). This was considered due to olfactory disturbance caused by zinc sulfate.
3. Five days after zinc sulfate application, the correct response of the group A was 94. 2%, indicating the recovery of olfactory function. The correct response of the group B has not changed.
4. Fifteen days after zinc sulfate application, the correct response was 92% in the group B indicating the recovery of olfactory function. The defference of the recovery peroids between two groups was statistically significant. We conclude that topical nasal application of steroids is useful method for the treatment of olfactory disturbance抄録全体を表示PDF形式でダウンロード (2237K) -
臨床応用への基礎的検討安田 範夫, 大槻 晃直, 後藤 達也, 久 育男, 村上 泰, 橘 正芳1989 年 92 巻 11 号 p. 1876-1883
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーNormal human laryngeal epithelia and laryngeal squamous cell carcinoma were assayed by Feulgen DNA cytofluorometry using free cell nuclei isolated from carnoy-fixed, paraffin-embedded specimens.
In all of the 12 normal specimens, the epithelium showed typical diploid cell clones with low proliferative activity. Polyploid cells were seen in only two specimens from subjects aged 61 and 69 years respectively, and the number of polyploid cells seen in these two specimens was only two.
Fifteen cancer cases were divided into three groups : an untreated group (5 cases), a chemother-apy group (5 cases) and a group of cases with recurrence after radiation therapy (5 cases). Among these three groups the DNA ploidy patterns were compared. In the untreated group, all cases showed a two-peak diploid pattern and a high proliferative activity, and polyploid cells were present. In the chemotherapy group, a wide one-peak histogram extending from 2C to about 5C was noted in 4 cases, and an aneuploid pattern in one case. Thus, the DNA ploidy pattern in the chemotherapy group differed from that in the untreated group. Of the 5 cases with recurrence after radiation therapy, one had a tetraploid pattern, but the remaining 4, a two-peak diploid pattern similar to that seen in the untreated group.
Polyploid cells were observed in all these cancer cases. However, because they were also seen in some normal subjects, the finding of polyploid cells is not considered to be conclusive of cancer diagnosis. Because of a large variety of nuclear DNA patterns in cancer patients as noted in the present study, carefully prepared specimens of a sufficient amount of cells are needed so as to utilize nuclear DNA cytofluorometry for the diagnosis of laryngeal squamous carcinoma and the evalua-tion of its prognosis抄録全体を表示PDF形式でダウンロード (1531K) -
その正当性と正常範囲内藤 義弘, 白戸 勝1989 年 92 巻 11 号 p. 1884-1894
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーThe nasal patency during respiration is today usually expressed by the nasal resistance. However, the nasal resistance is not the same throughout the total respiratory phase. Therefore, the reference point to express the resistance is therefore necessary to facilitate the mutual compari- son of the data. The international committee for standardization of rhinomanometry has been paying a great effort to decide where this reference point should be set up, but has not yet reached the final consensus. The purpose of this study is to present a new method to estimate nasal respiratory conductivity, regardless of the reference point.
Pressure flow curves during nasal respiration are quite similar in nature and rarely cross one another. The parabolic curves which do not cross each other can be superimposed by multiplying the standard equation, V =n •f (P). Accordingly, n is only one parameter in comparing these curves. A standard curve is decided as follows.
Rohrer's equation was examined by polynomial regression analysis and concluded to be adequate to simulate a pressure flow curve. Rohrer's equation is converted to the function of P. Integration of this equation along P gives the value of the area under the curve (AUC). The total AUC can be obtained by simply adding the AUC of right and left sides. Definite integration from the origin to 1. 0 and 2. 0 on the abscissa gives the numerical value of AUC in each curve. The mean AUC is easily calculated by simple mathematical averaging of the data. K, and K2 of the standard curve are calculated by solving simultaneous equations using mean AUC. K, and K2 during expiration and inspiration are calculated, respectively.
718 subjects who had not been recently suffered from nasal diseases were examined by active anterior rhinomanometry. 47 functionally normal subjects in twenties were selected for calcula-tion of the standard curve using the above mentioned method. In expiration, the values of K, and KZ were 0. 5476 and 1. 3653, respectively. In inspiration, they were 0. 4080 and 1.4750.
Individual curve can be expressed by only one parameter. The normal range during nasal respiration is considered to be more than 0. 7. The method presented in this study is convenient for the mutual comparison of the data both in clinical and basic research.抄録全体を表示PDF形式でダウンロード (1452K) -
堀内 康治1989 年 92 巻 11 号 p. 1895-1910
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーA tone on tone simultaneous masking paradigm was used to determine tuning curves of ABR both from the normal and hearing-impaired subjects. ABR tuning curves were constructed to define masker intensity that resulted in a 50% reduction in probe elicited wave V amplitude. The frequency specificity of each probe stimulus was evaluated by Q10, low cut-off slope, high cut-off slope and the maximum masker frequency calculated for the tuning curves.
The results were as follows ;
1) Q10, low cut-off slope and high cut-off slope increased gradually with the increase in rise time. However, prolongations of the rise time beyond 3 cycles of probe frequency yielded little improvement in Q10, low cut-off slope and high cut-off slope.
2) Q10, low cut-off slope and high cut-off slope for normal-hearing subjects increased gradu- ally with the increase in stimulus frequency or the decrease in stimulus pressure. Maximum masker frequency of the tuning curves was not always equal to the frequency of probe without the 2-kHz. For the 0. 5, 1kHz probe, the maximum masker frequency of the tuning curves showed higher values than the frequency of probe. For the 4kHz probe, the maximum masker frequency of the tuning curves showed lower values than the frequency of probe. The results indicate that the tone pip stimuli will allow to assess certain conditions of auditory function at different fre- quencies, and they show wider frequencies' spread in the cochlea area near stimulus frequencies.
3) For subject with abrupt high-frequency hearing loss (30dB/oct), a pronounced down-ward shift of maximum masker frequency, down-ward shift of high cut-off slope and up-ward shift of low cut-off slope were found when the probe was placed in the region of elevated threshold. For subject with low-frequency hearing loss (25dB/oct), a pronounced up-ward shift of maximum masker frequency, down-ward shift of low cut-off slope were found.
Maximum masker frequency, low and high cut-off slope of hearing-impaired subjects were not always equal to those of normal subjects for same probe. Especially the value of the maximum masker frequency shifted to the direction in which the most sensitive frequency was observed in audiogram. The threshold of ABR reflected the cochlea function of the most sensitive area near stimulus frequencies. Greatest predictive error was observed in steeply sloping audiograms.抄録全体を表示PDF形式でダウンロード (1096K) -
横山 壽一1989 年 92 巻 11 号 p. 1911-1924
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーUnder adequate stimulus intensities, the power spectra of normal auditory evoked brainstem responses (ABR) are mainly composed of three major parts, i.e. component A (0. 350Hz), B (350 -700Hz), and C (700-1200Hz). By means of digital filter using fast Fourier transform, three derived ABR waveforms consist of each component of the power spectrum were obtained and named component waves A, B, and C, respectively. For the purpose of discussing the possibilities of clinical use of derived ABR waveforms, these three component waveforms were analized in normal hearing subjects and patients with central disorders. In addition, the changes of these waveforms were studied in a series of lesion experiments of brainstem auditory pathway in cats. Before and after destructions of cochlear nerve, cochlear nuclei, superior olivary nuclei, lateral lemniscus and inferior colliculus, these three derived waveforms were compared.
The following results were obtained :
1) In normal subjects, the changes in ABR waveforms according to the changes of the rise-time, interstimulus interval and frequency of the stimulus were mainly attributed to component wave C.
2) In patients with central disorders, component wave C were initially affected. Therefore, it seemed that the earliest waveform alterations in ABR occur in high frequency parts of the power spectrum.
3) The resultant experimental data in cats indicated that component wave C seems to be the most sensitive to reveal the lesion sites.
4) It was suggested that the analysis of ASR by three component waveforms was useful to detect the neurological disorders.抄録全体を表示PDF形式でダウンロード (1026K) -
永原 國彦, 三宅 洋一1989 年 92 巻 11 号 p. 1925-1934
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーA method for automatic boundary detection of the maxillary sinus from a cranial X-ray radiograph has been developed. An algorithm using the local segmental properties of the X-ray image to transform a continuous tone image into a bi-level image is introduced. In addition, the global shape information such as the area, the perimeter, and the complexity, are considered for the boundary detection. The boundary of the maxillary sinus detected by this method coincided precisely with the area plotted by experienced otolaryngologists. Furthermore, the cumulative distribution function (CDF) calculated from the density histogram of the maxillary sinus has been employed to perform the tonal evaluation of the intra-maxillary pathological changes. The distance between the CDFs successfully demonstrated the difference in pathological stages of the chronic sinusitis.抄録全体を表示PDF形式でダウンロード (2211K) -
高分解能CTによる検討一條 宏明, 朴沢 二郎, 太田 修司, 宮野 和夫1989 年 92 巻 11 号 p. 1934-1938
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーUsing high-resolution computed tomography, the relationship between the superior jugular bulb and the tympanic cavity was analysed in 40 subjects.
Until now, the superior jugular bulb was thought to lie below the floor of the hypotympanum, however, the following observations were made from this study :
1) In 48 (60%) out of 80 temporal bones (40 cases), the top of the superior jugular bulb was situated in the higher level than the floor of the hypotympanum.
2) In 9 cases, the jugular bulb was separated from the tympanic cavity by only thin bony wall. This finding was noticed on the right side in 8 cases and was bilateral in a case.
3) In 21 cases (52.5%), the right jugular bulb was situated in higher level than the left, and the reverse finding was noticed only in 4 cases (10.0%). The reason why the right jugular bulb is frequently higher than the left was thought to be related to its function. Namely, the jugular bulb is useful to absorb the pulsation of the carotid artery, therefore, it was considered that the anatomical and physiological differences between the right and left carotid arteries induce the asymmetry of the jugular bulbs.抄録全体を表示PDF形式でダウンロード (1528K) -
丸岡 健一, 村岡 道徳, 中井 義明, 八木 英晴1989 年 92 巻 11 号 p. 1939-1946
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーWe encountered 21 cases of congenital ear lobe anomalies at our clinic during the past seven years.
This report presents our system for classification of these cases and describes some typical cases. We divided ear lobe anomalies into four groups according to the type of lobe as follows; large, adhesive, defective and cleft ear lobe type. In the large lobe type, the ear lobe is characteris-tically large. For the adhesive lobe type, no angle is formed between the ear lobe and the face, i.e. the helix is elongated in a straight line towards the face. The cleft ear lobe type is classified into two surgical categories, viz. the cleft and appendage types. The former is recognized by a cleft on the lobe which continues from the helix, whereas the latter type has an appendage on the lobe. Combinations of these two types are included in the cleft type because a cleft in the lobe is more significant in terms of the shape of the repaired ear lobe.
As regards the surgical repair of these anomalies, careful consideration is required in order to accomplish tridimensional reconstruction and create the natural curve of the lobe using z-plasty and other local flaps.抄録全体を表示PDF形式でダウンロード (2309K) -
視運動性眼振と関連して岡田 智幸1989 年 92 巻 11 号 p. 1947-1957
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーRecent neurophysiological studies have disclosed that the nucleus of the optic tract (NOT) in the pretectum is the first relay station responsible for horizontal optokinetic nystagmus (OKN) both in non-foveate and foveate animals. However, what parts of the retina and what kinds of retinal ganglion cells project their fibers into the NOT have been controversial. In the present study, horseradish peroxidase cojugated with wheatgerm agglutin (WGA-HRP) was injected into the NOT of rats. The retina and injection sites were processed for the histochemical demonstration of WGA-HRP in order to investigate the distribution of the retinal ganglion cells projecting into the NOT.
The present study indicated that visual signals responsible for OKN are mainly conducted from the contralateral retinal ganglion cells, and only from the ventral area of the ipsilateral retina. The retinal ganglion cells projecting into the NOT ipsilateral to the injection site were larger than those on the contralateral side. Large retinal ganglion cells existed on the peripheral areas including ipsilateral ventral area. The density of the ventral ganglion cells of the retina contralateral to the injection site was lower than that in other areas of retina, and the density of the ventral ganglion cells ipsilateral to the injection site tented to be greater than that on the contralateral side. Since the ventral area of retina corresponded to the upper visual field in front of the nose, it may receive visual signal of OKN and fire OKN. In conclusion, visual signals responsible for OKN are conducted through the retinal ganglion cells mainly cotralaterally, and only from the ventral area of the retina ipsilateral to the injection site.抄録全体を表示PDF形式でダウンロード (2264K) -
梁 耀, 原渕 保明, 形浦 昭克1989 年 92 巻 11 号 p. 1958-1963
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーEmploying various monoclonal antibodies and immunoperoxidase technique, we studied the distribution of the activated lymphocytes in human tonsillar tissue. Both the activated T-cells positive for IL2-receptor (IL2-R) and the activated B-cells defined by L29 were seen in the interfollicular area. Vast majority of the lymphocytes in the germinal center was stained with the L29, the anti-transferrin-receptor antibody, and the Ki-67 antibody which reacts with cycling cells in G1, S, or G2+M phase. On the other hand, scarcely any cells in the mantle zone were stained with those. The Ki-67 positive cells in the germinal center were identified as two types of staining pattern, i. e., with strong nucleolar staining found in the dark zone and with nuclear staining found in the light zone. Small number of IL2-R positive cells was found in the mantle zone. The cell number per unit area of the activated lymphocytes in the interfollicular area as well as in the germinal center was decreased as the increment of patients' age. From these results, the im-munological activation system of T- and B-cells in the tonsils was discussed.抄録全体を表示PDF形式でダウンロード (2300K) -
奥田 稔1989 年 92 巻 11 号 p. 1996-1997
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーPDF形式でダウンロード (92K) -
高橋 宏明1989 年 92 巻 11 号 p. 1998-1999
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーPDF形式でダウンロード (100K) -
第2回日本口腔•咽頭科学会熊沢 忠躬1989 年 92 巻 11 号 p. 2000-2001
発行日: 1989/11/20
公開日: 2008/03/19
ジャーナル フリーPDF形式でダウンロード (171K)
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