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Volume 103 (1971)
- Issue 4 Pages 317-
- Issue 3 Pages 221-
- Issue 2 Pages 119-
- Issue 1 Pages 1-
Volume 103, Issue 3
Displaying 1-6 of 6 articles from this issue
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RYO KATORI, TAKASHI HANEDA, KOZUI MIYAZAWA, KINJI ISHIKAWA, KAI TSUIKI ...1971 Volume 103 Issue 3 Pages 221-230
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRegional difference of the amplitude of respiratory variations (Δp) in pulmonary arterial wedge pressure was investigated at different sites of the lung at various body positions in man and dogs. In 6 patients without pulmonary hypertension and 6 dogs, simultaneously measured Δp of wedge pressures in the right and left lungs was compared in supine, left lateral, right lateral and prone positions. The mean value of Δp of the left lung was always larger than the right one in any body positions. This was statistically significant except for right lateral and left lateral decubitus positions in man. In the other 5 dogs, Δp in the upper lung area and lower lung area in the right lung was compared in supine, head-up and head-down positions, and there was no statistically significant difference between the mean Δp in both wedge pressures in any body positions. No significant differences of the end-expiratory pulmonary arterial wedge pressures were found between the left and right lungs in different body positions in both patients and dogs and between upper and lower lung areas of the right lung in supine, head-up and head-down positions in dogs. The results suggest that the gravitational force does not cause regional difference of Δp of the wedge pressure, and it seems that significant difference of Δp between the left and right lungs is caused by the difference of the respiratory variations in intrathoracic pressure in both lungs.View full abstractDownload PDF (1903K) -
SEIJI NAGAI, CHISATO YAMADA1971 Volume 103 Issue 3 Pages 231-245
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe sucking ability of newborns was measured using an electronic manometer and analyzed for the following parameters: 1) sucking rate, 2) intraoral pressure, 3) continuous sucking time, 4) sucking time, and 5) actual sucking time. These five parameters were essentially the same among the normal newborns and it was also indicated that in the normal newborns, any difference was not exhibited by different feeding methods. The results also suggested that sucking was first of all an adequate stimulus of newborns to the mother's nipples. The sucking time was prolonged significantly in the newborns whose intraoral pressure during sucking maintained positive or alternately positive--negative for a while, but this prolongation was not recognizable on the 7th day of birth. The respiratory rate during sucking did not differ significantly from that immediately before or after sucking.View full abstractDownload PDF (729K) -
TOKUTARO SATO, MAKIO OKUYAMA, TATSUO TORIKAI1971 Volume 103 Issue 3 Pages 247-255
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBiosynthesis of glycoproteins in the connective tissue of the rat epididymal fat pads was studied in vitro. After incubation of the adipose tissue with glucose-1-14C, the carbohydrate containing polymers such as glycogen, several glycoproteins and acid mueopolysaccharides were extracted by the procedure of Robert et al. It was shown that glucose-1-14C was incorporated into glycoproteins in the stroma and into glycogen in the cells of the adipose tissue. However, no radioactivity was detected in acid mucopolysaccharides under the present experimental conditions.View full abstractDownload PDF (490K) -
AKIRA OHNEDA, SHOICHI YAMAGATA1971 Volume 103 Issue 3 Pages 257-268
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe radioimmuno assay for glucagon using two-antibody system was described in detail. The value of sensitivity ranged 0.06 to 0.60mμg on the standard curves obtained with crystalline glucagon (0 to 14mμg per ml) in buffer solution. The precision of the standard curves was 0.8 to 1.5 in per cent precipitated radioactivity for 0 to 14mμg per ml range of glucagon. Glucagon added to human plasma was recovered at the rate of 74.6 to 116.3 per cent. The glucagon level in fasting human plasma measured by this method showed a wide range of variety and even high values (2.2 to 7.1mμg/ml) were obtained in non-diabetics than in diabetics who gave the values of 1.5 to 5.6 mμg/ml. Human plasma globulin reduced the percentage of precipitated radioactivity, whereas human plasma albumin did not appear to interfere with the immunological reaction. Since human plasma globulin did not exhibit any effect upon the rate of bound radioactivity in paper chromatography, it is suggested that the human plasma globulin may inhibit the immunological reaction at the second reaction. The cross reaction between antirabbit serum goat serum (ARGS) and human plasma or plasma globulin was observed on the immunoelectrophoresis and this was regarded as one of the inhibitors. EDTA failed to reduce the inhibition. The inhibition could be minimized by the extraction of plasma glucagon using acid-ethanol acetone method, by absorption of cross reactant in ARGS by a small amount of human globulin and by the use of anti-rabbit serum globulin goat serum. Even in the assay using anti-rabbit serum globulin goat serum as the second antibody, however, the rate of precipitated radioactivity in the assay of the standard glucagon added to the pooled human plasma with the minimun glucagon was lower than expected. This suggests the presence of another inhibitor (s) in human plasma and the necessity of the use of glucagon-free human plasma in the preparation of the standard glucagon solution.View full abstractDownload PDF (1841K) -
TAKASHI A. SUZUKI, JERRY H. JACOBSON1971 Volume 103 Issue 3 Pages 269-283
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWhen the eye was exposed to a steady background light, the visually evoked cortical response to a test flash consisted of the primary complex and a series of distinct spike-like discharges. The discharges, which are observed within a circumscribed part of area 18, are designated by the authors as the light adapted discharges (LAD). Effects of the reticular stimulation upon the cortical response especially on the LAD are studied. The primary complexes are inhibited by the RF-stimulation, while the LAD are greatly facilitated. The effect is usually observed in association with the arousal pattern of EEG. RF-stimulation effect on the LAD increases gradually with increase in intensity of RF-stimuli (5-20 volts) and with decrease in RF train off-flash on interval. However, RF-effect on the subcortical (OT and LGN) responses are never observed. The conditioning train stimuli given to the LGN have complicated the effect on the LAD, i.e., facilitate at lower intensity of the conditioning stimuli (1-10v.), while they depress at higher (12-50v.). On the other hand, they have only a depressive effect on the primary complex. The effects of RF-stimulation upon the electrically evoked cortical response to OT single shock are observed. The intracortical genetic component are selectively increased by either RF-stimuli or stready light adaptation.View full abstractDownload PDF (1363K) -
AKIRA RIKIMARU, TAIZO SUZUKI1971 Volume 103 Issue 3 Pages 303-315
Published: 1971
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPhysiological and pharmacological analyses were made on the relaxing responses of intestinal smooth muscle elicited by the electrical stimulation and by ganglion stimulants. The relaxation produced by the perivascular nerve stimulation and the transmural stimulation at high frequencies were prevented by adrenergic blocking agents, whereas those produced by the transmural stimulation at low frequencies and by the ganglion stimulant (nicotine) were resistant to them. Furthermore, this resistant type was abolished in the presence of tetrodotoxin. These results imply that the relaxing responses elicited by the transmural stimulation of low frequencies may involve the non-adrenergic inhibitory nerve system. Some substances were tested to mimic the relaxing response to the transmural stimulation. Dopamine produced a relaxation which was abolished by an adrenergic blocking agent (phentolamine). 5-Hydroxytryptamine (5-HT) caused a contraction which was reversed to a relaxation by atropine. This relaxing effect of 5-HT is mediated by the nerve, since the relaxation by 5-HT is completely prevented by tetrodotoxin. GABA produced only contractions and the other amino acids tested failed to produce a relaxation. These trials to mimic the relaxing response due to the transmural stimulation by some naturally occuring substances were unsuccessful, and at the present time, the nature of the transmitter of the non-adrenergic inhibitory nerves remains unknown.View full abstractDownload PDF (771K)
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