The Tohoku Journal of Experimental Medicine

A Further Study of the Augmenting Action of Nictine upon the Epinephrine Secretion from the Suprarenals of the Non=Anaesthetized Dog

Masao Wada, Takuji Hirano, Masari Tiba

1938 Volume 33 Issue 3-4 Pages 189-212
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.189

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Influence of nicotine upon the epinephrine output rate, the mean arterial blood pressure and the blood sugar concentration were determined in the dogs, non-fastened, non-anaesthetized, without evoking pain.
Although the epinephrine output was measured by Watanabe in the dogs, in physiological conditions as normal as possible, other than nicotine poisoning, the short interval of time just after injection was regrettably omitted there, owing to difficulties of managing the animal in the intoxication period. But this time is in fact just that betraying a maximally accelerated secretion of epinephrine, judging from the experiments undertaken under narcosis.
Our expectation has been realized, the blood samples from the suprarenals, collected 30 seconds long from the moment of starting injection (1 mgrm. nicotine per kilo intravenously), showed the maximum acceleration. The absolute value was 0.01 mgrm.-0.0007 mgrm. per kilo per minute from the one gland, or several hundreds to seventy times the preinjection rate. That in the second or subsequent 30 seconds period was about two-thirds of the preceding period, then afterwards it diminished quickly, so that usually about 5-10 minutes later the epinephrine output rate was found almost similar to the pre-injection period. But this length of the hyperepinephrinaemic period is thus far longer in nonanaesthetized dogs, compared to the animals under narcosis.
The period of the great acceleration must be taken as very brusque.
The period of the largest acceleration in the epinephrine liberation corresponds to the spell where the blood pressure fell abruptly, and at the end of this first 30 seconds period the pressure set in to elevate, and in the second 30 seconds period the elevation reached its maximum.
Thus it may be comprehensible that the maximum acceleration in the epinephrine discharge occurs almost simultaneously with the blood pressure fall and precedes the pressure elevation.
The changes in the blood sugar concentration occurred more slowly than those in the arterial pressure.
The denervation of the suprarenal gland, -there the splanchnic nerves were cut-, caused some diminution in the acceleration of the epinephrine output rate if the figures obtained in one and the same dog, one gland with the intact innervation, another denervated, be compared with each other. This finding might be explained by assuming some action of nicotine on the nervous mechanism for regulating the epinephrine liberation, besides on the suprarenal medulla. But the authors will not pronounce it now because of the smallness of experience.

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Action of Nicotine upon the Blood Pressure in Rabbits, Deprived of the Coeliac and Superior Mesenteric Ganglia and the Suprarenals

Masari Tiba

1938 Volume 33 Issue 3-4 Pages 213-218
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.213

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Nicotine was intravenously administered into normal. rabbits, anal rabbits indefinitely surviving removal of the suprarenals, and the coeliac and upper mesenteric ganglia, in doses of 0.5 mgrm. and 1 mgrm. per kilo of body weight with the mean blood pressure recording.
The removal does not alter at all the magnitude of the pressure fall occurring immediately after the nicotine injection and that of the subscquent pressure elevation. Neither is the time when they occur altered.
The low resistance of the animals so. operated, on, though they were indefinitely well surviving, against the drug, has been also proved here.

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Über die Wirkung des Cumarincarbonsauren Diäthylaminoäthylephedrins

Koji Arai

1938 Volume 33 Issue 3-4 Pages 219-223
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.219

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Dried Natural Digestive Juices: II. Further Experiments

W. N. Boldyreff, W. B. Lewis, Charles E. Stewart

1938 Volume 33 Issue 3-4 Pages 224-229
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.224

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Data are presented on the properties of digestive juices before and after drying. The juices have been dried at 0°C in an especially constructed vacuum desiccator to prevent auto-digestion during the process of desiccation.

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Die Bedeutung der Flockungszahlreaktion für die Klinik

Gabriele Seitz

1938 Volume 33 Issue 3-4 Pages 230-246
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.230

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“Es ist gelungen auf Grund der Sublimat-Puchsin-Reaktion Takatas eine neue Methode zur Bestimmung des Blutserums zu schaffen, die die Möglichkeit bietet, den Grad der Labilität resp. Stabilität der Blutkolloide in exakten Zahlen auszudrücken”. Ihre klinische Bedeutung ist ähnlich der der Blutkörperchensenkung. In allen Fällen, wo die Skg vom übrigen klinischen Befund abzuweichen scheint, kann die Flz das BildvomKolloidzustand des Serums erhärten oder berichtigen and einen verstecktenKrankheitsherdaufdeckenhelfen. Bemerkenswertist, dass die Flz-Reaktion desto deutlicher and leichter ablesbar wird, je schwerer das Krankheitsbild sich gestaltet, während bei der Senkung leider das Umgekehrte der Fall ist.
Besondere Bedeutung scheint der Flz füvr die Beurteilung der Therapieeinwirkung bei Dekompensation des Kreislaufs und für die Prognose der Lungentuberkulose zuzukommen. Mit ihr ist eine Serumreak-tion geschaffen, deren Beachtung in der Klinik durchaus zu empfehlen ist.

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Über den Einfluss der innerlichen Darreichung einiger gerbsäurehaltiger Drogen auf die Blutgerinnung

Yutaka Noda

1938 Volume 33 Issue 3-4 Pages 247-258
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.247

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Über den respiratorischen Gaswechsel bei der Lungentuberkulose

I. Mitteilung. Über den Grundumsatz bei der Lungentuberkulose

Masao Ikari

1938 Volume 33 Issue 3-4 Pages 259-270
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.259

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Über den respiratorischen Gaswechsel bei der Lungentuberkulose

II. Mitteilung. Gaswechselsteigerung nach Belastung mit körperlicher Arbeit und die Rückkehr zum Ausgangswert bei Lungentuberkulösen

Masao Ikari

1938 Volume 33 Issue 3-4 Pages 271-274
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.271

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Über den respiratorischen Gaswechsel bei der Lungentuberkulose

III. Mitteilung. Über die zahlenmässige Darstellung der Dyspnoe bei der Lungentuberkulose

Masao Ikari

1938 Volume 33 Issue 3-4 Pages 275-278
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.275

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Erfahrungen mit Chromocystoskopie bei chirurgischen Nierenerkrankungen

Takasi Tamaki

1938 Volume 33 Issue 3-4 Pages 279-291
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.279

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Studien über die Oberflächenspannung des Harns und Blutserums bei chirurgischen Nierenerkrankungen

Haruo Matuda

1938 Volume 33 Issue 3-4 Pages 292-303
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.292

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Further Study on Application of Blood Picture to Topical Diagnosis

16th Hematological Paper

Masavuki Shindo, Yutaka Kokubo, Shizuo Kimura

1938 Volume 33 Issue 3-4 Pages 304-320
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.304

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On an average, the ratio “Comma-typed”: “C-typed”: “O-typed” is 26:43:31_??_5:9:6, and “Semicolon-typed” cells are 2.0% of seg-mented neutrophiles in healthy persons.
We can endorse with Suzuki the assertion made by Hayes, Spizin and Oransky, and may add here that almost all of our cases with constipation or diarrhoea showed a dominancy of “C-” and/or “O-typed” cells.
As to the frequent occurrence of “Semicolon-typed” cells, we may inversely use it for the diagnosis of some pulmonary affection, though the nuclear picture of rod shaped cells cannot always have a reverse application, or at least we feel we must take great care in regard to excluding some lung affection in a case with that picture.
The variety ratio in the classification of nuclei of neutrophiles will return to normal or at least nearly normal in the convalescent phase.

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The Significance of Crystal=like Needles in Leucocytes with Positive Sato=Sekiya's Copper Peroxidase Reaction

17th Hematological Paper

Tamotsu Suzuki

1938 Volume 33 Issue 3-4 Pages 321-327
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.321

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Hematology of Pyuria in Children

18th Hematological Paper

Masayuki Shindo, Yutaka Kokubo, Shizuo Kimura

1938 Volume 33 Issue 3-4 Pages 328-341
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.328

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Studien über die Veränderungen des Gewebseiweisses und dessen kolloid=osmotischen Drucks unter verschiedenen Bedingungen

I. Gewebseiweiss und dessen kolloid-osmotischer Druck bei Schlafmittelvergiftungen mit besonderer Berücksichtigung des Hirneiweisses

Shingo Yamamoto

1938 Volume 33 Issue 3-4 Pages 342-353
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.342

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Studien über die Veränderungen des Gewebseiweisses und dessen kolloid=osmotischen Drucks unter verschiedenen Bedingungen

II. Gewebseiweiss und dessen kolloid-osmotischer Druck im Hunger

Shingo Yamamoto

1938 Volume 33 Issue 3-4 Pages 354-368
Published: June 25, 1938
Released on J-STAGE: November 28, 2008

DOIhttps://doi.org/10.1620/tjem.33.354

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