The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 76, Issue 4
Displaying 1-8 of 8 articles from this issue
  • Masayoshi Kamo
    1962 Volume 76 Issue 4 Pages 319-325
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    In dogs anesthetized with sodium pentobarbital, the adrenal venous blood was collected by the lumbar route method. Differential estimation of adrenaline and noradrenaline contents of the whole blood samples was made by a modification of the Weil-Malherbe and Bone method. After atropinization, an intravenous injection of acetylcholine, carbaminoylcholine, or benzoylcholine was made.
    By the injection of choline esters the adrenal adrenaline and noradrenaline secretion rates were increased markedly. The relative amount of noradrenaline to the total catecholamines liberated after injection of carbaminoylcholine was on the average 31% and that after acetylcholine and benzoylcholine was 14% and 11%, respectively.
    The author is grateful to Dr. K. Hirai who provided valuable assistance in the present study and to Prof. T. Suzuki for criticizing the manuscript.
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  • Saburo Endo
    1962 Volume 76 Issue 4 Pages 326-349
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
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  • Junji Okuda
    1962 Volume 76 Issue 4 Pages 350-364
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    A single electric pulse was applied to various subcortical structures and its effect upon the evoked potential of the lateral geniculate body (the LGD response.) to a single test pulse applied to the optic tract was investigated in the cat. The interval between both stimuli was 100 msec and the test stimulus used was submaximal.
    1. Conditioning stimulation of any part of the brain stem reticular formation, mesencephalic or bulbar, caused augmentation of the LGD response.
    2. All cortical relay nuclei in the thalamus were ineffective.
    3. The so-called association nuclei which project to the association areas of the cortex were almost ineffective.
    4. N. centrum medianum (CM) and N. centralis lateralis (CL) were found facilitatory, the effectiveness being about 70 per cent of that of the reticular formation. N. ventralis anterior (VA) was the sole inhibitory area found in the present experiment.
    5. Forel's fields (H1, H2), Zona incerta (ZI) and N. subthalamicus (STh) were found as effective as CM and CL. N. ruber (NR) was also slightly effective.
    I wish to thank Prof. K. Motokawa for his invaluable discussion and suggestions throughout the course of the experiment and the preparation of the manuscript.
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  • Soitsu Fukuchi
    1962 Volume 76 Issue 4 Pages 365-373
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    1. The content of corticosteroids in adrenal tissue was estimated in 10 cases of primary aldosteronism, a case of Cushing's syndrome, adrenogenital syndrome, Kimmelstiel-Wilson's syndrome, malignant pheochromocytoma and essential hypertension.
    2. The content of corticosteroids in the adrenal tissue was not parallel to the urinary excretion of these hormones. A large amount of aldosterone was contained in the adrenal tissue of primary aldosteronism. Cortisol occupied a large part of adrenal corticosteroids in Cushing's syndrome.
    3. The adrenal tissue of primary aldosteronism, Kimmelstiel-Wilson's syndrome and essential hypertension contained a large amount of cortisol and corticosterone. In the light of this fact, it is assumed that corticosteroids secretion from adrenals of the patient with hypertension is similar in pattern to the adrenal secretion in primary aldosteronism.
    The author owes a debt of gratitude to the staff members of Prof. Yamada's Clinic, Hokkaido University School of Medicine; Prof. Ishikawa's Clinic, Hirosaki University School of Medicine; Nakadori Hospital, Akita Prefecture, and Prof. Nakamura's Clinic, Prof. Yamagata's Clinic, Prof. Katsura's Clinic, and Prof. Shishido's Clinic, Tohoku University School of Medicine for the supply of tissue, and to Prof. T. Torikai for his continuous leadership thoroughout this study.
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  • Susumu Shibata
    1962 Volume 76 Issue 4 Pages 374-387
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    The changes in the adipose tissue of the visceroptotic patients were examined and the following results were obtained.
    1. The thickness of the subcutaneous adipose tissue of visceroptotic patients is markedly reduced compared with that of the control cases.
    2. The diameter of the fat cells of visceroptotic patients is also smaller than that of the control cases.
    3. The connective tissue fibers in the adipose tissue are thin and scarce in the interlobular connective tissue and around the fat cells in these patients.
    From these results is may be concluded that the function of the adipose tissue as a supporting tissue of the abdominal organs in visceroptotic patients is decreased, and it contributes to the ptosis and displacement of the addominal organs. The quantitative reduction of adipose tissue may also induce lowering in the intra-abdominal temperature and affect the pathophysiology of abdominal organs of visceroptotic patients.
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  • Michiko Furuyama
    1962 Volume 76 Issue 4 Pages 388-414
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    1) A histometrical method was described, with which arterial cross sections of autopsy cases were reduced to the state, in which internal elastic membrane was perfectly stretched. The distance from the center of the arterial lumen to the middle point of the media in this condition was defined as anatomical arterial radius, R, and the thickness of the media in this condition as anatomical medial thickness, D. The values of R and D were determined by
    R=S/√L2+4πS-L and D=√L2+4πS-L/2π, respectively, in which L was the length of internal elastic membrane and S was the surface area of the muscular coat in arterial cross section.
    2) A regular relation was confirmed between R and D, which was represented by a general equation D=aRb, a and b being constants. On a logarithmic scale, the relation gave a linear regression and was represented by a linear regression equation _??_=bX+A, in which X=log R, Y=log D and A=log a. Statistical treatments of the histometrical results were discussed.
    3) The histometrical method was applied to renal and superior mesenteric arteries. Non-hypertensive cases were divided into 3 age groups, and in each age group common regression equations were determined of each artery to demonstrate the characteristics of arterial pattern. Each artery was composed of two parts divided at R=100μ. In the part R>100μ, b was smaller than, but very close to, 1. Superior mesenteric artery had stronger muscular coat than renal artery at R=1000μ. In the other part, R<100μ; b was remarkably lower than 1, especially in renal artery, indicating rapid elevation of the ratio D/R with reduction of arterial radius. At the point R=10μ, renal artery had a higher value of D/R. The difference of arterial pattern was discussed in relation to different regulatory function of the two arteries.
    4) The ratio D/R was defined as media index and employed as the estimate of medial strength. The value of the index was determined to the major part by blood pressure, arterial radius and arterial system, and to a lesser extent by age. Media index of the non-hypertensive was strikingly constant at a given radius of a given arterial system, in spite of remarkable arterial growth with age, with the exception at R=10μ, where the index gradually fell with age. By an elevation of media index medial hypertrophy was defined and hypertension was concluded.
    5) Upper rejection limit of estimated D from the regression equations of the non-hypertensive was statistically determined at R=1000μ, R=100μ and R=10μ of each artery. Arteries with larger estimated D than the upper rejection limit at any R were not regarded to belong to the non-hypertensive. The rejection limit at R=100μ of renal artery was the most effective and reliable anatomical standard in screening hypertensive cases.
    6) In the hypertensive, medial hypertrophy was confirmed in both renal and superior mesenteric arteries. Medial hypertrophy was very unequal according to the dimension of arterial branches. It was prominent in the region R>100μ, but less pronounced in the region R<100μ, and practically ceased to be noticed at R=10μ in the majority of cases with essential hypertension. Blood pressure was regarded to be abruptly lowered in the vicinity of R=100μ and arterioles were in all probability not exposed to abnormally high blood pressure in an average. The unequal medial hypertrophy induced a transformation of general arterial pattern in hypertension.
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  • Kwang-Do Koh
    1962 Volume 76 Issue 4 Pages 415-419
    Published: May 25, 1962
    Released on J-STAGE: November 28, 2008
    1. Serum 5-nucleotidase determinations were made in 30 normal persons and in 111 hospitalized patients with various diseases of the liver and alimentary tract.
    2. Serum 5-nucleotidase levels were found to be normal in all cases of peptic ulcer and of cancer of the gastrointestinal tract without hepatobiliary or pancreatic complications.
    3. Three cases of ulcerative colitis and four of acute pancreatitis showed elevations of the enzyme in the serum.
    4. Serum 5-nucleotidase elevation was frequently associated with an increase in alpha-1-globulin fraction of serum.
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  • 1962 Volume 76 Issue 4 Pages e1
    Published: 1962
    Released on J-STAGE: November 28, 2008
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