The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 201, Issue 3
November
Displaying 1-8 of 8 articles from this issue
Regular Contributions
  • Min-Hyung Chung, Chu-Yeop Huh
    2003 Volume 201 Issue 3 Pages 131-138
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    To evaluate the efficacy of various treatments for pelvic congestion syndrome in patients with different stress levels, we analyzed one hundred six patients with pelvic congestion syndrome, confirmed with laparoscopy and venography, who did not respond to medication after 4-6 months medication. They were divided into three groups: (embolotherapy; hysterectomy with bilateral oophorectomy and hormone replacement therapy; and hysterectomy with unilateral oophorectomy). The visual analog scale was used to measure degree of pain; stress level data were scored with the revised social readjustment rating scale. Embolotherapy was significantly more effective at reducing pelvic pain, compared to the other methods (p<0.05). The mean percentage decrease in pain was significantly greater in the patients with lower stress scores (p<0.05). Ovarian and/or internal iliac vein embolization appears to be a safe, well-tolerated, effective treatment for pelvic congestion syndrome that has not responded to medication.
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  • Suleyman Goren, Mehmet Subasi, Yasar Tirasci, Serdar Kemaloglu
    2003 Volume 201 Issue 3 Pages 139-145
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    The current study is based on a retrospective investigation of firearm deaths in Diyarbakir, which were autopsied by the Diyarbakir Branch of the Council of Forensic Medicine during the 6- year period. Four hundred-forty four deaths were investigated from January 1996 through December 2001, including homicide (296 cases, 66.7%), suicide (120 cases, 27%) and accidental shootings (28 cases, 6.3%). The age range of all firearm deaths in the study period was 5 to 75 years with a median age of 29.8 years. The majority were in the groups aged 16-25 years (38.7%). In the homicide group, 248 subjects (83.8%) were male, and 48 (16.2%) were female. The 31.1% of the homicide victims were in the group aged at 20-30 years. Of the 120 suicide victims, 56 (46.7%) were in the group aged 16-20 years. The head was by far the favoured site, accounting for 82 (68.3%) deaths: entry wounds in the right temple accounted for 72 of these. Twenty-eight cases were accidental shootings and 18 of them were male (64.3%). Twelve of the 28 accidental victims (42.9%) were in the group aged 0-10 years. The eight cases were due to their own accidental shootings, and the remaining 20 cases were shot by others. Our findings show that the contributing factors for increasing death by firearm are terrorists’ activities, traditional habits of obtaining and using guns and blood feuds.
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  • Belgin Süsleyici Duman, Melek Öztürk, Selma Yilmazer, H ...
    2003 Volume 201 Issue 3 Pages 147-155
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    Non-insulin-dependent (Type 2) diabetes mellitus (NIDDM) is a risk factor for cardiovascular diseases (CVD). Oxidative stress mechanisms are often reported to be implied in type 2 diabetes mellitus. In order to determine their clinical relevance, we investigated several plasma indicators in the Turkish patients with NIDDM: (i) homocysteine (Hcy) and cysteine (Cys) which contribute to increase the risk of atherosclerosis during NIDDM, (ii) glutathione (GSH) and cysteinylglycine (CysGly) resulting from GSH degradation catalyzed by γ-glutamylcysteine transferase (GGT), (iii) malonaldehyde (MDA) as a marker for lipid peroxidation, and (iv) total antioxidant status (TAS). Our main results were evaluated based on sex and diabetic status. In female patients, plasma concentrations of MDA and Hcy were significantly higher than in controls, while GSH levels were significantly lower. In males, a difference between control and diabetic groups was noticed only for Hcy, levels being also higher in patients. In the diabetic group, increase in serum glucose concentration was significantly correlated with increased GGT activity. In both controls and diabetic patients, GGT activity was correlated with a raised Cys concentration and a decreased GSH level. In both controls and diabetic patients, there were significant positive correlations between Cys and Hcy and between GSH and Hcy. We concluded that GSH and MDA levels are clinical indicators for an oxidative process linked to type 2 diabetes mellitus, especially in women.
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  • Keiji Kanemitsu, Hiroyuki Kunishima, Tomoo Saga, Hideo Harigae, Shiho ...
    2003 Volume 201 Issue 3 Pages 157-163
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    We isolated five bacterial strains from patients diagnosed as having nocardiosis. Bacterial species were identified based on the similarities in the nucleotide sequences of 16S ribosomal RNAs. Three of the five strains were identified as Nocardia asteroids, but unexpectedly other two were Streptomyces hygroscopicus and Rothia dentocariosa. The latter two species are not members of the family Nocardiaceae. We investigated the susceptibilities of these five strains to the following nine antimicrobial agents: trimethoprim/sulfamethoxazole (TMP/SMX), minocycline (MINO), erythromycin (EM), amikacin (AMK), cefotaxime (CTX), faropenem (FRPM), imipenem (IPM), ciprofloxacin (CPFX), and sparfloxacin (SPFX). The minimum inhibitory concentration (MIC) ranges (mg/ml) were as follows: TMP-SMX, 4->32; MINO, 0.125-8; EM, ≤0.016->32; AMK, 1-2; CTX, 0.063->32; FRPM, 0.063-16; IPM, 0.125-2; CPFX, 4-32; and SPFX, 0.5-16. Moreover, the synergistic effects of AMK in combination with each of TMP-SMX, MINO, EM, CTX, IPM, and SPFX were investigated by checkerboard synergy testing. No antagonism was recognized for the three N. asteroides strains. Synergistic and additive effects were observed for the combinations of AMK with CTX, IPM, or SPFX.
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  • Günfer Turgut, Bünyamin Kaptanoglu, Sebahat Turgut, Osman Ge ...
    2003 Volume 201 Issue 3 Pages 165-170
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    Insulin-like growth factor-I (IGF-I) is a polypeptide hormone and present in human urine. Insulin-like growth factor binding protein-3 (IGFBP-3) is the major form of binding protein in human circulation and functions as a carrier for IGF-I. Our goal was to determine the effects of volleyball exercise on the concentrations of urine protein, creatinine, IGF-I, and IGFBP-3 in children and to find out whether these effects differ between boys and girls. Volunteer children (13 females and 14 males), aged 10-13 years old were included in this work. Weight and height of the subjects were measured, and urine samples of their were collected before and after 2 hours of exercise. Urinary protein, creatinine, IGF-I and IGFBP-3 levels were analysed. Urinary protein, creatinine and IGF-I concentrations were increased after two hours of exercise wheres urinary IGFBP-3 concentrations did not change. In addition, no statistically significant difference in all parameters analysed was observed between boys and girls of similar age and body mass index.
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  • Shingo Fukayo, Koichi Nonaka, Teruo Shimizu, Eiji Yano
    2003 Volume 201 Issue 3 Pages 171-179
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    Contrary to intuitive preconceptions, patients with Parkinson’s disease (PD) have been reported to have less carious teeth. The present study was undertaken to seek responsible factors for this unexpected finding. The PD patients consisted of 31 consecutive university hospital outpatients who were 60 years old or over, and the controls of 104 comparable outpatients at a dental clinic. They were inspected for their dental status, and interviewed on their toothbrushing habits and dietary preferences. Their unstimulated saliva samples were collected and their flow volume and pH were measured. The total numbers of carious teeth (DMFT: Decayed, Missing, and Filled Teeth) and other related variables were compared between the two groups by stratification. In total, the DMFT for the PD patients was significantly fewer than for the control. The salivary flow and pH were correlated to the DMFT, but the difference between the two groups was not significant. Frequency of toothbrushing was higher among the PD patients. The lower DMFT among the patients became insignificant when salivary pH was 6 or less, toothbrushing was 2 times a day or less, or the response was positive to the question on the habit of eating snacks between regular meals. In summary, the oral health of PD outpatients with mild symptoms was better than the controls. However, in cases with poor oral hygiene status, the PD patient’s oral health was not different from the control. This suggests that they are not invariably protected from caries-associated factors. The generic property of PD may not fully explain the apparent difference in DMFT.
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  • Ye Tun, Wataru Hida, Shinichi Okabe, Hiromasa Ogawa, Yoshihiro Kikuchi ...
    2003 Volume 201 Issue 3 Pages 181-190
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    Obstructive sleep apnea (OSA) is commonly associated with systemic hypertension and now recognized as an independent risk factor for daytime hypertension. We aimed to study the short- and long-term effect of nasal continuous positive airway pressure (CPAP) in hypertensive and normotensive patients with OSA. Forty-six patients with moderated to severe OSA were treated with nasal CPAP and followed after one year of treatment. Clinic blood pressure, heart rate, and body weight were taken before and followed up for one year after beginning nasal CPAP. In this study 25 patients with OSA were found to have hypertension (54.3%). The hypertensive group showed a significant reduction in clinic blood pressure after nasal CPAP, whereas the normotensive group showed no changes. The subgroup of hypertensive patients with OSA who had no anti-hypertensive medication revealed a decrease in clinic blood pressure comparable to those with anti-hypertensive drugs. The heart rate was not significantly changed in any patients. There was no significant correlation between the decrease in body weight and the reduction in blood pressure. These results suggest that nasal CPAP alone might have a substantial blood pressure lowering effect in hypertensive patients with OSA. This effect could decrease the morbidity and mortality related to cardiovascular complications in patients with OSA.
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  • Leyla Kuntsal, Deniz Firat, Yigit Sirin
    2003 Volume 201 Issue 3 Pages 191-199
    Published: 2003
    Released on J-STAGE: August 13, 2004
    JOURNAL FREE ACCESS
    This study was designed to explore the protective effects of selenium on submandibular glands of rats that were maintained on liquid diet. The animals kept on liquid diet for 10 days following 20 days of solid diet, had severe degeneration on both acinar and ductal cells: pycnotic nuclei, enlarged granular endoplasmic reticulum, swollen mitochondria with separated cristae, reduction of secretory granules and abundant lipid droplets were observed. Body and gland weights of these animals were found to decrease significantly compared to those of control group given solid diet for 30 days. The animals that were fed 20 days with solid diet + 10 days liquid diet and also given selenium 0.4 mg/kg for 30 days, did not have any remarkable sign of degeneration on submandibular glands, and their gland weights significantly increased when compared to the animals fed with liquid diet without selenium supplementation. Submandibular glands of the group that was maintained on solid diet for 30 days and supplemented with selenium in drinking water were found to be normal. They showed consistent gain in both body and gland weights almost equal to that of control group. As a result, we assume that adding selenium in liquid diet can prevent the detrimental effects of liquid diet consumption on submandibular glands.
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