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Volume 167 (1992)
- Issue 4 Pages 247-
- Issue 3 Pages 171-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 167, Issue 3
Displaying 1-10 of 10 articles from this issue
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AKIO KOIZUMI, MIKAKO TSUKADA, SIGETOSI KAMIYAMA1992 Volume 167 Issue 3 Pages 171-180
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKOIZUMI, A., TSUKADA, M. and KAMIYAMA, S. A Skin-Specific MMTV Provirus is Stably Transmitted by Horizontal Transmission. Tohoku J. Exp. Med., 1992, 167 (3), 171-180 -Mouse mammary tumor virus (MMTV) is a retrovirus with a life cycle that remains to be elucidated. In establishing Mtv-4 congenic mice, an extra copy of the MMTV provirus was found specifically in the skin of both sexes of SHN mice but not in C3H/He mice. This extra copy was not, however, found in other normal tissues such as brain, lung, liver, spleen, kidney, uterus, testis, and mammary glands from SHN or C3H/He mice. In the skin of SHN mice, an 11-kb DNA fragment, which approximates in size to the entire MMTV genome, was detected in undigested high-molecular weight DNA. This unique MMTV provirus was shown to be transmitted horizontally from SHN mice to exogenous-MMTV-free C3H/He mice through nursing. The virus is thus concluded to be exogenous. Clusters of MMTV type A particles were found in sebaceous glands by electronmicroscopic examination. The present findings indicate that exogenous MMTV may be Stably maintained in the skin as an unintegrated provirus during its life cycle.View full abstractDownload PDF (2700K) -
SUSUMU YAMADA, ROKO KUBOTA, KAZUO KUBOTA, KIICHI ISHIWATA, TATSUO IDO1992 Volume 167 Issue 3 Pages 181-184
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMADA, S., KUBOTA, R., KUBOTA, K., ISHIWATA, K. and IDO, T. Efficiency of Grain Production and Latent Image Fading in F-18 Micro-autoradiography. Tohoku J. Exp. Med., 1992, 167 (3), 181-184 -In 18F micro-autoradiography using a frozen section method, the grain production was measured relative to the exposure time and radioactivity. The grain production increased until 6-hr exposure, but 7-hr or longer exposure induced a characteristic of latent image fading. However, the ratios of the efficiency of grain production between two different 18F-radioactivities (11.9 and 2.3mBq/100μm2) were constant over experimental exposure times, thus indicating that quantitative analysis by grain counting is preserved.View full abstractDownload PDF (308K) -
TADASHI OHARA, RIKUKO SASAKI, DAISUKE SHIBUYA, SHIGERU ASAKI, TAKAYOSH ...1992 Volume 167 Issue 3 Pages 185-188
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHARA, T., SASAKI, R., SHIBUYA, D., ASAKI, S. and TOYOTA, T. Effect of Omeprazole on Ascorbate Free Radical Formation. Tohoku J. Exp. Med., 1992, 167 (3), 185-188-In order to study the effect of omeprazole on the K/[H+] value of ascorbic acid (K=the ascorbic acid-ascorbic free radical equilibrium constant), changes of the concentration of ascorbate free radical in guinea pig sera were examined after intraperitoneal administration of omeprazole. Furthermore, to see the in vitro effect of omeprazole on ascorbate free radical, changes were examined in ascorbate solutions after addition of omeprazole. It was found that the K/[H+] value in the serum increased significantly after administration of omeprazole and also that the drug amplified the electron spin resonance (ESR) signal intensity of ascorbate free radical in vitro. These results suggested that omeprazole acts like oxygen radicals.View full abstractDownload PDF (389K) -
SEKOIYA ARITAKI, HIROO MIYAZAWA, MASAAKI OGIHARA, MASATAKA USHIO, AKIR ...1992 Volume 167 Issue 3 Pages 189-196
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSARITAKI, S., MIYAZAWA, H., OGIHARA, M., USHIO, M. and IZUMIZAWA, A. An Endocrinological Study of Persistent Pubertal Macromastia. Tohoku J. Exp. Med., 1992, 167 (3), 189-196-We performed an endocrinological study on three males with persistent pubertal macromastia. The blood testosterone (T) level in these patients was either elevated or at the upper normal limit, estrone (E1) and estradiol (E2) levels were high, and T/E1 and T/E2 ratios were decreased. Persistence of low T/E1 and T/E2 ratios was thought to be the cause of the macromastia. Results of therapy using drugs (cyproterone acetate, tamoxifen citrate, danazol, and clomiphene citrate) were unsatisfactory. Persistent pubertal macromastia is an extreme condition of physiological pubertal gynecomastia, a transient phenomenon in more than half of pubertal males. It is a pathological condition characterized by a great degree of breast enlargement and abnormal endocrinological findings, and its clinical course and treatment are different from those of physiological pubertal gynecomastia.View full abstractDownload PDF (959K) -
MASAHITO KARIYA, MASAMICHI GOTO, KAZUHISA HASUI, NORIKO YAMAMOTO, YUKI ...1992 Volume 167 Issue 3 Pages 197-205
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKARIYA, M., GOTO, M., HASUI, K., YAMAMOTO, N, TASHIRO, Y. and SATO, E. Is There Any Effect of Volcanic Eruptions of Mount Sakurajima on Canine Lungs Exposed Naturally?-Morphometric Analysis of Intrapulmonary Particulate Deposit Amount and Histopathological Investigations. Tohoku J. Exp. Med., 1992, 167 (3), 197-205-In order to see whether any effect of inhalation of volcanic ash and gases from Mt. Sakurajima on canine lungs is observed or not, we examined the amount of intrapulmonary particulate deposits (IPD) and histopathological changes. Twenty-five abandoned or stray dogs (group A) in the areas affected enormously by volcanic ash and gases were examined in comparison with 13 abandoned or stray dogs (group B) in the area scarcely influenced. The amount of IPD was measured by using an image analyzer combined with a microscope. Age-associated increase of IPD values was noted, but mean IPD values were not different between groups A and B. Incidence of goblet cell hyperplasia was not different between the two groups. In none of the cases examined, squamous metaplasia of respiratory epithelia, pulmonary fibrosis, silicotic nodules, emphysematous change, or histopathological findings, which are indicative of bronchial asthma, were observed. In conclusion, obvious effect of volcanic eruption on canine lungs was not observed through both the measurement of IPD value and the histopathological evaluation.View full abstractDownload PDF (1424K) -
SHIGEHARU MORIYAMA, NOBUYOSHI SEIMIZU, SHIGERU TERAMOTO1992 Volume 167 Issue 3 Pages 207-218
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMORIYAMA, S., SHIMIZU, N. and TERAMOTO, S. Experimental Tracheal Allotransplantation Using Omentopexy: Histological Process of Rejection Reaction without Immunosuppression. Tohoku J. Exp. Med., 1992, 167 (3), 207-218-A large defect in the thoracic trachea was produced by rejecting 10 rings of tracheal cartilage in each of 11 adult mongrel dogs. An allograft of the five tracheal rings was interposed in this site via end-to-end anastomosis and then wrapped with the pedicled omental flap. These animals received no immunosuppressive therapy. The pseudostratified tracheal epithelia were remained and the graft revascularization through the omental pedicle proved to be established within about one week after surgery without immunosuppression. Marked mononuclear cell infiltration was observed beneath the epithelia and around the capillaries in the subepithelial layer over one week after surgery, which was followed by phagocytosis of the tracheal cartilages by macrophages. After the completion of rejection reaction, inflammation finally induced scarring or necrosis of the tracheal allograft, resulting in asphyxia or perforation. Only one animal survived 71 days after surgery without graft trouble. However, even in this animal, weak rejection reaction was observed microscopically and the structure of the graft was not that of the normal trachea. We think these results suggest that allotransplantation of trachea induces rejection, and therefore, that the use of immunosuppressants is necessary.View full abstractDownload PDF (6651K) -
KATSUO USUDA, YASUKI SAITO, CHIAKI ENDO, SATOMI TAKAHASHI, KEIJI KANMA ...1992 Volume 167 Issue 3 Pages 219-230
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSUSUDA, K., SAITO, Y., ENDO, C., TAKAHASHI, S., KANMA, K., SATO, M., SAGAWA, M., NAGAMOTO, N., FUJIMURA, S. and OTA, S. Cytologic Assessment of Peroperative Pleural Effusion and Prognosis in Lung Cancer Patients Who Underwent Resection. Tohoku J. Exp. Med., 1992, 167 (3), 219-230-Twenty-five of 108 lung cancer patients who underwent resection had cytologically positive pleural effusions. The rate at which cancer cells were detected was not related to the amount of the effusion. Almost one third of patients with cancer cells in effusion were alive at the end of the third postoperative year, provided that the pleura itself was free of metastasis at the time of operation. Correlation of the cytologically positive rate of pleural effusion (Y) with the degree of pleural metastasis (X1), the degree of pleural involvement (X2), or the degree of nodal involvement (X3) was analyzed using the Hayashi's quantification method type I. The multiple correlation coefficient was 0.843. Partial correlation coefficients of X1, X2 and X3 were 0.733, 0.446, and 0.653, respectively. Pleural metastasis had the strongest effect on the cytologically positive rate of pleural effusion.View full abstractDownload PDF (1042K) -
ATSUSHI NAGAI, ATSUSHI CHIYOTANI, TOSHIO NAKADATE, KIMIO KONNO1992 Volume 167 Issue 3 Pages 231-237
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAGAI, A., CHIYOTANI, A. and KONNO, K. Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis. Tohoku J. Exp. Med., 1992, 167 (3), 231-237-We investigated lung cancer in 99 patients with idiopathic pulmonary fibrosis (IPF). Lung cancer was found in 31 (31.3%) of 99 patients with IPF. Most (87.9%) tumors, including squamous cell carcinoma, were observed in the peripheral region of the lung, whereas the distribution of histologic types of cancers was similar to that seen in ordinary lung cancer. Peripheral tumors were frequently seen in the lower lobe, where fibrotic shadow was prominent. However, the severity of fibrosis was not related with the prevalence or histologic type of lung cancer. Two-thirds of IPF patients having a smoking history of over 40 years developed lung cancer. When compared with nonsmoking IPF control subjects, the relative risk of smoking in IPF patients was 3.5, identical with that reported for smokers in the general population. We suggest that smoking in patients with IPF is an additive risk factor for the development of lung cancer. We also speculate that the high prevalence of peripheral squamous cell carcinoma might be associated with cigarette smoking.View full abstractDownload PDF (727K) -
MASAHITO HATORI, JOSEPH P. DUTKOWSKY, RICHARD A. SMITH, ROBERT S. WILL ...1992 Volume 167 Issue 3 Pages 239-242
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHATORI, M., DUTKOWSKY, J.P., SMITH, R.A., WILLIAMS, R.S., YOKOTA, T. and SAKURAI, M. Tissue Distribution of 125I-Labeled Fetal Thyroid Hormone in Nude Mice Xenografted with Ewing Sarcoma. Tohoku J. Exp. Med., 1992, 167 (3), 239-242-Biodistribution of fetal thyroid hormone (RT3) was studied in nude mice with Ewing's sarcoma xenografts. At 30min and 1, 2, 4, 8, and 12hr after injection, blood, tumor and normal organs were measured to determine the amount of radioactivity per gram of tissue. The amount of radioactivity in the blood of tumor-bearing mice decreased sharply from 7.64% of injected dose per gram of tissue (% ID/g) at 30min after inoculation to 0.45% ID/g at 12hr. The % of injected dose per gram for 125I-labeled RT3 in the tumor reached 1.92 at 1hr after injection and decreased to 0.22 at 12hr. The radiolocalization indices for tumor to other organs at 12hr ranged from 1.35 to 4.43. This study suggests increased localization of RT3 in the Ewing's sarcoma as compared to other tissues in the nude mouse.View full abstractDownload PDF (443K) -
CHIKASHI ISHIOKA, TAKAO SUZUKI, RYUNOSUKE KANAMARU1992 Volume 167 Issue 3 Pages 243-245
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISHIOKA, C., SUZUKI, T, and KANAMARU, R. Mutations of p53 Gene in Human Colorectal Tumor in Japan: Molecular Epidemiological Aspects. Tohoku J. Exp. Med., 1992, 167 (3), 243-245-Effects of environmental carcinogens on DNA can be detected, because, while each carcinogenic agent is inherently different, its corresponding “fingerprint” is unique to a specific mutation pattern. The p53 tumor suppressor gene is of particular interest because the relationship between environmental factors and genetic alterations of carcinogenesis can be investigated. In this report, we compared the mutation patterns of the p53 gene in human colorectal tumors from Japanese patients with those from US patients. The results show different rates of transversion and transition among these two populations, which suggests a difference between Japan and the US in the etiological factors underlying colorectal tumorigenesis.View full abstractDownload PDF (329K)
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