All issues
Volume 185 (1998)
- Issue 4 Pages 227-
- Issue 3 Pages 161-
- Issue 2 Pages 79-
- Issue 1 Pages 1-
Volume 185, Issue 3
July
Displaying 1-7 of 7 articles from this issue
- |<
- <
- 1
- >
- >|
Regular Contributions
-
Ying Tian, Xuekui Xie, Fengyuan Piao, Toru Yamauchi1998 Volume 185 Issue 3 Pages 161-171
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSDelayed neuropathy and inhibition of soluble neuropathy target esterase (NTE) and acetylcholinesterase (AChE) activities in different regions of brain and spinal cord of adult hens were studied after the intravenous administration of leptophos (30 mg/kg), tri-o-cresyl phosphate (TOCP 40 mg/kg) or dipterex (200 mg/kg). The level of NTE activity varied according to the regions of the central nervous system (CNS) of the control (normal) hen, being higher in the cerebrum (74.1 μmol of phenyl valerate hydrolyzed/10 minutes/mg protein) and in the cerebellum (68.7), and lower in the spinal cord (44.5 in cervical, 55.6 in thoracic and 50.0 in lumbar cord). Hens given leptophos and TOCP demonstrated delayed neuropathy with obvious inhibition of NTE, but the times of onset and the degrees of peak inhibition of NTE activity were different: 6-24 hours after dosing and 73-82% of normal activity for leptophos, and 24-48 hours and 45-80% for TOCP, respectively. Furthermore, the average inhibition of NTE during 6-48 hours after dosing, (called here ‘period average inhibition') was also significantly different between the leptophos group (63-73%) and TOCP group (40-64%). Hens given dipterex did not demonstrate delayed neuropathy, and had the least peak inhibition and period average inhibition of NTE activity among the 3 groups. Ratios of NTE inhibition/AChE inhibition were higher in the leptophos group (0.91-1.24) and TOCP group (1.13-2.45) than in the dipterex group (0.25-0.79). These results indicate that the distribution of NTE in the soluble fraction of membrane proteins is different in different regions of the CNS, and that the degree of peak inhibition of NTE activity and the time of onset of peak inhibition induced by organophosphorus compounds (OPs) also differ for different OPs. Thus, practical and useful NTE measurements should identify the peak inhibition and period inhibition in several nervous tissue regions.View full abstractDownload PDF (698K) -
Kazunari Sato, Ryusei Sasaki, Yasunobu Ogura, Naotake Shimoda, Hisafum ...1998 Volume 185 Issue 3 Pages 173-184
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSWe investigated expression of the vascular endothelial growth factor (VEGF) gene and its receptor gene (flt-1) in 30 patients with transitional cell carcinoma (TCC) of the urinary bladder by Northern blot hybridization analysis. The VEGF transcript was observed in all of the tumors and the normal mucosae. Of the 20 tumors in which a comparative study was done, eight (40.0%) overexpressed the gene with a tumor versus normal ratio of equal to and greater than 3.0. Invasive TCCs expressed significantly more VEGF gene than superficial TCCs. Cytoplasm of tumor cells was positively stained by immunohistochemistry with an anti-VEGF monoclonal antibody, while the intratumoral endothelial cells and the vascular smooth muscle cells were weakly positive for the staining. TCCs, normal mucosae and human umbilical endothelial cells expressed flt-1 gene, while leucocytes from peripheral blood did not. The expression level of flt-1 gene significantly correlated with that of the VEGF gene in the tumor. These results indicate that the VEGF gene is frequently overexpressed in TCC of the urinary bladder, especially in muscle invasive tumors, and that a paracrine system including VEGF and flt-1 exists between the TCC cells and the adjacent endothelial cells so as to regulate the angiogenesis in this tumor.View full abstractDownload PDF (1299K) -
Yutaka Morimura, Kaoru Yanagida, Toshihiro Hashimoto, Yoshimasa Takano ...1998 Volume 185 Issue 3 Pages 185-197
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSIn this study, we evaluated whether proliferative activity and metastatic potential are prognostic factors in adenocarcinoma of the cervix. Formalin-fixed, paraffin-embedded sections from 34 patients with cervical adenocarcinoma or adenosquamous carcinoma were immunostained with monoclonal antibody MIB1, expressed in proliferating cells, and anti-nm23 antibody, reacts with metastasis suppression gene products. MIB1 positivity ranged from 0.2∼54.7% with a mean of 21.4%. The level did not differ significantly between various clinicopathological categories. Although patient survival of high or low MIB1 expressing tumor was not significantly different, the disease-free interval of high (≥25%) expressing tumor was significantly lower than that of low (<25%) expressing tumor. Strong and medium expression for nm23 were detected in 7 (21%) and 3 (9%) of patients. Tumor with strong nm23 expression tended to have a higher relapse rate. Although the survival of strong and weakly nm23 expressing tumor was not significantly different, the disease-free survival of strong nm23 expressing tumor was lower than that of weakly nm23 expressing tumor. MIB1 and nm23 immunostaining might be some of prognostic indicators of recurrence in cervical adenocarcinoma. In cervical adenocarcinoma, the nm23 gene products may not function as metastatic suppression but reflect proliferative activity.View full abstractDownload PDF (2045K) -
Juro Iriuchijima1998 Volume 185 Issue 3 Pages 199-207
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSIn conscious rats, changes in renal or superior mesenteric flow were observed when arterial pressure was elevated by occluding the terminal aorta. Blood flow was measured with an implanted electromagnetic flow probe and terminal aorta occlusion (TAO) was induced with an implanted pneumatic occluder. Arterial pressure was recorded with an indwelling catheter in the common carotid. Each TAO lasted for 20 seconds and flow and pressure at the end of this period were noted as those during TAO. After elimination of the reflexive compensation of arterial pressure by ganglionic blockade, the renal flow increase during TAO was slight but significiant (p<0.01), although the relative increase in flow was less than that in pressure. In other words, renal autoregulation, constancy of renal blood flow in the face of arterial pressure change, was imperfect. After further pentobarbital anesthesia, however, renal autoregulation was more complete to such an extent that the renal flow increase was insignificant during TAO. In contrast, the relative increase in superior mesenteric flow during TAO was larger than that in pressure with or without anesthesia.View full abstractDownload PDF (431K) -
Atif Aydinlioglu, Fuat Akpinar, Nihat Tosun1998 Volume 185 Issue 3 Pages 209-216
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSThe mathematical relationship between the lengths of the metacarpals and phalanges is important in hand surgery because of its role in determining the lengthening of the tubular bone size or the length of a prosthesis. The purpose of the present study is to perform the measurements on the hand radiographs, and to determine possible mathematical relations between the lengths of the metacarpals and phalanges. The lengths and widths of metacarpals and phalanges were measured in millimeters on hand roentgenograms of 100 normal voluntary subjects (50 men, 50 women) and the results were evaluated with a descriptive analysis test. The relations between the lengths of the metacarpals and phalanges were mathematically investigated on several sets of data. Unchangeable proportions between the metacarpals and phalanges lengths were found and formulated. Because any defects or faults of the hand, especially shortness, can corrected with current improved surgical techniques, a knowledge of the morphometric relations between the lengths of metacarpals and phalanges may be useful for such surgical interventions.View full abstractDownload PDF (384K)
Case Report
-
Jun-ichi Akahira, Kiyoshi Ito, Ryuji Nakamura, Akira Yajima1998 Volume 185 Issue 3 Pages 217-222
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSIntraperitoneal hemorrhage due to uterine leiomyoma is extremely rare. Recently, we encountered such two cases and herein describe them. Case 1 involved a 34-year-old, nulliparous woman referred to our hospital because of a sudden onset of shock while she was playing a softball game. She had a large abdominal tumor and a hemoperitoneum, and was diagnosed as having a ruptured ovarian tumor. Exploratory laparotomy showed a rupture of the coronary vein of a large uterine leiomyoma. The patient was treated with myomectomy and did well postoperatively. Case 2 involved a 44-year-old, multiparous woman referred to our hospital because of sudden onset of lower abdominal pain while defecating. She had a uterine leiomyoma and a hemoperitoneum, and was diagnosed as having a ruptured splenic artery. Exploratory laparotomy showed rupture of the coronary artery of a uterine leiomyoma. The patient was treated with total abdominal hysterectomy and did well postoperatively. These cases suggest that intraperitoneal hemorrhage associated with uterine leiomyoma, although rare, should be considered in women with hypovolemic shock and a large pelvic mass.View full abstractDownload PDF (1498K)
Short Report
-
Shuji Suzuki, Yasuiki Umezu, Yasuo Saijo, George Satoh, Yoshinao Abe, ...1998 Volume 185 Issue 3 Pages 223-226
Published: 1998
Released on J-STAGE: November 15, 2005
JOURNAL FREE ACCESSWe investigated whether expressions of MHC class I and class II antigens relevant to tumor antigen presentation were changed on human tumor cells cultured with or without recombinant human IL-12(rhIL-12). We showed that the expression of MHC class I antigen on UTC-8, 28-1Cl and SBC-3 cells was augmented when these cancer cells were cultured with rhIL-12. The expression of class II antigen was slightly raised on UTC-8 and 28-1Cl cells by rhIL-12, but not enhanced on SBC-3 cells. These results suggest that rhIL-12 may provide possible enhancement of immunologic tumor recognition, and cytotoxic activity of lymphocytes against tumors through the enhanced expression of MHC class I antigen.View full abstractDownload PDF (250K)
- |<
- <
- 1
- >
- >|