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Volume 118 (1976)
- Issue 4 Pages 299-
- Issue 3 Pages 199-
- Issue 2 Pages 101-
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Volume 118, Issue 4
Displaying 1-12 of 12 articles from this issue
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SHIGERU ARAI, TOSHIO NAKAMURA, NORIO SUWA1976 Volume 118 Issue 4 Pages 299-309
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn almost all the cases of cardiac hypertrophy due to sustained hypertension, left ventricular capacity is increased in proportion to increased left ventricular weight, even in the absence of manifest cardiac insufficiency. The condition is regarded as the general expression of cardiac response to pressure load, and the concept of “isomorphic hypertrophy” is proposed. Concentric hypertrophy of the current concept is observed only on rare special occasions, and its role in cardiac adaptation to pressure load is obscure. The increase in myocardial mass is sufficient to maintain the work done by a unit myocardial volume at a normal level. However, the calculation on pertinent models demonstrates that hypertrophied hearts of any type expel the normal stroke volume with smaller shortening of muscle fibers under larger stress, which is further elevated with the progress of cardiac contraction. Because the maximum force generated by muscle fibers declines with advancing cardiac contraction, hypertrophied hearts harbor a latent risk of mechanical insufficiency. Even under pressure load, ventricular dilatation seems to precede the re-inforcement of ventricular wall in the development of cardiac hypertrophy. A common mechanism may be therefore assumed underlying the development and performance of all types of hypertrophied hearts, regardless of the difference in the character of physical loads.View full abstractDownload PDF (648K) -
TAKASHI HANEDA, SHIGEAKI IKEDA, KAI TSUIKI, KINJI ISHIKAWA, RYO KATORI1976 Volume 118 Issue 4 Pages 311-315
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRespiratory changes in pleural pressure were recorded simultaneously from the left and right pleural spaces in 6 anesthetized closed-chest dogs in the supine, prone, left lateral and right lateral positions. Saline-filled radiopaque catheters connected to strain-gauge manometers were inserted percutaneously in the left and right pleural spaces by an air tight technique and their tips were placed in the mid-thoracic plane. The esophageal pressure was also recorded with the saline-filled system. The value of respiratory pressure amplitude (Δp, the difference between end-expiratory and minimal inspiratory pressures) in the pleural spaces was significantly greater in the left thorax than in the right in the supine, prone and right lateral positions. In 4 body positions, Δp in pleural pressure was significantly greater than in esophageal pressure. It is concluded that respiratory variations in pleural pressure of the left and the right thorax are not the same and that postural change does not produce significant regional difference of the respiratory variations.View full abstractDownload PDF (1733K) -
TAKASHI KITABATAKE, SHIGEKI KUROKAWA, KUNIQ SAKAI1976 Volume 118 Issue 4 Pages 317-322
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPatients with pulmonary tuberculosis treated in 4 sanatoria in Niigata prefecture during the period from 1941 to 1961 were followed up. Of 2, 756 patients, 1, 193 responded and sent us effective information. However, 1.224 did not come into contact because of changed and unknown address, 326 did not respond, and 13 were omitted because of incomplete answers. Of 1, 193 effective responders, 568 had been treated by artificial pneumothorax (the pneumothorax group), and 552 had been treated by the other measures than pneumothorax (the control group). There were 65 deaths in the pneumothorax group, and 40 deaths in the control group. No deaths from chest malignancies were reported in the pneumothorax group, while 4 chest malignancies in the control. In this survey, no evidence of increased frequency of chest malignancies including leukemia following multiple fluoroscopies during artificial pneumothorax was detected.View full abstractDownload PDF (324K) -
SINOBU HIGAMI, KOJI NISHIZAWA, KIYOSHI OMURA, KOICHI SUGIMOTO, GEN ISS ...1976 Volume 118 Issue 4 Pages 323-330
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn 6 cases of high risk pregnancies for Tay-Sachs disease, prenatal diagnosis was successfully carried out by examining hexosaminidase A activity in the supernatant of amniotic fluid and the uncultured and cultured amniotic fluid cells. In 5 out of 6 cases, the activity of hexosaminidase A was found to be within normal or heterozygous levels. They continued their pregnancies and were delivered of healthy children. In the remaining 1 case, the activity was undetected. Her pregnancy was terminated at the 23rd week of gestation. There was no activity of hex-osaminidase A in the brain and liver from the aborted fetus. A moderate increase in GM2 ganglioside was found in the brain. Electron-microscopic findings revealed membranous cytoplasmic bodies in the spinal ganglion cells as well as in the nerve cells of the retina. These biochemical and histological findings of the Tay-Sachs fetus suggest that the disease proceeds early in fetal period. It was found that the cultured amniotic fluid cells was the most reliable material for the prenatal diagnosis of Tay-Sachs disease, because the values of hexosaminidase A in the cultured cells were well in accord with those in serum from the consequently born children. Hexosaminidase pattern in the supernatant of amniotic fluid on DEAE-cellulose columnchromatogram showed a distinct difference between homozygote, heterozygote and normal. This procedure also may be useful for prenatal diagnosis of Tay-Sachs disease.View full abstractDownload PDF (2532K) -
GORO KAKIZAKI, MASAMI SASAHARA, TAKAYU'KI SAITO, TAKEHIKO SOENO, YOSHI ...1976 Volume 118 Issue 4 Pages 331-348
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe blood sugar level, blood insulin level, serum amylase level and organ amylase level in the pancreas were measured in a total of 110 rats examined at 12, 24, 48, 72 and 96 hr, and 1, 2, 3, 4, and 5 weeks after bilateral ligation of the parotid gland ducts. In parallel with this functional study, light microscopic study of the pancreas and the parotid gland and electron microscopic observations of the pancreas obtained from the rats were performed at the respective periods. The following results were obtained: 1) The serum amylase level was most elevated in the group examined at 12 hr after ligation and it decreased gradually and returned to the normal level at 96 hr after ligation and thereafter. 2) As for the pancreatic exocrine function, the organ amylase level of the pancreas was significantly elevated in the groups examined at 24 hr to 3 weeks after ligation. Electron-microscopically, hyperfunctional state in the pancreatic acinar cells was recognized as evidenced by the dilatation of the granular endoplasmic reticulum. 3) With regard to the endocrine function of the pancreas, the blood sugar level and blood insulin level did not show any significant changes after ligation as compared with the control group. Morphologically, electron microscopy showed a decrease in electron density and swelling of the cored granules, disintegration and fusion of their limiting membranes in the beta cells. These changes are interpreted as indicating the discharge of secretory granules in the beta cells. It is concluded that an impairment of the parotid glands influences the function of the pancreas to a certain degree.View full abstractDownload PDF (7768K) -
AKIRA ISHIMORI, TAKESHI KAWAMURA, HIROYUKI SAKURADA, AKIO SHIRANE, SUS ...1976 Volume 118 Issue 4 Pages 349-354
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAcid proteolytic zymogens contained in biopsy specimens obtained from the area surrounding peptic ulcer of the stomach were analyzed by means of agar gel electrophoresis and compared with histopathological findings. It was demonstrated that the specimens obtained from the base of ulcer contained only slow moving protease (SMP) while mucosa located near the margin of ulcer showed the pyloric mucosal type of electrophoretic pattern and increase in distance between the margin of ulcer and the site of biopsy changed the electrophoretic pattern of specimens to the fundic mucosal type. The electro-phoretic findings of acid proteolytic zymogens were found to be correlated closely to histological findings, and these changes were found to distribute in a patchy form around ulcer. It was also found that endoscopically healed scar was covered with regenerated epithelium containing parietal and chief cells of which the electrophoretic pattern of acid proteolytic zymogens was fundic mucosal type.View full abstractDownload PDF (643K) -
NOBUHIKO FURUYA, TAKEHISA HIRAO1976 Volume 118 Issue 4 Pages 355-363
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA special substrain mouse in ddN strain was classified by cross agglutination reaction of the red blood cells with anti-ddN mice red blood cells rabbit immune serum. The agglutination reactivity in the full-grown substrain mouse was as high as in an infant ddN mouse. Incidence of the substrain mouse in ddN strain aged older than 9 weeks was about 10%. The full-grown substrain mouse revealed a form of excitation after long-term administration of methamphet-amine while other mice in the same strain were depressed. The behavioral and serological properties of histocompatible strain mice such as C57BI and C3H were studied to compare with those of the ddN substrain mouse.View full abstractDownload PDF (1239K) -
TERUO ISHIBASHI, YOH IMAI1976 Volume 118 Issue 4 Pages 365-371
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRemoval of lipids from the microsomes with 90% acetone resulted in 50% or more decrease of NADH-cytochrome c reductase activity. The decrease of the enzyme activity was a result of lowering of Vmax and increase in Km. When sufficient amounts of phospholipids such as phosphatidylserine or phosphatidylinositol were added to the acetone-treated microsomes, the reductase activity was restored completely to the original level. On the other hand, when ferricyanide was used in place of cytochrome c as electron acceptor, the rate of reduction of ferricyanide was not affected by the lipid depletion and Vmax and Km for ferricyanide remained unchanged.View full abstractDownload PDF (346K) -
HIROSHI IZUMI, MAKOTO HAYAKARI, HIKARU OZAWA1976 Volume 118 Issue 4 Pages 373-380
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the process of studying the inhibition of dopamine-β-hydroxylase by cysteine, we observed an interesting relationship between cysteine and catalase. This suggests that two different patterns of the inhibition of dopamine-β-hydroxylase exist; the one is reversible inhibition, the other is irreversible inhibition. In the present experiments, we have particularly investigated the irreversible inhibition of dopamine-β-hydroxylase by cysteine, and the following conclusions were drawn: (a) The rate of the inhibitory effect of cysteine pretreatment on dopamine-β-hydroxylase is independent of a function of the temperature, while at temperature above 20°C the extent of the reversibility of cysteine inhibition by N-ethylmaleimide is temperature dependent. (b) The rate of inhibitory effect is dependent on the time of cysteine pretreatment at 37°C, and the ability of N-ethylmaleimide to reverse the cysteine-induced inhibition is gradually diminished by increasing the time of cysteine pretreatment. (c) The inhibitory effect of cysteine pretreatment (37°C, 10min) is not reversed by the addition of Cu++. (d) In the presence of higher concentrations of catalase, the cysteine-induced inhibition is recovered after the addition of equimolar concentration of N-ethylmaleimide. (e) Both inhibitions of cysteine on dopamine-β-hydroxylase with and without pretreatment were the noncompetitive type to the substrate, tyramine. (f) Similar inhibitory effects can be observed in case of ascorbate, but not of glutathione.View full abstractDownload PDF (404K) -
TAKAYOSHI TOYOTA, KANJI ABE, MIKIHIKO KUDO, YOSHIO GOTO1976 Volume 118 Issue 4 Pages 381-385
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe present study revealed that glucose-induced insulin secretion was significantly inhibited by preperfusion with trypsin (10μg/ml) in the isolated rat pancreas perfusion. However, when trypsin was interposed during perfusion of 16.6mM glucose, glucose-induced insulin secretion was not suppressed during trypsin infusion. The insulin level was significantly lower in the trypsin treated animals than in the control after completion of trypsin infusion. The results suggest that trypsin does not attack the glucoreceptor bound with glucose but attacks the free glucoreceptor. Interestingly a biphasic pattern of glucose-induced insulin secretion disappeared by the pretreatment with trypsin. The possibility was suggested that tyrpsin prevented the initial binding of glucose to the B-cell.View full abstractDownload PDF (248K) -
HIROKI WATANABE, DAIROKU IGARI, YOSHIKATSU TANAHASHI, KAZUYA HARADA, M ...1976 Volume 118 Issue 4 Pages 387-392
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new type of equipment for transrectal ultrasonotomography was described in a previous paper. This equipment was evaluated from the data obtained from 205 cases in which examinations were performed. Tomograms were successfully recorded in 94% of cases. Tomograms sufficiently useful for diagnosis and the measurement of organs were obtained in 89% of cases for the prostate, 78% for the urinary bladder, and 80% for the seminal vesicles. No basic problems in the procedure were found, although hypotension of unknown origin was observed during the examination in a few cases.View full abstractDownload PDF (1159K) -
HIROKI WATANABE, MASAHITO SAITOH, DAIROKU IGARI, YOSHIKATSU TANAHASHI, ...1976 Volume 118 Issue 4 Pages 393-394
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe successfully obtained ultrasonic Doppler signals, presumably caused by the renal vessels, through the body surface without invasion. An outline of the method and several results are presented in this preliminary report.View full abstractDownload PDF (724K)
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