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Volume 186 (1998)
- Issue 4 Pages 225-
- Issue 3 Pages 151-
- Issue 2 Pages 71-
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Volume 186, Issue 1
September
Displaying 1-9 of 9 articles from this issue
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Regular Contributions
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Tadako Nakatsuji1998 Volume 186 Issue 1 Pages 1-11
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSFive male and 7 female Lewis rats unilaterally nephrectomized at the ages of 44-46 days were transplanted with the mesenteric lymph nodes (MLN) obtained from syngeneic rats 4 months after the nephrectomy. In addition, 6 males received unilateral nephrectomy plus splenectomy at the age of 38 days. All of these rats were observed for 8.5 months after the nephrectomy. Flow cytometry analyses indicated that 17-32% of MLN lymphocytes and 4-20% of peripheral blood (PB) lymphocytes lost CD2 antigen in the unilaterally nephrectomized rats. Approximately 20% of PB and MLN lymphocytes had lost CD2 antigen in the males with combined splenectomy and nephrectomy, one of which died of severe infection. The survival rates of the MLN graft after 4.5 months were 100% in the 5 nephrectomized males and 14% in the 7 nephrectomized females. The CD2 antigen on immunologically activated T cells was up-regulated. Twenty-eight% lymphocytes of the survived MLN graft and 51% PB T cells of the 7 females with MLN graft rejection showed the CD2 up-regulation. It was shown immunohistochemically that not only CD2-positive (+) cells but also CD4+ cells were increased in the cortex of the survived MLN graft. The hepatocyte growth factor receptor gene, c-met gene, was shown to be present in lymphocytes. The c-met was considered to cooperate with the CD2. Interstitial mononuclear cell infiltrations with glomerulosclerosis were found in the remaining kidneys of the males with unilateral nephrectomy plus MLN grafts. Glomerular angiogenesis and accompaning endothelial cell apoptosis were demonstrated without mesangial cell proliferation in the males with unilateral nephrectomy plus splenectomy.View full abstractDownload PDF (1869K) -
Kouki Mori, Katsumi Yoshida, Tadao Funato, Tomonori Ishii, Takashi Nom ...1998 Volume 186 Issue 1 Pages 13-17
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSTo study the possible role of viral infection in the etiology of subacute thyroiditis (SAT), we measured serum virus-specific antibodies to measles, rubella, mumps, type I herpes, chicken pox, human parvovirus B19 and cytomegalovirus (CMV) in 10 patients with SAT during the course of illness. In spite of the presence of IgG to each virus in more than 70% of patients, no significant changes in the IgG titers were observed except those to measles, rubella, chicken pox or CMV in only 10% of patients, respectively. Then we examined the presence of virus DNA in specimens of 9 patients with SAT obtained by fine-needle aspiration biopsy (FNAB) of the thyroid. DNA was amplified to detect that of Epstein-Barr virus and CMV by polymerase chain reaction. However, none of them were detected in all the specimens. Whereas previous studies suggest the involvement of viral infection in the pathogenesis of SAT, we failed to demonstrate significant changes in serum antiviral antibody titers or to detect viral DNA in the specimens obtained by FNAB of the thyroid. Thus further studies are clearly required to establish the definite role of viral infection in the pathogenesis of SAT.View full abstractDownload PDF (318K) -
Ten-Jen Liao, Shigeru Urata, Hiroyasu Nishikawa1998 Volume 186 Issue 1 Pages 19-25
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSDeh-chi is described as a kind of soreness, numbness, or heavy swelling in deep tissues during manual acupuncture. This finding is important in acupuncture therapy, although the mechanism of this phenomenon remains unclear. Skin resistance response (SRR) and skin resistance level (SRL) are expressed as a component of alternating current and direct current changes in electrodermal activity (EDA) respectively. In the present study, we recorded SRR and SRL, skin blood flow and perspiration simultaneously in an attempt to determine the relationship between skin sympathetic nerve activity and EDA at the deh-chi stage. We found that SRR, SRL and skin blood flow decrease, and that perspiration increases transiently at the deh-chi stage. Our findings indicate that manual acupuncture causes an increase in vasomotor and sudomotor activities, a decrease in skin blood flow, and increased perspiration. These SRR and SRL recordings may be taken as an indicator of deh-chi.View full abstractDownload PDF (385K) -
Masaru Mizuno, Tetsuo Kato, Tatsuzou Hebiguchi, Hiroaki Yoshino1998 Volume 186 Issue 1 Pages 27-32
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSAnte- or neonatal ovarian cysts can be often diagnosed by routine ultrasonography. Small simple ovarian cysts, which can be followed with serial ultrasonography, usually resolve spontaneously. Large simple cysts and complicated cysts should undergo surgical treatment to reduce the potential for serious complications. Seventeen ovarian cysts were experienced between 1983 and 1997. Sixteen cases underwent surgical treatment at less than 1 month of age according to our protocols. In this report, we reviewed these cases for clinical presentation, ultrasound data, management, intraoperative findings, complications, and outcome. At operation, nine of them showed torsion, and seven of them showed necrotic changes. Only five of them was considered to fall into torsion by preoperative ultrasonography. In five cases whose blood flow could not improve after reduction of torsion, salpingo-oophorectomy was performed. We consider that small simple ovarian cysts under 4 cm in diameter can be observed carefully with serial ultrasonography. But, not only complicated ovarian cysts and simple cysts over 5 cm in diameter, but smaller cysts showing no decrease in size should be considered for surgical indication to rescue the ovarian tissue.View full abstractDownload PDF (312K) -
Norito Kawakami, Noboru Iwata, Shigeki Fujihara, Toshinori Kitamura1998 Volume 186 Issue 1 Pages 33-41
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSIn order to know the prevalence of chronic fatigue syndrome (CFS) in a community population in Japan, we analyzed data from a population-based interview survey. Two cases out of 137 respondents experienced chronic fatigue during a period of nine months, suffered from 50% or more reduction of daily activity due to fatigue and had no other physical or psychiatric diagnosis. Both of the two cases fulfilled the 1994 Centers for Disease Control (CDC) criteria and the British criteria. The point and nine-month prevalence rates of CFS were both 1.5% (95% confidence intervals, 0.4-5.2%). None fulfilled the 1989 CDC criteria for CFS. The prevalence rate of CFS was higher than those in previous studies in the Western countries, suggesting a need for future research on cross-cultural differences in the definition, prevalence and symptomatology of CFS.View full abstractDownload PDF (614K) -
Michio Hongo, Takayuki Kimpara, Satoshi Moriyama, Shuichi Ohara, Shin- ...1998 Volume 186 Issue 1 Pages 43-50
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSIn this study, we examined the effect of rabeprazole (E3810), a novel proton pump inhibitor, on gastric acidity under physiological conditions in healthy volunteers using 24-hour intragastric pH monitoring. Twenty-four-hour intragastric pH monitoring was performed three times to seven subjects randomly assigned in a cross over fashion to one of the following groups; without drug administration (basal), and with 10 mg or 20 mg of rabeprazole for four days. The median pH for 24 hours was 2.15 in the basal study, while the corresponding median pH were 5.05 and 5.90 after treatment with 10 mg and 20 mg of rabeprazole, respectively. Significant differences in the median pH were observed between the basal study and that after administration of the 10 mg and 20 mg doses of rabeprazole. The cumulative percentage of pH readings above the threshold pH 4 value, was 34.1% in the basal study, and 72.6% and 78.3% after treatment with 10 mg and 20 mg doses of rabeprazole, respectively. This result indicates that the efficacy of rabeprazole allows for substantial control of gastric acidity with once-daily dosing, and that both the 10 mg and 20 mg doses result in potent inhibition of gastric acid secretion.View full abstractDownload PDF (460K)
Case Reports
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Katsuhisa Ikeda, Mika Watanabe, Takeshi Oshima, Seiichiro Nakabayashi, ...1998 Volume 186 Issue 1 Pages 51-59
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSWe present a 73-year-old female with an enlarged mass in the right parotid gland. Fine-needle aspiration cytology suggested pleomorphic adenoma. Diagnostic imaging revealed that the tumour had a well-defined margin arising from the deep lobe of the parotid gland. A total parotidectomy with preservation of the facial nerve was performed. The final histopathological diagnosis including immunohistochemical studies was basal cell adenocarcinoma, which is a recently defined entity and a rare epithelial neoplasm. No sign of local recurrence or metastasis 24 months postoperatively has been observed.View full abstractDownload PDF (5263K) -
Hiroshi Tanaka, Ryosuke Ito, Norio Onodera, Shinobu Waga1998 Volume 186 Issue 1 Pages 61-66
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSA boy with hyperimmunoglobulin E syndrome (HIE syndrome), who was successfully treated with long-term sulfamethoxazole-trimethoprim (SMX-TMP) is reported. He had been suffering from recurrent pruritic dermatitis soon after birth and had a significant high level of serum immunoglobulin E. Although an initiation of SMX-TMP therapy resulted in resolution of his clinical manifestations, cessation of the treatment exacerbated the symptoms. Chemoprophylaxis of other oral antibiotics, which were suitable for Staphylococcus aureus isolated from lesions of the patient were unsuccessful. Another trial of low-dose SMX-TMP therapy resulted in gradual subsidence of the clinical manifestations. From these observations, efficacy of SMX-TMP therapy to prevent bacterial infection in the patient is clinically apparent. Although precise mechanism of the therapy remains speculative, long-term SMX-TMP therapy might be of benefit and low clinical toxicity in HIE syndrome.View full abstractDownload PDF (370K)
Short Report
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Shigeru Fujimura, Yutaka Tokue, Hiroshi Takahashi, Toshihiro Nukiwa, A ...1998 Volume 186 Issue 1 Pages 67-70
Published: 1998
Released on J-STAGE: October 27, 2005
JOURNAL FREE ACCESSFour arbekacin (ABK)-resistant clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) were studied regarding their mechanism of aminoglycoside-resistance. Metabolites of amikacin (AMK) and gentamicin(GM) were obtained by reaction with excess amounts of crude enzyme preparation extracted from the ABK-resistant MRSA strains. Then the metabolites were then isolated and analyzed by means of 1H, 13C-nuclear magnetic resonance. The AMK-modification was 4'''-N-acetylation. However, the site of GM-acetylation may be 6'-N-position by these strains.View full abstractDownload PDF (219K)
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