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Volume 161 (1990)
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Volume 161, Issue 4
Displaying 1-9 of 9 articles from this issue
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KOJU KOBAYASHI, HIROSHI SUZUKI, YOSHIYUKI UENO, RYOICHI NAGATOMI, ATSU ...1990 Volume 161 Issue 4 Pages 261-271
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKOBAYASHI, K., SUZUKI, H., UENO, Y., NAGATOMI, R., KANNO, A., OTSUKI, M. and TOYOTA, T. Anti-Idiotypic Antibodies Directed against Anti-HBs among the Patients with Chronic Hepatitis B. Tohoku J. Exp. Med., 1990, 16 (4), 261-271 -Anti-idiotypic antibodies (anti-Id) against anti-HBs were found in the sera of patients with chronic hepatitis type B. Anti-idiotypic antibodies were detected by an enzyme-linked immunosorbent assay using horseradish peroxidase conjugated mouse monoclonal anti-HBs. Ten of 72 HBsAg positive sera contained anti-Id (13.9%). The prevalence of anti-Id did not appear to correlate with HBeAg/anti-HBe system. However, HB virus specific DNA polymerase activity was significantly higher in anti-Id positive sera. In the sera obtained from the patients treated with predonisolone before, anti-Id positive rate was higher than that in the patients without a history of predonisolone therapy. These results suggest that anti-Id may be related to the immunoregulatory mechanism of HB virus replication.View full abstractDownload PDF (1067K) -
TAKASHIGE MIYAZAKI, SHIGERU KOHNO, MITSUO KAKU, HIRONOBU KOGA, KEIZO Y ...1990 Volume 161 Issue 4 Pages 273-281
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIYAZAKI, T., KOHNO, S., KAKU, M., KOGA, H. and YAMAGUCHI, K. Liposome-Encapsulated Amphotericin B in the Treatment of Experimental Murine Candidiasis. Tohoku J. Exp. Med., 1990, 161 (4), 273-281-The efficacy of liposome-encapsulated amphotericin B in treating experimental murine candidiasis was compared with that of the commercially available amphotericin B (Fungizone®). The LD50 of liposomal amphotericin B in ddY mice exceeded 10.0mg/kg while that of Fungizone® was 3.0mg/kg. Experimental candidiasis was induced by injecting a clinical isolate of Candida albicans strain 0925-107-01, through the tail vein. With the injection of 1.7×106 colony forming units, the number of colonies in the kidneys remained between 2.1×105 and 1.2×106, whereas the number of colonies in blood, liver, spleen, lungs and heart decreased rapidly. Histological examination revealed severe pyelonephritis with fungal infiltration and a mild invasion of the heart, lungs, liver and spleen. The survival rate of mice with experimental candidiasis treated with Fungizone® at a dose of 0.8mg/kg was 50% (the maximum tolerated dose without acute lethality), whereas all mice treated with the liposomal amphotericin B at a dose of 5.0mg/kg were alive even 42 days after the inoculation (p<0.01). Using liposome as a carrier for amphotericin B decreased this drug's systemic toxicity making it possible to administer doses higher than feasible with the commercial preparation and thus obtaining better therapeutic efficacy.View full abstractDownload PDF (1427K) -
KATSUHIRO NAKAMURA, TORU SATO, GORO KAKIZAKI1990 Volume 161 Issue 4 Pages 283-301
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAMURA, K., SATO, T. & KAKIZAKI, G. Changes in the Intercellular Junction of Rat Exocrine Pancreatic Cells Induced by Long Term Ethanol Ingestion. Tohoku J. Exp. Med., 1990, 161 (4), 283-301-The findings of electron microscopic observation of the intercellular junctions of pancreatic exocrine cells from male Wistar rats that had been given ethanol ad libitum in place of water are described. In control animals, numerous tight junctions having a distinct penta-lamellar structure were observed in the well developed interdigitations of the baso-lateral domain of both the ductal and centroacinar cells. This type of junction differed structurally as well as topographically from the occluding junctions situated in the apical part of the lateral domain and exhibited a tri-lamellar rather than a penta-lamellar structure. Further, this type of junction was not observed in the interdigitations between the acinar and centroacinar cells or in those between acinar cells. These specialized membrane structures became hypertrophic after 1 and 2 months of ethanol ingestion. That is, the interdigitated cell processes became elongated but the distribution density of the tight junctions was similar to that in control animals, so that the total number of tight junctions increased. After 3 months of ethanol ingestion., the interdigitated cell processes atrophied, the intercellular spaces widened, and the number of tight junctions markedly decreased. Thereafter, these changes were observed continuously in ethanol-treated animals. However, the occluding and adhering junctions were not markedly affected by ethanol intake.View full abstractDownload PDF (9223K) -
MASUMI ENDOH, TAKESHI TABIRA1990 Volume 161 Issue 4 Pages 303-309
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSENDOH, M. and TABIRA, T. Effect of Thymic Hormones on Induction of Experimental Allergic Encephalomyelitis in Old Mice. Tohoku J. Exp. Med., 1990, 161 (4), 303-309-This study was aimed at restoring decreased T-cell functions and reduced susceptibility to proteolipid apoprotein (PLP) induced-experimental allergic encephalomyelitis (EAE) in old mice with thymic hormones. Thymosin fraction 5 (TF-5) and serum thymic factor (FTS) had no significant in vitro and in vivo effect on proliferative responses to PLP and concanavalin A (Con A), and on EAE induction in young and old mice. These results suggest that decreased T-cell functions cannot be restored by these thymic hormones tested.View full abstractDownload PDF (600K) -
TSUNEHARU BABA, SHUYA MURABAYASHI, TSUKIKO TOMIYAMA, KAZUO TAKEBE1990 Volume 161 Issue 4 Pages 311-318
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSBABA, T., MURABAYASHI, S., TOMIYAMA, T. and TAKEBE, K. Uncontrolled Hypertension is Associated with a Rapid Progression of Nephropathy in Type 2 Diabetic Patients with Proteinuria and Preserved Renal Function. Tohoku J. Exp. Med., 1990, 161 (4), 311-318-The relationship between blood pressure and progression of nephropathy was studied the mean follow-up period of 32.6± 17.9 (S.D.) months in 20 Type 2 (non-insulin-dependent) diabetic patients with clinical nephropathy (proteinuria >0.5g/day) and preserved renal function (serum creatinine level <150μmol/liter). Fifteen hypertensive patients under antihypertensive treatment were divided into 2 groups: those with the mean diastolic blood pressure ≥90mmHg and/or the mean systolic blood pressure ≥150mmHg during the follow-up period were designated as Group A (n=6) and the remainders as Group B (n=9). Five normotensive patients without any antihypertensive treatment throughout the follow-up period served as a control group (Grgoup C). The decline rate in GFR was significantly greater (p<0.05) in Group A (1.15±0.39 (S.E.) ml/min/month) than those in Groups B (0.33±0.08ml/min/month) and C (0.40±0.09ml/min/month), respectively. The decline rate in GFR showed significant positive correlations both with systolic (rs=0.553, p<0.05) and diastolic (rs=0.493, p<0.05) blood pressures in the 15 hypertensive patients. The age, initial glomerular filtration rate, duration of diabetes and mean HbA1C level during the observation period were comparable in Groups A, B and C, respectively. The results indicate that an uncontrolled hypertension is associated with a rapid progression of kidney impairment in Type 2 diabetic patients with overt nephropathy, as has been suggested in Type 1 (insulin-dependent) diabetic patients.View full abstractDownload PDF (836K) -
KIYOSHI HANEDA, TAKAO TOGO, KOICHI TABAYASHI, YUSUKE TSURU, HITOSHI MO ...1990 Volume 161 Issue 4 Pages 319-327
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHANEDA, K., TOGO, T., TABAYASHI, K., TSURU, Y. and MOHRI, H. Long-Term Results after Repair of Tetralogy of Fallot. Tohoku J. Exp. Med., 1990, 161 (4), 319-327-One hundred sixty-six patients with tetralogy of Fallot including 15 pulmonary atresia repaired since 1971 were analyzed with respect to their physical activities, school or social life, hemodynamics, ECG, reoperation and late mortality. Follow-up period ranged from 1 to 19 years with an average of 9.1. There were 9 late deaths including 4 sudden deaths. Actuarial survival rates at 5 and 13 years were 96.4% and 90.5%, respectively. Eighty-five patients (72.0%) of 118 replied were in NYHA functional class I, 31(26.3%) in class II and 2 (1.7%) in class III. Thirteen patients (7.8%) demonstrated right ventricular/left ventricular systolic pressure ratio over 0.80 because of inadequate relief of the pulmonary stenosis or obstruction, hypoplasia of the pulmonary artery or external conduit stenosis. Although the left ventricular ejection fraction was maintained at the normal range (0.65±0.09), that of the right ventricle was below the normal level (0.52±0.09). Two patients developed complete heart block postoperatively and underwent pacemaker implantations. Complete right bundle branch block was observed in 85 patients including 6 with left axis deviation. Most of the patients after correction of tetralogy of Fallot are in satisfactory conditions. However, some patients have limitations in school or social life because of residual lesions or postoperative complications. It is important to consider the proper operative procedures to avoid these problems.View full abstractDownload PDF (791K) -
REIKO FUKATSU, TOSHIKATSU FUJII, ITARU KIMURA, SHUN-ICHI SASO, KYUYA K ...1990 Volume 161 Issue 4 Pages 329-333
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUKATSU, R., FUJII, T., KIMURA, I., SASO, S, and KOGURE, K. Effects of Hand and Spatial Conditions on Visual Line Bisection. Tohoku J. Exp. Med., 1990, 161(4), 329-333-This study examined the effects of hand and spatial conditions on a visual line bisection task with normal right-handers and proposed a normal range of deviation for this task in middle and advanced age. Twenty-four normal dextrals in their fifties and sixties performed a visual line bisection task using either the left or right hand under three spatial conditions: at the midline and in the left and right hemispaces. Our results revealed that performance was significantly affected by the hand used but not spatial conditions: Left hand performance was significantly further leftward than right hand performance. There was no significant interaction between the hand and spatial conditions. The mean deviation of the right hand was 2.2% of the half line length to the right of the true center. The possibility of left unilateral spatial neglect should be considered if a patient bisects a line with a deviation greater than 10% of the half line length to the right.View full abstractDownload PDF (479K) -
MASARU KURIYAMA, RYO-ICHI HIWATARI, AKIHIRO IGATA1990 Volume 161 Issue 4 Pages 335-341
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKURIYAMA, M., HIWATARI, R. and IGATA, A. Thin-Layer Chromatography of Urinary Neutral Oligosaccharides: The Detection of Blood Group-Related Oligosaccharides and Screening for Lysosomal Storage Disease. Tohoku J. Exp. Med., 1990, 161(4), 335-341-We devised an improved technique of thin layer chromatography, which permitted the high resolution of urinary neutral oligosaccharides and the qualitative determination of blood group related oligosaccharides as well as oligosaccharides pathologically secreted in lysosomal storage diseases. This procedure can be used inscreening for disorders associated with abnormal excretion of oligosaccharides, as well as in the purification of oligosaccharides.View full abstractDownload PDF (1085K) -
MASARU KURIYAMA, RYO-ICHI HIWATARI, MITSUHIRO OSAME, AKIHIRO IGATA1990 Volume 161 Issue 4 Pages 343-351
Published: 1990
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKURIYAMA, M., HIWATARI, R., OSAME, M. and IGATA, A. Leucocyte α-1, 4- and α-1, 6-Glucosidase Activities Towards Olggosaccharides in Late Onset Glycogenosis Type II. Tohoku J. Exp. Med., 1990, 161(4), 343-351-We describe the partial characterization and some properties of leucocyte α-glucosidase towards disaccharides with the α-1, 4 (maltose) and α-1, 6-glucosidic linkage (isomaltose) and tetrasaccharides with the α-1, 4 (maltotetraose) and α-1, 6-glucosidic linkage (tetrasaccharide, Glcα1→6Glcα1→4Glcα1→4Glc, which was isolated from the urine of a patient with glycogenosis type II). Leucocyte α-glucosidase showed optimal activity towards all four oligosaccharides under two conditions, acidic (pH 4.0-4.5) and neutral (pH 6.0-6.5) regions. Our comparative studies on enzyme kinetics showed that leucocyte α-glucosidase was able to hydrolyze both the 1→4 isomers and the 1→6 isomers at acidic and neutral pH. Acid α-glucosidase could hydrolyze maltose about 10 times faster than isomaltose, and maltotetraose about 5 times faster than tetrasaccharide isolated from urine. In leucocytes of the patient with late onset glycogenosis type II, acid α-glucosidase activities towards maltose, isomaltose, maltotetraose and tetrasaccharide isolated from urine showed 75.3%, 67.4%, 76.5% and 41.4% of normal control values, respectively. Neutral α-glucosidase activities towards these four oligosaccharides were normal. Tetrasaccharide with α-1, 6-glucosidic linkage might be accumulated by the impaired hydrolysis in the circulation as well as the leakage of undegraded glycogen to the circulation from the affected muscle.View full abstractDownload PDF (912K)
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