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Volume 182 (1997)
- Issue 4 Pages 271-
- Issue 3 Pages 185-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 182, Issue 2
June
Displaying 1-9 of 9 articles from this issue
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Regular Contributions
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Minoru Sato, Hiroshi Izumi, Keishiro Karita, Naofumi Iwatsuki1997 Volume 182 Issue 2 Pages 103-113
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSElectrical stimulaion of the central cut end of the lingual nerve (as reflex activation of parasympathetic nerve) or of the peripheral cut end of the facial (VIIth cranial) nerve (as direct activation of parasympathetic nerve) elicited the ipsilateral blood flow increases in lower lip, palate and common carotid artery (CCA) but not in frontal cerebral cortex in α-chloralose-urethane anesthetized, vagosympathectomized cats. No significant difference, in terms of the vasomotor changes examined, was found between lingual nerve and facial nerve stimulation. The results suggest that there is no somato-parasympathetic reflex vasodilator mechanism serving the frontal cerebral cortex, and that changes in CCA blood flow should not be taken to be indicative of blood flow changes in cerebrocortical blood flow. However, we cannot entirely rule out the possibility of a neurogenic vasodilator influence of the facial pathway, since small blood flow increases in the frontal cerebral cortex were sometimes observed on facial nerve stimulation.View full abstractDownload PDF (693K) -
Hideaki Suzuki, Akira Shimomura, Katsuhisa Ikeda, Takeshi Oshima, Tomo ...1997 Volume 182 Issue 2 Pages 115-124
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSEffects of long-term low-dose macrolide administration were studied in patients with chronic sinusitis. Twelve patients with non-allergic chronic sinusitis were orally given 150 mg roxithromycin once a day without other treatments. The patients underwent computed tomography before and after the treatment, and paranasal sinus aeration was analyzed quantitatively. The number of neutrophils in the nasal smear was semiquantitatively assessed on a grading scale, and the IL-8 concentration in the nasal discharge was measured by enzyme immunoassay. The aeration of all four sinuses significantly improved, and recruited neutrophils and the IL-8 level in the nasal discharge were simultaneously reduced after the treatment. These findings suggest that long-term low-dose roxithromycin administration inhibits the positive feedback mechanism of neutrophil recruitment and IL-8 production by the recruited neutrophils, which is considered to be an essential cause of the prolongation of sinusitis.View full abstractDownload PDF (1530K) -
Nobuyuki Shiba, Yutaka Kagaya, Nobumasa Ishide, Daiya Takeyama, Yuriko ...1997 Volume 182 Issue 2 Pages 125-138
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSMyocardial glucose metabolism has been shown to be heterogeneous in patients with hypertrophic cardiomyopathy (HCM). We tested the hypothesis that myocardial glucose metabolism differs between patients with HCM and those with hypertensive heart disease (HHD) associated with asymmetrical septal hypertrophy. We studied 12 patients with HCM, 7 HHD patients associated with asymmetrical septal hypertrophy using 18F 2-deoxyglucose (FDG) and positron emission tomography. We calculated % FDG fractional uptake in the inter-ventricular septum and posterolateral wall. Heterogeneity of FDG uptake was evaluated by % interregional coefficient of variation of FDG fractional uptake in each wall segment. In both the interventricular septum and posterolateral wall, % FDG fractional uptake was not significantly different between the two groups. The % interregional coefficient of variation for both interventricular septum (10.6±1.6 vs. 4.1±0.5, p<0.01) and posterolateral wall (5.9±0.7 vs. 3.8±0.5, p<0.05) was significantly larger in patients with HCM than in HHD patients associated with asymmetrical septal hypertrophy. Echocardiography demonstrated that the degree of asymmetrical septal hypertrophy was similar between the two groups. These results suggest that myocardial glucose metabolism may be more heterogeneous in patients with HCM compared to HHD patients associated with asymmetrical septal hypertrophy, although the left ventricular shape is similar. The difference in the heterogeneity might have resulted from differences in the pathogeneses of the two diseases.View full abstractDownload PDF (907K) -
Yoshio Naya1997 Volume 182 Issue 2 Pages 139-150
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSThe present study was designed to test the predictability of color Doppler flow imaging of the bladder in determining the cause of bladder hypertrophy. The blood flow in the anterior bladder wall was measured in 35 patients with an abnormally increased ultrasound estimated bladder weight (UEBW) of more than 35.0 g. Of these, 18 were diagnosed as having infravesical obstruction due to benign prostatic hyperplasia (obstructive group). The remaining 17 were diagnosed as having neurogenic bladder dysfunction (NB group). Scanning to detect blood flow was continued for 5 minutes, the bladder having been filled with 100 ml of saline. Blood flow was detected in 83.3% (15/18) of the obstructive group, compared to 23.5% (4/17) in the NB group (p<0.001). Infravesical obstruction was detected with a diagnostic accuracy of 80.0% (28/35) by color Doppler flow imaging. Color Doppler flow imaging was useful in predicting the cause of bladder hypertrophy in patients with abnormally increased UEBW.View full abstractDownload PDF (2562K) -
Shoji Tsutaya, Hitomi Kitaya, Yuka Saito, Shinichi Nakata, Hideetsu Ta ...1997 Volume 182 Issue 2 Pages 151-155
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSTo assess the potential association between the angiotensin converting enzyme (ACE) gene polymorphism and the activity of the renin-angiotensin system in a Japanese population, we determined the ACE genotype and its enzyme activity in serum in 108 young Japanese females. Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intron 16 of the ACE gene. The distribution of the DD, ID and II ACE genotypes was 10, 55 and 35%, respectively. The estimated allele frequencies of the deletion and the insertion were 0.375 and 0.625, respectively. The mean serum ACE activity in DD subjects was about 1.4 times that of II subjects (p<0.01), with ID subjects having intermediate levels (p<0.05), whereas the renin profile were not statistically different among the three groups. These results indicate a significant association between ACE gene polymorphism and serum ACE activity levels, suggesting a mechanism by which genotype might have a bearing on the physiology of the renin-angiotensin system axis.View full abstractDownload PDF (327K) -
Shigeru Tsuchiya, Atsushi Kikuta, Yukitoshi Shimizu, Nagakuni Takano, ...1997 Volume 182 Issue 2 Pages 157-162
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSIn order to ascertain the cytological features of peripheral hematopoietic progenitor cells (PHPC) mobilized after administration of chemotherapeutic agents and G-CSF, lineage- and progenitor cell-specific surface markers on CD34 positive (+) cells were sequentially examined. Nineteen evaluable samples were obtained from a malignant lymphoma, an acute lymphoblastic leukemia and 5 neuroblastoma patients. CD38 and HLA-DR were respectively expressed on more than 95% and approximately 85% of CD34+PHPC cells. CD19 was also expressed on the majority and CD117 on 10 to 20% of the CD34+cells. The most striking finding was that the Thy-1(CDw9O)+/CD34+ population was decreased at the peak of mobilization of CD34+ cells as compared to the early phase after G-CSF administration (approximately 20% vs. 60%). These results suggest that decrease in Thy-1 expression on CD34+ cells is related to mechanisms easing CD34+ cell mobilization to the peripheral blood.View full abstractDownload PDF (361K)
Case Reports
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Katsunori Suzuki, Satoshi Hirayama, Seiki Ito1997 Volume 182 Issue 2 Pages 163-173
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSA 74-year-old diabetic patient had been treated with oral hypoglycemic agents from the age of 40 years until the age of 72, when his treatment regimen was changed to human insulin. He began experiencing hypoglycemic attacks 14 months after the initiation of insulin therapy. He continued to experience hyperglycemia every morning and hypoglycemia every day at 5: 30 p.m. even after insulin therapy was withdrawn. His plasma levels of C-peptide immunoreactivity, total and free immunoreactive insulins were 4.2 ng/ml, 740 μU/ml and 141.8 μU/ml, respectively. His 125I-insulin binding rate was 94.4%. These findings suggest that his hypoglycemic attacks may have been due to insulin antibodies. Analysis revealed that insulin binding antibodies belonged to IgG with κ light chains. The patient's genotype was HLA-DR4. He had not received animal insulin or any medications containing a sulfhydryl group. Although the IgG antibody was produced against injected human insulin, his HLA type and the characteristics of his antibodies resembled those of a patient with insulin autoimmune syndrome (IAS). We hypothesize that this patient represented a rare instance of a patient constitutionally similar to a patient with IAS, but whose hypoglycemic attacks resulted from the antibodies induced by the administration of human insulin. This case seems to be the first one with hypoglycemic attacks due to anti-human insulin antibody produced by human insulin therapy.View full abstractDownload PDF (641K) -
Muneshige Tobita, Hiroshi Mochizuki, Shoki Takahashi, Hiroshi Onodera, ...1997 Volume 182 Issue 2 Pages 175-179
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSSerial CT and MR imaging findings in a 44-year-old woman with Marchiafava-Bignami disease (MBD) are reported. In the acute stage, CT studies disclosed subtle hypodensity in the splenium, and T2-weighted MR images revealed apparent high signal intensity of the splenium and the central portion of the corpus callosum. Treatment with vitamin B complex resulted in complete recovery. T2-weighted MR images obtained three weeks after admission revealed dramatic resolution of imaging abnormalities, with only faint high signal intensity remaining in the splenium. The sequential changes observed on CT and MR images provided early diagnosis of MBD and the resolution of the lesion considered as brain edema, which suggested that edema might, in addition to demyelination or necrosis, be involved in the acute progression of MBD.View full abstractDownload PDF (1290K)
Short Report
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Mareyuki Endoh, Ryoji Chiba, Tohru Takahashi1997 Volume 182 Issue 2 Pages 181-184
Published: 1997
Released on J-STAGE: March 01, 2006
JOURNAL FREE ACCESSThe morphogenesis of cirrhotic septa in chronic hepatitis B was studied assuming that they arise at the sites of hepatocellular necrosis invoked by host immune reaction against HBcAg-expressing hepatocytes. Sections from three livers with chronic hepatitis B, all in cirrhotic stage, were immunostained with HBcAg and subjected to morphometry to analyze the distribution of HBcAg(+) hepatocytes and its relation with septa. HBcAg(+) cells were not distributed randomly over the nodules but forming focal areas. The septum formation along these foci was shown by 2-D distance distribution analysis, a technique we devised. Upon a sheet of color microphotograph of immunostained section, hundreds of test points each 400 μm apart were arranged by overlaying a tessellated grid. From each of the points hitting the nodules, the distance to the nearest nodulo-septal border D(min) was measured. Measurement was performed on a total of 2,585 test points. It was shown that the mean D(min) in the HBcAg(+) areas was significantly smaller than in HBcAg(−) areas. Thus, the cirrhotic septa are considered to arise at the places of HBcAg(+) foci, connecting them by postnecrotic collapsing.View full abstractDownload PDF (528K)
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