All issues
Volume 168 (1992)
- Issue 4 Pages 539-
- Issue 3 Pages 449-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 168, Issue 1
Displaying 1-7 of 7 articles from this issue
- |<
- <
- 1
- >
- >|
-
TAKASHIGE MIYAZAKI, SHIGERU KOHNO, KOTARO MITSUTAKE, HIROSHI YAMADA, A ...1992 Volume 168 Issue 1 Pages 1-9
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIYAZAKI, T., KOHNO, S., MITSUTAKE, K., YAMADA, H., YASUOKA, A., MAESAKI, S., KAKU, M., KOGA, H, and HARA, K. Combination of Conventional and Endotoxin-Specific Limulus Tests for Measurement of Polysaccharides in Sera of Rabbits with Experimental Systemic Candidiasis. Tohoku J. Exp. Med., 1992, 168 (1), 1-9-Factor G, the coagulation enzyme from limulus amebocytes, is activated by (1→3)-β-D-glucan but not by endotoxin. The endotoxin-specific limulus test, which is devoid of fator G, reacts only with endotoxin. However, the conventional limulus test which includes factors G and C, reacts with not only endotoxin but also with (1→3)-β-D-glucan. In this study, the culture supernatant of Candida albicans in RPMI medium activated the conventional limulus test, but not the endotoxin-specific limulus test. All five rabbits inoculated intravenously with Candida albicans (1.0×107 CFU/rabbit) showed increased levels of reactivity with the conventional limulus test, whereas no elevation in the levels of the endotoxin-specific limulus test was observed in the sera of any infected rabbits. Only one serum sample from rabbit No. 5 on day 8 showed a positive Cand-tectest. The difference in the titers of the two limulus tests was suggestive of a diagnosis of Candida infection.-limulus test; serological diagnosis; β-glucan; polysaccharide; candidiasisView full abstractDownload PDF (785K) -
RYUICHI NAKAMURA, SANAE MORIYAMA, YOSHIAKI YAMADA, KAZUNORI SEKI1992 Volume 168 Issue 1 Pages 11-20
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAMURA, R., MORIYAMA, S., YAMADA, Y. and SEKI, K. Recovery of Impaired Motor Function of the Upper Extremity after Stroke. Tohoku J. Exp. Med., 1992, 168 (1), 11-20-Manual function score (MFS) of 174 hemiparesic stroke patients was examined every week for 8 weeks after starting the occupational therapy with programs based on MFS recovery profile, and the relation between the time since stroke onset (x) and MFS (y) was approximated by a hyperbolic function, y=A-B/x. The patients were classified into two groups, 125 cases (71.8%) with statistically significant fit of the function (fit group) and 49 without fit (non-fit). Using demographic and neurological variables of each patient, characteristics of the patients with regular recovery were analyzed. The results indicated that the gain of MFS during 8 weeks of the therapy was large in the fit group compared to the non-fit, and the regular recovery could be mostly expected in rather young patients, those with early start of the therapy, and those without ataxia, mental deterioration, and cortical lesions.-arm function; hemiparesis; manual function test; prediction of recovery; strokeView full abstractDownload PDF (923K) -
SETSUKO KAWAMURA, YOSHIKO TAMAI, MASAKI AKIYAMA, JUICHI SAKAMOTO, YUZU ...1992 Volume 168 Issue 1 Pages 21-28
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKAWAMURA, S., TAMAI, Y., AKIYAMA, M., SAKAMOTO, J., KONUMA, Y., FUKUSHIMA, K., TSUSHIMA, K., SAWADA, Y., SAKATA, Y. and YOSHIDA, Y. Postremission Therapy without Prednisolone Improves Survival in Adults with Acute Leukemia. Tohoku J. Exp. Med., 1992, 168 (1), 21-28-This prospective randomized clinical trial was to clarify whether postremission therapy without prednisolone (PSL) was more effective than therapy with PSL in improving the 5-year survival of adults with acute leukemia. Thirty consecutive adult patients with newly achieved complete remission were randomized to receive postremission therapy either with or without PSL between September 1985 and September 1988. The patients ranged from 16 to 57 years in age. Patients treated without PSL had a significantly better 5-year survival rate than those receiving PSL according to Kaplan-Meier analysis (53.5% vs 15.3%, p<0.05). In the group treated without PSL, eight out of 15 patients were alive at 72 months, and seven patients maintained their first complete remission at 72 months. Among patients with acute lymphoblastic leukemia (ALL) who were treated without PSL the median duration of remission was 24 months, and the survival rate at 72 months was 50.0%. On the other hand, the median survival was only 13 months for the 5 patients with ALL treated with PSL. Thus, it is desirable that adults with acute leukemia are treated by postremission therapy without PSL.-Postremission therapy; acute myelogenous leukemia; acute lymphoblastic leukemia; prednisoloneView full abstractDownload PDF (720K) -
KOUICHI KAMIO, TAIRI JIN, SHINSEI GASA, MOTOYUKI OHHIRA, KOICHI HONKE, ...1992 Volume 168 Issue 1 Pages 29-35
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKAMIO, K., JIN, T., GASA, S., OHHIRA, M., HONKE, K., KASAI, N. and MAKITA, A.Inconsistent Expression of Glycolipid Sulfotransferase Activity between Hepatoma and Serum. Tohoku J. Exp. Med., 1992, 168 (1), 29-35-Glycolipid sulfotransferase activity in human and rat hepatocellular carcinoma tissues was studied, since an elevated level of the enzyme activity in serum had been demonstrated in cancer patients. The level of the enzyme activity in carcinoma tissues, however, could not be distinguished from that of normal controls. Similar observations were made for rat hepatoma. A higher level of enzyme activity was observed in the female than in the male. Inconsistent expression between hepatoma tissue and serum suggests that humoral factor(s) derived from hepatoma tissue stimulates production of the sulfotransferase, which is released into the blood-stream in the host.-glycolipid sulfotransferase; hepatocellular carcinoma; LEC ratView full abstractDownload PDF (650K) -
NAOKI TAMASAWA, KAZUO TAKEBE1992 Volume 168 Issue 1 Pages 37-45
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAMASAWA, N. and TAKEBE, K. Analytical Examination of Oxidized Free and Esterified 7-Ketocholesterol and Related Oxysterols in Human Plasma Incubated with Copper. Tohoku J. Exp. Med., 1992, 168 (1), 37-45-Oxygenated derivatives of cholesterol (oxysterols) have been demonstrated to possess a wide variety of biological properties and evaluated for their abilities to inhibit cholesterol biosynthesis. We investigated a method to analyze copper-catalyzed oxidation products of human plasma cholesterol. Free and esterified oxysterols produced were mainly 7-ketocholesterol, and small amounts of 7β-hydroxy- cholesterol and 5, 6α-epoxy-cholesterol were also identified. Quantitatively, the sterol nucleus of ester was less susceptible to oxidation than that of the free form. This finding suggested that the cholesterol nucleus of ester form was more resistant against oxidative stress than free form. Additionally we demonstrated that the addition of probucol, a powerful antioxidant used clinically to lower blood cholesterol, inhibited this copper-catalyzed oxdiation of cholesterol.-7- ketocholesterol; free oxysterol; esterified oxysterol; cholesterol oxdiation; probucolView full abstractDownload PDF (845K) -
YASUKAZU HAMADA, MASASHI IMAI, TAKAO AOKI, RYOJI SUZUKI, AKIRA KAMIYA1992 Volume 168 Issue 1 Pages 47-62
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHAMADA, Y., IMAI, M., AOKI, T., SUZUKI, R. and KAMIYA, A. Simulation of the Profile of Water, NaCl, and Urea Transport in the Countercurrent Multiplication System between Thin Ascending Limb and Inner Medullary Collecting Duct. Tohoku J. Exp. Med., 1992, 168 (1), 47-62-We simulated the profiles of water, NaCl, and urea transport in the countercurrent multiplication system between thin ascending limb (TAL) and inner medullary collecting duct (IMCD) by a mathematical model consisting of three compartments (TAL, IMCD, and CNW [capillary network]), using phenomenological coefficients for hamsters. They are separated by two membranes with distinct permeability properties. The primary driving force which generates “single effect” has a lower reflection coefficient for urea than for NaCl in IMCD. The difference in urea and NaCl concentrations between CNW and IMCD provides an effective osmotic driving force which is favorable for water absorption from IMCD without physicochemical osmotic gradient. The entry of water in the CNW reduces the concentration in CNW and generates the concentration gradients which are favorable for these solutes to diffuse out of TAL. Thus, the fluid in IMCD is concentrated and that in TAL is diluted. The results of simulation showed that the concentration gradients were generated along the medullary axis, resulting in excretion of hypertonic urine. In addition, we examined effects of changes in phenomenological coefficients of IMCD on this concentrating system. Decreases in permeability and in reflection coefficient for urea and increase in hydraulic conductivity increased the osmotic gradients along each compartment.-urine concentration mechanism ; countercurrent multiplication system; inner medullary collecting duct; thin ascending limbView full abstractDownload PDF (1756K) -
BOON-HUAT BAY, KWOK-HUNG SIT1992 Volume 168 Issue 1 Pages 63-66
Published: 1992
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSBAY, B.-H. and SIT, K.-H. Coarse to Fine Hair Conversion Induced by Zinc in C57/6J Mice. Tohoku J. Exp. Med., 1992, 168 (1), 63-66-The cytotoxic effects of excessive zinc is well documented but its effect on cytodifferentiation appears relatively unknown. We show here that chronic administration (25 days) of zinc chloride in C57/6J mice (11 to 56μg/g body weight, 5 times per week), which was lower than the in vitro cytotoxic level, caused a loss of long coarse hairs, which were replaced by short fine (vello) hairs. Histological architecture of the skin appeared normal except for the confinement of hair follicles to the dermis without any extension into the hypodermis.-zinc; coarse to fine hair conversion; cytodifferentiationView full abstractDownload PDF (2443K)
- |<
- <
- 1
- >
- >|