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Volume 77 (1962)
- Issue 4 Pages 311-
- Issue 3 Pages 205-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 77, Issue 2
Displaying 1-10 of 10 articles from this issue
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Naoe Kikuchi1962 Volume 77 Issue 2 Pages 99-119
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1) The structure and development of the terminal respiratory unit of the lung in late gestational and neonatal stages were histologically investigated with lungs expanded by intrabronchial formalin infusion under mild pressure. The pulmonary parenchyma in the 7th and 8th fetal months was practically composed of alveolar ducts without distinct alveoli. Beginning alveolar formation was indicated by slight protrusions of interductal septa. Alveolar development advanced with fetal months by increasing septal protrusions, and at the end of gestation terminal respiratory units were equipped with small alveoli of 30-40 μ in radius. Alveolar development continued to progress in postnatal life. The total number of alveoli in the adult was estimated to be about 2 times larger than that of normally developed neonatal lung. Histometrically determined proportion of alveolar space in the total lung capacity increased likewise with alveolar development and attained the level of the adult in 3-4 years.
2) In some full-term newborns alveolar development was distinctly retarded, and the structure of their lungs, practically devoid of well-differentiated alveoli, corresponded to a stage of fetal lungs from the 7th to 9th fetal months. The condition was designated as alveolar hypoplasia and was regarded to represent a developmental anomaly of the lung. The number of alveoli and the proportion of alveolar space in the total lung capacity were lower than those of normally developed neonatal lungs.
3) The concept of congenital alveolar dysplasia of Mac Mahon was discussed in reference to the author's investigation. Although abnormally thick “alveolar” walls were acknowledged as a concomitant finding of immature lungs, fundamental structures of underdeveloped lungs could not be regarded to be represented by the character of alveolar walls alone. Expansion of lungs was recommended for proper evaluation of fundamental lung structures.View full abstractDownload PDF (3992K) -
Part 1: Total Bial-positive Substance in Cerebrospinal Fluid in Schizophrenic SubjectsAkira Mukai, Tatsunori Ejima1962 Volume 77 Issue 2 Pages 120-127
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe estimated the total Bial-positive substance in the cerebrospinal fluid in various mental and nervous disorders following the Bogoch's method. Our results showed disagreement with Bogoch's conclusion. Namely, no tendency of a low level appeared in the schizophrenic subjects as compared with that in our control group or in the other mental and nervous disorders. No characteristic relation could be established between the total Bial-positive substance and the total protein or the protein-bound sialic acid in the cerebrospinal fluid either.View full abstractDownload PDF (363K) -
Part 2: Methodology of Determination by Direct Ehrlich ReactionAkira Mukai, Tatsunori Ejima1962 Volume 77 Issue 2 Pages 128-135
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe studied the direct Ehrlich reaction as a method for determination of sialic acid in human cerebrospinal fluid. This reaction is clearly less useful as compared with Bial's reaction or the diphenylamine reaction. And it is not suitable for protein-free samples containing trichloracetic acid. But it is expected that the reaction may be serviceable in determining the sialic acid content in samples of the whole cerebrospinal fluid or the protein-free cerebrospinal fluid containing no trichloracetic acid. The existence of a large amount of the free sialic acid as compared with the protein-bound sialic acid in the cerebrospinal fluid is denied.View full abstractDownload PDF (428K) -
Atsushi Ichikawa, Yasuko Nakajima1962 Volume 77 Issue 2 Pages 136-149
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe fine structure of the lacrimal gland and its changes of the secretory cycle have been studied by light and electron microscopy, on the rat.
1. The acinar cell contains only one kind of the secretory granule which is surrounded by a thin membrane originated from the Golgi membranes, and its contents are low in density, water-rich and not mucous. The secretory granule is extruded in a typical mode of merocrine secretion into the lumen.
2. Both in the small and larger ducts, dense secretory granules are found in their epithelial cells and seem to be formed within the Golgi complex. The mechanism of granule release is not clear but the apocrine-like processes are often found. No typical infolding of the basal plasma membrane is observable and intercellular boundaries are characterized by well-developed cellular interdigitation in complex arrangement.
3. The myoepithelial cells are present in the terminal portion and duct system which is lined with the epithelial cells containing secretory granules.
4. Unmyelinated nerve fibers are sometimes found in the interstitial connective tissue among acini, but there is no evidence of direct attachment of nerve fibers to the acinar cells or myoepithelial cells.View full abstractDownload PDF (4895K) -
Zensaku Yosizawa, Eiaki Tsutsumi, Tokutaro Sato1962 Volume 77 Issue 2 Pages 150-163
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe monosaccharides constituents of the walls of Rhodopseudomonas spheroides grown under light-anaerobic and dark-aerobic conditions were studied.
The light-anaerobic walls contained glucose (1.5%), ribose (0.8%), methylpentoses (rhamnose and fucose) (5.0%, as rhamnose) and aminosugar (as glucosamine) (2.3%, by Dische-Borenfreund reaction; 3.4%, by Elson-Morgan reaction). On the other hand, glucose (0.6%), ribose (0.7%), methylpentoses (rhamnose and fucose) (5.3%, as rhamnose) and aminosugar (as glucosamine) (2.1%, by Dische-Borenfreund reaction; 4.2%, by Elson-Morgan reaction) were also found in the dark-aerobic walls.
Sialic acid, uronic acid, heptose, 2-deoxyaldose and 3-deoxyaldose were not detected in the walls.
Acknowledgement The present authors were indebted to Prof. G. Kikuchi for supply of the walls of R. spheroides, for which and for his encouragementthroughout this work, they wish to express their acknowledgement.View full abstractDownload PDF (591K) -
Studies on the Estimation of Cancer Cells in Blood by Acridine Orange Fluorescence Microscope MethodYoshinobu Ishikawa, Matsuro Fukushima, Hiroharu Uno1962 Volume 77 Issue 2 Pages 164-170
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (882K) -
Report I. Pathway of Hemoglobin Catabolism in RabbitsIsao Rokugo1962 Volume 77 Issue 2 Pages 171-178
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRabbit oxyhemoglobin, rabbit methemoglobin and equine metmyoglobin were intravenously administered to male rabbits, respectively, and the occurrence of their metabolic products in urine and blood stream was followed.
1) Rapid and massive excretion of choleglobin, together with hemoglobin, was observed to occur after the oxyhemoglobin administration. Also biliverdin could be obtained from urines, though attempts to demonstrate the occurrence of verdohemoglobin in urines failed. A small amount of choleglobin was also found in the circulating blood.
2) When methemoglobin was infused in place of oxyhemoglobin, the occurrence of choleglobin in urine was delayed.
3) Further delay was noticed when metmyoglobin was used. In this case, however, the appearance of verdoheme in urine was clearly demonstrated.
4) Extents of heme breakdown were very small when oxyhemoglobin was incubated with citrated whole blood.
On the basis of the above experimental results, the path of hemoglobin catabolism was assumed to proceed in a similar way as in the well-defined model system of hemoglobin breakdown using ascrobic acid. Also the reaction of hemoglobin catabolism in vivo was presumed to be participated by activities of living cells.View full abstractDownload PDF (383K) -
Tetsuo Maki, Tomonobu Sato, Takeo Sato1962 Volume 77 Issue 2 Pages 179-186
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
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Toyoji Wada, Takamaro Shimizu1962 Volume 77 Issue 2 Pages 187-194
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to record directly the period (viz. frequency) of alpha-rhythm of human EEGs, the authors have designed an apparatus consisting of electrotachometric units, which were inserted into the circuit of a routine EEG recording machine. By this means, it is easily possible to measure the frequency of alpharhythm quantitatively and qualitatively in absolute values. Preliminarily technical notes on this apparatus and several findings obtained from normal subjects by practical application were reported in this paper.View full abstractDownload PDF (322K) -
Tadashi Ohno1962 Volume 77 Issue 2 Pages 195-203
Published: July 25, 1962
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to ascertain the effect of ACTH and stress on the X-zone of the mouse adrenals, starvation and administration of ACTH and formalin were performed on normal, bypophysectomized and ovariectomized virgin animals. Stress and the administration of ACTH induced a particular kind of regression in the X-zone of normal and hypophysectomized mice, which could not be prevented by preliminary ovariectomy or cortisone administration. The most severe lesions of the X-zone were observed in the starved group.
The X-zone was maintained and even hypertrophied by the administration of hydrocortisone, and this was ascribed to the decreased secretion of ACTH.View full abstractDownload PDF (2467K)
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