The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 65, Issue 1
Displaying 1-12 of 12 articles from this issue
  • Report No. 1 On the Fate and Distribution of Antimony in the Body under the Ordinary-Treatment with Sodium Antimonyl Tartrate
    Keizo Ozawa
    1956 Volume 65 Issue 1 Pages 1-9
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Report No. 2 On the Sb Concentration in Blood and the Sb Distribution in Organs during the Intensive Treatments of Goats and at the Sb Poisoned Death of Rabbits and on the Effects of Bal and Hypo as
    Keizo Ozawa
    1956 Volume 65 Issue 1 Pages 11-21
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Takeshi Onoki
    1956 Volume 65 Issue 1 Pages 23-32
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Retinal induction was studied in normal and color-defective subjects by means of Motokawa's method.
    1. The effect of light in terms of ζ was investigated with spectral lights, and it was found that the ζ value for red lights was dicidedly small in a protanomalous.
    2. ζ-time curves for spectral lights were found much different from those of the normal. The curve for blue-green light was the same as the curve for white light. This fact may be correlated with the situationn that the light of 480-490mμ looked to the subject as gray. The curves for yellow and blue were found similar to those of the normal.
    3. The two parts of the spectrum, blue-green and red caused no retinal induction in the protanomalous. Lights of yellow and yellow-green were more effective to cause retinal induction in the color-defective than in the normal. Blue light was found equally effective in both cases.
    4. Effectiveness of spectral lights for retinal induction was investi-gated systematically, plotting contrast effects as ordinates against the wave-lengths of inducing spectral lights as abscissas, and it was found that orange and blue-green are optimal in the normal, while blue and yellow-green are favorable in the protanomalous.
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  • Kiitiro Suzuki, Juzaburo Umetsu
    1956 Volume 65 Issue 1 Pages 33-36
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    By means of the method of electric flicker (EF), we measured, for 60 minutes, variations of electric flicker values (EFV) of 6 patients after transfusion of venous blood (VB) and of blood saturated with oxygen (OB). After transfusion of VB and OB, EFV decreased gradually, re-ached a minimum in about 20 minutes, and then increased again. The decrease of EFV was much more conspicuous for OB than for VB. This effect lasted longer than one hour in case of OB transfusion, but dis-appeared in about 50 minutes in case of VB transfusion.
    The authors have pleasure in acknowledging their indebtedness to Prof. K. Motokawa who has guided them kindly.
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  • Makoto Kobayashi, Juzaburo Umetsu, Mitsuru Kameyama
    1956 Volume 65 Issue 1 Pages 37-44
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In 26 healthy adults the threshold for appearance of flicker, S1, and ΔS, that is, the difference of S1 and the threshold for disappearance, S2, were measured by the method of electric flicker, and the data obtained were treated statistically.
    1. Some significant nt practice effect was observed in experiments on beginners, so that it is advisable to have at least one session for practice in such measurements.
    2. There was a high correlation between S1 and ΔS, and between S2 and its standard deviation (S. D.) or ΔS and its S. D.
    3. A threshold load with a bicycle ergometer, at which ΔS just increased significantly at 5 percent level was determined. After exercise with a load 1.5 times as great as the threshold load, both Sl and ΔS increased remarkably, where no significant correlation could be found between ΔS and its S. D.
    4. ΔS was found more sensitive to threshold loads than was S1, where stimulation with Röntgen rays, vestibular stimulation and exercise with a bicycle ergometer were used as threshold loads. It was concluded from these findings that ΔS is a more sensitive indicator than S1, while both of them may be. used equally well for measuring effects of heavier loads.
    We are greatly indebted to Prof. K. Motokawa for his generous guidance and valuable suggestions.
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  • Tosisada Mita, Enkichi Fujimaki, Sadao Yaegashi
    1956 Volume 65 Issue 1 Pages 45-56
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Using light sensation (electrical phosphenes) produced by the sinusoidal alternating current flowing through the eyeball as an indicator for determination of the electric threshold of the eye, we studied dependence of the electric threshold upon intensity of illumination as well as the time course of the electric threshold during dark adaptation. Frequencies of electric current ranging from 2 to 20 cps were used for stimulation.
    1. The form of the electric threshold strength-log-illumination curve varies according to the frequency of the alternating current. Among the curves obtained, the curves for 2, 3 and 4 cps are of duplex nature and their form is quite similar to Ferry-Porter's law of critical fusion frequency (CFF), namely, the electric threshold for frequencies around 3 cps has the closest correlation with CFF. But the same correlation is not found in case of the other higher frequencies.
    2. The electric threshold for frequencies at 2, 3 and 4 cps decreases progressively in the course of dark adaptation. This relation is, though qualitatively, in accordance with the progressive decrease of the light threshold during dark adaptation. There appears an abrupt inflection on the electric threshold strength-time curve for 2-4 cps, when the preillumination is sufficiently intense and long. This inflection is not coincident in time for appearance with the so-called “Kohlrausch's Knick” lying on the normal dark adaptation curve obtained by the adequate stimulus.
    3. It is suggested that the structures stimulated by the sinusoidal alternating current at 3 cps may be the cone and rod cells, while those stimulated by the current at 15 or 20 cps may be supposedly the bipolar cells.
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  • CXC. Sugar Components of Snail Mucus Mucin
    Hajime Masamune, Zensaku Yosizawa
    1956 Volume 65 Issue 1 Pages 57-62
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • CXCI. Esteric and Ethereal Links in the Molecule of Group Mucopolysaccharide from Pig Stomach Mucus
    Hajime Masamune, Sen-itiroh Hakomori, Osamu Masamune
    1956 Volume 65 Issue 1 Pages 63-78
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    1. In continuation of the foregoing work, the group mucopolysaccharide, prepared by alkaline scission of pig stomach mucus at room temperature, (MP I) was investigated with respect to the union between its polypeptide and carbohydrate moieties.
    2. A partial degradation product of MP I, which was still group active, (MP II) was obtained in crystalline form. It contains three molecules of acetylglucosamine, two molecules of acetylgalactosamine, five molecules of galactose and one molecule each of L-fucose, serine and alanine per unit molecule and is devoid of sialic acid. Moreover, it lacks acetal link.
    3. As products by alkaline hydrolysis of MP II, a tetrasaccharide composed of one molecule of acetylglucosamine, two molecules of galactose and one molecule of L-fucose (“gastro-N-tetrasaccharide”) and two undialyzable high-molecular polypeptide-polysaccharide complexes were separated. In gastro-N-tetrasaccharide, one of the galactose molecules stands at the reducing terminal and the L-fucose molecule is bound in a manner stable against acetic acid. One of the polypeptide-polysac-charide complexes is most probably a fragment whose multiple makes up MP II deprived of the tetrasaccharide.
    4. Ester linkage between the carboxyl of alanine and a hydroxyl in gastro-N-tetrasaccharide was suggested.
    5. Crystalline N-acetylglucosamine-galactoside serine ether was isolated from a H2SO4-hydrolysate of MP II.
    6. From the findings above and those in other articles from this laboratory a partial structure of MP I and II are discussed.
    Through the Grant Committee for Scientific Researches the Ministry of Education gave a grant in aid to us, which is gratefully acknowledged. H. Masamune.
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  • CXCII. Sugar Components Unstable against Metaperiodate and Hypoiodite of the Group Mucopolysaccharide from Pig Gastric Mucus
    Hajime Masamune, Zensaku Yosizawa, Mituo Haga
    1956 Volume 65 Issue 1 Pages 79-82
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • CXCIII. A Hydrolysis Experiment of the AO Mucopolysaccharide from Pig Stomach Mucus
    Zensaku Yosizawa
    1956 Volume 65 Issue 1 Pages 83-86
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Mitsuo Tanno
    1956 Volume 65 Issue 1 Pages 87-95
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Takeshi Onoki, Hiroshi Yamamoto
    1956 Volume 65 Issue 1 Pages 97-105
    Published: December 25, 1956
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    By means of Motokawa's method, the dependence of direct retinal induction on the saturation of inducing colored light was studied in normal and protanomalous subjects.
    1. White light was mixed with spectral light of certain brightness in various proportions, and the mixtures were used as inducing light. So long as the amount of white light mixed was below a certain critical value, retinal induction was caused to the same degree, but above the critical value no induction whatever was produced.
    2. The minimal saturations for various spectral lights required to produce retinal induction were determined, and the curve for saturation obtained in this way was found to coincide with the curve of colorimetric purity subjectively determined. In the normal, the most unsaturated part of the spectrum was found at 570mμ, the both ends of the spectrum being most saturated. In the protanomalous, however, the curve of saturation showed two minima at 490 and 570mμ; the former was much deeper than the latter.
    3. The amount of white light required to check retinal induction was found to be much smaller in the color-defective than in the normal. From these facts it may be concluded that any colored light discriminable from white can cause retinal color induction.
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