Investigations were made on the direct action of various steroid hormones and the related compounds in contraction produced by electrical stimulation. Estrogen dominated rabbit uterus was used for experiment. 1. Progesterone, cortisone and testosterone showed an apparent dintution of uterine contraction, while the inhibitory action of Viadril and DOC was of a very mild degree in small dose. 2. In a dose of 2 mg., progesterone, estradiol, DOC, Viadril and 4-chlorotestosterone revealed to be complete, but testosterone and cortisone produced some irreversible influence on the uterine muscle. 3. Progesterone showed a linear decrease of tension when the time elapsed. Testosterone and cortisone exhibited an exponential diminution of contraction height. 4. On the interaction of steroids, while antagonistic effect was observed in the combination of testosterone+progesterone, testosterone+estradiol, testosterone+DOC, testosterone+Viadril, cortisone+Viadril and cortisone+DOC, gynergetic action was obtained in progesterone+estradiol, progesterone+DOC, DOC+Viadril and progesterone+Viadril. 5. To strong stimulus, when testosterone and cortisone kept a marked nhibitory action, progesterone gave almost no change in contraction.
The cat intraretinal ERG was recorded with microelectrodes. Repetitive stimulation of the optic nerve reduced the amplitude of the ERG, especially that of the c-wave. This effect on the intraretinal ERG was tentatively attributed to centrifugal fibers in the optic nerve, although the possibility that it was a secondary effect resulting from an alteration of the retinal circulation could not be excluded completely.
Unit discharges in response to a spot of colored light subtending 0.5° in visual angle were recorded from the lateral gyros of the cat immobilized with Flaxedil. 1. Two types of responses, “on” and “off”, were most frequently obtained from postgeniculate neurons, optic radiation fiber and cortical units. The cortical unit responded with a lower rate and had a smaller receptive field than the radiation unit. 2. All the units showed scotopic spectral sensitivity curves, having a maximum at about 500 mμ. 3. The peak of the spectral sensitivity curve could not be shifted by light adaptation, although the sensitivity was much reduced. 4. Spectral response curves (spike frequency-wavelength relation) obtained with a high intensity of stimulus showed a dominant peak at about 500 mμ and a submaximum or hump around 580 mμ. 5. Some units reversed its response type from “off” to “on” after light adaptation.
The clinical histories and pathologic findings have been reviewed in nine autopsied cases of superior vena caval obstruction. Carcinoma of the lung or bronchus was the cause in eight cases while there were one case each of Hodgkin's disease, gastric carcinoma, and malignant tumor of the neck (probably of thyroid origin).
A case with acrodermatitis continua Hallopeau, 12 years old female, was reported. The results of various investigations with the patient revealed that she might have a disposition of congestion at the periphery of her extremities. She was, therefore, treated by Kallilrein (pancreatic circulatory hormone) and Tolazoline (priscol, sympatholytic agent) and it was very successful. From these findings, it is assumed that acrodermatitis continua may occur in the following sequences; hormonal disturbance→unbalance of autonomic nervous system→vasomotoric nervous disturbance→congestion→acceleration of congestion due to the presence of arterio-venoanastomosis→local nutritional disturbances→acrodermatitis continua.
1. In the carp's isolated retina a positive potential was produced within and very closely around an illuminated area, and a negative one in the surrounding area. 2. The configuration of the potential recorded at the center of the illuminated part varied with the area of illumination in such a manner that the negative component increased with increasing areas of illumination. This effect was attributed to the summation of negative potentials coming from all parts of the illuminated area. When the central part was isolated from the surrounding area by a mechanical cut, the negative component decreased so that the recorded potential became more positive. 3. The distribution of positive and negative potentials in the retina subjected to stimuli of various patterns was mapped, and the zero-potential line separating the positive field from the negative one was determined for each stimulus. The contour of the zero-potential line was circular for a circle, about triangular for a triangle, but cruciform for a square. 4. The potential fields around Müller-Lyer figures were mapped, and the extent of the positive field was correlated with the perceptual effect of these figures. 5. The electrical field caused by a set of two concentric circles was mapped. The positive field of the inner circle of definite diameter was found to be displaced towards the center, when the outer circle was relatively large, and displacement occurred in the reverse direction when the outer circle was relatively small. These phenomena were correlated with under- and overestimation of the size of the inner circle when viewed within large and small outer circles, and accounted for in terms of interaction between positive and negative potentials.