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Volume 95 (1968)
- Issue 4 Pages 317-
- Issue 3 Pages 203-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 95, Issue 3
Displaying 1-11 of 11 articles from this issue
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Tsuneo Arakawa, Tsunenobu Tamura, Keiya Tada, Haruko Hirono1968 Volume 95 Issue 3 Pages 203-205
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFree amino acid levels of the liver were estimated in riboflavin deficient rats. The results revealed that there were a considerable decrease in glycine and a slight decrease in methionine. It was assumed that the decrease in glycine and methionine levels might have resulted from a decreased activity of both N5.10 methylene-tetrahydrofolate reductase and N5 methyltetrahydrofolate transferase induced by riboflavin deficiency.View full abstractDownload PDF (164K) -
Hiroshi Saito1968 Volume 95 Issue 3 Pages 207-220
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn chronic glomerulonephritis with hypercreatininemia (Group 1), there was a significant correlation between the changes in urinary protein excretion (Uprot•V) and those in GFR during both quiet standing and walking.
In chronic glomerulonephritis without hypercreatininemia (Group 2), there was a significant correlation between the changes in Uprot•V and those in GFR during quiet standing, but no correlation during walking. In nephrotic syndrome with definite evidence of chronic glomerulonephritis on renal biopsy (Group 3), there seemed to be a good correlation between the changes in Uprot•V and these in GFR during both quiet standing and walking, but in nephrotic syndrome with minimal changes on renal biopsy (Group 4), no correlation was found during both quiet standing and walking.
Relative clearances of urinary protein estimated by acrylamide gel electro-phoresis and immunodiffusion method did not differ among supine bed rest, quiet standing and walking, although urinary protein excretion was either increased or decreased by postural changes.
Relative clearances of urinary protein showed that permeability of protein through the glomerular membrane was more selective in Group 2 than in Group I of chronic glomerulonephritis, and that also more selective in Group 4 than in Group 3 of nephrotic syndrome.
The changes in protein excretion by postural changes were explained by the concurrent decrease of GFR in Groups 1 and 2 of chronic glomerulonephritis, and also in Group 3 of nephrotic syndrome.
On the other hand, the alterations by postural changes in tubular reasbsorptive capacity for protein might determine to some extent protein escape into urine in Group 4 of nephrotic syndrome.View full abstractDownload PDF (1303K) -
Seigi Tsuchida, Takashi Someno, Nobumichi Nakano1968 Volume 95 Issue 3 Pages 221-234
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUreteral electromyograms were taken from patients with spinal injuries, and studies were made of the electroureterographic findings in relation to affected sites, periods after injury, and renal and cystic functions.
Abnormal findings on the electroureterograms were represented by significant prolongation and shortening of discharge intervals as well as by partial changes in the amplitude, duration and travel-rate associated with retrograde peristaltic discharges.
There was no marked relation between the site of injury and the electro-ureterographie findings. The period after injury correlated with the findings, and the longer the period after injury, the higher the incidence of the abnormal discharge. On the other hand, patients with the complication of renal dysfunction showed electroureterographically a higher incidence of abnormal findings. Abnormal discharge was more frequent in cases of hypotonic bladder than in cases of normo-tonic or hypertonic bladder, but the difference was not significant.View full abstractDownload PDF (729K) -
Keiya Tada, Toshio Yoshida, Yoshimasa Yokoyama, Tetsuo Sato, Hiroshi N ...1968 Volume 95 Issue 3 Pages 235-242
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn infantile case of cystathioninuria was described. The patient had retarded development and marked cystathioninuria. Large doses of vitamin B6, were of no effect in diminishing cystathionine excretion, this finding being different from that in other patients with cystathioninuria so far reported. Using liver specimens biopsied from the patient, a difinitely low activity of cystathionase was demonstrated in the presence of an excess of pyridoxal phosphate.
Both in vivo and in vitro studies indicate a defect in cystathionase itself. The present patient is thought to have a new type of cystathioninuria without vitamin B66 dependency.View full abstractDownload PDF (380K) -
Minoru Hirooka, Seiji Ikeda, Naoki Kubota1968 Volume 95 Issue 3 Pages 243-252
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLittle attention has been hitherto paid to the relationship between dietary fat content and intestinal iron absorption. The present experiments were carried out to examine the influence, if any, of soybean oil on the intestinal iron absorp-tion in rats.
Female albino rats were fed on a diet consisting of polished rice powder with or without 4% vitamin mixture (basic diet) and another kind of diet consisting of the basal diet supplemented with soybean oil (3-12%). On the last day of 2 weeks' feeding, 59FeSO4 (10μc) was given with a gastric tube. 59Fe activity in the blood 15, 30, 45 and 60 minutes after the dosage and 59Fe uptake into the liver 120 minutes after the administration were measured with a well type scintillation counter.
Significantly higher activity of 59Fe in both the blood and the liver was found in rats fed on the diet containing soybean oil than in those on the basic diet.
The increase of iron absorption in cases of the diet containing 6% soybean oil was almost the same as that observed with the diet containing 18% casein.View full abstractDownload PDF (565K) -
Yoshiro Wada, Tsuneo Arakawa, Kinjiro Koizumi1968 Volume 95 Issue 3 Pages 253-260
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe incorporation of 14C-8-inosine into uric acid, GMP and AMP was investigat-ed by using liver homogenates from a one-year-9-month-old boy with Lesch-Nyhan syndrome, and the result revealed that the incorporation of 14C-8-inosine into uric acid and xanthine was markedly increased and that into GMP, adenine and adenosine was markedly reduced as compared with those in a control. At autopsy of the patient, the cerebrum was found to be changed into a thin layer of gliosis with degenerative and necrotic nerve cells.View full abstractDownload PDF (1684K) -
Seigi Tsuchida1968 Volume 95 Issue 3 Pages 261-269
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA Simplified Technique for Extracorporeal Bypass in Hemodialysis Seigi Tsuchida A simplified technique was devised for extracorporeal bypass in hemodialysis, which was based on the principle of selective renal angiography described by Edholm and Seldinger.1 The procedures were described of hemodialysis by using a hemodialvtic shunt consisting of catheters intubated into the artery and vein and an A-V shunt made of silicon rubber tube which could be connected to the inlying catheters for intervals between dialyses. The results of clinical trial with this dialyzing circuit system on four patients with chronic renal insufficiency showed its effectiveness in correcting fluid and electrolyte unbalance, and its simplicity and potential usefulness was confirmed.View full abstractDownload PDF (2027K) -
Tsuneo Suzuki1968 Volume 95 Issue 3 Pages 271-287
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectron-microscopic changes of the heart muscle of rats after administration of cyanide were described in detail with the purpose of demonstrating the direct effects of cyanide on the heart muscle.
The most prominent electron-microscopic changes were elongation of the sarcomere, dissociation of the myofibrils at the level of I band, swelling, destruction and disappearance of the mitochondria, enlargement of the vesicles of sarcoplasmic reticulum, margination of chromatin granules in the nucleus, and swelling of the capillary endothelial cells. These findings were most prominent in cases of death in 10 to 15 minutes after injection of 10 mg per kg of potassium cyanide. On the other hand, the above changes were slight in cases of death within 5 minutes after the same dosage, because the rats died rapidly from paralysis of the respiratory center rather than cardiac disturbances. The rats with the dosage of 2 mg per kg of potassium cyanide survived cyanide poisoning, and the ultrastruc-tural changes in 15 minutes after the injection were only slight swelling of mito-chondria and of vesicles of sarcoplasmic reticulum, and these changes were not found in 60 minutes after the injection.
These results suggest that the cyanides in a larger dose exert a direct influence nott only on the metabolic systems but also on the contractile elements of the heart, muscle, but those in a smaller dose cause only slight and reversible changes in the metabolic systems.View full abstractDownload PDF (5584K) -
Hiromu Hayashi1968 Volume 95 Issue 3 Pages 289-295
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing the iodine-starch method for visualizing sweat, the functional activity of the eccrine sweat glands of the mouse foot-pads was studied.
The sweat glands of the pad were stimulated by local injection of parasym-pathomimetic agents, such as acetylcholine, carbaminoylcholine, mecholyl and pilocarpine, and sympathomimetic ones, such as adrenaline, noradrenaline and iso-p ropyl noradrenaline. In general, the parasympathomimetic agents were more effective in eliciting sweat responses than the sympathomimetic ones.
The fact that spontaneous sweating was eliminated by relatively low con-centrations of atropine, but not by relatively high concentrations of dihydro-ergotamine suggests that the sweat glands of the plantar surface of the mouse receive a cholinergic nerve supply. Nicotine and lobeline, injected intradermally, did not provoke an axon reflex sweating.View full abstractDownload PDF (2362K) -
Masao Wada, Seiichi Sato, Wataru Koyama, Hiromu Hayashi, Juko Hanawoka1968 Volume 95 Issue 3 Pages 297-311
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of procaine, Ca, Mg and K on the release of transmitter from the cholinergic sweat nerve endings in the forearm skin were studied. Sweating was visualized by the iodine-starch method of Wada and Takagaki.
At a concentration of 10-7, intradermal injections of eserine did not produce a local sweating in a cool environment, but they became effective in eliciting sweat response on the injection wheals by entering a warm or hot environment. Local sweat responses to eserine in 10-6 and 10-5 were also intensified on exposure to heat.
Procaine in 10-4 inhibited the sweat responses to eserine very probably by affecting the acetylcholine release from the sweat nerve endings. It was found that Ca ions contained in Krebs solution are important in the process of the acetylcholine release and excessive Ca facilitates this release. In contrast, Mg and K ions present in Krebs solution were without any effect. But, when Mg was in excess relative to Ca, it was observed that Mg antagonized the effect of Ca. The antagonism between Mg and Ca was demonstrated also in the case of spontaneous thermoregulatory sweating. The effect of Ca on the acetylcholine release seems to be antagonized by Mg in a ratio of approximately 1:2 in molality.View full abstractDownload PDF (5057K) -
Masafumi Shirai, Shozaburo Matsushita, Manabu Kagayama, Sadatoshi Ichi ...1968 Volume 95 Issue 3 Pages 313-316
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSexual behavior of 156 sterile males was investigated by personal interview in association with our previous report on fertile males. The intensity of sexual desire of sterile males is weaker than that of fertile males in the corresponding age groups, especially in 34-40 years of age. The frequency of morning erection in sterile males is highest between 24-30 years of age, and it decreases steadily as the age advances. On the other hand, there is no considerable reduction in the intensity of erection at sexual intercourse. In the group of 24-30 years of age, sterile males have lower frequencies of marital intercourse than fertile males. There is no remarkable difference by age in the feeling of orgasm. Six per cent of the sterile males are found to lack orgasm. Sixteen per cent of the wives expressed some dissatisfaction with their sexual life.View full abstractDownload PDF (213K)
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