KOBAYASHI, K., ARAKAWA, T., NAKAMURA, H., CHONO, S., YAMADA, H., SATOH, H, and ONO, T.
Effect of Gefarnate on Endogenous Prostacyclin, Prostaglandin E2 and Thromboxane in Water-Immersed Rats. Tohoku J. exp. Med., 1983,
140 (2), 181-185 - The level of endogenous prostacyclin (PGI
2), prostaglandin E
2 (PGE
2) and thromboxane A
2 (TXA
2) in rat gastric mucosa was determined by radioimmunoassay to examine whether gefarnate, an antiulcer agent, maintained the endogenous prostaglandin (PG) level in rats subjected to water-immersion stress. Seven-hr immersion induced gastric lesions and a marked reduction in PGI
2 and PGE
2. When gefarnate was injected subcutaneously before stress exposure, the mean ulcer index was reduced and the PGI
2 and PGE
2 levels were maintained. Our results suggest that the reduction of endogenous PGI
2 and PGE
2 is a major factor in water-immersion-induced ulcers in rats, and that gefarnate inhibits this ulcer formation by inhibiting a reduction in those PGs induced by water-immersion stress.
View full abstract