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Volume 164 (1991)
- Issue 4 Pages 251-
- Issue 3 Pages 183-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 164, Issue 3
Displaying 1-8 of 8 articles from this issue
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AKIRA OGAWA, TAKASHI YOSHIMOTO, YOSHIHARU SAKURAI1991 Volume 164 Issue 3 Pages 183-190
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOGAWA, A., YOSHIMOTO, T. and SAKURAI, Y. Clinical Analysis of STA-SCA Bypass for Vertebrobasilar Occlusive Disease. Tohoku J. Exp. Med., 1991, 164 (3), 183-190 - In order to clarify the effectiveness of extracranial- intracranial bypass in cases of vertebro-basilar occlusive disease, we investigated the operative complication, clinical course and follow-up study of 30 cases undergoing superficial temporal artery - superior cerebellar artery (STA-SCA) bypass surgery. Postoperative angiogram showed the patency of the anastomosess in all cases. No serious surgical complications were observed. The outcome on discharge was excellent, with no morbidity and one mortality which was due to cardiac infarction. In the follow-up study, there were four cases with ischemic symptoms, two with transient ischemic attack and two with completed stroke, one of which was a supratentorial infarction due to internal carotid artery occlusion and the other was a small infarction of pons. There were also two deaths due to cardiac infarction and diabetes mellitus. Favorable outcomes were obtained for the remaining cases. The present study suggests that, STA-SCA bypass, can be performed without surgical and systemic complications and used as an effective therapy for vertebrobasilar ischemia.View full abstractDownload PDF (1443K) -
MASATSUGU MORIYAMA, ISAMU SUGAWARA, HIROFUMI HAMADA, TAKASHI TSURUO, T ...1991 Volume 164 Issue 3 Pages 191-201
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMORIYAMA, M., SUGAWARA, I., HAMADA, H., TSURUO, T., KATO, T., SATO, K., HIKAGE, T., WATANUKI, T. and MORI, S. Elevated Expression of P-Glycoprotein in Kidney and Urinary Bladder Cancers. Tohoku J. Exp. Med., 1991, 164 (3), 191-201 - A monoclonal antibody MRK16, recognizing specifically an epitope of P-glycoprotein (P-GP), a highly active efflux transporter of chemotherapeutic agents, was used to determine the degree of expression of P-GP in the normal human kidney and urinary bladder, and in kidney and urinary bladder cancers. P-glycoprotein was localized in the microvilli of the epithelial cells of the proximal renal tubules by immunoelectron microscopy, and detected immunohistochemiccally in 6 of 20 untreated kidney cancers and 11 of 31 untreated urinary bladder cancers. Some of the cancerous tissues were further examined with regard to P-GP expression by immunoprecipitation. In urinary bladder cancers, the degree of P-GP expression seemed to be somewhat correlated with tumor grading. These results indicate that our method to detect the degree of expression of P-GP by MRK16 may be applicable for the diagnosis of clinical multidrug resistant urinary cancers.View full abstractDownload PDF (8153K) -
KAZUYA KITAMURA, TOSHIO TAKAHASHI, AKINORI NOGUCHI, HIROSHI TSURUMI, K ...1991 Volume 164 Issue 3 Pages 203-211
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKITAMURA, K., TAKAHASHI, T., NOGUCHI, A., TSURUMI, H., TAKASHINA, K., OKUZUMI, J. and YAMAGUCHI, T. Pharmacokinetic Analysis of the Monoclonal Antibody A7-Neocarzinostatin Conjugate Administered to Nude Mice. Tohoku J. Exp. Med., 1991, 164 (3) 203-211 - The pharmacokinetics of a disulfide linked conjugate of a murine monoclonal antibody A7 with neocarzinostatin (A7-NCS) was studied following its intravenous administration to nude mice. Disappearance of the conjugate from the circulation was biphasic: an early rapid phase was followed by a much slower phase. The conjugate was removed from the blood circulation with a half-life of 12hr, showing nearly the same kinetics as the free antibody. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis showed that the disulfide linkage in A7-NCS was stable at least for 48hr after administration of the conjugate to nude mice. The conjugate concentration in a human colon cancer SW1116 derived tumor reached maximum at 24hr after injection and remained high for an additional 24hr. The passive hemagglutination inhibition assay revealed that NCS in the conjugated form can be efficiently delivered to the target tissue. The present report indicates that A7-NCS was sufficiently stable in circulation to reach the target tumor without releasing NCS.View full abstractDownload PDF (992K) -
YASUO TAKAHASHI, TETSURO OGAWA1991 Volume 164 Issue 3 Pages 213-221
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHASHI, Y. and OGAWA, T. Composition of the Excitatory Postsynaptic Potentials Recorded from Rat Visual Cortical Neurons in Layer II/III: An In Vitro Electrophysiological and Pharmacological Studies. Tohoku J. Exp. Med., 1991, 164 (3), 213-221 - Intracellular recordings were performed on layer II/III neurons of rat brain slices. Neuronal responses to electrical stimulation of the white matter was analyzed pharmacologically using D-2-amino-5-phosphonovalerate (APV), a specific antagonist of the N-methyl-D-aspartate (NMDA) receptor, and kynurenate (Kyn), a broad-spectrum antagonist of both the NMDA and the non-NMDA (kainate and quisqualate) receptors. Fifty-five neurons produced an excitatory postsynaptic potential (EPSP) in response to a single shock. In forty-eight neurons (87%) of them, the EPSP consisted of an APV-sensitive component and an APV-insensitive component. While in seven neurons (13%), it consisted of only the APV-insensitive component. The APV-sensitive component was preceded by the APV-insensitive component and was enhanced in amplitude and duration by the following procedures: a) applying repetitive stimulations to the white matter, b) reducing Mg2+ concentration in the bathing solution and c) depolarizing cell membrane. The APV-insensitive component was affected by neither repetitive stimulation nor reduction of Mg2+ concentration. Both APV-sensitive and APV-insensitive components were reduced by the treatment of Kyn. These suggest that in bathing medium containing Mg2+, the APV-sensitive (i.e. the NMDA receptor-mediated) EPSP is generated by the non-NMDA receptor-mediated depolarization, which removes the Mg2+ blockade in NMDA receptor-gated channel.View full abstractDownload PDF (848K) -
KUNIHIKO GOTO, SHIGETOSHI HOSAKA, HIROTADA ISHII, HIROSHI NAGURA1991 Volume 164 Issue 3 Pages 223-230
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSGOTO, K., HOSAKA, S., ISHII, H. and NAGURA, H. Follicle-Like Hemicysts Reorganized in Monolayer Culture of Rat Thyroid Cells in a Medium Supplemented with Isologous Serum. Tohoku J. Exp. Med., 1991, 164 (3), 223-230 -Monolayer culture of the cells isolated from rat thyroid glands formed a number of large and three-dimensional (about 200-μm diameter) hemicysts in media supplemented with isologous and high-concentration serum. The higher was the concentration of isologous serum, the larger was the hemicysts and the higher was the uptake of 131I of hemicysts. Substitution of heterologous serum, such as calf or fetal calf serum, for the isologous serum failed to form hemicysts.View full abstractDownload PDF (2805K) -
KUNIHIKO GOTO, SHIGETOSHI HOSAKA, HIROTADA ISHII, HIROSHI NAGURA1991 Volume 164 Issue 3 Pages 231-236
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSGOTO, K., HOSAKA, S., ISHII, H, and NAGURA, H. Dynamic Movement of Hemicyst Reconstructed from Monolayer Cultures of Rat Thyroid Cells in Isologous Serum. Tohoku J. Exp. Med., 1991, 164 (4), 231-236 - Time-lapse studies using cine-microscopic observation showed that the hemicysts formed in a culture of rat thyroid cells in a high concentration of isologous serum were found to arise by swelling from the monolayer sheet, gradually increase in size, and then rapidly collapse. The hemicyst volume increased linearly. We speculate that each hemicyst epithelium transport a constant volume of liquid into the hemicyst lumen.View full abstractDownload PDF (2192K) -
YUJIRO SHIROYAMA, TSUTOMU NAGAMITSU, KATSUHIRO YAMASHITA, TETSUO YAMAS ...1991 Volume 164 Issue 3 Pages 237-246
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSHIROYAMA, Y., NAGAMITSU, T., YAMASHITA, K., YAMASHITA, T., ABIKO, S. and ITO, H. Changes in Brain Stem Blood Flow under Various Grades of Brain Stem Ischemia. Tohoku J. Exp. Med., 1991, 164 (3), 237-246 - This report describes a study of brain stem blood flow (BBF) change under various grades of brain stem ischemia in a new experimental rat model. The main damage was caused by occlusion of the median and paramedian perforating arteries of the basilar artery. In this model, hyperperfusion was generally observed in cases of mild or moderate ischemia within 1hr after recirculation and lasted for approximately 1hr. During hyperperfusion, BBF increased to over 60ml/100g brain/min and was significantly greater than basal values (p<0.01). The fact that hyperperfusion was unobserved in some cases might be due to the degree of damage to the medulla oblongata. Hypoperfusion or lack of reflow phenomena was also followed by severe ischemia with remarkable hypotension. It is fairly clear from our results that the pattern of postischemic hyperperfusion is responsible for decreased oxygen availability in the brain stem and dysfunction of autoregulation. Acetazolamide reactivity was disturbed and had an inverse response during hyperperfusion. Such phenomena can be explained by paralytically dilated vessels due to ischemia. If BBF falls below a critical level, as we have seen, postischemic hyperperfusion may be induced with dysfunction of autoregulation and inverse acetazolamide reactivity due to vasoparalysis in the brain stem.View full abstractDownload PDF (2503K) -
SHINICHI OKUYAMA1991 Volume 164 Issue 3 Pages 247-249
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S. Probable Binary Fission in a Reed-Sternberg Cell. Tohoku J. Exp. Med., 1991, 164 (3), 247-249 - A Reed-Sternberg cell in binary fission was observed in a case of Hodgkin's disease of nodular sclerosis type. This was thought to possibly represent a primitive eukaryotic manifestation or a retrograde replay of the endosymbiotic evolution of the modern eukaryotes as a part of devolution of malignancy (Okuyama and Mishina 1990).View full abstractDownload PDF (2095K)
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