The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 69, Issue 1
Displaying 1-12 of 12 articles from this issue
  • Masanao Kato
    1958 Volume 69 Issue 1 Pages 1-11
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Tadao Saito
    1958 Volume 69 Issue 1 Pages 13-23
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Based on the principle of neutralization of retinal induction the velocity of spreading induction was measured in various regions of the human retina.
    1. No significant regional difference could be observed. For example, 1.751±0.035 and 1.716±0.019mm./sec. were obtained at the fovea, while 1.719±0.035, 1.735±0.036 and 1.688±0.030mm./sec. were obtained in peripheral areas 20° from the fovea.
    2. No significant difference was found among velocities of propagation in different directions.
    3. The extent of the field of retinal induction caused by a definite stimulus was measured in various regions of the retina. The extent was greater at the fovea than at 20° from the fovea.
    4. The horizontal extent of the field caused by a vertical line stimulus was greater than the vertical extent of the field caused by a horizontal line of the same length.
    5. It was argued that the extent of the field depends greatly on the energy of spreading induction, while its velocity is almost independent of energy.
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  • Kiichiro Suzuki, Yoshio Toratani, Tetsuo Oiso, Tsugio Inoue
    1958 Volume 69 Issue 1 Pages 25-32
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    By means of Motokawa's method of electric flicker (EF), we measured variations of electric flicker values (EFV) of 5 subjects caused by exposure to pure tones or noise. The pure tones used were 500, 1000, 2000, 4000 and 6000 cps.
    1. 4 subjects were exposed to a tone of 500 cps and 70 db for 30 minutes. EFVs increased and reached a highest level in about 5-10 minutes and continued so long as the stimulus lasted.
    2. Measurements of EFVs in exposure to each of 5 pure tones of 70 db were made in 4 subjects. EFVs in response to tones of 500 and 6000 cps were remarkably great in comparison with those to tones of 1000 and 2000 cps.
    3. In 3 subjects similar measurements were made at various intensity levels of tones, and it was found that the higher the intensity, the greater the change of EFV caused.
    4. Hearing loss caused by two kinds of ear plugs A and B were investigated by an audiometer. With A hearing loss occurred above 2000 cps and with B over the whole range of frequencies. EFVs measured with the ear plug A were found to be remarkably low in comparison with control over the frequency range higher than 2000 cps. This finding corresponds with the audiometric one mentioned above.
    5. In 3 subjects, the relation between intensity of noise and EFVs was investigated, and it was found that the larger the intensity of noise, the greater the change of EFV caused by exposure to noise.
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  • Masaru Wakabayashi, Fumio Kawamura, Shinbei Nakaya, Akio Yoshikawa, Ya ...
    1958 Volume 69 Issue 1 Pages 33-37
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Ikuzo Minato
    1958 Volume 69 Issue 1 Pages 39-40
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Isamu Awano, Fukumi Tuda, Keiji Takano
    1958 Volume 69 Issue 1 Pages 41-51
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    We made a karyological study of cancer-cells in ascites of a case of gastric cancer, complicated with secondary liver-cancer and cancerous peritonitis. The results of observation about the number of chromosomes and the karyotype formula are as follows:
    1. The number of the chromosomes of our observed human cancer cells ranged from 37 to 46 but most of them were between 44 and 46, especially a greater number of them being those containing 44.
    2. Comparing the number of chromosomes in our observed human cancer cells with that of the chromosomes of the somatic cells in human bone-marrow, we found the former vary a little more than the latter in number, but on the whole both of them were found almost the same.
    3. As for the karyotype formula, our observed human cancer cells comprised of 18 to 26 Jj-shaped chromosomes, of 10 to 20 rod shaped chromosomes, of 1 to 9 small V-shaped ones, of 3 to 4 large V-shaped ones.
    4. As regards the constituent element of karyotype formula of our human cancer-cells, our special attention is attracted to the fact that the number of large V-shaped chromosomes is generally fixed, namely only one cell shows 3 V type and all the others have four large V-shaped chromosomes, and so they show 4 V type.
    5. As regards the large V-shaped chromosomes in comparing the human cancer cells with the somatic cells in human bone-marrow, the somatic cell is 2 V type, while the human cancer cells show 4 V type, and so an increase in number is found.
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  • Sixth Report: The Group Mucopolysaccharide From Pig Stomach Mucus Acts as a Weak Toxohormone
    Hajime Masamune, Hyogo Sinohara, Sin-iti Abe, Hirosi Kaketa
    1958 Volume 69 Issue 1 Pages 53-57
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • CCXXIV. Oligosaccharides Separated after Acetolysis of the Group Mucopolysaccharide from Pig. Stomach Mucus Fourth Report: “Gastro-trisaccharide”
    Hajime Masamune, Hyogo Sinohara
    1958 Volume 69 Issue 1 Pages 59-63
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A trisaccharide composed of two molecules of galactose and one molecule of L-fucose has been isolated after acetolysis of the group mucopoly-saccharide from pig stomach mucus. One of the galactose residues stands at the reducing end, and the L-fucose residue is readily split off with alkali, suggesting structure 1G-1G-1F or 1G_??_1_??_1F of the trisaccharide. The trisaccharide is named “gastrotrisaccharide”.
    The expenses of this work were defrayed by a grant given from the Ministry of Education through the Grant Committee for Scientific Researches. H. Masamune.
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  • CCXXV. Oligosaccharides Separated after Acetolysis of the Group Mucopolysaccharide from Pig Stomach Mucus Fifth Report: On Gastro-N-trisaccharide (A Supplement of the First Report)
    Hajime Masamune, Hyogo Sinohara
    1958 Volume 69 Issue 1 Pages 65-67
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    From Div. IV in the Fourth Report of this series of investigation were separated gastro-N-disaccharide, N-acetyllactosamine and gastro-N-trisaccharide as oligosaccharides. Gastro-N-trisaccharide has been established to have the structure of N-acetylglucosamine-4-β-galactopyranosido-4-α-N-acetylgalactopyranosaminide.
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  • Koiti Motokawa, Mitsuo Komatsu, Kei Watanabe, Tadao Saito
    1958 Volume 69 Issue 1 Pages 69-78
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The mechanism of neutralization of retinal induction was investigated by Motokawa's method of electrostimulation of the eye. By neutralization it is meant that an after-effect of a colored stimulus is extinguished by a second stimulus complementary to the former.
    1. When two complementary stimluli are separated by a sufficiently great lateral distance, neutralization occurs at all values of the interval between both stimuli.
    2. When the separation of both stimuli is small, no neutralization occurs for time intervals shorter than a certain limit. For example, the critical interval was found to be 500 msec. for a separation of 3mm. on a plane at 30cm. from the eye.
    3. The mechanism of this phenomenon was investigated, and it was elucidated that for a certain period after establishment of retinal induction the latter remains “inert” and suffers from no neutralization. This period was designated an “inert period”.
    4. Within the “inert period” the second stimulus is ineffective to neutralize the prestablished induction, but has the power to establish its own induction. Therefore the “inert period” cannot be a kind of refractoriness. In the “inert period” both kinds of induction can coexist without neutralizing one another.
    5. The absence of “inert period” for a greater separation of both stimuli is only apparent, because the “inert period” is over before the neutralizing effect (spreading induction) caused by the second stimulus reaches the point at which neutralization is tested.
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  • Koiti Motokawa, Toshihiko Oikawa, Tetsuro Ogawa
    1958 Volume 69 Issue 1 Pages 79-88
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Evoked potentials to electrical stimulation of the optic nerve were recorded by a wick electrode and also with a KCl-filled microelectrode from the optic tectum of the carp.
    1. The potential consisted of two positive spikes of about 1 msec. in duration, a positive deflection of a few msec. and a negative one of about 10 msec. The latter was followed by a second negative deflection when the stimulus was sufficiently strong.
    2. The negative deflections, especially the second, were facilitated at first, but depressed later by topical application of d-tubocurarine. The second negative deflection was augmented by strychnine. All the positive components were not affected by these drugs.
    3. The negative deflection could not follow repetitive stimulation at a rate higher than about 60 cps., but the positive components could.
    4. When a microelectrode was inserted into the optic tectum, the negative deflections reversed their sign at a certain depth. The depth of phase reversal was a little deeper with the second deflection. The positive components showed no phase reversal.
    5. By simultaneous recording of the action potential of the opti nerve and the evoked potential it was confirmed that the two precedin; positive spikes of the evoked potential are of presynaptic origin.
    6. Based on the findings stated above it was inferred that the firs negative deflection represented synaptic potentials at receiving cells, an_??_ that polysynaptic excitation produced the second negative deflection.
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  • Kazumi Yamagiwa
    1958 Volume 69 Issue 1 Pages 89-101
    Published: December 25, 1958
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The principle of initiation of impulse derived theoretically by myself was applied to various phenomena of conduction. As the result, many experimental facts could be understood or explained quite reasonably. A few suggestions were obtained, too.
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