The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 118, Issue 2
Displaying 1-10 of 10 articles from this issue
  • NORIO SUWA, TOHRU TAKAHASHI, KEN SAITO, TAKASHI SAWAJ
    1976 Volume 118 Issue 2 Pages 101-111
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The general equations to correlate the distribution of the radius r of spheres randomly dispersed in the three-dimensional space with measurements on a random test plane are
    Nvo = Nao/2r
    and (δn) = 2n-1√ π[n_??_ (n/2)/(n+l) _??_( n+1/2)]Qn+1rn
    for the diameter S of circular sections of spheres; and
    Nvo = Nλo/πr2Q2
    and λn=2n+1/n+2•Qn+2/Q2r2
    for the length λ of chords delivered by intersection of a random test line. In the above expressions Nvo, Nao and Nλo are the numbers of spheres in a unit volume, of circles on a unit surface area and of chords per unit length of a test line, respectively; n is 0 or a positive integer; r the arithmetical mean of r; (δn) and (λn) the means of the n-th powers of S and A, respectively; and Qn a quotient defined by Qn=(rn)/rn The ratio of measured (δ2)/δ2 or (λ2)/λ2 is used for calculating one of the parameters of assumed theoretical distribution functions. A second parameter is then estimated from δ or λ. The method was applied to the normal pancreatic islets, and the use of chord length λ was preferred to that of diameter δ, because the error due to the failure in identifying very small islet sections was minimized in the former.
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  • HIROSHI KURIHARA, TOSHIYUKI TANAKA, FUJIO TERASAWA, MASUJI SEKI, MASAO ...
    1976 Volume 118 Issue 2 Pages 113-125
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    High plasma renin concentration (PRC) and hematocrit (Ht) were observed in hypertensive rabbits with one renal artery clipped and an intact opposite kidney (Group A), while rather low PRC and Ht in hypertensive ones with one renal artery clipped and the opposite kidney removed (Group B). Plasma volume (PV), blood volume (BV), and packed cell volume (PCV) were estimated in these two types of hypertensive rabbits, and also in sham-operated rabbits (Group C). In Group A, 4 weeks after clipping of a renal artery, PV was decreased and significant inverse correlations' were observed between PV and the elevation of blood pressure and between PV and PRC. A significant correlation between PRC and the elevation of blood pressure was also found 4 and 12 weeks after the clipping. PCV was increased until 12 weeks after clipping. In Group B, PV was increased 1 and 4 weeks after clipping, then returned to the initial level. Ht was decreased 1 and 12 weeks, and PCV was decreased 12 weeks after clipping. These results would indicate that a high Ht seen in Group A was partly due to the decreased PV and partly due to the increased PCV, while, in Group B, a low Ht in early stage might be mainly due to the increased PV, but in the late stage, a decreased PCV appeared to play a role to lower Ht. PRC seems to be affected differently by PV in these two types of hypertension.
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  • SADATOSHI ICHIJO, IWAO IMAMURA, TOMONORI DATE, TUNED HIRAI, JUN YOKOYA ...
    1976 Volume 118 Issue 2 Pages 127-129
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    To block the vessels of the prostate, extracapsular pulling sutures were placed from the 4 and 8 o'clock positions on the bladder neck to the perineum prior to enucleation in 25 cases of prostatectomy. The removable pulling sutures successfully reduced blood loss during and after prostatectomy. Besides, the average operating time was markedly shortened. Postoperative courses of the patients were uneventful on the whole and there was no remarkable complication.
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  • YOGO OKA, ICHIRO MATSUDA, SHINICHIRO ARASHIMA, MICHIYA ANAKURA, TAKASH ...
    1976 Volume 118 Issue 2 Pages 131-135
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A 5-year old boy with intermittent sopor, severe vomiting and ataxia since 2 1/2 years old was described. During attack period the patient showed elevation of blood pyruvate and alanine and also cerebrospinal-fluid pyruvate, whereas during the time free from attack only blood pyruvate was increased. Deficiency of pyruvate decarboxylase was found in patient's leukocyte and in cultured skin fibroblasts. Addition of thiamine in assay medium did not correct the enzyme activity. Oral administration of citrate seemed to be most effective and during the treatment only a mild attack was once observed.
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  • CHIHARU HIRAMINE, KENJI HOJO
    1976 Volume 118 Issue 2 Pages 137-143
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Macrophage migration inhibitory factor (MIF) activity and in vitro lymphocyte transformation to homologous thyroid antigen were compared in cultures of lymph node cells obtained from 123 guinea pigs at weekly intervals after a single injection of homologous thyroid extracts in complete Freund's adjuvant (CFA). MIF activity was not detectable at the early stage of immunization but became manifest 2 and 3 weeks after sensitization and a high level was maintained during 4-7 weeks. On the other hand, lymphocyte transformation preceded the appearance of MIF activity and attained its maximum 2 weeks after sensitization before the establishment of thyroiditis. It is indicated that MIF activity and lymphocyte transformation predominate separately in the course of immunization. There was a considerable correlation between intensity of MIF activity and severity of thyroiditis in idividual animals during the advanced stage (4-6 weeks after sensitization) of the disease. Also, a lower but significant correlation was seen between lymphocyte transformation and severity of thyroiditis. However, about half of animals in the advanced stage of thyroiditis failed to exhibit antigen-stimulated lymphocyte transformation, despite a positive MIF activity.
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  • SHOTARO MATSUDA, SHIRO MITSUKAWA, NOBUHISA ISHII, MASAFUMI SHIRAI
    1976 Volume 118 Issue 2 Pages 145-151
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A 31-year-old male had a sudden onset of painful swelling in the penile root region. He then developed necrosis of the penis and further a progressive, chemotherapy-resistant ulcer which involved the perineal region also. Histologi-cally there was evidence of neither malignancy nor specific inflammation, but there were granulomatous tissues with cellular infiltration and scattered vascular necrosis. Examination of the nose suggested gangrenous rhinitis with perforation of the nasal septum. X-ray examination revealed that the nasal septum and conchae had disappeared. Chest roentgenogram also revealed increased hilar shadows in both fields of the chest. Routine laboratory examinations showed slight albuminuria and a normal BUN level. Positive findings included leucocytosis, hyper-gamma-globulinemia, accelerated ESR, positive RA and CRP tests. The patient's death was caused by bleeding from gastric ulcer and pulmonary failure.
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  • MOTOHIKO ICHIJO, TAKEO SHIMIZU, YOICHIRO SASAI
    1976 Volume 118 Issue 2 Pages 153-161
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    There is a close relationship between the rate of the uterine cervix opening during parturition and the presence or absence of a completely ripened cervix. In order to learn the basic pattern of the ripening of cervix, histological and histochemical studies were performed on the human uterine cervix during pregnancy. It was noted that the collagen bundles disintegrated into fine fibers and also underwent quantitative changes during the ripening process of the cervix. During pregnancy, the number of connective tissue cells was increased, but that of mast cells was decreased. Acid mucopolysaccharides in the cervical ground substance were found to increase in late pregnancy.
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  • RIKIYA ABE
    1976 Volume 118 Issue 2 Pages 163-171
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In order to study the causes of postmastectomy lymphedema, venography, lymphangiography and RISA absorption test were performed on the patients following radical mastectomy. Venous obstruction was a rare cause of postmastectomy lymph-edema. Edema patterns in arm lymphangiography were observed in the patients with lymphedema and even in some of the non-edematous upper extremities. The finding of axillary lymphangiography was correlated with the degree of edema of the upper extremity. The absence of adequate lymphatic pathway across the axilla (type 2, collateral and type 3, blocking) was thought to provide the pathologic base for the postmastectomy lymphedema. RISA absorption test also provided precise information of the lymphatic flow in the extremity. It was lower in the patients with edema, as comparied with the patients without edema.
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  • SETSUO KOMURA, MASAO UEDA, TOSHIKIYO KOBAYASHI
    1976 Volume 118 Issue 2 Pages 173-179
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Eight strains of male mice, C57BL, C3H SWM, SW, KK, KSB, KR and DBA, were fed on a standard pelletized diet and offered a choice of water or 10% sake solution (sake containing 10% alcohol). Both young (3 months of age) and old (8 months of age) groups were studied simultaneously. The degree of intoxication was measured by recording the drinking behavior on a pulse recorder, by calculating gaschromatographically the blood alcohol concentration, by taking depth electroencephalogram readings and so on. Intoxication, shown by lack of coordination such as grossly impaired gait, was observed only in the older mice of strain with a moderate natural alcohol preference such as C3H, SWM, SW, KK and KSB. In general, the intoxicated mice were over 9 months of age, tended to consume fluids regardless of the time of day or night and suffered a loss of body weight. The blood alcohol levels of them were over 4.6‰. The threshold elevation of the ascending reticular activating system on electroencephalogram in a intoxicated mouse reached about 167%. The present study provides a successful method for the development of voluntary alcohol intoxication in mice.
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  • TSUGUYOSHI SUZUKI, TAI-ICHIRO TAKEMOTO, HIROSHI KASHIWAZAKI, MASAMI TO ...
    1976 Volume 118 Issue 2 Pages 181-198
    Published: 1976
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    This paper examines the differentiating patterns of subsistence activities, fish-eating habit, mercury level in human biological specimens, and the interrelation among these variables on several small Japanese islands. The catch and supply of fish vary according to patterns of division of labour on each island. The frequency of fish-eating is generally regulated by the availability of fish, and is well associated with the level of mercury in hair or red cells. Difference in variety of fish consumed has a modifying effect on the mercury level. The importance of understanding the total ecological setting relating to any environmental problem should be emphasized.
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