The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 80, Issue 3
Displaying 1-7 of 7 articles from this issue
  • Hiroshi Ishida
    1963 Volume 80 Issue 3 Pages 205-217
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
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  • Keiya Tada, Toshio Yoshida, Toshio Morikawa, Akibumi Minakawa, Yoshiro ...
    1963 Volume 80 Issue 3 Pages 218-226
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
    A case of idiopathic hyperglycinemia was reported. This was the third case of this particular disorder next to Childs et al.'s and Nyhan et al.'s cases. A striking elevation of glycine in urine and serum from the patient was demonstrated by the use of Automatic Amino Acid Analyzer.
    (This work was supported in part by a Grant in Aid for Developmental Scientific Research of Ministry of Education. Prof. Ts. Arakawa)
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  • II. Distribution of Streptomyces Proteases Assayed by the Diffusion Method on Gelatin and Casein Plates
    Masashi Ito, Kazuyoshi Toriyama, Osamu Chiyo, Totaro Yamaguchi
    1963 Volume 80 Issue 3 Pages 227-236
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
    The toxic principles of various streptomyces cultures, which are responsible for the desquamation and degeneration of HeLa cell cultures in vitro and the formation of necrosis in the skin of guinea pigs, were shown to be protease in nature. Although an attempt to crystallize one of these principles was unsuccessful, protective effect of calcium ion the activity was established.
    Along the line of such studies, the distribution of these proteases in the filtrates of streptomyces culture were examined with a newly designed pulp disc diffusion assay procedure on gelatin- or casein-agar plates. Among the strains subjected to the screening, some 60% produced proteases in the routine culture media used in this laboratory. Although majority was responsible for degeneration of HeLa cells and are basic in nature, the presence of various proteases different in electrophoretic and paper-chromatographic characters as well as in their biological activities was demonstrated. Further classification of these enzymes and their use in streptomyces taxonomy or the use as helminthics were left for the future studies.
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  • II. Effect of Splenectomy on Hematology
    Toshio Sato, Kunio Koseki, Kenji Watanabe, Masakatsu Miya
    1963 Volume 80 Issue 3 Pages 237-253
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
    The present paper reports on cases of Banti's syndrome which survived splenectomy at the authors' department. Post-operative changes in hematology were studied at the time of discharge from the hospital as well as on late examinations performed one half year or longerr after the operation. The results were as follows, suggesting favorable effects of splenectomy on the impaired hematology of this syndrome.
    1. The incidence of anemia, with red cell count less than 4 millions per cubic millimeter, was 32.9 per cent at the time of discharge from the hospital and 51.4 per cent on late examinations, compared with the pre-operative rate of 79.6 per cent. A positive correlation was found between the grade of splenomegaly and the grade of post-splenectomy improvement of anemia; the higher the former the more remarkable the latter.
    2. The above increase in the number of red cells was associated with a more marked increase in hemoglobin content of the blood, resulting in an increase in the color index. Hypochromic anemia, which had been observed pre-operatively in 49 per cent of the cases, was found on late examinations in only 16.2 per cent.
    3. White cell count of less than 4, 000 per cubic millimeter, which had predominanted (73.8 per cent) in the pre-operative cases, became uncommon after splenectomy, being observed in 5.4 per cent at the time of discharge and in 10.8 per cent on late examinations.
    4. The above improvement of leucopenia was accompanied with an increase in lymphocytes and a relative decrease in neutrophils.
    5. On late examination, none of the cases was found to be associated with marked thrombocytopenia, in contrast to the high pre-operative incidence of 56.6 per cent. In most of the cases prolonged bleeding time was also brought into the normal range after splenectomy.
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  • III. Effect of Splenectomy on Increased portal Pressure and Its Manifestations
    Toshio Sato, Kenji Watanabe, Masakatsu Miya, Michitoshi Ottomo
    1963 Volume 80 Issue 3 Pages 254-267
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
    In cases treated surgically at the authors' department, Banti's syndrome was studied from the viewpoint of portal pressure. The results are as follows:
    1. Using control data from 50 surgical cases of gastric and other upper abdominal diseases, the upper limit of normal portal pressure was estimated to be 200 mm H2O.
    2. Of 66 cases of Banti's syndrome examined, the portal pressure was above normal in 59 cases (89.4 per cent) and within the normal range in seven (10.6 per cent). Approximately half of the cases showed a pressure between 300 mm H2O and 400 mm H2O.
    3. On late investigations, 19 of 21 cases with pre-operative portal pressure ranging from 300 to 400 mm H2O and all five cases with the pressure more than 400 mm H2O were found to be alive in good condition several years after splenec tomy, indicating that splenectomy was capable of providing patients of Banti's syndrome with a long life span even when they were associated with a considerably elevated portal pressure.
    4. The incidence of hematemesis after splenectomy was as low as 3.1 per cent. compared to that of 28.1 per cent before operation. No significant difference was detected in end-result of splenectomy between cases with preoperative episodes of hematemesis and those without hematemesis. These results suggest that splenectomy can inhibit occurrence of hematemesis, to a large extent, without further surgery.
    5. X-ray examinations of the esophagus at various post-operative stages revealed a complete disappearance or significant improvement of esophageal varices in 75 per cent of the cases. No cases without pre-operative varices developed them after splenectomy.
    6. These results were interpreted to suggest the significance of a splenic factor or factors in pathogenesis of Banti's syndrome.
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  • Report 15. Causative Treatment of Infectious Diseases from the Standpoint of the Hematopoietic Phases of the Bone Marrow and the Fields of Blood Defense Reaction
    Akira Saito
    1963 Volume 80 Issue 3 Pages 268-287
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
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  • R. J. H. Oberholzer
    1963 Volume 80 Issue 3 Pages 288-314
    Published: August 25, 1963
    Released on J-STAGE: November 28, 2008
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