Some evidences suggesting an entity of proteolytic enzyme multiplicity in the euglobulin fraction were discussed from clinical and experimental observations. 1. The spontaneous caseinolytic activity was not always parallel with the spontaneous fibrinolysis in the euglobulin fraction. A marked fluctuation of the fibrinolytic activity during surgical operations with spinal anesthesia was noted; however, the changes of caseinolysis and TAMe-lysis were unremarkable. On the other hand, the caseinolysis in parturient women with postpartum hemorrhage fluctuated markedly, while the fibrinolysis and TAMe-lysis did not give any remarkable change. 2. There were 4 chromatographically different enzymes demonstrated in the euglobulin fraction on DEAE-cellulose column chromatography.
Attempts to use photoconductive cells in a direct writing earpiece and cuvette densitometer were made. The major advantages of this instrument are simple electric circuit, high sensitivity and stability, and immediate linear response to changes in dye concentration. The design of the circuit, by obtaining the difference of each output voltage of the two independent red and infrared channels, made it possible to minimize the drift and pulsatile fluctuations of the baseline caused by factors other than dye concentration. Direct writing necessitated only a low gain amplifier, the baseline drift of which during five minutes was within two per cent of the total deflection. Response to a rapid change in light intensity was within 0.24 second for 90 per cent of the maximum deflection, which was proved to bear a linear relationship to changes in dye concentration over a range of practical use. Dye dilution curves from the earpiece in patients with intracardiac shunts presented accurate information in detecting their abnormalities.
The acute effects of intravenous lanatoside C on cardiopulmonary dynamics were studied in 11 patients with mitral valve disease and 3 patients with chronic pulmonary diseases. All patients were not in cardiac failure, and control data revealed that pulmonary hypertension of mild to severe degrees was present in 11 patients. In studying parameters of cardiopulmonary dynamics including the left side of the heart, before and after administration of the drug, the following results were obtained. 1. Mean pulmonary artery pressure decreased in 5 cases, and cardiac output rose in 3 and fell in 2. 2. The cardiodynamic responses were distinguished by 3 patterns. In the first pattern, a complete absence of hemodynamic changes except for diminished pulse rate was noted. The second pattern demonstrated a reduction in left atrial pressure accompanied by a reduction in pulmonary artery pressure. The third pattern was characterized by a reduction in left atrial pressure with little or no change in pulmonary artery pressure. 3. All patients with normal hemodynamics showed the first pattern. The second pattern was observed in patients with unobstructed outflow from the pulmonary artery to the left atrium, while the third pattern was observed only in patients who had obstruction to the passage of blood into the pulmonary vascular system. 4. Pulmonary blood volume was unchanged irrespective of changes in cardiac output or in pressures in the lesser circulation. 5. On the basis of the data obtained, mode of action in reducing pulmonary hypertension and its clinical significance were related.
A histopathological examination was made on 71 cases of gastric polyp resected at the Surgical Department of Tohoku University during the last 22 years. The results obtained are as follows: 1. Of the 71 cases of gastric polyp, 41 were single, 28 were multiple cases, and two cases were so-called polyposis of the stomach. In the 69 cases excluding two polyposis, a total of 155 polyps were recognized, the macroscopic nature of which varied widely. 2. The grade of development of polyps varied from a simple mucosal hyperplasia to a typical polyp having characteristic features of adenoma or fibroadenoma. Therefore, 71 cases were classified histologically into three types and the relationship with chronic gastritis and malignant degeneration was studied. 3. Concerning the relationship between gastric polyp and chronic gastritis, 61 polyps (18 of Type I, 23 of Type II, 20 of Type III) of the 155 polyps were found not to be associated with perifocal chronic gastritis, but 94 polyps (26 of Type I, 41 of Type II, 27 of Type III) showed evidence of chronic gastritis in their vicinities. Moreover, in polyps accompanying chronic gastritis, frequent mucosal hyperplasia which is presumable for prepolypoid stage was seen on the surrounding gastric mucosa. Therefore, though it is impossible to conclude that all polyps originate from gastritis, the existence of polyps originated by the mechanism as pointed out by Konjetzny is undoubtful. 4. Malignant degeneration was observed in 13 cases (18.3 per cent) of the 71 cases. Six of these 13 cases manifested malignant degeneration limited on the superficial portion of the gastric mucosa. All of these polyps in 6 cases measured under index finger tip and attention was paid to the fact that three of these four cases had polyps of Type II, polyps of relatively early stage. 5. Nine of the 13 cases of manifest malignant degeneration were advanced cases measuring thumb tip size or over, but glandular structure in the basal region of pedicle had been relatively well preserved. Therefore, it was presumed that the cancerous tissue was originated on the superficial portion and proliferated towards the gastric lumen, showing less remarkable deep infiltration.
(1) A comparative study of the renal plasma flow was carried out with the Fick principle, employing PAH and sodium thiosulfate at the same time and firstly, keeping the the plasma PAH concentration low, i.e. between 2.01 and 11.6 mg/dl. in normal dogs whose renal vein has been catheterized. Thus CPAH/EPAH and CT/ET were determined in a total of 31 measurements on 11 dogs and the results were compared. It was found that CPAH/EPAH did not agree with C/TET; while CPAH/EPAH per unit body weight gave a mean value of 9.60 cc/min/kg., CT/ET per unit body weight gave a mean value of 8.02 cc/min/kg., and the two values were significantly different on statistical basis. The ratio of CPAH/EPAH to CT/ET was 1.25 on the average. (2) A similar experiment was performed with the same plasma concentration of thiosulfate but with higher PAH concentrations, i.e. 32.5-94.5 mg/dl. A total of 21 determinations of CPAH/EPAH and CT/ET were done on 7 dogs. CPAH/EPAH per unit body weight gave a mean value of 10.00 cc/min/kg. and CT/ET per unit body weight gave a mean value of 10.30 cc/min/kg.; two values were not significantly different on statistical basis. In this case CPAH/EPAH bore a ratio of 0.98 in respect to CT/ET on the average. (3) The two ratios were significantly different on statistical basis, i.e. 1.25 obtained at low plasma concentrations of PAH on one hand, and 0.98 obtained at higher plasma concentrations of PAH. (4) From these observations the author infers that a considerable fraction of the administered thiosulfate is carried out of the kidneys other than by way of the glomerulus into urine, i.e. postglomerular loss by way of the renal lymph. According to this view, the observed CT/ET does not represent the real renal plasma flow; it should give a value lower than CPAH/EPAH determined at low plasma PAH concentration. This view seems to be supported by the fact that the ratio of CPAH/EPAH to CT/ET approaches unity, when plasma concentration of PAH is high, i.e. where extraction ratio for PAH approaches the extraction ratio for thiosulfate.