The end-result of splenectomy for Banti's syndrome was reviewedin 74 cases of the author's series with reference to the pre-operative histopathology and functions of the liver. All two cases of normal liver histology (Type I) were alive, while nine (19.3 per cent) of 52 cases with chromic inflammation of fibrosis of the Glisson capsules and four (40 per cent) of 10 cases with liver cirrhosis (Type III) had died of hepatic insuffciency after operation. It was further revealed that cases with increased icteric index and those with disturbed B. S. P. excretion were associated with less favorable end-results than other cases. Thus the morphologic as well as functional aspects of the liver seem to be fair estimates of the prognosis of Banti's syndrome.
In most of 64 patients of Banti's syndrome who survived splenectomy for six months or more, there were marked improvements of liver functions in terms of the icteric index, B. S. P. test and serum colloidal reactions. Of 35 cases subjected to liver biopsy at various postoperative stages, on the other hand, the histopathology of the liver exhibited a considerable improvement in 15 cases, little change in 18 cases and an aggravation in only two cases, as compared with the findings at the time of splenecomy. These results indicate a favorable effect of splenectomy upon pathologic as well as functional aspects of the liver and may suggest the significance of the spleen in pathogenesis of this condition.
Idiopathic hypervalinemia is suggested for a case of probably new inborn error of metabolism, aged 2 months, who is characterized clinically by vomiting. failure to thrive and drowsiness and biochemically by hypervalinemia without increase in serum leucine and isoleucine levels
A case of Ewing's sarcoma which originated from the right zygomatic arch of 23-year-old female was presented and 52 cases of Ewing's sarcoma reported in Japan from 1950 to 1961 including authors' case were reviewed
Based upon the findings of 3 cases with metastasizing adenoma, the histologic features of 7 items as well as vascular invasion were proposed for the evaluation of histologic malignancy of 177 surgical cases with follicular adenoma. Nodular goiters of 29 cases with other types and of 32 autopsy cases and thyroid carcinoma of 90 surgical cases were used for control study. Invasion into the vascular lumen, a sign of unquestionable malignancy, was most frequently accompanied by capsular invasion and further by mitosis, nuclear pleomorphism, clear cells and large nuclei. Any one of the following two items, psammoma bodies and mixed histologic types, was an important sign of malignancy although its incidence was considerably limited. The features of the above histologic malignancy were frequently observed in the subcapsular regions and had a significant incidence in relation to the size of adenoma and sclerotic lesions of the arterioles with or without muscular cushions surrounding or within adenoma. Regressive changes, e.g. cyst formation, edema, necrosis and fibrosis had the same relation but were frequently found in the central region.
The dromotropic action of the cardiac nerve was studied in the toad by observing the change of membrane action potentials of the A-V conducting tissue when the septal nerve was electrically stimulated. By shifting the microelectrode stepwise along the A-V pathway, three different types of action potentials were observed from the atrial part, the atrial margin, and the middle and ventricular parts of A-V pathway. Electrical stimulation of the septal nerve had a preferential effect on the membrane action potential of the atrial margin. The upstroke was slowed, the amplitude was diminished and the plateau was shortened. This effect was reversed after atropinization: acceleration of upstroke, increase of amplitude and lengthening of plateau phase. It is concluded that both negative and positive dromotropic effects of cardiac nerves in this animal are attributable to the special susceptibility of action potential of the atrial margin of the A-V conducting pathway to both vagal and sympathetic transmitters.
A dextrorotatory polysaccaride recently isolated from whale lung and intestine has been demonstrated to have a high anticoagulant activity. in vitro and in vivo. Protamine neutralization and lipolytic activities are similar to those of beef heparin. The sulfur content of the new polysaccharide is lower than that of beef heparin. The new substance was used successfully as an anticoagulant in 221 dog perfusion experiments.