YUKI, H., SATO, S., ARISAKA, Y., KATO, S. and TOMOIKE, H.
Orally Administered Beraprost Sodium Inhibits Pulmonary Hypertension Induced by Monocrotaline in Rats. Tohoku J. Exp. Med., 1994,
173 (4), 371-375-Rats were fed on distilled water (DW) or DW containing beraprost sodium (BPS). BPS concentration was 1.5 or 3.0μ/ml in DW for the low BPS groups and 6.0 or 10.0μ/ml in DW for the high BPS group. Monocrotaline (MCT) was subcutaneously given (60 mg/kg), and saline was injected as control. Data were analyzed among the following groups; Groups (Saline+DW), (Saline+Low BPS), (MCT+DW), (MCT+Low BPS) and (MCT+High BPS). Three weeks later, pulmonary (Ppa) and systemic (Psa) arterial pressure were measured under anesthesia. MCT caused significant elevation of Ppa {18.3±0.6cmH
2O for Group (Saline+DW) vs. 27.2± 1.2cmH
2O for Group (MCT+DW), p<0.001, mean±S.E.} and Ppa was significantly and dose-dependently suppressed by BPS; Group (MCT+DW) vs. Groups (MCT+Low BPS), 23.4±0.7cmH
2O and (MCT+High BPS), 22.5±0.5 cmH
2O, p<0.05, mean±S.E.). Psa was not lowered dose-dependently by BPS. We conclude that oral beraprost sodium suppresses pulmonary hypertension produced by monocrotaline in rat.
View full abstract