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Volume 98 (1969)
- Issue 4 Pages 303-
- Issue 3 Pages 215-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 98, Issue 3
Displaying 1-11 of 11 articles from this issue
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Tetsuro Ogawa, Yoshiyuki Imazawa, Shingo Chu1969 Volume 98 Issue 3 Pages 215-222
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe running course of intraretinal optic nerve fibers was traced on a tangent screen at 1m by plotting centers of receptive fields of units as many as possible recorded at a given electrode position in the cat's retina. Antidromic activation of units by stimulation of either the contralateral or ipsilateral optic tract allowed the separation of the contralaterally projecting portion (nasal retina) from the bilaterally projecting portion in the retina. The bilaterally projecting portion includes the vertical median strip of overlap and the temporal retina. Multunit potentials recorded in the retina in response to antidromic stimulation of the optic tract consisted of two separate peaks which indicated the presence of two separate fiber groups in the optic nerve fibers. These peaks correspond to 2.75m/sec and 1.75m./sec in conduction velocity of intraretinal optic nerve fibers.View full abstractDownload PDF (1001K) -
Michio Yamasaki, Takashi Kitabatake, Shinichi Kobayashi, Ryo Nozaki, H ...1969 Volume 98 Issue 3 Pages 223-228
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the last ten years, three cases of Zenker's diverticulum were found in our department. All of them were those of Japanese females. Two of them were of the second type of Brombert's classification, and one was of the first type. The roentgenological frequency of this condition was about 0.03 per cent in recent years in our department.View full abstractDownload PDF (1612K) -
Toshio Yoshida, Tasuke Konno, Tsuneo Arakawa1969 Volume 98 Issue 3 Pages 229-239
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe case of a 3-month-old girl was described who was characterized by a clinical picture consisting of mental retardation, abnormalities in PEG and EEG, and portal cirrhosis of the liver, and by biochemical findings of hypocupremia not associated with hypoproteinemia and hypoferremia. A defective absorption of copper from the gastrointestinal tract was suggested to be of primary importance in the etiology of this syndrome.View full abstractDownload PDF (1317K) -
Ryosei Kuribayashi1969 Volume 98 Issue 3 Pages 241-247
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of Nn, Zn and Mg ions on the contraction of smooth muscle of taenia coli from guinea-pig were studied. Both Mn and Zn ions suppress both spontaneous and electrically induced contractions. The suppressing effect of Mn ion appears promptly and is reversible, while the effect of Zn appears slowly and is irreversible. These results suggest that Mn ion acts on the excitation process in the memb-rane and Zn ion acts not only on excitation in the membrane, but also directly on the contractile system. Ca ion competes with Mn and Zn ions in the suppression of both spontaneous and electrically induced contractions. However, the competition of Ca ion with Zn ion is effective only when Ca is present prior to the addition of Zn ion.View full abstractDownload PDF (394K) -
Ryosei Kuribayashi1969 Volume 98 Issue 3 Pages 249-257
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of Nn, Zn and Mg ions on the membrane potential and contraction of the smooth muscle from the guinea-pig taenia coli were investigated. The simultaneous recording of electrical and mechanical activities was performed using the sucrose-gap method and a mechano-electric transducer.
Mn ions depressed spontaneous spike discharge without changing the membrane potential, and also perfectly depressed the spontaneous contraction. These effects of Mn ions were reversible. Mn ions competed with Ca ions in the spike discharge and contraction. The effects of Zn ions on the spontaneous spike discharge and contraction were similar to those of Mn ions, but they were irrever-sible. Mg ions at a high concentration depressed the spontaneous spike discharge, but did not influence the membrane potential. Reduction or lack of Mg ions induced an increase of spontaneous spike discharge. In media of high Mn or Zn, electrical stimulation was effective in eliciting the spike potential but failed to induce tension development.
Such a dissociation between electrical and mechanical activities was also confirmed by KCl- and ACh-depolarization in media of high Mn or Zn. KCl-depolarizations without tension development were observed in high Mn and Zn media. ACh-depolarization without tension development was observed in high Mn media, but neither depolarization nor tension development was observed in high Zn media.
Mg did not exert a suppressive effect on the KCl- or ACh-depolarization and contracture.View full abstractDownload PDF (2370K) -
Ryosei Kuribayashi1969 Volume 98 Issue 3 Pages 259-264
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing glycerinated taenia coli of the guinea-pig, the effects of divalent ions (Ca, Mg, Mn and Zn) on the contractile system of the smooth muscle were studied.
Mg ion is essential for ATP contraction of glycerinated smooth muscle. Mn ion can substitute perfectly for Mg ion, but Ca ion cannot. The initiation of ATP-contraction in the presence of Mn ion is suppressed by addition of higher concentra-tion of Ca ion. Zn depresses the initiation of ATP-contraction, but it is ineffective in relaxing the ATP-contraction.
The present results imply that Zn ion depresses the initiation of contraction by blocking all stages of contractile process in the smooth muscle.View full abstractDownload PDF (344K) -
Teruo Nakayama1969 Volume 98 Issue 3 Pages 265-272
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe rate of sweating was continuously recorded on the palm and the chest over a skin area of 20cm2. It was found that the sweating pattern on both regions is quite similar in so far as the periodic variation in the rate is concerned. A hypothesis is proposed that the secretion of the sweat gland is related mainly to thermal factors and the contraction of the myoepithelial capsule of the gland to emotional factors. It appears that increased sweating at the very beginning of exercise is due to the emotional influences.View full abstractDownload PDF (434K) -
Mitsuo Takahashi, Kazuyoshi Toriyama, Hiroshi Maeda, Mikio Kikuchi, Ka ...1969 Volume 98 Issue 3 Pages 273-280
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNeocarzinostatin, a new polypeptide which had shown antitumor activity in animals, was given to 17 patients with advanced malignant tumors. Five of 17 patients showed objective regression of tumors and disappearance of clinical symptoms. On account of the limited clinical experiences, no assertion can be made as to the range of therapeutic indication or to the comparison of neocarzino-statin with other antitumor substances. These preliminary observations, however, justify further extensive therapeutic trials.View full abstractDownload PDF (441K) -
Nobuko Sato, Minoru Ota, Kijuro Obara1969 Volume 98 Issue 3 Pages 281-288
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS[4-14C] testosterone was incubated with liver homogenates of normal or carbon tetrachloride (CCl4) injured male rats in the presence of NAD at 37°C for 90min. The metabolites produced were identified by thin layer chromatography and chemical transformation.
In the normal liver homogenates, 5a-androstane-3a, 17β-diol, epiandrosterone and 16α-hydroxy testosterone were the predominant metabolites amounting to as much as 72% of the total metabolites.
In the injured liver homogenates, an unmetabolized substrate was detected in a large amount. Δ4-androstene-3, 17-dione, 5a-androstane-3, 17-dione and androsterone were present in larger amounts, while the amount of their end product, 5α-androstane-3α, 17β-diol, was less than that in the normal. 16α-, 7α-and 6β-hydroxy testosterones were in smaller amounts compared with those in the normal.
These findings suggest that the hydroxylation of testosterone and the reduction of the 17-ketone to a 17-hydroxyl, i.e., the conversion of androsterone to 5α-androstane-3αa, 17β-diol, might be impaired by the administration of CCl4.View full abstractDownload PDF (547K) -
Keiya Tada, Kuniaki Narisawa, Toshio Yoshida, Tasuke Konno, Yoshimasa ...1969 Volume 98 Issue 3 Pages 289-296
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA girl with hyperglycinemia of nonketotic type was presented. The liver biopsied from the patient was studied for glycine metabolism. It was found that the yield of 14CO2 from glyeine-l-14C and the rate of 11C incorporation into serine from glyeine-l-14C as well as glycine-2-14C were extremely low in the patient's liver than in control livers, while the patient's liver showed normal activities of serine-hydroxyrnethylase and serine-dehydratase.
These findings indicate that the primary lesion of hyperglycinemia of nonketotic type is a defect in the glyeine cleavage reaction which gives rise to the formation of CO2, methylene-tetrahydrofolate and ammonia from glyeine.View full abstractDownload PDF (473K) -
Tatsuo Koyanagi, Yasumasa Yuguchi, Kozo Kitaura1969 Volume 98 Issue 3 Pages 297-301
Published: 1969
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of iron deficiency on the sulfhydryl compounds in blood and on the structure of gastric mucosa of rats was experimentally studied. Iron-deficient rats exhibited lower values of sulfhydryl compounds of blood than those of iron supplemented controls. Significant degenerative changes were found in parietal cells of the stomach from iron deficient animals.View full abstractDownload PDF (706K)
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