Sodium and potassium movements in the isolated preparation of guinea-pig's taenia coli soaked in high KCl Krebs solution and LiCl Krebs solution were estimated. In high KCl Krebs solution, both inward and outward movements of
42K were increased in proportion to the degree of depolarization. In LiCl solution
42K uptake was reduced though
24Na uptake was not influenced,
42K efflux increased and
24Na efflux was reduced slightly. The electrical stimuli of both 1V/cm and 10V/cm were effective to increase the efflux of
42K of taenia coli immersed in normal Krebs and in K
2SO
4 Krebs solutions, although in the latter medium, 1V/cm stimulus was ineffective to cause contraction.
24Na efflux was also increased by 10V/cm electrical stimulation in normal and in K
2SO
4 Krebs solution, though the change was not so significant as
42K results.
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