The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 82 , Issue 2
Showing 1-10 articles out of 10 articles from the selected issue
  • Taizo Suzuki, Keisuke Okamura, Jeunichiro Nagasawa
    1964 Volume 82 Issue 2 Pages 93-102
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Mechanical activities of the estrogen dominated rabbit uterus were studied in Na- and/or Cl-deficient media in vitro. In chloride-deficient media (Cl in solution was replaced by equimolar amount of anions), marked potentiation of tonic contraction was observed. The order of the potentiating effect is; Br<NO3<I<SCN. In Na2SO4-Krebs solution, cessation of phasic contraction without any detectable potentiation in tonicity was produced. Choline-, TEA-and Li-Krebs solutions produced a marked increase in tonicity. Sucrose-Krebs solution produced a slight and progressive increase in tonicity.
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  • Jeunichiro Nagasawa
    1964 Volume 82 Issue 2 Pages 103-116
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Sodium and potassium movements in the isolated preparation of guinea-pig's taenia coli soaked in high KCl Krebs solution and LiCl Krebs solution were estimated. In high KCl Krebs solution, both inward and outward movements of 42K were increased in proportion to the degree of depolarization. In LiCl solution 42K uptake was reduced though 24Na uptake was not influenced, 42K efflux increased and 24Na efflux was reduced slightly. The electrical stimuli of both 1V/cm and 10V/cm were effective to increase the efflux of 42K of taenia coli immersed in normal Krebs and in K2SO4 Krebs solutions, although in the latter medium, 1V/cm stimulus was ineffective to cause contraction. 24Na efflux was also increased by 10V/cm electrical stimulation in normal and in K2SO4 Krebs solution, though the change was not so significant as 42K results.
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  • Tetsuo Maki, Takeo Sato, Noriyoshi Suzuki
    1964 Volume 82 Issue 2 Pages 117-123
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Calcium bilirubinate, a water-insoluble salt of bilirubin forming the major component of the pigmented calcium stone, was synthesized in vitro either by addition of calcium hydroxide into solutions of sodium bilirubinate or potassium bilirubinate, or by suspending free bilirubin immediately into a solution of calcium hydroxide. In this case, it was revealed that no structural change took place in the bilirubin moiety since free bilirubin, associated with the same absorption characteristics as the standard preparation, could be recovered from the synthesized calcium bilirubinate by treatments with hydrochloric acid followed by a chloroform extraction.
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  • Toshimi Ishibashi, Hiroshi Hori, Koh Endo, Tokijiro Sato
    1964 Volume 82 Issue 2 Pages 124-139
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Electrical stimulation of the temporal lobe was performed in chronic schizophrenic patients to treat the auditory hallucinations. During electrical stimulation, there appeared different kinds of hallucinations.
    The characteristics of the hallucinations produced by the temporal lobe stimulation greatly differ from those of the schizophrenic hallucinations. Visual and auditory hallucinations by the temporal lobe stimulation might depend on different pathopysiological mechanisms. The kinesthetic and vestibular hallucinations could be considered as a basis of the pathophysiological mechanism of the auditory hallucinations. The temporal lobe stimulation for the auditory hallucinations in schizophrenic patients showed some therapeutic effectiveness.
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  • Kazuo Makabe
    1964 Volume 82 Issue 2 Pages 140-151
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    In order to clarify the genesis of hemorrhagic lipemia, the following procedures were performed in rabbits; bleedings and injections of saline, plasma, corpuscle suspension, and macromolecular substance solution, respectively, simultaneous with bleedings. Then changes in plasma lipids and blood volume were studied once a day for three days. Separate injections of identical amounts of plasma and of corpuscle suspension, respectively, corresponding to twice the amount of blood withdrawn, inhibited the development of hemorrhagic lipemia and increased the blood volume. However, injections of isotonic saline corresponding to twice the amount of blood withdrawn failed to inhibit the occurrence of hemorrhagic lipemia and also failed to increase the blood volume. Injections of macromolecular substance solution in the same amount as blood withdrawn inhibited hemorrhagic lipemia. It is concluded, therefore, that the development of hemorrhagic lipemia in rabbits cannot be ascribed solely to bleeding, plasma removal or corpuscle removal, but is due to reduction in blood volume.
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  • Sentaro Shishito, Michio Kurihara, Takeshi Saito, Ken-ichi Imabayashi
    1964 Volume 82 Issue 2 Pages 152-157
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Cystometric examinations were done in 20 dogs with alloxan diabetes of 7-300 days duration. In 5 cases abnormal findings were noted on the cystometrogram. Of these 5 cases, one case showed a moderate increase of the intravesical pressure and autonomous cystometrogram, while other 4 cases revealed a hypotonic bladder.
    In 20 cases the nerves innervating the bladder were examined histologically. In 6 cases of them the degeneration of the myelinated fibers was revealed. The degeneration occurred most commonly in the small- and medium-sized myelinated fibers. The presence of degenerated myelinated fibers was proved in the pelvic nerve in 5 cases which showed an abnormal findings on the cystometrogram. Hence, it is assumed from these findings that the vesical dysfunction due to diabetes mellitus is originated from the lesions of the nerves controlling the bladder.
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  • Takashi Miura, Tatsuya Kasai
    1964 Volume 82 Issue 2 Pages 158-163
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Autofluorescence of pathogenic fungi was investigated. Smears were made from the surface of the growth on 4% glucose agar and were fixed by heating, absolute alcohol or formalin, and were placed under the fluorescence microscope.
    The fungi tested showed various kinds of autofluorescence. There were considerable differences in brightness or in color tone of autofluorescence due to the difference of species, but none due to the difference of strains. Of all fungal species tested, Microsporum japonicum and Epidermophyton floccosum gave the most brilliant autofluorescence and its color tone was pale blue.
    Fixation methods fairly affected the brightness of autofluorescence, and heating was most effective in causing the most brilliant autofluorescence.
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  • Keiya Tada, Toshiyuki Ando
    1964 Volume 82 Issue 2 Pages 164-167
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Idiopathic hyperglycinemia which was discovered by Childs et al. is thought to be an inherited metabolic disorder. There is, however, no evidence that the disorder is genetically determined.
    Our investigation was made on glycine metabolism in the parents of a patient with this particular disorder. The fasting level of glycine and ratio of glycine to serine in serum were found to be significantly higher in the parents than in controls. Glycine loading test (0.5g/kg) indicated that the parents had to some extent a handicap of glycine utilization as compared with control individuals. These results suggest that the parents are probably heterozygous for the disorder.
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  • Keiya Tada
    1964 Volume 82 Issue 2 Pages 168-171
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    Glycogensis and glycolysis in the liver from a galactosemic patient were investigated. The activity of glycogenesis in galactosemic liver showed a signi-ficantly low level as compared with that in control livers, while there was no remarkable difference in the activity of glycolysis between the patient's and control livers. It was suggested that the decrease in glycogensis in galactosemic liver was due to inhibitory effect of galactose-l-phosphate on phosphogluco-mutase process.
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  • Goro Shiokawa, Yoshitomo Yamaguchi, Takao Tashiro
    1964 Volume 82 Issue 2 Pages 172-180
    Published: March 25, 1964
    Released: November 28, 2008
    JOURNALS FREE ACCESS
    This is a report on three cases with massive bleeding into the digestive tract. In all cases, blood was found coming from the biliary tract via the biliary canaliculi. The hemorrhage was due to inflammatory bleeding in the Glisson's capsule caused by acute interstitial hepatitis.
    All patients were complicated with gallstone-like symptoms, urinary abnormal findings due to acute nephritis and impairment of the liver functions besides massive melena. They were all cured by administration of tetracycline.
    The author has found out that acute interstitial hepatitis could be one of the causes of massive melena.
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