The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 112, Issue 3
Displaying 1-13 of 13 articles from this issue
  • NOBUAKI SASANO, NORIKO HORIKAWA, KATSUHIRO NAKAMURA
    1974 Volume 112 Issue 3 Pages 197-203
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The adrenal venous system demonstrated by the postmortem tissue microvenography varied with the length of clinical course of portal hypertension. Veins passing vertically through the cortex, e.g., the emissary and corticomedullary veins, increased remarkably in number without noticeable dilatation in chronic cases. The venous tree dilated and proliferated in the periadrenal tissue communicating with the capsular vein. In fulminant cases, the original emissary and corticomedullary veins dilated severely and irregularly without increase in number. Signs of the hepato-adrenal collateral circulation were severer in the right gland than in the left.
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  • TAKASHI KITABATAKE, MICHIO YOKOYAMA
    1974 Volume 112 Issue 3 Pages 205-208
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The tendency and frequency of stomach X-ray examination in patients with peptic ulcer were surveyed in Niigata City based on applications from the medical facilities to the health insurances. The average frequency of stomach X-ray examination in patients insured by the high-benefit health insurances was significantly higher than that in patients insured by the low-benefit insurances. If all patients consult directly specialists for X-ray examination, 5.7% of examinations or exposure would be reduced.
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  • TAKASHI KITABATAKE, TSUYOSHI WATANABE, TOSHIRO SATO
    1974 Volume 112 Issue 3 Pages 209-212
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Ques-tionnaires were sent to 1, 005 radiological technicians of ages over 60 years in order to know the frequency of sterility including infertility. Of these, 418 responded and 393 (39.1%) were usable for analysis. In 110 (28.0%), their wives had no childbirth in the first three years of marital life, and 33 (8.4%) have never had childbirth until 60 years of age. These rates of sterility are signifi-cantly higher than those of the general population in Japan in 1951. In persons who married before 1930 and are considered to have been exposed to radiation more than 400 R/year, absolute sterility tended to occur more frequently.
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  • ITARU OHARA, TOMIO MATSUOKA
    1974 Volume 112 Issue 3 Pages 213-224
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Experimental and clinical studies were carried out to determine the effective dosage of uronase, a preparation of urokinase for blood clot lysis. In vitro study showed that canine and human clots were lysed with about 20-30 units of uronase per ml. Uronase was used in a circulating model, in which an isolated canine liver was perfused for 24 hours. In the perfusion system, a mesh was inserted to remove fibrin during the study. Practically no fibrin was caught on the mesh when uronase was added to the perfusion fluid at the dose as used in the in vitro study. Uronase was administered in 17 cases with acute thromboembolism of the lower extremities with and without surgery. Nine of 11 cases, to which over 30, 000 units were given as an initial dose and then 10, 000 units as a maintenance dose for about a week showed clot lysis, while 3 of 6 cases which received less initial and maintenance dosages of uronase showed less clot lysis.
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  • AKIRA AOKI
    1974 Volume 112 Issue 3 Pages 225-239
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Continuous cell cultivation was tried on the surgical biopsy specimens from 40 clinical brain tumor cases and only one long-termed culture was obtained from a case of astrocytoma. The culture has so far been maintained 39 passages for 297 days and showed a pseudo-diploid character which consistently had three marker chromosomes. As a reference experiment, normal diploid cells were isolated from the cerebellar cortex of a human embryo and maintained in vitro. By comparison with this reference experiment in culture history, growth characteristics and chromosome constitution, it was strongly suggested that the long-termed culture has established a cell line. As to the drug sensitivity, the cells in the long-termed culture were more sensitive to Vinblastine than the normal cells in vitro, while both the cells had a similar sensitivity to Japanese encephalitis virus.
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  • TAKAHARU MORIYA, HIDEO KANOH
    1974 Volume 112 Issue 3 Pages 241-256
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In vivo incorporation of intrafemorally injected [9, 10-3H2]-palmitic acid and [2-3H]-glycerol into molecular species of rat lung glycerolipids was studied in relatively early periods after injection (from 2 to 30 min). The pool size of 1, 2-diacylglycerols was also determined in the tissue. When [9, 10-3H2]-palmitic acid was injected, approximately 60% of the radioactivity was distributed in 1, 2-disaturated species of phosphatidic acids and 1, 2-diacylglycerols in 2min, and this labeling pattern was reflected on the synthesis of lecithin species, although the calculated turnover of molecular species of lecithins and the results obtained with [2-3H]-glycerol injection suggested that the pathway of synthesis de novo could not be regarded as being fully responsible for the formation of dipalmitoyl lecithin in rat lung. Analysis of the distribution of radioactivity in the 1- and 2-positions of the formed glycerolipids after administration of [9, 10-3H2]-palmitic acid showed that approximately 75% of the incorporated radioactivity was located in the 2-position of dipalmitoyl lecithin during the present experimental periods, while the ratio of the distribution was almost 1:1 in disaturated species of 1, 2-diacylgly-cerols. This phenomenon could reasonably explain the discrepancy observed between the experimental results with [9, 10-2H2]-plamitic acid and [2-3H]-glycerol, suggesting that there exists other unknown mechanism than de novo synthesis to introduce palmitic acid of a higher specific radioactivity to the 2-position of dipalmitoyl lecithin.
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  • TOSHIO YOSHIDA, TSUNEO ARAKAWA
    1974 Volume 112 Issue 3 Pages 257-259
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A tendency was found in patients with diphenylhydantoin administration that there was a delay in serum histidine clearance during a period from 60min to 180min after an intravenous injection of L-histidine-HCL, 0.2g/kg.
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  • TOGO HORIUCHI, EIJI ISHIZAWA, YASUYUKI SUZUKI, YUTAKA SHIBOTA, YUZURU ...
    1974 Volume 112 Issue 3 Pages 261-270
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    This paper presents 124 patients operated upon for tetralogy of Fallot in the past 6-year period between 1966 to 1971 at the Tohoku University Hospital, Sendai, Japan. The hospital and late mortalities for 124 patients were 11% and 4%, respectively. The clinical status was good to excellent in 92% of the patients at long-term follow up study. Also we have found that previous Blalock-Taussig operation has caused no unfavorable effects on the secondary total correction, nor any rise in operative mortality, and we have found no relationship between operative mortality and polycythemia. Recent reports have advocated the definitive intracardiac repair of tetralogy of Fallot in young children and infants. Our preference is, however, to defer definitive repair until the child reaches 5 years old, using surgical palliation when necessary for the younger child with severe symptoms. In relieving pulmonary stenosis, which vitally affects the overall results of total correction, our technique of right heart outflow tract reconstruction has been generally favorable by either pericardial valved patch or the autologous pericardial valve-bearing tube graft.
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  • OTOTAKA HIGASHI, YOKO KIKUCHI
    1974 Volume 112 Issue 3 Pages 271-278
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The hydrogen peroxide (H2O2)-induced platelet aggregation could be inhibited by vitamin E-nicotinate and less effectively by vitamin E-acetate. The adenosine diphosphate (ADP)-induced platelet aggregation could be slightly inhibited by vitamin E-nicotinate. The lipid peroxidation of platelet exposed to H2O2 could also be inhibited by vitamin E-nicotinate. The lipid peroxide formation associated with membrane disruption may be involved in the mechanism underlying the H2O2-induced platelet aggregation.
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  • YOSHIO GOTO, TAKAYOSHI TOYOTA, YUTAKA ISHITOYA
    1974 Volume 112 Issue 3 Pages 279-284
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Blood sugar contents of three hundred and thirty blood specimens were determined by six different analytical methods, i.e., the glucose-oxidase method (G), the autoanalyser method with Hoffman's method (A), the Somogyi-Nelson method (S), the o-toluidine method (T), the Momose's method (M) and the Hage-dorn-Jensen method (H). The values determined by micromethods of Hagedorn-Jensen, of Momose and of Somogyi-Nelson are usually higher, and the values obtained by o-toluidine method are mostly lower than those estimated by the glucose-oxidase method. The values determined by the autoanalyser method are most consistent with those of the glucose-oxidase method among the five analytical methods. With the values of six series, the regression equations were obtained as following: A=0.86 G + 13, S=0.90 G + 34, T=0.76 G + 8, M=0.98 G + 28, H=0.85 G + 40, S=1.02 A + 23, T=0.88 A-3, M=1.10 A + 17, H=0.98 A + 26, T=0.75 S-7, M=0.99 S+4, H=0.83 8+23, M=1.22 T+24, H=0.78 M+26.
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  • SHUNZO CHIBA, TATSURU YAMANAKA, TOORU NAKAO
    1974 Volume 112 Issue 3 Pages 285-288
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Results of a preliminary study of cell-mediated immunity to measles virus employing 51Cr release lymphocytotoxic assay are described. The subjects consist of 5 patients with typical measles, 4 with measles encephalomyelitis, and 11 children and adults with or without prior histories of measles. Specific cytotoxic reactivity to target cells carrying measles specific surface membrane antigen is observed with lympho-cytes from all of measles patients and seropositive individuals. Lymphocytes from 3 out of 4 seronegative individuals without prior histories of measles failed to exhibit specific reactivity to measles virus. No relation was found between serum antibody titers and values of specific lymphocyte reactivity to measles virus. There seems to be no significant difference in cell-mediated immunity between the patients with typical measles and those with complicated encephalitis as evaluated from the results of this study.
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  • KATSURO IGARASHI
    1974 Volume 112 Issue 3 Pages 289-290
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The microvibration (MV) on the scalp as a substitute for the conventional ballistocardiogram (BCG) and the electrocardiogram (ECG) of the limb lead II were simultaneously recorded on 120 healthy subjects ranging in age from newborn to school children. The duration from the Q wave of the ECG to J deflection of the MV was measured in seconds as the Q-J interval. The Q-J interval may be thought to represent the duration from the ventricular depolarization to the ejection period of the ventricular mechanical systole. The Q-J interval ranges between 0.160 and 0.280 seconds.
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  • KINJI ISHIKAWA, TAI LEE, TAKASHI HANEDA
    1974 Volume 112 Issue 3 Pages 291-292
    Published: 1974
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A method was presented to make an acute artificial reduction of the coronary artery blood flow in the beating heart of the open-chest dog.
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