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Volume 124 (1978)
- Issue 4 Pages 297-
- Issue 3 Pages 197-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 124, Issue 2
Displaying 1-10 of 10 articles from this issue
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YOICHI SAITO, KOUKI TOKUTAKE, SEIKI MATSUNO, NOBORU NOTO, TSUYOHIKO HO ...1978 Volume 124 Issue 2 Pages 99-115
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSInhibiting effects of hypertonic glucose and amino-acids on pancreatic exocrine function were studied using mongrel dogs with chronic gastric and pancreatic fistulae. Under the basal stimulation with secretin and pancreozymin, 20% glucose, 30% glucose and 12% amino acids were given intravenously. Infusion of these substances caused the maximal decreases in pancreatic juice volume and amylase output, to 23% and 11%, respectively (20% glucose), 32% and 29% (30% glucose), and 53% and 42% (12% amino acids). But no significant changes were noted in bicarbonate concentration. When glucose was infused, the rise in levels of blood sugar and IRI was associated with the inhibition of pancreatic exocrine secretion. Aminoacid infusion produced the greatest inhibitory effect on the pancreatic secretion and markedly elevated both the levels of IRI and IRG. Intravenous infusion of glucagon suppressed notably the exocrine function of the pancreas.View full abstractDownload PDF (911K) -
EIICHI SATO, MASAYOSHI TOKUNAGA, KIYOHIRO SAKAE, TAKEO MUKADA, NOBUAKI ...1978 Volume 124 Issue 2 Pages 117-128
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSubserial examinations of the noncancerous esophagus from 86 autopsy materials (male 47, female 39) in Kagoshima Prefecture revealed epithelial dysplasia in 54 instances (63%); 32 males (68%) and 22 females (57%). Higher grades of dysplasia were shown in 17 males (36%) and 3 females (8%). Histologically a formation of the rete ridge-like elongation of basal epithelium was characteristically conspicuous in these materials. Tabacco and alcohol intakes were regarded as promoting factors of dysplasia. Distribution and severity of dysplasia around carcinoma were histologically examined on semiserial blocks in 100 surgical materials under the consideration of preoperative treatment. A coexistence of carcinoma with extensive dysplasia was found in 24 instances and that with multifocal dysplasia in 46. Multicentric in situ carcinoma was found in 19 patients. These in situ carcinomas were frequently surrounded by severe dysplasia and occasionally showed gradual transition to the latter. The lesion of invasive carcinoma sometimes did not show sharp demarcation from the surround ing mucosa, especially in cases of well differentiated squamous cell carcinoma. The results indicate that dysplasia plays a significant role on carcinogenesis of the esophagus as a precursor lesion.View full abstractDownload PDF (3127K) -
TETSUHIKO HATAFUKU, TAKAHIRO HIGUCHI, KOICHI SETA1978 Volume 124 Issue 2 Pages 129-138
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA technique of valvuloplastic esophagogastrostomy in proximal gastrectomy to control postoperative reflux esophagitis is reported. After proximal resection of the stomach, the medial stump is closed in two layers. The mucosal layers of the lateral stump are sewn but leaving the seromuscular layers open. The esophagus is anastomosed to the mucosal stoma at the middle of the gastric stump. The distal esophagus is wrapped by the lateral stump like Nissen's fundoplication to create the artificial fundus. Intragastric esophageal wall facing the fundus acts as a long one-way flap valve to prevent reflux. Ten dogs were prepared with this method and were compared with end-to-end and end-to-side anastomosis prepared in five dogs each. Cinefluoroscopy and esophageal pH demonstrated various degrees of reflux in all the dogs with end-to-end and end-to-side anastomosis, and mild reflux in one out of the ten dogs with valvular anastomosis. A sharp rise in pH at the anastomotic site was consistent in the remaining nine valvuloplastic dogs. High pressure zone, 9.9mmHg on an average at the site of anastomosis was present in valvuloplastic dogs, while the pressure was 0mmHg in end-to-end and 5.2mmHg in end-to-side anastomosis dogs. Clinical application of this procedure in ten patients obtained satisfactory results. The technique offers a reliable method of valvuloplastic anastomosis in esophagogastrostomy.View full abstractDownload PDF (1093K) -
YOSHITAKA AOI1978 Volume 124 Issue 2 Pages 139-144
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe levels of glycoprotein-glycosyl transferases increased at the late G1 -early S phase during the cell cycle both in the plasma membrane and in the microsomal fraction. The levels of the enzymes showed a “peak pattern” during the cell cycle. Elevation of the enzyme activity at earlier stages was not influenced by cytosine arabinoside but that at late G1 was completely inhibited.View full abstractDownload PDF (408K) -
HIYOSHIMARU OYAMADA, TOSHIO TABEI, TAKESHI YONEYAMA, KENJI EGUCHI, HIR ...1978 Volume 124 Issue 2 Pages 145-151
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSOne hundred and six patients having adenocarcinoma of the lung were studied by whole body bone scanning with 99mTc-phosphates in connection with their clinical stages. Abnormal accumulation was found in 64 patients (60%). There were 64 patients who received surgical treatment. Among these 64 patients, 38 underwent bone scanning within 3 months after the establishment of their clinical stages. Twenty-two of them were classified as Stage I clinically. Pathological stage classification after the surgery revealed these 22 to be classified into 3 groups; 6 for Pathological Stage I, 4 for Pathological Stage II and 12 for Pathological Stage III. None of these 6 in Stage I showed abnormal accumulations. However, 1 of 4 in Stage II and 6 of 12 in Stage III were found to have abnormal accumulations. Therefore, if bone scintigrams had been taken into consideration for clinical stage classification, 7 patients would have never been placed into Clinical Stage I and could be expected more precise treatment. The authors recommend application of the results of whole body bone scanning to stage classification of adenocarcinoma of the lung. Needle biopsy is also recommended to confirm the metastasis at the site of radioisotope accumulation in the rib.View full abstractDownload PDF (764K) -
TAKAO KUNORI, TETSURO NISHIHIRA, MASAKI TAN, EIAKI TSUTSUMI, MORIO KAS ...1978 Volume 124 Issue 2 Pages 153-159
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSReactive lymphocyte blastogenesis was investigated by 3H-thymidine uptake of peripheral lymphocytes. Canine renal allotransplantations were performed in 19 dogs, which were divided into three groups by different immunosuppressive therapies. The first group, not treated with any im-munosuppressants, showed the highest 3H-thymidine uptake, but the third group, treated with prednisolone (1.5mg/kg/day) and azathioprine (4mg/kg/day), did not show remarkable 3H-thymidine uptake except for 2 dogs which died of severe acute rejection. Single use of prednisolone (second group) was less effective in suppression of blastogenesis compared with the combined use of azathioprine and prednisolone. In addition to these experiments, the effects of surgical operation, blood transfusion, and infection on lymphocyte blastogenesis were investigated. Renal autotransplantation did not produce remarkable blastogenesis, but blood transfusion and infection caused strong lymphocyte blastogenesis. Periodical increases in 3H-thymidine uptake were observed in the infected animal.View full abstractDownload PDF (373K) -
TAKAO KUNORI, TETSURO NISHIHIRA, MASAKI TAN, YOSHIO TAGUCHI, EIAKI TSU ...1978 Volume 124 Issue 2 Pages 161-168
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSImmunopathological investigations of the small round cells infiltrating into the tissues of human renal allografts and also those in urinary sediments were performed, using anti-human T-lymphocyte serum (AHTS). AHTS made from ALS is highly specific for T cells, but not for B cells. Tissues obtained by needle biopsy were examined by immunofluorescent staining and conventional histopathological methods. Urinary sediments were obtained from centrifugated fresh urine. Sediments were checked by immunofluorescent and Giemsa staining. Fluorecent positive cells were seen in the interstitial tissues and occasionally in renal glomeruli. Clustered cell-debris in the lumen of renal tubules was also stained by AHTS. In the urinary sediments, about a half of the lymphoid cells were stained by AHTS. The relationship between lymphocyturia and numerous infiltrating cells in the grafts during the rejection crisis has not been clarified. In this experiments, we tried to identify the detailed process of excretion of T cells to urine from renal tissues, using immunopathological methods.View full abstractDownload PDF (3181K) -
HIKARU WATANABE1978 Volume 124 Issue 2 Pages 169-176
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSResults of cytological examination in 120 cases of colon and rectum cancer during the 11-year period ending in 1968 prior to the practical use of fibercolonoscope were first studied. At that time, quite favorable results were obtained in cancer of the lower colon and the rectum, but the results were not so satisfactory in cancer of the right side of the colon. After 1969 when the fibercolonoscope was introduced into the clinical practice, the range of cytological diagnosis under direct vision was at once expanded to the entire colon. Consequently, diagnosis by the cytological method in 140 cases of cancer of the colon and rectum experienced in 6-year period between 1969 and 1974 revealed favorable results. The results of the cytological diagnosis in cancer of the right side of the colon, previously not always favorable, improved markedly after the introduction of the cytological method under direct vision through fibercolonoscope. When early cancer of the colon and rectum is defined as in early gastric cancer, 40 lesions in 36 patients were detected during the past 19 years. The rate of positive result in cases of early cancer obtained by various diagnostic methods was 83% by the cytological method, 78% by biopsy and 91% by polypectomy. In cases in which both biopsy and cytological method were used, one or both frequently gave positive results. These results would indicate the possibility of correct diagnosis in many cases through the combined use of the cytological method and biopsy, without polypectomy.View full abstractDownload PDF (472K) -
KEN SAITO, NORIYUKI IWAMA, TOHRU TAKAHASHI1978 Volume 124 Issue 2 Pages 177-186
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSeven pancreases from nondiabetic autopsy cases were submitted to morphometrical analysis of the islets of Langerhans as a preliminary investigation of the diabetic pancreas. The pancreatic islets were approximately simulated by spheres of different sizes randomly dispersed in the three-dimensional space; thereon the parameters of Weibull function assumed for the distribution of islet radii were estimated stereologically from chord length measurements on histologic sections taken from different portions of the pancreas. By means of the estimated parameters topographical comparison of the number, volume, mean radius and size distribution of islets in a unit volume was performed. The islet distribution appeared to change the pattern gradually according to the position from the pancreatic head to the tail: the head was characterized by abundance of small islets that corresponded to a slightly higher islet population thereat, whereas the tail by moderate increase of larger islets that caused a steep increase of islet volume here. To estimate parameters for the whole pancreas a histologic section from a range between the midposition of the pancreas and the one-fourth position from the splenic end was regarded to be a fairly good representative.View full abstractDownload PDF (1854K) -
TAKASHI MATSUSHIRO, NOBUYUKI KOBAYASHI, NORIYOSHI SUZUKI, HIDEMI YAMAU ...1978 Volume 124 Issue 2 Pages 187-196
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBy oral administration of chenodeoxycholic acid (CDCA) varying in dose for 7 consecutive days to patients who underwent cholecystectomy with biliary drainage for cholesterol gallstone, the biliary cholesterol dissolubility was studied in pursuit of the optimum dose in CDCA therapy for cholesterol gallstone. The rate of dissolution of biliary cholesterol by CDCA administration was highest in cases of 250mg/day in dose, followed by those of 750mg/day. When the dose was observed from per kg of body weight, the dissolubility of cholesterol was highest in the case of 6.3mg/kg, followed by one of 12mg/kg. Thus, it is presumed that in CDCA therapy for cholesterol gallstone a dose of 250mg/day is too small and 750mg/day too large in amount from the viewpoint of its effectiveness. The optimum dose probably lies between 5mg/kg and 12mg/kg. A transient elevation in levels of SGOT and SGPT was observed only in one case treated with 750mg/kg.View full abstractDownload PDF (565K)
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