We studied the effects of various diets for the treatment of diabetic rats induced by alloxan administration. The progress of diabetic symptoms was improved favorably in the group of standard diet but deteriorated both in the glucose tolerance and histological studies in the group of high-protein high-fat diet. The changes of the adrenal cortex such as the thickening of the fascicular layer and the distinction between the light and dark cells in it and that of the pituitary such as the increase in number of small sized basophilic cells shown in the rats fed with high-protein high-fat diet were parallel with a decreased glucose tolerance. Therefore, the dietary system containing three main food stuffs in well-balanced propotion as our standard diet is superior to others in the treatment of diabetic animals induced by alloxan administration.
1. Aqueous extracts of the gastric carcinoma tissues inhibited the growth of Paramecium more intensely than those of the normal gastric mucosae. 2. A carbohydrate fraction and a basic substance of low molecular weight were responsible for this effect. 3. Intensity of the inhibitory effect of the cancerous extract was not dependent upon the nature of the tumor from which the extract had been prepared.
Silicosis, as Aschoff16) has classed it in his text-book, is an “Abkapselnde Entzündung” (encapsulating inflammation) caused by aseptic foreign bodies and represents a mesenchymal defence reaction. In the case when a granuloma is led toward formation of a typical hyaline nodule, the differentiation of the mesenchyma into capillary endothelium seems to be inhibited. The granuloma formed in the arterial wall hampers the nutritional plasma flow and thus causes the formation of the specific hyaline nodule. In this case, whether a detention of dust by collagen is postulated or not, the situation is certainly unfavorable to coalescence and the description Abkapselung (encapsulation) may be rightly applied. The acute silicosis cases apparently show an exaggerated picture of the formation of coalesced foci, and in such cases, another phlogogenic factor besides SiO2 seems to have come into play, causing a prosperous proliferation of granulation tissues and the characteristic feature of “encapsulation” above may be said severely injured. When tuberculous infection comes into combination, the caseation of the inflammation granulation brings about a peculiar pathological picture.
1. Suzuki's mucoid and a mucopolysaccharide made up chiefly of acetylglucosamine, galactose and sulfuric acid were isolated in an electro-phoretically pure state from bull cornea and examined physically and chemically. 2. Analyses disclosed that the carbohydrate moiety of the mucoid is composed of acetylglucosamine, galactose and sulfuric acid in the molecular proportions of 1:1:0.5, which was substantiated on the moiety separated after digestion with pepsin and trypsin of the mucoid. 3. The mucopolysaccharide existing as a chemical entity in the cornea contains acetylglucosamine, galactose and sulfuric acid in the molecular proportions of 1:1:1. 4. The glucidamins from chondro- and osseomucoid and cornea-mucoid contain most probably the same carbohydrate in the molecule. 5. It is concluded that Meyer's preparation of “keratosulfate” was a mixture of the mucopolysaccharide as a digestion product of cornea mucoid and the above free mucopolysaccharide in cornea, which differ from each other in hydrolyzable sulfur content as expressed in molecular proportion to acetylglucosamine or galactose.
1) Polarographic behaviours of solutions containing 500-800 γ in 6.0 cc. of the urinary mucoprotein fraction adsorbable to benzoic acid (Kaketa fraction) of cancerous, inflammatory or normal urine were compared with one another. And an index signifying the ratio in height of the wave at about -1.2 mV to that at about -1.6 mV has been proposed for rough diagnosis whether the individual suffers either cancer or inflammation or is normal, although it can not be availed for strict sense. 2) The indices of urinary KIK-active and KIK-inactive toxohor-mones of cancerous urine and those of the corresponding normal urine components resemble the corresponding indices of cancerous and normal Kaketa fractions respectively. 3) Polarographic behaviours of various derivatives of Kaketa fractions were also compared with one another. Noticeable finding was that treatment with monoiodoacetate gives rise to wave-heightening in the cancerous fraction and to wave-lowering in the inflammatory and normal fractions. 4) Pursuing the polarographically active factors in whole urine by anion-exchange chromatography, a remarkably active fragment was obtained, though its position in the chromatogram was nearly the same regardless whether the urine was cancerous, inflammatory or normal.