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Volume 163 (1991)
- Issue 4 Pages 233-
- Issue 3 Pages 149-
- Issue 2 Pages 77-
- Issue 1 Pages 1-
Volume 163, Issue 3
Displaying 1-9 of 9 articles from this issue
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HIDEAKI KONO, YOUNG CHIN LIN, YAN GU, MAMORU YAMAGUCHI, FREDERICK P. Z ...1991 Volume 163 Issue 3 Pages 149-156
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKONO, H., LIN, Y.C., GU, Y., YAMAGUCHI, M., ZUSPAN, F.P., FURUHASHI, N., TAKAYAMA, K. and YAJIMA, A. Gossypol Effects on Monoamine Oxidase (MAO) Activity in Several Organs of Term Rats. Tohoku J. Exp. Med., 1991, 163 (3), 149-156 - In order to study the effect of gossypol on the monoamine oxidase (MAO) activity in pregnant rat organs, 20 day pregnant rats were sacrificed, and MAO activity/0.02g tissue of several organs and total MAO activity/organ, were determined. The control group (n=5) were injected with vehicle intramuscularly on the 17th, 18th and 19th day of pregnancy, and the gossypol treated group (n=4) were injected with gossypol acetic acid (GAA) (25mg/kg of body weight) intramuscularly on the 17th, 18th and 19th day and were decapitated on the 20th day of pregnancy. Maternal liver, uterus, placenta, and fetal liver were collected and examined. In placenta, total MAO activity/organ was significantly (p<0.05) lower in the GAA treated group than that in the control group. However, in maternal liver, uterus and fetal liver, there was no significant difference in total MAO activity/organ between the two groups. There was no significant difference in MAO activity/0.02g tissue (specific activity), weight of organ, protein weight/organ and protein/g tissue between the two groups in maternal liver, uterus, placenta and fetal liver. These results suggest that, after intramuscular injection of GAA, total MAO activity/organ in the placenta of pregnant rats might decrease significantly.View full abstractDownload PDF (765K) -
HIDEKI WANIBUCHI, TERUO FUJIMOTO, MAKIKO UEDA1991 Volume 163 Issue 3 Pages 157-165
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWANIBUCHI, H., FUJIMOTO, T. and UEDA, M. Accelerated Glomerulosclerosis in Alooxan-Induced Diabetic Rabbits with Anti-Glomerular Basement Membrane Nephritis. Tohoku J. Exp. Med., 1991, 163 (3), 157-165 - To find how diabetes affects the processes of proliferative glomerulitis, we induced anti-glomerular basement membrane (GBM) nephritis by injection of anti-GBM antiserum in rabbits with alloxan diabetes (the DM-GN group) and in rabbits without the diabetes (the GN group), and compared the glomerular lesions between the two groups. Rabbits with alloxan diabetes only (the DM group) were also studied as control. Morphological examination showed that in the acute phase, the DM-GN and GN groups underwent histolysis of the glomerular loops, which gave rise to proliferative glomerulitis. In the later stages of glomerulitis, proliferating cells were crowded toward the axial portion of glomerular loops with an increase of intercellular matrix, and glomerular capillaries in the periphery of the glomerular loops recanalized. The amount of intercellular matrix of the axial portion increased more in the DM-GN group than in the GN group. Some of the glomerular lesions in the DM-GN group showed a formation of large nodules. The results suggested that diabetes could accelerate the formation of the intercellular matrix of glomerular loops in proliferative glomerulitis in rabbits, resulting in accelerated glomerulosclerosis.View full abstractDownload PDF (3893K) -
TOMOYUKI YAMBE, SHIN-ICHI NITTA, SHIGEKI CHIBA, YOSHIFUMI SAIJOH, SHIG ...1991 Volume 163 Issue 3 Pages 167-174
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMBE, T., NITTA, S., CHIBA, S., SAIJOH, Y., NAGANUMA, S., AKIHO, H., KAKINUMA, Y., IZUTSU, K., KIKUCHI, Y., NAGANUMA, T., SUGAWARA, S., TANAKA, M., MEGURO, T., SASAKI, H., MITSUOKA, M., TERASAWA, Y., NITTA, K., KATAHIRA, Y., OHTOMO, T., ENDOH, N., TAKEDA, H., SONOBE, T., TAKAHASHI, K., MIURA, M., SATO, N. and MOHRI, H. Silent Obstruction of the Coronary Stenosis between Diagnostic Angiography and Later Percutaneous Transluminal Coronary Angioplasty without Myocardial Infarction. Tohoku J. Exp. Med., 1991, 163 (3), 167-174 - Among 204 patients with severe coronary artery senosis amenable to percutaneous transluminal coronary angioplasty (PTCA), 5 (2.5%) developed new silent total coronary occlusion of the vessel to be dilated without any chest symptom during the period between diagnostic coronary angiography and repeat coronary angiography at the time of the operation. We evaluated the clinical and angiographical characteristics of the patients with silent obstruction of the coronary artery in a short time, compared with the patients with unstable angina pectoris, who is considered to be suffering from acute myocardial infarction with severe chest symptom. None of the clinical variables studied showed a significant difference between the two groups. Among the angiographic variables, the degree of collateral was higher and impaired coronary perfusion distal to the lesion was more frequently found in unstable angina group. These results suggest that unstable angina is in a later stage of the ischemic heart disease compared with the time of the diagnostic angiography in patients with silent obstruction. Silent obstruction of high degree coronary stenosis is presumably due to the development of collateral circulation.View full abstractDownload PDF (1398K) -
YUUICHI INOUE, SHIGERU KOHNO, TAKASHIGE MIYAZAKI, KEIZOU YAMAGUCHI1991 Volume 163 Issue 3 Pages 175-185
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSINOUE, Y., KOHNO, S., MIYAZAKI, T. and YAMAGUCHI, K. Effect of a Platelet Activating Factor Antagonist and Antithrombin III on Septicemia and Endotoxemia in Rats. Tohoku J. Exp. Med., 1991, 163 (3), 175-185 -Disseminated intravascular coagulation (DIC) or renal damage associated with septicemia was induced in rats by ligating the cecum or by injecting endotoxin. In the septicemia model, the number of E. coli and Bacteroides spp in the blood increased concomitantly with an increase of endotoxin. In this model the development of hypercoagulability with mild fibrinolysis was observed. Histopathologic findings in the kidneys, including the formation of microthrombi in the glomeruli and the vacuolization and dilatation of renal tubular cells, suggest the development of mild DIC. In the endotoxin-induced DIC model, both remarkable state of hypercoagulability and fibrinolysis were observed with fibrin thrombi in glomeruli. The administration of the platelet-activating factor antagonist, CV-6209, or of human antithrombin III, ameliorated DIC significantly by limiting the increases in prothrombin time, activated partial thromboplastin time and fibrin degradation products. These agents significantly reduced the deposition of fibrin in the glomeruli and significantly prolonged the survival time of the endotoxin injected rats. These observations suggest that the PAF antagonist CV-6209 and ATIII merit clinical evaluation in the management of DIC caused by septicemia.View full abstractDownload PDF (2078K) -
MASARU SHOJI, TOKIHISA KIMURA, KOZO OTA, MINORU INOUE, KAZUTOSHI SATO, ...1991 Volume 163 Issue 3 Pages 187-197
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSHOJI, M., KIMURA, T., OTA, K., INOUE, M., SATO, K., OHTA, M., YAMAMOTO, T., ABE, K. and YOSHINAGA, K. Responses of Atrial Natriuretic Peptide, Vasopressin, Aldosterone and Renal Function to Intracerebroventricular Infusion of Angiotensin II in Dogs. Tohoku J. Exp. Med., 1991, 163 (3), 187-197 - To assess the mechanisms how angiotensin II (Ang II) given intracerebroventricularly (i.e. v.) induces natriuresis, the effects of Ang II (10ng/kg/min, for 30min) on the renin-angiotensin-aldosterone system, the release of vasopressin (AVP) and atrial natriuretic peptide (ANP) and on cardiovascular and renal functions were investigated in anesthetized dogs. In control dogs, vehicle alone (artificial cerebrospinal fluid) was infused at a rate of 10μl/min. Ang II given i.c.v, produced a gradual increase in urine flow, urinary sodium and potassium excretion and osmolar clearance, but had no effect on plasma ANP, aldosterone, arterial blood pressure, and renal blood flow. However, i.c.v. Ang II increased plasma AVP and decreased heart rate, plasma renin activity, inulin clearance and filtration fraction. In the cotrol group, vehicle treatment had no effect on these parameters except for decreases in inulin clearance and filtration fraction. These results suggest that circulating ANP and blood pressure may not play an important role in i.c.v. Ang II-induced natriuresis, but increased AVP release and decreased renal sympathetic nervous activity may contribute to the natriuresis.View full abstractDownload PDF (979K) -
SEIKI MATSUNO, YUKINORI SASAKI, MASAO KOBARI, KAZUNORI TAKEDA, RYUJI N ...1991 Volume 163 Issue 3 Pages 199-210
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMATSUNO, S., SASAKI, Y., KOBARI, M., TAKEDA, K., NAKAMURA, R. and RAHMAN, M.M. Initial Pathophysiological Changes in Chronic Pancreatitis Induced by Pancreatic Ductular Obstruction Model. Tohoku J. Exp. Med., 1991, 163 (3), 199-210 -An experimental chronic pancreatitis model was made in five dogs with chronic pancreatic fistula by injection of microspheres into the peripheral pancreatic duct. Sequential changes of pancreatic exocrine and endocrine functions with morphology were studied. Significant decreases in volume, bicarbonate output and amylase output were detected in each sample collected separately on secretin and secretin cerulean stimulation. While the viscosity of pancreatic juice was significantly increased with a concomitant increase in hexosamine concentration, chronic pancreatitis was demonstrated morphologically. These results suggest that concentrated pancreatic juice caused by a decrease in volume and an increase in viscosity of pancreatic juice with a concomitant increase in hexosamine concentration brings about the progression of chronic pancreatitis in this experimental model.View full abstractDownload PDF (2325K) -
KEIICHIRO MATSUNAGA, TAKAKO KAWAI, KIYOSHI KATO, KENJI TANI, TAKAO OHK ...1991 Volume 163 Issue 3 Pages 211-218
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMATSUNAGA, K., KAWAI, T., KATO, K., TANI, K. and OHKUBO, T. Antimyosin Antibodies in CNS-Lupus. Tohoku J. Exp. Med., 1991, 163 (3), 211-218 -Anti-myosin antibodies (AMA) in the sera of patients with systemic lupus erythematosus (SLE) and healthy subjects were measured by ELISA. AMA were IgM dominant. The titers of AMA were significantly higher in active SLE than in inactive SLE and healthy subjects. AMA negative SLE patients have significantly lower serum IgM than that in AMA positive subjects. Frequency analysis of HLA antigens in SLE revealed that AMA positivity was associated with HLA-A11, AMA negativity with HLA-B40 and DR2, and those with central nervous system involvement (CNS-SLE) were associated with HLA-B40. The patients with CNS-SLE have low serum IgM, low titer of AMA and HLA-B40.View full abstractDownload PDF (581K) -
MINORU YASUJIMA, KEISHI ABE, MASAYUKI KANAZAWA, KAZUNORI YOSHIDA, MASA ...1991 Volume 163 Issue 3 Pages 219-227
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYASUJIMA, M., ABE, K., KANAZAWA, M., YOSHIDA, K., KOHZUKI, M., TAKEUCHI, K., TSUNODA, K., KUDO, K., HIWATARI, M., SATO, T. and YOSHINAGA, K. Antihypertensive Effect of Captopril and Enalapril in Endothelin-Infused Rats. Tohoku J. Exp. Med., 1991, 163 (3), 219-227 - Comparative effects of angiotensin converting enzyme inhibitors and calcium channel blockers were assessed in rats infused chronically with synthetic endothelin. When 50mg/kg/day of captopril orally or 6mg/kg/day of enalapril intraperitoneally was administered simultaneously with 60μg/kg/day of endothelin, the systolic blood pressure was on Day 1142.7±5.9mmHg (p<0.05) or 128.7±6.7mmHg (p<0.05), respectively, compared to the rise to 163.8±4.7mmHg when endothelin alone was infused. The antihypertensive effect of captopril or enalapril was sustained for the entire experimental period and was not associated with a significant change in urinary sodium excretion, whereas both drugs induced a significant increase in urine volume. Chronic infusion of angiotensin II intraperitoneally at a subpressor dose (400μg/kg/day) reversed the antihypertensive effect of captopril in endothelin-infused rats. When 6mg/kg/day of benidipine or 10mg/kg/day of nilvadipine orally was administered simultaneously with 60μg/kg/day of endothelin, the systolic blood pressure was on Day 1137.0±2.4mmHg (p<0.05) or 119.7±5.9mmHg (p<0.05), respectively, compared to the rise when endothelin alone was infused. The antihypertensive effect of benidipine or nilvadipine was sustained for the entire experimental period and was not associated with any significant changes in urine volume and urinary sodium excretion. These results indicate that the reduced sensitivity of the peripheral arteries to endothelin may be involved in the mechanism of the hypotensive action of angiotensin converting enzyme inhibitors, dependent on the suppressed angiotensin II formation.View full abstractDownload PDF (909K) -
HIROMI WATANABE, TACHIO SATO, TAKASHI HISINUMA, YUKO OGATA1991 Volume 163 Issue 3 Pages 229-231
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, H., SATO, T., HISHINUMA, T. and OGATA, Y. Comparison of MRI, CT and Bone Scintigraphy in Metastases of Experimental Neoplasm. Tohoku J. Exp. Med., 1991, 163 (3), 229-231 - We compared MRI, CT and bone scintigraphy in the examination of experimentally produced metastatic bone tumors. Three Japanese white rabbits with VX-2 bone tumor were used. T1 weighted (T1W) and T2 weighted (T2W) images were obtained in each MRI examination. All the tumors distributed from the bone marrow to the extraosseous region. T2W images were the best to detect the extraosseous tumors. CT was the best to detect the destructions of bone. T1W and T2W images equally detected the invaded bone marrow. Bone scintigraphy detected all the lesions but could not distinguish the lesions of bone marrow, bone and extraosseous regionsView full abstractDownload PDF (469K)
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